ExchangeSeed-ATP

Reaction 2-ISOPROPYLMALATESYN-RXN

• ec-number:
  • ec-2.3.3.13
• direction:
  • left-to-right
• common-name:
  • pyruvate carboxyltransferase

Reaction formula

• 1 2-KETO-ISOVALERATE[c] + 1 ACETYL-COA[c] + 1 WATER[c] => 1 3-CARBOXY-3-HYDROXY-ISOCAPROATE[c] + 1 CO-A[c] + 1 PROTON[c]

Gene(s) associated with this reaction

• Gene: FSU_RS00040
  • Category: orthology
    • Source: ecoli, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: bifidobacterium, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: faecalibacterium, Tool: orthofinder, Assignment: n.a, Comment: n.a
• Gene: FSU_RS13820
  • Category: annotation
    • Source: fibrobacter_succinogenes1, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: ecoli, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: bifidobacterium, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: faecalibacterium, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: bthetaiotaomicron, Tool: orthofinder, Assignment: n.a, Comment: n.a
• Gene: FISUC_RS11850
  • Category: annotation
    • Source: fibrobacter_succinogenes2, Tool: pathwaytools, Assignment: ec-number, Comment: n.a

Pathway(s)

• PWY-6871, 3-methylbutanol biosynthesis (engineered):
  • 6 reactions found over 7 reactions in the full pathway
• LEUSYN-PWY, L-leucine biosynthesis:
  • 6 reactions found over 6 reactions in the full pathway

Reconstruction information

• category: orthology; source: ecoli; tool: orthofinder; comment: n.a
• category: orthology; source: bthetaiotaomicron; tool: orthofinder; comment: n.a
• category: orthology; source: bifidobacterium; tool: orthofinder; comment: n.a
• category: orthology; source: faecalibacterium; tool: orthofinder; comment: n.a
• category: annotation; source: fibrobacter_succinogenes1; tool: pathwaytools; comment: n.a
• category: annotation; source: fibrobacter_succinogenes2; tool: pathwaytools; comment: n.a

External links

• RHEA:
  • 21525
• LIGAND-RXN:
  • R01213
• UNIPROT:
  • P06208
  • Q58595
  • P09151
  • Q9PLV9
  • Q9JUK6
  • Q58787
  • P94565
  • Q9JP75
  • Q02141
  • P48575
  • O86511