RXN-8991

Reaction RXN-8991

• common-name:
  • 3-isopropylmalate dehydratase
• direction:
  • reversible
• synonymous:
  • (2r,3s)-3-isopropylmalate hydro-lyase
  • β-isopropylmalate dehydratase
  • 3-isopropylmalate hydro-lyase
  • α-isopropylmalate isomerase

Reaction formula

• 1 2-D-THREO-HYDROXY-3-CARBOXY-ISOCAPROATE[c] <=> 1 CPD-9451[c] + 1 WATER[c]

Gene(s) associated with this reaction

• Gene: FISUC_RS00340
  • Category: annotation
    • Source: fibrobacter_succinogenes2, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: FISUC_RS00345
  • Category: annotation
    • Source: fibrobacter_succinogenes2, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: FSU_RS02210
  • Category: annotation
    • Source: fibrobacter_succinogenes1, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: ecoli, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: bifidobacterium, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: faecalibacterium, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: bthetaiotaomicron, Tool: orthofinder, Assignment: n.a, Comment: n.a
• Gene: FSU_RS02215
  • Category: annotation
    • Source: fibrobacter_succinogenes1, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: ecoli, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: bifidobacterium, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: faecalibacterium, Tool: orthofinder, Assignment: n.a, Comment: n.a
    • Source: bthetaiotaomicron, Tool: orthofinder, Assignment: n.a, Comment: n.a

Pathway(s)

• PWY-6871, 3-methylbutanol biosynthesis (engineered):
  • 6 reactions found over 7 reactions in the full pathway
• LEUSYN-PWY, L-leucine biosynthesis:
  • 6 reactions found over 6 reactions in the full pathway

Reconstruction information

• category: orthology; source: ecoli; tool: orthofinder; comment: n.a
• category: orthology; source: bthetaiotaomicron; tool: orthofinder; comment: n.a
• category: orthology; source: bifidobacterium; tool: orthofinder; comment: n.a
• category: annotation; source: fibrobacter_succinogenes2; tool: pathwaytools; comment: n.a
• category: annotation; source: fibrobacter_succinogenes1; tool: pathwaytools; comment: n.a
• category: orthology; source: faecalibacterium; tool: orthofinder; comment: n.a

External links

• RHEA:
  • 10676
• LIGAND-RXN:
  • R04001