Chondrus 1.3

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 <model substanceUnits="mole" timeUnits="second" extentUnits="mole">
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       <geneAssociation id="ga_6" reaction="R_PHOSCHOL__45__RXN">
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       <geneAssociation id="ga_10" reaction="R_HISTIDINE__45__AMMONIA__45__LYASE__45__RXN">
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smiles: Nc1c(N[C@@H]2O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]2O)[nH]c(=O)[nH]c1=O

mass: 352.1958

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smiles: O*

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smiles: [O-]P([O-])(=O)OC([*])=O

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inchikey: VKOBVWXKNCXXDE-UHFFFAOYSA-M

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inchikey: UYOKHWFEUAJFMG-UIYHDVLFSA-J

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inchikey: XZKIHKMTEMTJQX-UHFFFAOYSA-L

smiles: [O-][N+](=O)c1ccc(OP([O-])([O-])=O)cc1

mass: 217.0739

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inchikey: CSCPPACGZOOCGX-UHFFFAOYSA-N

smiles: CC(C)=O

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inchikey: NIXOWILDQLNWCW-UHFFFAOYSA-M

smiles: [O-]C(=O)C=C

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smiles: CC(C)=CCNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)O*)[C@@H](OP([O-])(=O)O*)[C@H]1O

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mass: 1387.2027

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mass: 967.813

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smiles: CC(=O)NCCCC[C@H]([NH2+]*)C(*)=O

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smiles: COc1c(oc2cc([O-])cc(O)c2c1=O)-c1ccc(O)cc1

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smiles: CC(=O)S[*]

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smiles: C[NH2+]CCCC[C@H]([NH2+]*)C(*)=O

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inchikey: CWYNVVGOOAEACU-UHFFFAOYSA-N

smiles: [Fe++]

mass: 55.844

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inchikey: CQGVNMQHZQJNII-UUSBZYPOSA-J

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mass: 915.738

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inchikey: GZIFEOYASATJEH-VHFRWLAGSA-N

smiles: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2cc(O)cc(C)c2O1

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inchikey: WMNWNRKMANJLHY-LFZQUHGESA-J

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inchikey: UHDGCWIWMRVCDJ-XVFCMESISA-N

smiles: Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1

mass: 243.2166

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inchikey: HHMKVXGZZUOMHM-XZRWTQCASA-L

smiles: CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])([O-])=O)OC(=O)CCCCCCC\C=C/CCCCCCCC

mass: 700.967

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inchikey: UNSKJTNUDHVNJT-PVMVIUQGSA-K

smiles: COC(=O)[C-]1C(=O)c2c(C)c3C=C4C(C=C)=C(C)C5=[N+]4[Mg--]46n3c2C1=C1[C@@H](CCC([O-])=O)[C@H](C)C(C=c2c(C)c(C=C)c(=C5)n42)=[N+]61

mass: 610.943

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smiles: [NH3+][C@@H]([*])C([O-])=O

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inchikey: PGAVKCOVUIYSFO-XVFCMESISA-J

smiles: O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)n1ccc(=O)[nH]c1=O

mass: 480.1115

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inchikey: VCKPUUFAIGNJHC-LURJTMIESA-N

smiles: Nc1c(O)cccc1C(=O)C[C@H]([NH3+])C([O-])=O

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mass: 766.1659

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smiles: SC[C@H]([NH2+]*)C(*)=O

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inchikey: GUBGYTABKSRVRQ-QUYVBRFLSA-N

smiles: OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O

mass: 342.2965

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inchikey: HXXFSFRBOHSIMQ-SXUWKVJYSA-L

smiles: OC[C@@H]1O[C@H](OP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@@H]1O

mass: 258.121

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smiles: CC(=O)N[C@@H]1[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO[C@H]4O[C@H](CO[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H]4O)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H]3O)[C@H](O)[C@H]2NC(C)=O)[C@@H](CO)O[C@H]1NC(=O)C[C@H](N*)C(=O)O*

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       <notes>
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smiles: CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@H](O[C@H]2O[C@H](CO)[C@H](O)[C@H](OS(O)(=O)=O)[C@H]2O)[C@H](O)[C@H]1O)NC([*])=O

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inchikey: LFQSCWFLJHTTHZ-UHFFFAOYSA-N

smiles: CCO

mass: 46.0684

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       <notes>
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inchikey: VMQMZMRVKUZKQL-UHFFFAOYSA-N

smiles: [Cu+]

mass: 63.545

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inchikey: PIUSLWSYOYFRFR-BQBZGAKWSA-M

smiles: [NH3+][C@@H](CCC(=O)N[C@@H](CSCO)C(=O)NCC([O-])=O)C([O-])=O

mass: 336.342

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smiles: CC(C[*])C(O)C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

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inchikey: FBWPWWWZWKPJFL-QMMMGPOBSA-N

smiles: COc1cc(ccc1O)[C@@H](O)CO

mass: 184.1892

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inchikey: REJJDEGSUOCEEW-RGGAHWMASA-J

smiles: CC1=C(CCC([O-])=O)C2=N\C\1=C/c1c(C)c(C=C)c3\C=C4/N=C(/C=c5/c(C)c(CCC([O-])=O)\c(=C\2)n5[Mg]n13)C(C=C)=C4C

mass: 582.932

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inchikey: PAWSVPVNIXFKOS-IHWYPQMZSA-N

smiles: [H]C(C)=C([NH3+])C([O-])=O

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smiles: [H]C(=O)CCCCCCCCCCC

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mass: 1578.5222

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inchikey: UFZDIMBXTVRBDS-SSQLMYNASA-N

smiles: CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CCC(C)=CCc1cc(O)c2ccccc2c1O

mass: 636.9885

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smiles: [NH3+]CCC[C@H](NC(=O)CC[C@H]([NH2+]*)C([O-])=O)C([O-])=O

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mass: 806.899

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smiles: [NH3+][C@@H](CO)C(*)=O

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smiles: CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])([O-])=O)OC(=O)CCCCCCCCCCCCC

mass: 590.7702

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mass: 611.95

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smiles: [H][C@]12CS[C@@H](CCCCC([O-])=O)[C@@]1([H])NC(=O)N2

mass: 243.303

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smiles: Cc1c(CCO)sc[n+]1Cc1cnc(C)nc1N

mass: 265.354

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mass: 412.6908

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inchikey: ZWEHNKRNPOVVGH-UHFFFAOYSA-N

smiles: CCC(C)=O

mass: 72.1057

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mass: 828.7183

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inchikey: ROSDSFDQCJNGOL-UHFFFAOYSA-O

smiles: C[NH2+]C

mass: 46.0911

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smiles: OC[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO

mass: 182.1718

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smiles: [*]C#N

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smiles: COc1cc(O)cc(CC=C(C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)c1O

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smiles: O[C@@H]1[C@@H](O)[C@H](O*)[C@@H](O[C@H]1O*)C([O-])=O

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smiles: CSCC[C@H](NC(C)=O)C([O-])=O

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smiles: CC(C)(O)[C@@H](O)C([O-])=O

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inchikey: XENHPQQLDPAYIJ-PEVLUNPASA-M

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smiles: CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])([O-])=O)OC([*])=O

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inchikey: NYZPDFUAZACYOT-PEAQSEFFSA-J

smiles: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

mass: 1056.004

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smiles: CSCC[C@H]([NH3+])C(=O)NCC(*)=O

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inchikey: KRIFZIRXAAITHR-KWFBMMABSA-J

smiles: CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

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inchikey: RKCOGGUHKPTOQJ-GNSUAQHMSA-J

smiles: CCCCCCCCCCCCCCCCCCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

mass: 1100.056

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smiles: [H]C([H])(O)[*]

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smiles: [O-]C([*])=O

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smiles: *NCC(=O)SCC(N*)C(*)=O

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inchikey: SBZWTSHAFILOTE-SOUVJXGZSA-N

smiles: O[C@H]1[C@@H](O)c2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1

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inchikey: GPNCBCJEDRRCDW-ACUQGRCXSA-I

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mass: 1620.8466

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inchikey: UINJNTYCVLNGTJ-YRMVCPMJSA-J

smiles: CCCCCCCCCC=CC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

mass: 985.828

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inchikey: NIPZZXUFJPQHNH-UHFFFAOYSA-M

smiles: [O-]C(=O)c1cnccn1

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inchikey: DCXYFEDJOCDNAF-REOHCLBHSA-N

smiles: NC(=O)C[C@H]([NH3+])C([O-])=O

mass: 132.1179

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inchikey: IISWKVFHQLAOMW-BTFUZUOASA-I

smiles: CC(C)(COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCCC\C=C/CCCCCCCC([O-])=O

mass: 1056.926

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inchikey: BEPLLRGJVXAEJI-TWAFKMGKSA-J

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mass: 985.828

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mass: 564.287

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mass: 773.6605

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smiles: CC[NH3+]

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mass: 462.537

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smiles: C[Se]CC[C@H]([NH3+])C([O-])=O

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smiles: *NCC(=O)SC[C@H](N*)C(*)=O

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smiles: CCCCCC\C=C/CCCCCCCC([O-])=O

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inchikey: INAPMGSXUVUWAF-PTQMNWPWSA-L

smiles: O[C@H]1[C@H](O)[C@H](O)[C@H](OP([O-])([O-])=O)[C@@H](O)[C@@H]1O

mass: 258.121

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inchikey: DSLZVSRJTYRBFB-LLEIAEIESA-L

smiles: O[C@@H]([C@H](O)[C@@H](O)C([O-])=O)[C@H](O)C([O-])=O

mass: 208.124

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smiles: [F,Cl,Br,I]

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inchikey: LSNNMFCWUKXFEE-UHFFFAOYSA-L

smiles: [O-]S([O-])=O

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         <body xmlns="http://www.w3.org/1999/xhtml"/>
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inchikey: DZQLQEYLEYWJIB-UHFFFAOYSA-O

smiles: [H]C(=O)CCC[NH3+]

mass: 88.1278

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smiles: [O-]C(=O)CCC[*]

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inchikey: IWNWMTZIJPUDPV-MDQHZGBLSA-J

smiles: [H][C@@]12CCC(=O)[C@@]1(C)CCC(=O)[C@H]2CCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

mass: 983.769

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inchikey: SIKJAQJRHWYJAI-UHFFFAOYSA-N

smiles: c1cc2ccccc2[nH]1

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inchikey: NIUVHXTXUXOFEB-UHFFFAOYSA-J

smiles: Cc1c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc([nH]2)c1CCC([O-])=O)c(C)c5CCC([O-])=O)c(C)c4CCC([O-])=O)c(CCC([O-])=O)c3C

mass: 656.727

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inchikey: ANVAOWXLWRTKGA-JLTXGRSLSA-N

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mass: 536.8726

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inchikey: MRVDZOHJMLTLHJ-STFCKWFXSA-J

smiles: CCCCCCCC\C=C/CCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

mass: 971.844

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smiles: CCCCCCCCCCCCC\C=C\C([O-])=O

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smiles: SC[C@H]([NH2+]*)C(*)=O

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smiles: [O-]C(=O)C=Cc1ccccc1

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inchikey: WTDRDQBEARUVNC-LURJTMIESA-N

smiles: [NH3+][C@@H](Cc1ccc(O)c(O)c1)C([O-])=O

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inchikey: GRHBQAYDJPGGLF-UHFFFAOYSA-N

smiles: N=C=S

mass: 59.09

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smiles: Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)O*)[C@@H](OP([O-])(=O)O*)[C@H]1O

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mass: 580.6315

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mass: 447.421

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inchikey: OGAHROYMEOBORV-XONGILKKSA-J

smiles: [H][C@](O)(C(=O)NCCC(=O)NCCSC(=O)CC(=O)[C@@]1([H])[C@]2([H])CCC(=O)[C@@]2(C)CC[C@@]1([H])O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@@]1([H])O[C@@]([H])(n2cnc3c(N)ncnc23)[C@]([H])(O)[C@]1([H])OP([O-])([O-])=O

mass: 999.768

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smiles: SC[C@H]([NH2+]*)C(*)=O

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smiles: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O

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mass: 674.3783

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smiles: OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC[C@@H](COC([*])=O)OC([*])=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

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inchikey: FVOLNXKBISLPQY-IBGZPJMESA-O

smiles: CCCCCCCCCCCCCCCCCC(=O)[C@@H]([NH3+])CO

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mass: 461.3135

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inchikey: UFAXPZAZHZPELJ-ROTSUDQPSA-N

smiles: CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CCC(C)=CCc1cc(O)c2ccccc2c1O

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inchikey: RMRCNWBMXRMIRW-WZHZPDAFSA-L

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mass: 1355.3652

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smiles: [NH3+]CC(*)=O

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inchikey: NQYBQBZOHCACCR-UHFFFAOYSA-N

smiles: CC(C)CC(=O)c1c(O)c(CC=C(C)C)c(O)c(CC=C(C)C)c1O

mass: 346.4605

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mass: 961.806

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inchikey: ZSLZBFCDCINBPY-ZSJPKINUSA-J

smiles: CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

mass: 805.541

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smiles: [H]C1(CO[*])OC(CO)C([H])(COCC2([H])OC(CO)C([H])(C[*])C([H])(O)C2([H])O)C([H])(O)C1([H])O

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inchikey: PSBDWGZCVUAZQS-UHFFFAOYSA-N

smiles: C[S+](C)CC([O-])=O

mass: 120.17

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smiles: [Fe+]*

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smiles: COc1cc(O)c(C)c(CC=C(C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)c1O

mass: 835.3334

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inchikey: SNICXCGAKADSCV-JTQLQIEISA-O

smiles: [H][C@]1(CCC[NH+]1C)c1cccnc1

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       <notes>
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inchikey: OCLCLRXKNJCOJD-UMMCILCDSA-L

smiles: Nc1nc(=O)c(N)c(N[C@@H]2O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]2O)[nH]1

mass: 351.211

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smiles: CCCC(O)=CC(=O)S[*]

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inchikey: PQMCQNOVNFNPFJ-HYIMLASBSA-K

smiles: CC1=N[C@H](SC1=CCOP([O-])([O-])=O)C([O-])=O

mass: 264.174

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inchikey: HEJOXXLSCAQQGQ-CNUSVTAZSA-J

smiles: CCCCCC\C=C\CCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

mass: 1027.951

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inchikey: YGSDEFSMJLZEOE-UHFFFAOYSA-M

smiles: Oc1ccccc1C([O-])=O

mass: 137.1133

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smiles: [NH3+]CCCC=[NH+]CCCC[C@H](NC([*])=O)C(=O)N[*]

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inchikey: ZHZITDGOAFCURV-VVTKTIMZSA-N

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mass: 1152.9995

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smiles: CCCCCCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n1cnc2c(N)ncnc12

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smiles: OC[C@H](NC([*])=O)C(=O)N[*]

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smiles: NC(=O)CCCNC(N)=[NH2+]

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       <notes>
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SUBSYSTEM: PWY-5856 , PWY-5871 , PWY-6978

GENE_ASSOCIATION: (CHC_T00002263001_1)

CATEGORIES: ORTHOLOGY

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GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

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SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00001157001_1) or (CHC_T00009034001_1) or (CHC_T00007335001_1) or (CHC_T00010072001_1)

CATEGORIES: ORTHOLOGY

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GENE_ASSOCIATION: (CHC_T00005163001_1) or (CHC_T00006166001_1) or (CHC_T00007222001_1)

CATEGORIES: ORTHOLOGY

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SUBSYSTEM: PWY-6737

GENE_ASSOCIATION: (CHC_T00009120001_1) or (CHC_T00009120001)

CATEGORIES: ORTHOLOGY and ANNOTATION

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SUBSYSTEM: PWY-7039 , PWY-3561 , LIPASYN-PWY

GENE_ASSOCIATION: (CHC_T00004230001_1)

CATEGORIES: ORTHOLOGY

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SUBSYSTEM: PWY-7094

GENE_ASSOCIATION: (CHC_T00009190001_1) or (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

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SUBSYSTEM: PWY0-1337

GENE_ASSOCIATION: (CHC_T00009190001_1) or (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

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       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6952

GENE_ASSOCIATION: (CHC_T00009254001)

CATEGORIES: ANNOTATION

         </body>
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         <speciesReference species="M_Glycerophosphodiesters_c" stoichiometry="1" constant="false"/>
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     <reaction id="R_HISTIDINE__45__AMMONIA__45__LYASE__45__RXN" name="HISTIDINE-AMMONIA-LYASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5028 , PWY-5030 , HISDEG-PWY , HISHP-PWY

GENE_ASSOCIATION: (CHC_T00004806001_1)

CATEGORIES: ORTHOLOGY

         </body>
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       <listOfProducts>
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         <speciesReference species="M_UROCANATE_c" stoichiometry="1" constant="false"/>
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     <reaction id="R_RXN__45__16151" name="RXN-16151" reversible="true" fast="false">
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SUBSYSTEM: PWY-6433 , PWY-7618

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
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       <notes>
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SUBSYSTEM: PWY-5367

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

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         <speciesReference species="M_3__45__oxo__45__petroselinoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
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         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
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       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6948 , PWY-6946 , PWY-6945

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13699_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13700_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ORNCARBAMTRANSFER__45__RXN" name="ORNCARBAMTRANSFER-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ARGSYNBSUB-PWY , CITRULLINE-DEG-PWY , PWY-7400 , PWY-4981 , CITRULBIO-PWY , ARGSYN-PWY , PWY-4984

GENE_ASSOCIATION: (CHC_T00005123001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CARBAMOYL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ORNITHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__CITRULLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12088" name="alpha-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008413001) or (CHC_T00008413001_1) or (CHC_T00008780001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alpha__45__D__45__Galactosides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ALPHA__45__D__45__GALACTOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Non__45__Galactosylated__45__Galactose__45__Acceptors_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GARTRANSFORMYL2__45__RXN" name="GARTRANSFORMYL2-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6122 , PWY-6277

GENE_ASSOCIATION: (CHC_T00006609001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14971" name="succinate dehydrogenase (Complex II) flavoprotein subunit precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-561 , PWY-5690 , P105-PWY , TCA , PWY-6969 , PWY-6728 , PWY-7254

GENE_ASSOCIATION: (CHC_T00008943001_1) or (CHC_T00007584001_1) or (CHC_T00007286001_1) or (CHC_T00006990001_1) or (CHC_T00001817001_1) or (CHC_T00008943001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ETR__45__Quinones_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ETR__45__Quinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UDPKIN__45__RXN" name="nucleoside-diphosphate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7176

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17789" name="RXN-17789" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19162_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19155_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__305" name="14-oxolanosterol deformylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4573_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__26__46__5__45__RXN" name="3.1.26.5-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1479

GENE_ASSOCIATION: (CHC_T00004542001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2352_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNA__45__fragment_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2353_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4726" name="RXN-4726" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2902

GENE_ASSOCIATION: (CHC_T00001656001_1) or (CHC_T00000989001_1) or (CHC_T00003244001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__332_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4617_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14026" name="RXN-14026" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7185

GENE_ASSOCIATION: (CHC_T00000267001_1) or (CHC_T00008300001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CYTIDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6522" name="ribonuclease E" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_120)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_9S__45__RRNA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5S__45__rRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_rRNA__45__fragments_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11598" name="RXN-11598" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006177001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_16S__45__rRNA__45__uracil1498_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_16S__45__rRNA__45__N3__45__methyluracil1498_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACYLCOADEHYDROG__45__RXN" name="Putative Acyl-COA dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: FAO-PWY

GENE_ASSOCIATION: (CHC_T00009166001_1) or (CHC_T00000795001_1) or (CHC_T00000207001_1) or (CHC_T00009166001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRANS__45__D2__45__ENOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__5__46__1__46__19__45__RXN" name="3-phosphoshikimate 1-carboxyvinyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6163

GENE_ASSOCIATION: (CHC_T00009255001) or (CHC_T00009255001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SHIKIMATE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENPRIBOSYLTRAN__45__RXN" name="ADENPRIBOSYLTRAN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P121-PWY , PWY-6605 , PWY-7805 , PWY-7807 , PWY-6610

GENE_ASSOCIATION: (CHC_T00004428001_1) or (CHC_T00005158001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1961" name="tRNA(Ile)-lysidine synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_1130)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cytidine__45__34__45__tRNAIle2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Lysidine__45__tRNA__45__Ile2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8665" name="RXN-8665" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7765 , PWY-6309 , PWY-7717 , PWY-5651 , TRPCAT-PWY

GENE_ASSOCIATION: (CHC_T00007484001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__FORMYLKYNURENINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16137" name="RXN-16137" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7606

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17388_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17312_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6382" name="RXN0-6382" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ITP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_IMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13892" name="RXN-13892" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7155

GENE_ASSOCIATION: (CHC_T00006481001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__14901_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14900_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TYROSINE__45____45__TRNA__45__LIGASE__45__RXN" name="Putative Tyrosyl-tRNA synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00009345001_1) or (CHC_T00009128001_1) or (CHC_T00009345001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TYR__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TYR_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__TYR__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UBIQUITIN__45____45__PROTEIN__45__LIGASE__45__RXN" name="ubiquitin-activating enzyme E1" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7511

GENE_ASSOCIATION: (CHC_T00007701001_1) or (CHC_T00006980001_1) or (CHC_T00006427001_1) or (CHC_T00003966001_1) or (CHC_T00005234001_1) or (CHC_T00003230001_1) or (CHC_T00005531001_1) or (CHC_T00002417001_1) or (CHC_T00002791001_1) or (CHC_T00002169001_1) or (CHC_T00008828001_1) or (CHC_T00010352001_1) or (CHC_T00010007001_1) or (CHC_T00004379001_1) or (CHC_T00002999001_1) or (CHC_T00004399001_1) or (CHC_T00004299001_1) or (CHC_T00000123001_1) or (CHC_T00006277001_1) or (CHC_T00003204001_1) or (CHC_T00006794001_1) or (CHC_T00007651001_1) or (CHC_T00008502001_1) or (CHC_T00000387001_1) or (CHC_T00008644001_1) or (CHC_T00009466001_1) or (CHC_T00009159001_1) or (CHC_T00010346001_1) or (CHC_T00005498001_1) or (CHC_T00008443001_1) or (CHC_T00002451001_1) or (CHC_T00009358001_1) or (CHC_T00004841001_1) or (CHC_T00004279001_1) or (CHC_T00010031001_1) or (CHC_T00005520001_1) or (CHC_T00010007001) or (CHC_T00008644001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Ubiquitin__45__C__45__Terminal__45__Glycine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquitin__45__activating__45__protein__45__E1__45__L__45__cys_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_S__45__ubiquitinyl__45__UAP__45__E1__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14213" name="RXN-14213" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PEPDEPHOS__45__RXN" name="pyruvate kinase I" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , PWY-5484 , PWY-1042 , PWY-5723 , PWY-7003 , GLYCOLYSIS , PWY-6142 , P122-PWY , PWY-6901 , PWY-6886 , PWY-2221 , NPGLUCAT-PWY , ANAGLYCOLYSIS-PWY , PWY-7218 , P341-PWY , PWY-7383 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00008482001_1) or (CHC_T00008652001_1) or (CHC_T00008530001_1) or (CHC_T00008482001) or (CHC_T00008652001) or (CHC_T00008530001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYOHMETRANS__45__RXN" name="GLYOHMETRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5497 , PWY-3661-1 , PWY-3661 , 1CMET2-PWY , PWY-1622 , PWY-181 , PWY-2161 , GLYSYN-PWY , PWY-3841 , PWY-2201

GENE_ASSOCIATION: (CHC_T00009460001_1) or (CHC_T00008323001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLENE__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__701" name="RXN-701" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PAPS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__5__45__ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOLOCYTOCHROME__45__C__45__SYNTHASE__45__RXN" name="HOLOCYTOCHROME-C-SYNTHASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002615001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cytochromes__45__c_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Apocytochromes__45__c_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HEME_C_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16024" name="glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7587

GENE_ASSOCIATION: (CHC_T00008773001) or (CHC_T00008773001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Stearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__2113_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9633" name="3-oxo-stearoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5989 , PWY3O-355

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__oxo__45__stearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_R__45__3__45__hydroxystearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16067" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7587

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2113_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Long__45__Chain__45__Acyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__Stearoyl__45__L__45__Phosphatidate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17019" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10269_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18379_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18380_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6__46__3__46__5__46__7__45__RXN" name="6.3.5.7-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5921

GENE_ASSOCIATION: (CHC_T00009018001_1) or (CHC_T00000761001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__glutamyl__45__tRNAGln_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__GLN__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7665" name="RXN-7665" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5064

GENE_ASSOCIATION: (CHC_T00009478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7004_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7006_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5144" name="RXN0-5144" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004341001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_tRNA__45__Containing__45__5AminoMe__45__2__45__ThioUrdines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNA__45__Containing__45__5MeAminoMe__45__2__45__ThioU_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__600" name="RXN-600" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY1F-823

GENE_ASSOCIATION: (CHC_T00009538001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__474_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__590_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__46__2__46__1__46__61__45__RXN" name="4.2.1.61-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5994 , PWY-5971

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_R__45__3__45__Hydroxypalmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__Hexadecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11135" name="putative DNA helicase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003277001_1) or (CHC_T00005746001_1) or (CHC_T00007327001_1) or (CHC_T00010267001_1) or (CHC_T00009451001_1) or (CHC_T00004316001_1) or (CHC_T00007861001_1) or (CHC_T00010224001_1) or (CHC_T00010085001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Double__45__helix__45__DNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Unwound__45__DNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NITRATE__45__REDUCTASE__45__NADH__45__RXN" name="NITRATE-REDUCTASE-NADH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-381

GENE_ASSOCIATION: (CHC_T00008899001_1) or (CHC_T00003369001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRITE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9868" name="RXN-9868" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6089

GENE_ASSOCIATION: (CHC_T00004692001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10608_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__294_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THYMIDYLATESYN__45__RXN" name="THYMIDYLATESYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7210 , PWY-7184 , PWY0-166 , 1CMET2-PWY , PWY-7199 , PWY-7187 , PWY-7198 , PWY-3841

GENE_ASSOCIATION: (CHC_T00010030001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DUMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLENE__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIHYDROFOLATE__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12535" name="ethylene forming enzyme" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_ARG_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="7" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETHYLENE__45__CMPD_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD0__45__1470_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12196" name="RXN-12196" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006198001_1) or (CHC_T00000060001_1) or (CHC_T00007176001_1) or (CHC_T00010157001_1) or (CHC_T00004941001_1) or (CHC_T00005746001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14280" name="perillyl aldehyde dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1084_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__12443_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FORMATETHFLIG__45__RXN" name="formate--tetrahydrofolate ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CODH-PWY , PWY-2201 , PWY-1722 , PWY-2161 , PWY-3841

GENE_ASSOCIATION: (CHC_T00009198001_1) or (CHC_T00009198001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FORMYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16389" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1121 , PWY-6733 , PWY-321

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_16__45__HYDROXYPALMITATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17621_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8028" name="RXN-8028" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5175

GENE_ASSOCIATION: (CHC_T00003979001_1) or (CHC_T00002318001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1F__45__115_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7414_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12570" name="RXN-12570" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6863

GENE_ASSOCIATION: (CHC_T00008882001_1) or (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_K__45__HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OH__45__HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7795" name="inositolphosphorylceramide synthase (IPCS)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5129

GENE_ASSOCIATION: (CHC_T00008908001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__1__45__phosphatidyl__45__inositols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD3DJ__45__82_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Inositolphosphoryl__45__Ceramides_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7694" name="RXN-7694" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5078

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_METHYLBUT__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7033_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11373" name="diphthamide synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008650001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__carboxy__45__3__45__dimethylammonio__45__propyl__45__L__45__his_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIPHTINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALLOPHANATE__45__HYDROLASE__45__RXN" name="allophanate hydrolase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5169 , PWY-5703

GENE_ASSOCIATION: (CHC_T00009441001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__578_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBOFLAVIN__45__SYN__45__RXN" name="RIBOFLAVIN-SYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6168 , PWY-6167 , RIBOSYN2-PWY

GENE_ASSOCIATION: (CHC_T00004285001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_RIBOFLAVIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5182" name="Starch phosphorylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLYCOCAT-PWY

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOTETRAOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOTRIOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_URIDINEKIN__45__RXN" name="URIDINEKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7193

GENE_ASSOCIATION: (CHC_T00004071001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_URIDINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_URACIL__45__PRIBOSYLTRANS__45__RXN" name="URACIL-PRIBOSYLTRANS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7183

GENE_ASSOCIATION: (CHC_T00000924001_1) or (CHC_T00004071001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_URACIL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10462" name="glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1319

GENE_ASSOCIATION: (CHC_T00008773001) or (CHC_T00008773001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACYL__45__SN__45__GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2542" name="RXN-2542" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1422

GENE_ASSOCIATION: (CHC_T00009101001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MPBQ_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DMPBQ_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14384" name="RXN-14384" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7250

GENE_ASSOCIATION: (CHC_T00008053001_1) or (CHC_T00000657001_1) or (CHC_T00009510001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__CD__45__Apo__45__SP__45__Complex_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CD__45__S__45__SP__45__Complex_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2301

GENE_ASSOCIATION: (CHC_T00008808001_1) or (CHC_T00008454001_1) or (CHC_T00008597001_1) or (CHC_T00003382001_1) or (CHC_T00001291001_1) or (CHC_T00007726001_1) or (CHC_T00002260001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__L__45__MYO__45__INOSITOL__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PPGPPSYN__45__RXN" name="PPGPPSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PPGPPMET-PWY

GENE_ASSOCIATION: (CHC_T00003835001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GUANOSINE__45__5DP__45__3DP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__23__45__RXN" name="3.2.1.23-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008905001_1) or (CHC_T00008606001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Beta__45__D__45__Galactosides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Non__45__Galactosylated__45__Galactose__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__galactopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17475" name="RXN-17475" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__3__45__HYDROXYACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CIS__45__D2__45__ENOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_APIGNAR__45__RXN" name="Naringenin chalcone isomerase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6787 , PWY1F-FLAVSYN , PWY-7397

GENE_ASSOCIATION: (CHC_T00008856001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_APIGENIN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NARINGENIN__45__CMPD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETYL__45__COA__45__ACETYLTRANSFER__45__RXN" name="acetyl-CoA acetyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-368 , PWY-6883 , PWY-5676 , PWY-5741 , PWY-7524 , CENTFERM-PWY , PWY-5177 , PWY-6863 , PWY-7779 , PWY66-367 , PWY-7391 , PWY-922 , PWY-7216 , PWY-6583 , ACETOACETATE-DEG-PWY , P162-PWY , PWY-6588 , P163-PWY , PWY-6876 , PWY-7401 , PWY1-3 , PWY-5789 , PWY-7778 , PWY-6174

GENE_ASSOCIATION: (CHC_T00008981001_1) or (CHC_T00009349001_1) or (CHC_T00008981001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETOACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BUTANAL__45__DEHYDROGENASE__45__RXN" name="BUTANAL-DEHYDROGENASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6883 , PWY-6583

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BUTANAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__127__45__RXN" name="2.1.1.127-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002187001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_Rubisco__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_Rubisco__45__trimethylated__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12568" name="RXN-12568" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6863

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HEXANAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_SULFATE" name="TransportSeed_SULFATE" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SULFATE_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SULFATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__3" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-161 , PWY66-21 , PWY66-162 , PWY-7387

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETALD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__316" name="4&alpha;-hydroxymethyl-5&alpha;-cholesta-8,24-dien-3&beta;-ol dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074 , PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4579_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4580_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ASPCARBTRANS__45__RXN" name="ASPCARBTRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7791 , PWY-7790 , PWY-5686

GENE_ASSOCIATION: (CHC_T00010056001_1) or (CHC_T00005123001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CARBAMOYL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBAMYUL__45__L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8976" name="RXN-8976" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6471 , PWY-5265

GENE_ASSOCIATION: (CHC_T00009362001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_C4_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7695_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15130" name="RXN-15130" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__CYSTATHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__OXOBUTANOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRIMSYN3__45__RXN" name="PYRIMSYN3-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7356 , PWY-7282 , PWY-6890 , PWY-7357 , PWY-6910

GENE_ASSOCIATION: (CHC_T00006163001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11245" name="RXN-11245" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6435

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12199_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10600_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__5__46__1__46__98__45__RXN" name="histone deacetylase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008970001_1) or (CHC_T00005509001_1) or (CHC_T00005143001_1) or (CHC_T00008698001) or (CHC_T00008970001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Histone__45__Acetyl__45__Lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Histone__45__L__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6__46__1__46__1__46__24__45__RXN" name="6.1.1.24-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008453001_1) or (CHC_T00002361001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLX__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLUTAMYL__45__GLX__45__TRNAS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16158" name="RXN-16158" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6433

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15363_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17404_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16402" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6733

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_18__45__HYDROXYOLEATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17370_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6427" name="RXN0-6427" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PPGPPMET-PWY

GENE_ASSOCIATION: (CHC_T00003835001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GDP__45__TP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__84__45__RXN" name="3.2.1.84-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008497001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__3__45__alpha__45__D__45__Glucans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__3__45__alpha__45__D__45__Glucans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6382" name="RXN-6382" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5760 , PWY-3981

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__6082_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_B__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYCOGEN__45__BRANCH__45__RXN" name="1,4-alpha-Glucan branching enzyme" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLYCOGENSYNTH-PWY

GENE_ASSOCIATION: (CHC_T00008662001) or (CHC_T00008662001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glycogens_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9234" name="RXN-9234" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5857 , PWY-5872

GENE_ASSOCIATION: (CHC_T00006372001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9865_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9869_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9653" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Dodecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1827" name="RXN-1827" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15717_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_Serine__45__threonine_dehydration_ASTERINA__45__330" name="Serine-threonine_dehydration_ASTERINA-330" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009480001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ASTERINA__45__330_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MAA1_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__1__46__1__46__170__45__RXN" name="1.1.1.170-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003646001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__5846_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__ALPHA__45__METHYL__45__5__45__ALPHA__45__CHOLEST__45__7__45__EN__45__3__45__ON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2382" name="tryptophan synthase alpha chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRPSYN-PWY

GENE_ASSOCIATION: (CHC_T00008705001_1) or (CHC_T00007475001_1) or (CHC_T00009102001_1) or (CHC_T00008842001_1) or (CHC_T00008746001_1) or (CHC_T00008401001) or (CHC_1120)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_INDOLE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TRP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__21__46__7__45__RXN" name="3.1.21.7-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005665001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DNA__45__containing__45__abasic__45__Sites_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Deoxy__45__Ribonucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12454" name="RXN-12454" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009368001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Uracil16__45__in__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_56__45__Dihydrouracil16__45__in__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5224" name="carbonic anhydrase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CYANCAT-PWY , PWY-7117 , PWY-7115 , PWY-6142 , PWY-241 , PWYQT-4429

GENE_ASSOCIATION: (CHC_T00007098001_1) or (CHC_T00002086001_1) or (CHC_T00010062001_1) or (CHC_T00010311001_1) or (CHC_T00010321001_1) or (CHC_T00010321001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HCO3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__46__45__RXN" name="2.4.1.46-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-401

GENE_ASSOCIATION: (CHC_T00008381001_1) or (CHC_T00008753001_1) or (CHC_T00009002001_1) or (CHC_T00008619001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14553_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__Galactosyl__45__12__45__diacyl__45__glycerols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__1439" name="Trehalose 6-phosphate synthase, family GT20 / Trehalose 6-phosphate phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00002090001_1) or (CHC_T00009495001_1) or (CHC_T00010201001_1) or (CHC_T00008273001) or (CHC_T00010201001) or (CHC_T00009495001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1G__45__774_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1G__45__1354_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9635" name="trans-octadec-2-enoyl-[acyl-carrier-protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5989

GENE_ASSOCIATION: (CHC_T00009325001_1) or (CHC_T00008438001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Octadec__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Stearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GSHTRAN__45__RXN" name="Glutathione S-transferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4061 , PWY-6842

GENE_ASSOCIATION: (CHC_T00009287001_1) or (CHC_T00009312001_1) or (CHC_T00008274001_1) or (CHC_T00009444001_1) or (CHC_T00008810001_1) or (CHC_T00008425001_1) or (CHC_T00006560001_1) or (CHC_T00008791001_1) or (CHC_T00003419001_1) or (CHC_T00009287001) or (CHC_T00008791001) or (CHC_T00008724001) or (CHC_T00008766001) or (CHC_T00009444001) or (CHC_T00008810001) or (CHC_T00008274001) or (CHC_T00009312001) or (CHC_T00008331001) or (CHC_T00008425001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RX_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_S__45__Substituted__45__Glutathione_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HX_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9287" name="heptaprenyldihydroxybenzoate methyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5873

GENE_ASSOCIATION: (CHC_T00007491001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9903_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9904_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5470" name="RXN-5470" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00010015001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__166_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5168_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__5169_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8616" name="RXN-8616" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5434

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12568_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__1438" name="Trehalose 6-phosphate synthase, family GT20 / Trehalose 6-phosphate phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00002090001_1) or (CHC_T00009495001_1) or (CHC_T00010201001_1) or (CHC_T00008273001) or (CHC_T00010201001) or (CHC_T00009495001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1G__45__773_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1G__45__1353_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALCOHOL__45__DEHYDROG__45__RXN" name="ALCOHOL-DEHYDROG-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5486 , PWY66-21 , PWY-5480 , PWY-6587 , P122-PWY , P161-PWY , ETOH-ACETYLCOA-ANA-PWY , PWY-7118 , PWY-6333 , PWY4LZ-257 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETOH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETALD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14986" name="RXN-14986" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7396

GENE_ASSOCIATION: (CHC_T00009293001_1) or (CHC_T00009162001_1) or (CHC_T00008852001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__1130_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__3618_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN0__45__277" name="NAD(P) transhydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NADPHOS-DEPHOS-PWY , NADPHOS-DEPHOS-PWY-1

GENE_ASSOCIATION: (CHC_T00008930001) or (CHC_T00008930001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14285" name="Starch phosphorylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOHEXAOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOPENTAOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13416" name="RXN-13416" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5905

GENE_ASSOCIATION: (CHC_T00005094001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_EIF5A__45__LYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__4__45__aminobutylidene__45__enzyme__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Deoxyhypusine__45__Synthase__45__Lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__4__45__aminobutylidene__45__eIF5A__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SUCCINATE__45__DEHYDROGENASE__45__UBIQUINONE__45__RXN" name="succinate dehydrogenase (Complex II) flavoprotein subunit precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1353 , PWY-4302 , PWY66-398 , PWY0-1329 , PWY-3781 , PWY-7279

GENE_ASSOCIATION: (CHC_T00008943001_1) or (CHC_T00007584001_1) or (CHC_T00007286001_1) or (CHC_T00006990001_1) or (CHC_T00001817001_1) or (CHC_T00008943001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Ubiquinones_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ubiquinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10704" name="RXN-10704" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00009190001_1) or (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11522_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11523_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__7192" name="RXN0-7192" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001081001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BIO__45__5__45__AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9666" name="RXN-9666" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-1121 , PWY-5996 , PWY-6733 , PWY-321

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OLEATE__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5471" name="dolichyl-P-Glc:Glc1Man2GlcNAc2-PPdolichol &alpha;-1,3-glucosyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00010015001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__166_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5169_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__5170_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DCDPKIN__45__RXN" name="nucleoside-diphosphate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7210 , PWY-7184 , PWY0-166 , PWY-7197 , PWY-7198 , PWY-6545

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DCDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DCTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SULFITE__45__OXIDASE__45__RXN" name="SULFITE-OXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5326

GENE_ASSOCIATION: (CHC_T00008628001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SULFATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_Light" name="TransportSeed_Light" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Light_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Light_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NICOTINAMID__45__RXN" name="NICOTINAMID-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PYRIDNUCSAL-PWY , PWY-5381 , P345-PWY

GENE_ASSOCIATION: (CHC_T00004131001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NIACINAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NIACINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8342" name="RXN-8342" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6823

GENE_ASSOCIATION: (CHC_T00006817001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Thiocarboxylated__45__MPT__45__synthases_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRECURSOR__45__Z_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MPT__45__Synthases_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_CPD__45__4_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRIOSEPISOMERIZATION__45__RXN" name="triose-phosphate isomerase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5484 , PWY66-399 , PWY-1042 , PWY-7003 , GLYCOLYSIS , PWY-6142 , ANAGLYCOLYSIS-PWY , CALVIN-PWY , GLUCONEO-PWY , P185-PWY , PWY66-373 , P341-PWY

GENE_ASSOCIATION: (CHC_T00009523001_1) or (CHC_T00009545001_1) or (CHC_T00009126001_1) or (CHC_T00009126001) or (CHC_T00009545001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIHYDROXY__45__ACETONE__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9951" name="isocitrate dehydrogenase (NADP+)" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009580001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_THREO__45__DS__45__ISO__45__CITRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXALO__45__SUCCINATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12994" name="3-oxoacyl-[acyl-carrier-protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7602 , PWY-7619 , PWY-7724

GENE_ASSOCIATION: (CHC_T00008477001) or (CHC_T00008496001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14422_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14419_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__474__45__R__45__2__45__HYDROXYSTEARATE__47__ATP__47__CO__45__A__47____47__CPD__45__14717__47__AMP__47__PPI__46__48__46__" name="RXN66-474-R-2-HYDROXYSTEARATE/ATP/CO-A//CPD-14717/AMP/PPI.48." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_R__45__2__45__HYDROXYSTEARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14717_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MALATE__45__DEH__45__RXN" name="malate dehydrogenase, mitochondrial precursor" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P23-PWY , P42-PWY , P108-PWY , PWY66-399 , PWY-561 , PWY-5392 , PWY-5913 , PWY-5690 , PWY-1622 , P105-PWY , PWY-6969 , TCA , PWY-7115 , GLYOXYLATE-BYPASS , PWY66-398 , GLUCONEO-PWY , MALATE-ASPARTATE-SHUTTLE-PWY , PWY-7383 , PWY-6728 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00009350001_1) or (CHC_T00008600001_1) or (CHC_T00008733001_1) or (CHC_T00009173001_1) or (CHC_T00009292001_1) or (CHC_T00008733001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXALACETIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17744" name="RXN-17744" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_STEAROYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7873_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16996" name="RXN-16996" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009043001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUCOSE__45__16__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Beta__45__phosphoglucomutase_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__6__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phosphorylated__45__beta__45__phosphoglucomutase_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_MN__43__2" name="TransportSeed_MN+2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MN__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MN__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__902" name="RXN-902" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-81

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_E__45__PHENYLITACONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBOXYMETHYL__45__HYDROXYPHENYLPROPCOA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7657" name="RXN-7657" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7396 , PWY-5057 , PWY-7111

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ISOBUTANOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7000_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRNA__45__GUANINE__45__N7__45____45__METHYLTRANSFERASE__45__RXN" name="TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000217001_1) or (CHC_T00000205001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Guanine46__45__in__45__tRNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNA__45__Containing__45__N7__45__Methylguanine__45__46_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8668" name="RXN-8668" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003328001_1) or (CHC_T00010005001_1) or (CHC_T00003259001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__methionine__45__S__45__S__45__oxides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__methionine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13641" name="RXN-13641" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7101

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1F__45__129_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14646_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__41" name="TRANS-RXN1HP7-41" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005840001_1) or (CHC_T00002066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__43__2_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__43__2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5180" name="RXN0-5180" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007345001_1) or (CHC_T00005639001_1) or (CHC_T00001389001_1) or (CHC_T00004833001_1) or (CHC_T00003042001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__1028_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__46__4__46__99__46__16__45__RXN" name="5.4.99.16-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2622

GENE_ASSOCIATION: (CHC_T00000730001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TREHALOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10703" name="RXN-10703" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11527_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11528_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12575" name="all-trans retinyl-ester hydrolase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6857

GENE_ASSOCIATION: (CHC_T00003680001_1) or (CHC_T00000998001_1) or (CHC_T00008784001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_All__45__trans__45__Retinyl__45__Esters_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13524_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Long__45__Chain__45__Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__148" name="RXN1F-148" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5947

GENE_ASSOCIATION: (CHC_T00009303001_1) or (CHC_T00003979001_1) or (CHC_T00002318001_1) or (CHC_T00009401001_1) or (CHC_T00009131001_1) or (CHC_T00008663001_1) or (CHC_T00009499001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008616001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1F__45__115_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1F__45__118_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NAD__43____45__ADP__45__RIBOSYLTRANSFERASE__45__RXN" name="NAD+-ADP-RIBOSYLTRANSFERASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003917001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADP__45__D__45__Ribosyl__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP__45__D__45__Ribosyl__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NIACINAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__6__46__3__46__51__45__RXN" name="3.6.3.51-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002266001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_General__45__Protein__45__Substrates_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13961" name="RXN-13961" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_14__45__alpha__45__methylsteroids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_Delta__45__14__45__steroids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__300" name="hydroxypyruvate reductase (NADP+)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009559001_1) or (CHC_T00009559001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OH__45__PYR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCERATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16630" name="3-oxoacyl-(acyl-carrier-protein) reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7663

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_11Z__45__3__45__oxo__45__icos__45__11__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3R__45__11Z__45__3__45__hydroxy__45__icos__45__11__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__3942" name="RXN0-3942" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1221

GENE_ASSOCIATION: (CHC_T00002862001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9000_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__AMINO__45__BUTYRATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17794" name="RXN-17794" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19154_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19157_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SULFITE__45__REDUCT__45__RXN" name="SULFITE-REDUCT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SO4ASSIM-PWY , PWY-6683

GENE_ASSOCIATION: (CHC_T00008333001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="5" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_HS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7663" name="RXN-7663" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5064

GENE_ASSOCIATION: (CHC_T00008377001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GERANYLGERANYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7005_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14799" name="RXN-14799" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7340

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15687_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15688_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_RXN66__45__28_CYCLOARTENOL" name="extended_RXN66-28_CYCLOARTENOL" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: early_SSR

GENE_ASSOCIATION: (CHC_T00002789001_1)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYCLOARTENOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4181_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_COBALADENOSYLTRANS__45__RXN" name="COBALADENOSYLTRANS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6268

GENE_ASSOCIATION: (CHC_T00002690001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_COB__45__I__45__ALAMIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYLCOBALAMIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P3I_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PRPPAMIDOTRANS__45__RXN" name="PRPPAMIDOTRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7282 , PWY-6122 , PWY-6121 , PWY-6277

GENE_ASSOCIATION: (CHC_T00009506001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11989" name="RXN-11989" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6681

GENE_ASSOCIATION: (CHC_T00004955001_1) or (CHC_T00003476001_1) or (CHC_T00004944001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7953_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12935_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRENAL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYCLOARTENOL__45__SYNTHASE__45__RXN" name="cycloartenol synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6098 , PWY-6109 , PWY-7155 , PWY-2541 , PWY-7154 , PWY-6115

GENE_ASSOCIATION: (CHC_T00008265001_1) or (CHC_T00008265001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_EPOXYSQUALENE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CYCLOARTENOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10917" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6342

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11876_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_VANILLYL_MANDELATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACYLPHOSPHATASE__45__RXN" name="ACYLPHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007234001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acyl__45__Phosphates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Carboxylates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALDEHYDE__45__DEHYDROGENASE__45__NADORNOP__43____45__RXN" name="ALDEHYDE-DEHYDROGENASE-NADORNOP+-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Aldehydes_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Carboxylates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ASPARAGINE__45____45__TRNA__45__LIGASE__45__RXN" name="ASPARAGINE--TRNA-LIGASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00008942001_1) or (CHC_T00008849001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ASN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASN__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__ASN__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17012" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Palmitoleoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__PALMITOYLGLYCEROL__45__3__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18350_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16997" name="phosphoglucomutase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005896001_1) or (CHC_T00008779001_1) or (CHC_T00008779001) or (CHC_T00003000001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phosphorylated__45__phosphoglucomutase_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Phosphoglucomutase_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALPHA__45__GLUCOSE__45__16__45__BISPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__6__46__4__46__4__45__RXN" name="Kinesin" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004170001_1) or (CHC_T00008788001_1) or (CHC_T00008574001_1) or (CHC_T00008860001_1) or (CHC_T00008293001_1) or (CHC_T00009514001_1) or (CHC_T00008417001_1) or (CHC_T00009576001_1) or (CHC_T00008330001_1) or (CHC_T00008903001_1) or (CHC_T00009273001_1) or (CHC_T00004624001_1) or (CHC_T00008922001_1) or (CHC_T00008272001_1) or (CHC_T00008278001_1) or (CHC_T00009419001_1) or (CHC_T00008261001_1) or (CHC_T00008484001_1) or (CHC_T00008636001_1) or (CHC_T00008924001_1) or (CHC_T00009302001_1) or (CHC_T00008694001_1) or (CHC_T00009533001_1) or (CHC_T00008995001_1) or (CHC_T00008426001_1) or (CHC_T00009561001_1) or (CHC_T00008769001_1) or (CHC_T00008337001_1) or (CHC_T00009262001_1) or (CHC_T00009468001_1) or (CHC_T00008351001_1) or (CHC_T00008985001_1) or (CHC_T00008786001_1) or (CHC_T00009397001_1) or (CHC_T00009310001_1) or (CHC_T00009232001_1) or (CHC_T00008859001_1) or (CHC_T00008809001_1) or (CHC_T00009260001_1) or (CHC_T00008913001_1) or (CHC_T00009447001_1) or (CHC_T00009085001_1) or (CHC_T00009138001) or (CHC_T00009381001) or (CHC_T00008641001) or (CHC_T00008304001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Kinesin__45__Microtubules__45__Complex_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Kinesin__45__Microtubules__45__Complex_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12508" name="2-(&alpha;-hydroxyethyl)-TPP:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine acetyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008442001_1) or (CHC_T00008732001_1) or (CHC_T00008732001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pyruvate__45__dehydrogenase__45__lipoate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__ALPHA__45__HYDROXYETHYL__45__THPP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pyruvate__45__dehydrogenase__45__acetylDHlipoyl_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIAMINE__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17023" name="Lysophosphatidic acid acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__PALMITOYLGLYCEROL__45__3__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TETRADECANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18390_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYOXIII__45__RXN" name="Putative glyoxalase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004118001_1) or (CHC_T00000393001_1) or (CHC_T00009136001_1) or (CHC_T00009321001_1) or (CHC_T00004807001_1) or (CHC_T00002702001_1) or (CHC_T00009567001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYL__45__GLYOXAL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__LACTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9280" name="octaprenyldihydroxybenzoate methyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5870

GENE_ASSOCIATION: (CHC_T00007491001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9894_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9899_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13709" name="4-methylsterol monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_4__45__METHYL__45__824__45__CHOLESTADIENOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4702_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HYDROXYMETHYLGLUTARYL__45__COA__45__SYNTHASE__45__RXN" name="HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-367 , PWY-7524 , PWY-7391 , PWY-7571 , PWY-922 , PWY-6174

GENE_ASSOCIATION: (CHC_T00008149001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETOACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MALTODEXGLUCOSID__45__RXN" name="alpha-glucosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000021001_1) or (CHC_T00009379001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACID__45__PHOSPHATASE__45__RXN" name="ACID-PHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6348

GENE_ASSOCIATION: (CHC_T00002031001_1) or (CHC_T00000494001_1) or (CHC_T00001956001_1) or (CHC_T00005741001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Orthophosphoric__45__Monoesters_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Alcohols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYRIBONUCSYN__45__RXN" name="GLYRIBONUCSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6121 , PWY-6277 , PWY-6122

GENE_ASSOCIATION: (CHC_T00000892001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTAMATE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="glutamate N-acetyltransferase / amino-acid N-acetyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ARGSYNBSUB-PWY

GENE_ASSOCIATION: (CHC_T00008260001_1) or (CHC_T00003449001_1) or (CHC_T00007246001_1) or (CHC_T00008260001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__ALPHA__45__ACETYLORNITHINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__GLU_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ORNITHINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FATTY__45__ACID__45__SYNTHASE__45__RXN" name="FATTY-ACID-SYNTHASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Long__45__Chain__45__Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13198" name="RXN-13198" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7013

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROPANOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__665_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14381" name="RXN-14381" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7250

GENE_ASSOCIATION: (CHC_T00009307001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__form__45__FeS__45__Cluster__45__Scaffold__45__Proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Persulfurated__45__L__45__cysteine__45__desulfurases_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_S__45__CD__45__Apo__45__SP__45__Complex_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11374" name="RXN-11374" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008650001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__3__45__CARBOXY__45__3__45__METHYLAMMONIOPROPYL__45__L__45___c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__carboxy__45__3__45__dimethylammonio__45__propyl__45__L__45__his_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__2__45__ENOYL__45__COA__45__REDUCTASE__45__NAD__43____45__RXN__45__CPD__45__10279__47__NAD__47____47__CPD__45__14281__47__NADH__47__PROTON__46__37__46__" name="TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN-CPD-10279/NAD//CPD-14281/NADH/PROTON.37." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14281_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__10279_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__320" name="RXN1G-320" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWYG-321

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_R__45__3__45__hydroxyarachidoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_trans__45__delta2__45__arachidoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTATHIONE__45__SYN__45__RXN" name="GLUTATHIONE-SYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLUTATHIONESYN-PWY

GENE_ASSOCIATION: (CHC_T00005227001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__GAMMA__45__GLUTAMYLCYSTEINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__1436" name="Trehalose 6-phosphate synthase, family GT20 / Trehalose 6-phosphate phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00002090001_1) or (CHC_T00009495001_1) or (CHC_T00010201001_1) or (CHC_T00008273001) or (CHC_T00010201001) or (CHC_T00009495001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1G__45__771_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1G__45__1345_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDROXYISOVALDEHYDRAT__45__RXN" name="DIHYDROXYISOVALDEHYDRAT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: VALSYN-PWY , PWY-7111

GENE_ASSOCIATION: (CHC_T00009385001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13357_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__KETO__45__ISOVALERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AICARTRANSFORM__45__RXN" name="phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase)-IMP cyclohydrolase (inosinicase) (IMP synthetase) (ATIC)" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6124 , PWY-6123

GENE_ASSOCIATION: (CHC_T00009056001) or (CHC_T00009056001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AICAR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12726" name="Cysteine synthase CYS1" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6936

GENE_ASSOCIATION: (CHC_T00008705001_1) or (CHC_T00008842001_1) or (CHC_T00008705001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYLSERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__678_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__SELENOCYSTEINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENOSINE__45__KINASE__45__RXN" name="probable adenosine kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6619

GENE_ASSOCIATION: (CHC_T00008498001) or (CHC_T00008498001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADENOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10939" name="RXN-10939" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008808001_1) or (CHC_T00008454001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__MYO__45__INOSITOL__45__34__45__BISPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17573" name="RXN-17573" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003446001_1) or (CHC_T00003240001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CAAX__45__proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Farnesylated__45__CAAX__45__proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NAD__45__KIN__45__RXN" name="NAD-KIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7268 , PWY-7269 , NADPHOS-DEPHOS-PWY , PWY-5083 , NADPHOS-DEPHOS-PWY-1

GENE_ASSOCIATION: (CHC_T00003138001_1) or (CHC_T00004045001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CARBOXYLESTERASE__45__RXN" name="Carboxylesterase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003680001_1) or (CHC_T00000998001_1) or (CHC_T00008784001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Carboxylic__45__esters_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Carboxylates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alcohols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GDPKIN__45__RXN" name="nucleoside-diphosphate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7221 , PPGPPMET-PWY

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HEXOKINASE__45__RXN" name="HEXOKINASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001373001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__Hexoses_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__HEXOSE__45__6__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THRESYN__45__RXN" name="threonine synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HOMOSER-THRESYN-PWY

GENE_ASSOCIATION: (CHC_T00009376001_1) or (CHC_T00009376001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_O__45__PHOSPHO__45__L__45__HOMOSERINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THR_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10702" name="RXN-10702" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11523_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11524_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__3__46__1__46__23__45__RXN" name="2.3.1.23-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6803 , PWY-7470

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__Lysophosphatidylcholines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHATIDYLCHOLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PNKIN__45__RXN" name="PNKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7282 , PLPSAL-PWY , PWY-7204

GENE_ASSOCIATION: (CHC_T00004634001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXINE__45__5P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6523" name="ribonuclease E" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_120)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RNASE__45__G__45__DEGRADATION__45__SUBSTRATE__45__MRNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_mRNA__45__Fragments_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10705" name="RXN-10705" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00009190001_1) or (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11526_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11527_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9537" name="RXN-9537" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5994 , PWY-5971

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_R__45__3__45__hydroxymyristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Tetradec__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__17__45__RXN" name="Phosphatidylethanolamine N-methyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6825

GENE_ASSOCIATION: (CHC_T00009414001_1) or (CHC_T00002431001_1) or (CHC_T00008258001) or (CHC_T00009414001) or (CHC_T00009046001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__405_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7967" name="RXN-7967" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007254001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_QUINATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEHYDROQUINATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5462" name="RXN-5462" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00007099001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ALPHA__45__D__45__MANNOSYLCHITOBIO_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5161_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_H2PTERIDINEPYROPHOSPHOKIN__45__RXN" name="H2PTERIDINEPYROPHOSPHOKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7539 , PWY-6797 , PWY-6147

GENE_ASSOCIATION: (CHC_T00003007001_1) or (CHC_T00007059001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROPTERIN__45__CH2OH__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13614" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7094

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__3617_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10267_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__499" name="3-oxo-lignoceroyl-[acyl-carrier protein] synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Behenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__lignoceroyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PSII__45__RXN" name="photosystem II protein Y" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-101

GENE_ASSOCIATION: (CHC_T00008339001_1) or (CHC_T00009123001_1) or (CHC_1160) or (CHC_615) or (CHC_125) or (CHC_205) or (CHC_50) or (CHC_1155) or (CHC_1170) or (CHC_610) or (CHC_1140) or (CHC_95) or (CHC_880)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Light_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PLASTOQUINONE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="4" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Plastoquinols_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="4" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11520" name="RXN-11520" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6632

GENE_ASSOCIATION: (CHC_T00006932001_1) or (CHC_T00000194001_1) or (CHC_T00006216001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__7__45__DIMETHYLXANTHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12483_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTAMINE__45____45__TRNA__45__LIGASE__45__RXN" name="GLUTAMINE--TRNA-LIGASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00001673001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__GLN__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PROTOPORGENOXI__45__RXN" name="PROTOPORGENOXI-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1415 , HEME-BIOSYNTHESIS-II , PWY-7159 , CHLOROPHYLL-SYN

GENE_ASSOCIATION: (CHC_T00000813001_1) or (CHC_T00001062001_1) or (CHC_T00004880001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_PROTOPORPHYRINOGEN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTOPORPHYRIN_IX_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTAMATE__45__DEHYDROGENASE__45__RXN" name="Glutamate dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5022 , PWY-7126 , P162-PWY , GLUTAMATE-DEG1-PWY , ALACAT2-PWY , PWY-6728

GENE_ASSOCIATION: (CHC_T00010235001) or (CHC_T00010235001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6201" name="RXN-6201" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5691 , PWY-7394

GENE_ASSOCIATION: (CHC_T00004512001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5821_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ALLANTOIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LONG__45__CHAIN__45__FATTY__45__ACYL__45__COA__45__REDUCTASE__45__RXN" name="LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009166001_1) or (CHC_T00000795001_1) or (CHC_T00000207001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Long__45__Chain__45__Aldehydes_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Long__45__Chain__45__Acyl__45__CoAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALPHAGALACTOSID__45__RXN" name="alpha-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1301

GENE_ASSOCIATION: (CHC_T00008497001_1) or (CHC_T00008780001_1) or (CHC_T00008413001_1) or (CHC_T00008413001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MELIBIOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__galactopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16065" name="RXN-16065" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008879001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PALMITYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__17313_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14283" name="alpha-glucosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000021001_1) or (CHC_T00009379001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__1133_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOHEXAOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9222" name="RXN-9222" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5855 , PWY-5873

GENE_ASSOCIATION: (CHC_T00002263001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__hydroxybenzoate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9852_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12384" name="RXN-12384" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6724

GENE_ASSOCIATION: (CHC_T00008493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Linear__45__Malto__45__Oligosaccharides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Linear__45__Malto__45__Oligosaccharides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SIROHEME__45__FERROCHELAT__45__RXN" name="SIROHEME-FERROCHELAT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5194

GENE_ASSOCIATION: (CHC_T00007728001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SIROHYDROCHLORIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FE__43__2_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SIROHEME_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13673" name="Glutathione S-transferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7112

GENE_ASSOCIATION: (CHC_T00009287001_1) or (CHC_T00006560001_1) or (CHC_T00008810001_1) or (CHC_T00009444001_1) or (CHC_T00008274001_1) or (CHC_T00009312001_1) or (CHC_T00008791001_1) or (CHC_T00003419001_1) or (CHC_T00008791001) or (CHC_T00009287001) or (CHC_T00008724001) or (CHC_T00008766001) or (CHC_T00009444001) or (CHC_T00008810001) or (CHC_T00008274001) or (CHC_T00009312001) or (CHC_T00008331001) or (CHC_T00008425001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10806_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14704_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NAD__45__SYNTH__45__GLN__45__RXN" name="glutamine-dependent NAD synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PYRIDNUCSYN-PWY , PWY-7761 , PYRIDNUCSAL-PWY , PWY-5381 , PWY-5653

GENE_ASSOCIATION: (CHC_T00008954001) or (CHC_T00008954001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEAMIDO__45__NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5293" name="RXN0-5293" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6536

GENE_ASSOCIATION: (CHC_T00008575001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SUCC__45__S__45__ALD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIPHOSPHOMEVALONTE__45__DECARBOXYLASE__45__RXN" name="DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-922 , PWY-7391

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__641_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ENOYL__45__COA__45__HYDRAT__45__RXN" name="enoyl-CoA hydratase, mitochondrial precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-391 , PWY-5136 , FAO-PWY , PWY-5138 , PWY-7007

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1) or (CHC_T00009110001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TRANS__45__D2__45__ENOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__3__45__HYDROXYACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_1__46__14__46__13__46__70__45__RXN" name="extended_1.14.13.70-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: early_SSR , late_SSR

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_29__45__NORLANOSTEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_4A__45__METHYLCHOLEST__45__8__40__9__41____44__14__44__24__45__TRIEN__45__3B__45__OL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__OCTAPRENYLTRANSTRANSFERASE__45__RXN" name="TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5805

GENE_ASSOCIATION: (CHC_T00004833001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GERANYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="7" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="7" constant="false"/>
         <speciesReference species="M_SOLANESYL__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11278" name="RXN-11278" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6446

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__513_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BENZALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHENYLALANINE__45__AMMONIA__45__LYASE__45__RXN" name="PHENYLALANINE-AMMONIA-LYASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-1121 , PWY1F-467 , PWY-6444 , PWY-6457 , PWY-5883

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__674_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__18" name="RXN66-18" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00003646001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8613_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8614_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__3542" name="RXN0-3542" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIAMINE__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_THIAMINE__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__198__45__RXN" name="2.4.1.198-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009304001_1) or (CHC_T00005098001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__1__45__phosphatidyl__45__inositols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__452_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14264" name="RXN-14264" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009166001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ISOVALERYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__METHYL__45__CROTONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FADH2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADOMET__45__DMK__45__METHYLTRANSFER__45__RXN" name="ADOMET-DMK-METHYLTRANSFER-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MENAQUINONESYN-PWY

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12115_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_REDUCED__45__MENAQUINONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSPHOMEVALONATE__45__KINASE__45__RXN" name="PHOSPHOMEVALONATE-KINASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-922 , PWY-7391

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__499_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__641_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MANNPDEHYDROG__45__RXN" name="MANNPDEHYDROG-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

SUBSYSTEM: MANNIDEG-PWY , PWY-6531

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MANNITOL__45__1P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12623" name="N,N'-diacetylchitobiose synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6902

GENE_ASSOCIATION: (CHC_T00004415001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Chitodextrins_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13227_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHITOBIOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__3142" name="RXN-3142" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY1F-FLAVSYN

GENE_ASSOCIATION: (CHC_T00009478001_1) or (CHC_T00008438001_1) or (CHC_T00009104001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_P__45__COUMAROYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_CPD__45__3041_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__45__HYDROXYPHENYLPYRUVATE__45__DIOXYGENASE__45__RXN" name="4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1581 , PWY-7432 , PWY-1422 , TYRFUMCAT-PWY

GENE_ASSOCIATION: (CHC_T00009321001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__HYDROXY__45__PHENYLPYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HOMOGENTISATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14304" name="RXN-14304" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008714001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15199_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__310" name="4,4-dimethylzymosterol 4-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074 , PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4575_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN6666__45__5" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7431 , PWY6666-2

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_34__45__DIHYDROXYPHENYLACETALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__782_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13677" name="RXN-13677" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7112

GENE_ASSOCIATION: (CHC_T00002549001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14705_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14706_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_BIOTIN" name="TransportSeed_BIOTIN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BIOTIN_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BIOTIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__949" name="Lipoate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-501 , PWY0-1275 , PWY-6987

GENE_ASSOCIATION: (CHC_T00008509001) or (CHC_T00008509001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Octanoylated__45__domains_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MET_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Oxidized__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Lipoyl__45__Protein__45__N6__45__lipoyllysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIAMINOPIMDECARB__45__RXN" name="diaminopimelate decarboxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: DAPLYSINESYN-PWY , PWY-2942 , PWY-5097 , PWY-2941

GENE_ASSOCIATION: (CHC_T00004243001_1) or (CHC_T00009352001_1) or (CHC_T00009352001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MESO__45__DIAMINOPIMELATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_LYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HEMEOSYN__45__RXN" name="heme o biosynthesis" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005639001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Heme__45__b_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HEME_O_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9191" name="RXN-9191" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5839

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12117_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12125_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12610" name="RXN-12610" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6907 , PWY-6893

GENE_ASSOCIATION: (CHC_T00006435001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__13576_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIAMINE__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_METHYLVALERATE__45__RXN" name="3-methyl-2-oxobutanoate dehydrogenase [(S)-2-methylbutanoyl-transferring)" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006349001_1) or (CHC_T00008584001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__lipoyl_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETO__45__3__45__METHYL__45__VALERATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__2MB__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__8__46__5__46__1__45__RXN" name="1.8.5.1-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2261 , PWY-6370

GENE_ASSOCIATION: (CHC_T00005252001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__DEHYDRO__45__ASCORBATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASCORBATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXIDIZED__45__GLUTATHIONE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10060" name="3-oxoacyl-[acyl-carrier-protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321 , PWY-6113

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__oxo__45__cerotoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_R__45__3__45__hydroxycerotoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ARGSUCCINLYA__45__RXN" name="ARGSUCCINLYA-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5154 , PWY-4983 , ARGSYNBSUB-PWY , PWY-7400 , ARGSYN-PWY , PWY-4984

GENE_ASSOCIATION: (CHC_T00004007001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__ARGININO__45__SUCCINATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ARG_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HYDROXYMETHYLGLUTARYL__45__COA__45__LYASE__45__RXN" name="HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5074 , LEU-DEG2-PWY , PWY66-367

GENE_ASSOCIATION: (CHC_T00004158001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__KETOBUTYRATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETOACETATE__45____45__COA__45__LIGASE__45__RXN" name="ACETOACETATE--COA-LIGASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005612001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__KETOBUTYRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETOACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__479" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-389

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14926_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__14927_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THIOESTER__45__RXN__91__CCO__45__CYTOSOL__93____45__CPD__45__10280__47__WATER__47____47__TETRACOSANOATE__47__CO__45__A__47__PROTON__46__57__46__" name="THIOESTER-RXN[CCO-CYTOSOL]-CPD-10280/WATER//TETRACOSANOATE/CO-A/PROTON.57." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10280_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TETRACOSANOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11707" name="RXN-11707" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6622

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Stearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__55_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9652" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Decanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__dodecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__982" name="RXN-982" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4621 , PWY-4202

GENE_ASSOCIATION: (CHC_T00010347001_1) or (CHC_T00008414001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ARSENATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__Glutaredoxins_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ox__45__Glutaredoxins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__763_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TCV3" name="TCV3" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NITRATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NITRATE_v" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__169" name="RXN66-169" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-221

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__2742_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__3188_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_OXALODECARB__45__RXN" name="OXALODECARB-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: METHYLGALLATE-DEGRADATION-PWY , PWY-6339 , P184-PWY

GENE_ASSOCIATION: (CHC_T00009563001_1) or (CHC_T00008878001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXALACETIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__26" name="TRANS-RXN1HP7-26" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000780001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRATE_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__OXOACYL__45__ACP__45__SYNTH__45__RXN" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: FASYN-ELONG-PWY

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Saturated__45__Fatty__45__Acyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_B__45__KETOACYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase, mitochondrial" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P23-PWY , PWY-6549 , REDCITCYC , PWY-5913 , PWY-5392 , PWY-5690 , PWY-5750 , PWY-7124 , PWY-6969 , P105-PWY , TCA , PWY66-398 , GLYOXYLATE-BYPASS , PWY-6728 , PWY-7254 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00008781001_1) or (CHC_T00009087001_1) or (CHC_T00008781001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CIT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CIS__45__ACONITATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__14__46__19__46__1__45__RXN" name="1.14.19.1-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5996

GENE_ASSOCIATION: (CHC_T00009557001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_STEAROYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LEUCINE__45__23__45__AMINOMUTASE__45__RXN" name="LEUCINE-23-AMINOMUTASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5075

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LEU_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__2041_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12199" name="RXN-12199" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7177 , PWY-7185

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_UTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14198" name="RXN-14198" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DCTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DCMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6PGLUCONOLACT__45__RXN" name="6PGLUCONOLACT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: RUMP-PWY , GLYCOLYSIS-E-D , P122-PWY , OXIDATIVEPENT-PWY

GENE_ASSOCIATION: (CHC_T00000675001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__2961_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_QUINOPRIBOTRANS__45__RXN" name="QUINOPRIBOTRANS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PYRIDNUCSYN-PWY , PWY-5316 , PWY-7342 , PWY-5653

GENE_ASSOCIATION: (CHC_T00000718001_1) or (CHC_T00004416001_1) or (CHC_T00009179001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_QUINOLINATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NICOTINATE_NUCLEOTIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9" name="RXN-9" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5

GENE_ASSOCIATION: (CHC_T00005123001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__CANALINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBAMOYL__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_O__45__UREIDOHOMOSERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TREHALOSE6PSYN__45__RXN" name="TREHALOSE6PSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRESYN-PWY

GENE_ASSOCIATION: (CHC_T00010201001_1) or (CHC_T00009495001_1) or (CHC_T00002090001_1) or (CHC_T00008273001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__glucopyranose__45__6__45__phosphate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TREHALOSE__45__6P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8391" name="RXN-8391" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5367

GENE_ASSOCIATION: (CHC_T00009465001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Delta4__45__hexadecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__petroselinoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GCVT__45__RXN" name="aminomethyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLYCLEAV-PWY

GENE_ASSOCIATION: (CHC_T00008727001_1) or (CHC_T00008727001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMINOMETHYLDIHYDROLIPOYL__45__GCVH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIHYDROLIPOYL__45__GCVH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLENE__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16041" name="RXN-16041" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6958

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17278_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14392_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17791" name="RXN-17791" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19158_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19147_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14219" name="RXN-14219" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DUTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DUDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6521" name="ribonuclease E" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_120)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RNASE__45__E__45__MRNA__45__PROCESSING__45__SUBSTRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_mRNA__45__Fragments_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RNASE__45__E__45__PROCESSING__45__PRODUCT__45__MRNA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__PHOSPHOGLYCERATE__45__PHOSPHATASE__45__RXN" name="3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_G3P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13300" name="RXN-13300" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7036

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14273_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14277_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16077" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Oleoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2113_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17319_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_R222__45__RXN" name="1-octanal dehydrogenase (NAD+)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P221-PWY

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__371_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__195_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALCOHOL__45__DEHYDROGENASE__45__NADPORNOP__43____45__RXN" name="ALCOHOL-DEHYDROGENASE-NADPORNOP+-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009372001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Aldehydes_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Alcohols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9361" name="RXN-9361" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5890

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12119_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12127_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_METHENYLTHFCYCLOHYDRO__45__RXN" name="METHENYLTHFCYCLOHYDRO-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CODH-PWY , PWY-5497 , 1CMET2-PWY , PWY-6613 , PWY-5030 , PWY-3841 , PWY-2201 , PWY-1722 , P164-PWY

GENE_ASSOCIATION: (CHC_T00008670001_1) or (CHC_T00008680001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__10__45__METHENYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FORMYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9535" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Dodecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADDALT__45__RXN" name="ADDALT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7179 , PWY-7179-1

GENE_ASSOCIATION: (CHC_T00001501001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEOXYADENOSINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEOXYINOSINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALANINE__45____45__TRNA__45__LIGASE__45__RXN" name="Alanine--tRNA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00008489001) or (CHC_T00009548001) or (CHC_T00008489001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALA__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__ALA__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17729" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7782

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Long__45__Chain__45__Acyl__45__CoAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__Alkyl__45__glycerol__45__3__45__phosphate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__Alkyl__45__2__45__acyl__45__glycerol__45__3__45__phosphate_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__150" name="RXN1F-150" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7591 , PWY-5943

GENE_ASSOCIATION: (CHC_T00009303001_1) or (CHC_T00003979001_1) or (CHC_T00002318001_1) or (CHC_T00009401001_1) or (CHC_T00009131001_1) or (CHC_T00008663001_1) or (CHC_T00009499001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008616001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1F__45__114_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1F__45__126_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENYLYLSULFATE__45__REDUCTASE__45__RXN" name="ADENYLYLSULFATE-REDUCTASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: P224-PWY , PWY-5278 , PWY-5279 , DISSULFRED-PWY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_APS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__6__46__3__46__1__45__RXN" name="3.6.3.1-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004602001_1) or (CHC_T00003209001_1) or (CHC_T00009522001_1) or (CHC_T00006146001_1) or (CHC_T00000225001_1) or (CHC_T00000829001_1) or (CHC_T00007060001_1) or (CHC_T00006675001_1) or (CHC_T00000505001_1) or (CHC_T00000226001_1) or (CHC_T00000723001_1) or (CHC_T00003061001_1) or (CHC_T00004261001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Phospholipids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Phospholipids_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9157" name="RXN-9157" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5826

GENE_ASSOCIATION: (CHC_T00005245001_1) or (CHC_T00000071001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9699_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__9700_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS__45__GLY_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11486" name="RXN-11486" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6520

GENE_ASSOCIATION: (CHC_T00004833001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="5" constant="false"/>
         <speciesReference species="M_GERANYLGERANYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SOLANESYL__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="5" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17793" name="RXN-17793" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008557001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19161_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19154_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5073" name="RXN0-5073" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ITP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_IDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11836" name="RXN-11836" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006820001_1) or (CHC_T00001402001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_23S__45__rRNA__45__uridine2605_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_23S__45__rRNA__45__pseudouridine2605_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THIOREDOXIN__45__REDUCT__45__NADPH__45__RXN" name="THIOREDOXIN-REDUCT-NADPH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: THIOREDOX-PWY

GENE_ASSOCIATION: (CHC_T00001349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIPHTINE__45____45__AMMONIA__45__LIGASE__45__RXN" name="DIPHTINE--AMMONIA-LIGASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6482 , PWY-7546

GENE_ASSOCIATION: (CHC_T00008649001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIPHTINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIPHTHAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4222" name="RXN-4222" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2541

GENE_ASSOCIATION: (CHC_T00002789001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__706_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4141_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GSADENYLATION__45__RXN" name="GSADENYLATION-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005714001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Glutamine__45__synthetase__45__Tyr_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glutamine__45__synthetase__45__adenylyl__45__Tyr_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16910" name="carbamoyl phosphate synthase small subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7693

GENE_ASSOCIATION: (CHC_T00008596001_1) or (CHC_T00010056001_1) or (CHC_70)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18238_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBAMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_biomass_rxn" name="biomass_rxn" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYCEROL_c" stoichiometry="2.375" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="0.3" constant="false"/>
         <speciesReference species="M_GLYCERATE_c" stoichiometry="0.123" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="26.6" constant="false"/>
         <speciesReference species="M_VAL_c" stoichiometry="0.85" constant="false"/>
         <speciesReference species="M_ARG_c" stoichiometry="0.1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="10.7" constant="false"/>
         <speciesReference species="M_SUC_c" stoichiometry="0.878" constant="false"/>
         <speciesReference species="M_4__45__AMINO__45__BUTYRATE_c" stoichiometry="0.01" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="3.35" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="3.8" constant="false"/>
         <speciesReference species="M_TRP_c" stoichiometry="0.115" constant="false"/>
         <speciesReference species="M_TYR_c" stoichiometry="0.125" constant="false"/>
         <speciesReference species="M_THR_c" stoichiometry="0.65" constant="false"/>
         <speciesReference species="M_GLYCOLLATE_c" stoichiometry="0.029" constant="false"/>
         <speciesReference species="M_MANNITOL_c" stoichiometry="331.4" constant="false"/>
         <speciesReference species="M_PRO_c" stoichiometry="1.35" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="18.85" constant="false"/>
         <speciesReference species="M_LYS_c" stoichiometry="0.35" constant="false"/>
         <speciesReference species="M_ASN_c" stoichiometry="0.75" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="0.3" constant="false"/>
         <speciesReference species="M_THREO__45__DS__45__ISO__45__CITRATE_c" stoichiometry="9.37" constant="false"/>
         <speciesReference species="M_L__45__ORNITHINE_c" stoichiometry="0.1" constant="false"/>
         <speciesReference species="M_PHE_c" stoichiometry="0.35" constant="false"/>
         <speciesReference species="M_GLC_c" stoichiometry="2.7615" constant="false"/>
         <speciesReference species="M_HIS_c" stoichiometry="0.1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="12.5" constant="false"/>
         <speciesReference species="M_CIT_c" stoichiometry="19.3055" constant="false"/>
         <speciesReference species="M_LEU_c" stoichiometry="0.3" constant="false"/>
         <speciesReference species="M_ILE_c" stoichiometry="0.2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BIOMASS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16032" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7589

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACYL__45__SN__45__GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__Palmitoyl__45__L__45__Phosphatidate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14217" name="RXN-14217" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DGTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DGDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17127" name="RXN-17127" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006203001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Lipoyl__45__Protein__45__L__45__Lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LIPOIC__45__ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Lipoyl__45__Protein__45__N6__45__lipoyllysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15560" name="RXN-15560" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7511

GENE_ASSOCIATION: (CHC_T00007701001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ubiquitinyl__45__HECT__45__E3__45__UCP__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTEIN__45__N__45__UBIQUITYL__45__LYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HECT__45__Ubiquitin__45__carrier__45__protein__45__E3__45__L__45__cys_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7836" name="RXN-7836" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5138 , PWY-6837

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Trans__45__3__45__enoyl__45__CoAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TRANS__45__D2__45__ENOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__14__46__19__46__3__45__RXN" name="1.14.19.3-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6000

GENE_ASSOCIATION: (CHC_T00008879001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__18_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_GAMMA__45__LINOLENOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7253" name="RXN-7253" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4702

GENE_ASSOCIATION: (CHC_T00008808001_1) or (CHC_T00008454001_1) or (CHC_T00008597001_1) or (CHC_T00003382001_1) or (CHC_T00001291001_1) or (CHC_T00007726001_1) or (CHC_T00002260001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__6746_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GMP__45__REDUCT__45__RXN" name="GMP-REDUCT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009518001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GMP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_IMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_2__46__1__46__1__46__143__45__RXN_DESMOSTEROL__45__CPD" name="extended_2.1.1.143-RXN_DESMOSTEROL-CPD" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009101001) or (CHC_T00000837001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DESMOSTEROL__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__706_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__ISOPROPYLMALISOM__45__RXN" name="3-isopropylmalate dehydratase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6871 , LEUSYN-PWY

GENE_ASSOCIATION: (CHC_T00009184001_1) or (CHC_T00009087001_1) or (CHC_T00009184001) or (CHC_T00009087001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9451_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_D__45__THREO__45__ALDOSE__45__1__45__DEHYDROGENASE__45__RXN" name="D-THREO-ALDOSE-1-DEHYDROGENASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010069001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8548_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8549_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETATE__45____45__COA__45__LIGASE__45__RXN" name="acetyl-CoA synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1313 , PWY66-21 , PWY-7118 , PWY66-161 , PWY66-162 , PWY-6672

GENE_ASSOCIATION: (CHC_T00008320001_1) or (CHC_T00008320001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PROTEIN__45__KINASE__45__RXN" name="Serine/threonine-protein kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005569001_1) or (CHC_T00008541001_1) or (CHC_T00008388001_1) or (CHC_T00009092001_1) or (CHC_T00009536001_1) or (CHC_T00008370001_1) or (CHC_T00009202001_1) or (CHC_T00009066001_1) or (CHC_T00004170001_1) or (CHC_T00000921001_1) or (CHC_T00002425001_1) or (CHC_T00009408001_1) or (CHC_T00008395001_1) or (CHC_T00009103001_1) or (CHC_T00007870001_1) or (CHC_T00008947001_1) or (CHC_T00008462001_1) or (CHC_T00009113001_1) or (CHC_T00009300001_1) or (CHC_T00009267001_1) or (CHC_T00009163001_1) or (CHC_T00008638001_1) or (CHC_T00009234001_1) or (CHC_T00008363001_1) or (CHC_T00009003001_1) or (CHC_T00002006001_1) or (CHC_T00008932001_1) or (CHC_T00008756001_1) or (CHC_T00009512001_1) or (CHC_T00008966001_1) or (CHC_T00008456001_1) or (CHC_T00009317001_1) or (CHC_T00009063001_1) or (CHC_T00008503001_1) or (CHC_T00008731001_1) or (CHC_T00009344001_1) or (CHC_T00008716001_1) or (CHC_T00009299001_1) or (CHC_T00008625001_1) or (CHC_T00008284001_1) or (CHC_T00009286001_1) or (CHC_T00008700001_1) or (CHC_T00008666001_1) or (CHC_T00009319001_1) or (CHC_T00008618001_1) or (CHC_T00008528001_1) or (CHC_T00008793001_1) or (CHC_T00008949001_1) or (CHC_T00008979001_1) or (CHC_T00008885001_1) or (CHC_T00008682001_1) or (CHC_T00008925001_1) or (CHC_T00003488001_1) or (CHC_T00009203001_1) or (CHC_T00008959001_1) or (CHC_T00009517001_1) or (CHC_T00009439001_1) or (CHC_T00009392001_1) or (CHC_T00008396001_1) or (CHC_T00008654001_1) or (CHC_T00009394001_1) or (CHC_T00008906001_1) or (CHC_T00008389001_1) or (CHC_T00008435001_1) or (CHC_T00009242001_1) or (CHC_T00008833001_1) or (CHC_T00008532001_1) or (CHC_T00010324001_1) or (CHC_T00008752001_1) or (CHC_T00008994001_1) or (CHC_T00007702001_1) or (CHC_T00008564001_1) or (CHC_T00002834001_1) or (CHC_T00005267001_1) or (CHC_T00000391001_1) or (CHC_T00001215001_1) or (CHC_T00008455001_1) or (CHC_T00008772001_1) or (CHC_T00008533001_1) or (CHC_T00009146001_1) or (CHC_T00008303001_1) or (CHC_T00000519001_1) or (CHC_T00004892001_1) or (CHC_T00009411001_1) or (CHC_T00003906001_1) or (CHC_T00009315001_1) or (CHC_T00008782001_1) or (CHC_T00008471001_1) or (CHC_T00008378001_1) or (CHC_T00008896001_1) or (CHC_T00008604001_1) or (CHC_T00008624001_1) or (CHC_T00008485001_1) or (CHC_T00009038001_1) or (CHC_T00008708001_1) or (CHC_T00009230001_1) or (CHC_T00008944001) or (CHC_T00009536001) or (CHC_T00010324001) or (CHC_T00008682001) or (CHC_T00008624001) or (CHC_T00008435001) or (CHC_T00008710001) or (CHC_T00008906001) or (CHC_T00008914001) or (CHC_T00008979001) or (CHC_T00008885001) or (CHC_T00009234001) or (CHC_T00009230001) or (CHC_T00008471001) or (CHC_T00008638001) or (CHC_T00009288001) or (CHC_T00008654001) or (CHC_T00008370001) or (CHC_T00009430001) or (CHC_T00009113001) or (CHC_T00009202001) or (CHC_T00009252001) or (CHC_T00008772001) or (CHC_T00008455001) or (CHC_T00008793001) or (CHC_T00009204001) or (CHC_T00009203001) or (CHC_T00008716001) or (CHC_T00008625001) or (CHC_T00009076001) or (CHC_T00009394001) or (CHC_T00009502001) or (CHC_T00008700001) or (CHC_T00008389001) or (CHC_T00008474001) or (CHC_T00008731001) or (CHC_T00008666001) or (CHC_T00008634001) or (CHC_T00009439001) or (CHC_T00009146001) or (CHC_T00008623001) or (CHC_T00009251001) or (CHC_T00008548001) or (CHC_T00009286001) or (CHC_T00009411001) or (CHC_T00008503001) or (CHC_T00008683001) or (CHC_T00008861001) or (CHC_T00008512001) or (CHC_T00009157001) or (CHC_T00008925001) or (CHC_T00009047001) or (CHC_T00008589001) or (CHC_T00009315001) or (CHC_T00008456001) or (CHC_T00008363001) or (CHC_T00008604001) or (CHC_T00009501001) or (CHC_T00009341001) or (CHC_T00009299001) or (CHC_T00008284001) or (CHC_T00008462001) or (CHC_T00009344001) or (CHC_T00009568001) or (CHC_T00008538001) or (CHC_T00008893001) or (CHC_T00009003001) or (CHC_T00008303001) or (CHC_T00009473001) or (CHC_T00008485001) or (CHC_T00008314001) or (CHC_T00009245001) or (CHC_T00008533001) or (CHC_T00008763001) or (CHC_T00008532001) or (CHC_T00008932001) or (CHC_T00008959001) or (CHC_T00009103001) or (CHC_T00008947001) or (CHC_T00008378001) or (CHC_T00008514001) or (CHC_T00009038001) or (CHC_T00008396001) or (CHC_T00009163001) or (CHC_T00008521001) or (CHC_T00009392001) or (CHC_T00008949001) or (CHC_T00008729001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__serine__45__or__45__L__45__threonine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__Ser__45__or__45__Thr__45__phosphate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17790" name="RXN-17790" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19155_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19158_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BETAGALACTOSID__45__RXN" name="&beta;-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: BGALACT-PWY

GENE_ASSOCIATION: (CHC_T00008905001_1) or (CHC_T00008606001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15972_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GALACTOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__9" name="TRANS-RXN1HP7-9" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006111001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FE__43__3_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FE__43__3_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11887" name="RXN-11887" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-4

GENE_ASSOCIATION: (CHC_T00006481001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__8646_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8730" name="probable inosine triphosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6362 , PWY-6364

GENE_ASSOCIATION: (CHC_T00009365001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__506_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8620" name="RXN-8620" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6668

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8848_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8846_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8847_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PNPOXI__45__RXN" name="PNPOXI-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7282 , PYRIDOXSYN-PWY , PLPSAL-PWY , PWY-7204

GENE_ASSOCIATION: (CHC_T00008142001_1) or (CHC_T00006254001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRIDOXINE__45__5P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXAL_PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14160" name="glycerophosphorylethanolamine phosphodiesterase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7409

GENE_ASSOCIATION: (CHC_T00009254001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__1__45__GLYCEROPHOSPHORYLETHANOL__45__AMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETHANOL__45__AMINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTAMIN__45__RXN" name="ferredoxin-dependent glutamate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLUTAMINDEG-PWY , CITRULBIO-PWY

GENE_ASSOCIATION: (CHC_T00000298001_1) or (CHC_T00008596001_1) or (CHC_T00010056001_1) or (CHC_T00009427001_1) or (CHC_T00000667001_1) or (CHC_T00004458001_1) or (CHC_T00002449001_1) or (CHC_T00007798001_1) or (CHC_1080) or (CHC_70) or (CHC_T00009427001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5468" name="peroxiredoxin, PRX3" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002035001_1) or (CHC_T00003196001_1) or (CHC_T00009369001) or (CHC_T00010097001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alkyl__45__Hydro__45__Peroxides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alcohols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5242" name="ent-kaurenol 19-dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5034 , PWY-5047

GENE_ASSOCIATION: (CHC_T00009499001_1) or (CHC_T00008616001_1) or (CHC_T00009131001_1) or (CHC_T00010004001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00008672001_1) or (CHC_T00009062001_1) or (CHC_T00008663001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ENT__45__KAUR__45__16__45__EN__45__19__45__OL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_ENT__45__KAUR__45__16__45__EN__45__19__45__AL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14728" name="RXN-14728" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009018001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__163" name="RXN66-163" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-221

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__2742_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__2751_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__11__46__2__45__RXN" name="3.1.11.2-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000526001_1) or (CHC_T00009154001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DNA__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Deoxy__45__Ribonucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DNA__45__N_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9650" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Hexanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__Oxo__45__octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13417" name="RXN-13417" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5905

GENE_ASSOCIATION: (CHC_T00005094001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__4__45__aminobutylidene__45__eIF5A__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9973_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__1" name="RXN66-1" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-162

GENE_ASSOCIATION: (CHC_T00007915001_1) or (CHC_T00005477001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETOH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_ACETALD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17895" name="RXN-17895" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7751

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18773_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19220_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12198" name="RXN-12198" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTAMATE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Glutamate dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLUDEG-I-PWY , ARGININE-SYN4-PWY , PWY-5766 , GLUTAMATE-SYN2-PWY

GENE_ASSOCIATION: (CHC_T00010235001) or (CHC_T00010235001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__46__2__46__1__46__59__45__RXN" name="4.2.1.59-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5994 , PWY-5971

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__Hydroxy__45__octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__Octenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5286" name="RXN-5286" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7760 , PWY-7758 , PWY-5086 , PWY-5064 , PWY-5526 , PWY-7759

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIVINYLCHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16027" name="RXN-16027" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008753001_1) or (CHC_T00008381001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14553_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17272_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__2187_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7659" name="RXN-7659" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5063

GENE_ASSOCIATION: (CHC_T00009478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7003_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7002_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CARBOXY__45__OXOHEPT__45__ENEDIOATE__45__DECARBOXY__45__RXN" name="CARBOXY-OXOHEPT-ENEDIOATE-DECARBOXY-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010274001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__785_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__787_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1461" name="RXN0-1461" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7159 , HEME-BIOSYNTHESIS-II , PWY0-1415 , CHLOROPHYLL-SYN

GENE_ASSOCIATION: (CHC_T00002160001_1) or (CHC_T00008857001_1) or (CHC_T00003096001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_COPROPORPHYRINOGEN_III_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTOPORPHYRINOGEN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7666" name="RXN-7666" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5064

GENE_ASSOCIATION: (CHC_T00009478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7006_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHLOROPHYLL__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_Serine__45__threonine_dehydration_MAA2" name="Serine-threonine_dehydration_MAA2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009480001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MAA2_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PALYTHENE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14120" name="nucleoside-diphosphate kinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_IDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ITP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14277" name="hexanoyl-CoA C-acyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2106_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYMALTOPHOSPHORYL__45__RXN" name="Starch phosphorylase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Glycogens_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOTETRAOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1TRANSKETO__45__RXN" name="1TRANSKETO-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , NONOXIPENT-PWY , PWY-5723 , PWY-1861 , P21-PWY , CALVIN-PWY , P185-PWY

GENE_ASSOCIATION: (CHC_T00005040001_1) or (CHC_T00009390001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__SEDOHEPTULOSE__45__7__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_XYLULOSE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RIBOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SUCCINATE__45____45__COA__45__LIGASE__45__GDP__45__FORMING__45__RXN" name="SUCCINATE--COA-LIGASE-GDP-FORMING-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-398

GENE_ASSOCIATION: (CHC_T00009212001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_PROTON" name="ExchangeSeed_PROTON" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FERREDOXIN__45____45__NITRITE__45__REDUCTASE__45__RXN" name="FERREDOXIN--NITRITE-REDUCTASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY490-3 , PWY-381

GENE_ASSOCIATION: (CHC_T00003048001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NITRITE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="6" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="8" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="6" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15513" name="RXN-15513" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5484 , PWY66-399 , PWY-1622 , GLYCOLYSIS , P122-PWY , ANAGLYCOLYSIS-PWY

GENE_ASSOCIATION: (CHC_T00001241001_1) or (CHC_T00007707001_1) or (CHC_T00000449001_1) or (CHC_T00001519001_1) or (CHC_T00004201001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__PG_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_G3P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9679" name="sarcosine N-methyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6004 , P541-PWY

GENE_ASSOCIATION: (CHC_T00006195001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SARCOSINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIMETHYL__45__GLYCINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12559" name="trans-2-hexenoyl-CoA  reductase (NAD+)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6863

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2121_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6__46__3__46__4__46__11__45__RXN" name="6.3.4.11-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001081001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Apo__45__3__45__methylcrotonoyl__45__CoA__45__carbon__45__dioxide_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__methylcrotonoyl__45__CoA__45__carbon__45__dioxide_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2001" name="RXN-2001" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6457

GENE_ASSOCIATION: (CHC_T00008160001_1) or (CHC_T00008472001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__674_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CINNAMOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__4__46__14__45__RXN" name="3.1.4.14-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6012

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_apo__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PANTETHEINE__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__323" name="RXN66-323" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3 , PWY66-341

GENE_ASSOCIATION: (CHC_T00006493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4187_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHOLESTEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__34" name="TRANS-RXN1HP7-34" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000913001_1) or (CHC_T00007675001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Sugar__45__Phosphate_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Sugar__45__Phosphate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__1__46__1__46__141__45__RXN" name="1.1.1.141-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5Z13E__45__15S__45__1115__45__DIHYDROXY__45__9__45__OXOPROS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROXY__45__915__45__DIOXOPROSTA__45__13__45__ENOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10657" name="RXN-10657" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6282

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Trans__45__D3__45__cis__45__D7__45__tetradecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cis__45__Delta7__45__tetradecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_NA__43__" name="TransportSeed_NA+" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NA__43___e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NA__43___c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENYLATECYC__45__RXN" name="putative adenylate cyclase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008790001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CAMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACSERLY__45__RXN" name="Cysteine synthase CYS1" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CYSTSYN-PWY

GENE_ASSOCIATION: (CHC_T00008842001_1) or (CHC_T00008705001_1) or (CHC_T00008705001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYLSERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THYMIDINE__45__TRIPHOSPHATASE__45__RXN" name="THYMIDINE-TRIPHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11726" name="RXN-11726" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CROTONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14378" name="RXN-14378" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-622

GENE_ASSOCIATION: (CHC_T00009277001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP__45__D__45__GLUCOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alpha__45__Amyloses_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16426" name="RXN-16426" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001867001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__ACETYL__45__D__45__GLUCOSAMINE__45__16__45__BIS__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phosphoacetylglucosamine__45__Mutase_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Phosphoacetylglucosamine__45__Mutase__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10068" name="RXN-10068" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7524 , PWY-6174

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10818_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NUCLEOSIDE__45__TRIPHOSPHATASE__45__RXN" name="NUCLEOSIDE-TRIPHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006198001_1) or (CHC_T00000060001_1) or (CHC_T00007176001_1) or (CHC_T00010157001_1) or (CHC_T00005746001_1) or (CHC_T00004941001_1) or (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Nucleoside__45__Triphosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Nucleoside__45__Diphosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GUANPRIBOSYLTRAN__45__RXN" name="GUANPRIBOSYLTRAN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6599 , PWY-6620

GENE_ASSOCIATION: (CHC_T00004960001_1) or (CHC_T00004428001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GUANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__46__1__46__1__46__16__45__RXN" name="5.1.1.16-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008746001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__L__45__serines_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__D__45__serines_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__12" name="RXN0-12" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000511001_1) or (CHC_T00004057001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ZN__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ZN__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10697" name="RXN-10697" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11518_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11519_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13722" name="RXN-13722" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009184001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMO__45__CIT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HOMO__45__I__45__CIT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NICOTINATEPRIBOSYLTRANS__45__RXN" name="NICOTINATEPRIBOSYLTRANS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PYRIDNUCSAL-PWY , PWY-5381

GENE_ASSOCIATION: (CHC_T00004416001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NIACINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NICOTINATE_NUCLEOTIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACECOATRANS__45__RXN__45__CPD__45__10280__47__ACET__47____47__TETRACOSANOATE__47__ACETYL__45__COA__46__42__46__" name="ACECOATRANS-RXN-CPD-10280/ACET//TETRACOSANOATE/ACETYL-COA.42." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10280_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TETRACOSANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_K__43__" name="ExchangeSeed_K+" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_K__43___C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_K__43___e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FARNESYLTRANSTRANSFERASE__45__RXN" name="FARNESYLTRANSTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7517 , PWY-6659 , PWY-6691 , PWY-5120 , PWY-7721 , PWY-7736 , PWY-7720 , PWY-7492

GENE_ASSOCIATION: (CHC_T00004833001_1) or (CHC_T00006851001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GERANYLGERANYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYSTATHIONINE__45__BETA__45__LYASE__45__RXN" name="CYSTATHIONINE-BETA-LYASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008829001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__CYSTATHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17015" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18348_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cis__45__vaccenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18353_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15635" name="RXN-15635" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6654

GENE_ASSOCIATION: (CHC_T00001868001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETO__45__ISOVALERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLENETETRAHYDROMETHANOPTERIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__DEHYDROPANTOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THMPT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5107" name="RXN0-5107" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__722" name="ribonucleoside-diphosphate reductase beta chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-166

GENE_ASSOCIATION: (CHC_T00008926001_1) or (CHC_T00008864001_1) or (CHC_T00008864001) or (CHC_T00008926001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__NrdH__45__Proteins_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__NrdH__45__Proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DUDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12561" name="acetyl-CoA acetyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008981001) or (CHC_T00008981001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROPIONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13534_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__DEHYDROSPHINGANINE__45__REDUCTASE__45__RXN" name="3-ketodihydrosphingosine reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SPHINGOLIPID-SYN-PWY , PWY3DJ-12 , PWY-5129

GENE_ASSOCIATION: (CHC_T00008374001) or (CHC_T00008374001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEHYDROSPHINGANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13612_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7811" name="RXN-7811" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5132

GENE_ASSOCIATION: (CHC_T00008265001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__METHYL__45__1__45__246__45__TRIHYDROXYPHENYLBUTAN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4211_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7109_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1133" name="pyruvate dehydrogenase E1 alpha subunit, mitochondrial precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PYRUVDEHYD-PWY

GENE_ASSOCIATION: (CHC_T00007488001_1) or (CHC_T00007380001_1) or (CHC_T00004322001_1) or (CHC_T00008732001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pyruvate__45__dehydrogenase__45__dihydrolipoate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pyruvate__45__dehydrogenase__45__acetylDHlipoyl_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PROTEIN__45__TYROSINE__45__PHOSPHATASE__45__RXN" name="PROTEIN-TYROSINE-PHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002485001_1) or (CHC_T00008580001_1) or (CHC_T00004298001_1) or (CHC_T00006530001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__tyrosine__45__phosphates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__Tyrosines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5055" name="acetyl-CoA carboxylase carboxytransferase beta subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1264

GENE_ASSOCIATION: (CHC_T00009359001_1) or (CHC_T00007145001_1) or (CHC_55) or (CHC_T00009359001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Carboxybiotin__45__BCCP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCCP__45__dimers_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16629" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7663

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Oleoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_11Z__45__3__45__oxo__45__icos__45__11__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10767" name="Carboxylesterase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003680001_1) or (CHC_T00000998001_1) or (CHC_T00008784001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Methyl__45__Jasmonates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Jasmonic__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METOH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4733" name="RXN-4733" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2881

GENE_ASSOCIATION: (CHC_T00001656001_1) or (CHC_T00000989001_1) or (CHC_T00003244001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4441_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4618_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6__46__3__46__5__46__6__45__RXN" name="6.3.5.6-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY490-4

GENE_ASSOCIATION: (CHC_T00009018001_1) or (CHC_T00000761001_1) or (CHC_T00008942001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__aspartyl__45__tRNAAsn_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__ASN__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12455" name="RXN-12455" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009368001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Uracil17__45__in__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_56__45__Dihydrouracil17__45__in__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7683" name="RXN-7683" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5107

GENE_ASSOCIATION: (CHC_T00001603001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHYTOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7025_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9518" name="3-hydroxyhexanoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994 , PWY-5971

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__hexanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_R__45__3__45__hydroxyhexanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17011" name="Lysophosphatidic acid acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18346_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18348_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18353_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12730" name="RXN-12730" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6936

GENE_ASSOCIATION: (CHC_T00009326001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__1302_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SELENOHOMOCYSTEINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SELENOMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1301_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_CPD__45__315" name="ExchangeSeed_CPD-315" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__315_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__315_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11334" name="RXN-11334" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002689001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__D__45__LACTONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CHORISMATEMUT__45__RXN" name="CHORISMATEMUT-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TYRSYN , PWY-7626 , PWY-6627 , PHESYN , PWY-3461 , PWY-6120 , PWY-3462

GENE_ASSOCIATION: (CHC_T00003833001_1) or (CHC_T00003465001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHORISMATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PREPHENATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11210" name="RXN-11210" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6430

GENE_ASSOCIATION: (CHC_T00006316001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_3__45__UREIDO__45__ISOBUTYRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__471_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_CL__45__" name="ExchangeSeed_CL-" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CL__45___C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CL__45___e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__707" name="RXN-707" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2541

GENE_ASSOCIATION: (CHC_T00006493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__700_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__706_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17780" name="RXN-17780" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19170_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19168_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__281" name="squalene synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001581001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__465_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SQUALENE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13290" name="15-tetracosenoate&mdash;CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14268_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14269_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETOOHBUTSYN__45__RXN" name="2-aceto-2-hydroxy-butyrate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5101 , ILEUSYN-PWY , PWY-5103 , PWY-5104

GENE_ASSOCIATION: (CHC_T00002409001_1) or (CHC_T00008160001_1) or (CHC_980)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__OXOBUTANOATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11354" name="RXN-11354" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6475

GENE_ASSOCIATION: (CHC_T00001067001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7535_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7526_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11479" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6519

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glutaryl__45__ACP__45__methyl__45__esters_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__Ketopimeloyl__45__ACP__45__methyl__45__esters_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SULFITE__45__REDUCTASE__45__FERREDOXIN__45__RXN" name="SULFITE-REDUCTASE-FERREDOXIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SULFMETII-PWY

GENE_ASSOCIATION: (CHC_T00008525001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="8" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="6" constant="false"/>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_HS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="6" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15007" name="RXN-15007" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7400

GENE_ASSOCIATION: (CHC_T00008340001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LysW__45__L__45__ornithine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_LysW__45__L__45__glutamate__45__5__45__semialdehyde_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYCLOEUCALENOL__45__CYCLOISOMERASE__45__RXN" name="CYCLOEUCALENOL-CYCLOISOMERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7155 , PWY-2541

GENE_ASSOCIATION: (CHC_T00002985001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYCLOEUCALENOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OBTUSIFOLIOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__15" name="TRANS-RXN1HP7-15" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000524001_1) or (CHC_T00000383001_1) or (CHC_T00007472001_1) or (CHC_T00009033001_1) or (CHC_T00003284001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cations_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Cations_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2601" name="RXN0-2601" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000546001_1) or (CHC_T00004281001_1) or (CHC_T00000985001_1) or (CHC_T00000177001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Damaged__45__DNA__45__Pyrimidine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DNA__45__containing__45__a__45__Apyrimidinic__45__Sites_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6525" name="RXN0-6525" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003097001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MUTATED__45__TRNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Nucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7813" name="RXN-7813" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5808 , PWY-5133

GENE_ASSOCIATION: (CHC_T00008265001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4211_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__PRENYLPHLORISOBUTYROPHENONE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7107_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__11__46__4__45__RXN" name="3.4.11.4-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004445001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRIPEPTIDES_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Amino__45__Acids__45__20_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIPEPTIDES_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_7KAPSYN__45__RXN" name="7KAPSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6578

GENE_ASSOCIATION: (CHC_T00004094001_1) or (CHC_T00004096001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__558_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_8__45__AMINO__45__7__45__OXONONANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__336" name="leukotriene-C4 gamma-glutamyl transferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-375

GENE_ASSOCIATION: (CHC_T00005245001_1) or (CHC_T00000071001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Amino__45__Acids__45__20_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LEUKOTRIENE__45__C4_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD66__45__21_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__5__46__1__46__20__45__RXN" name="1.5.1.20-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CODH-PWY , PWY-2201 , 1CMET2-PWY , PWY-3841

GENE_ASSOCIATION: (CHC_T00008486001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLENE__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__METHYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12611" name="thiamin phosphate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6894

GENE_ASSOCIATION: (CHC_T00006435001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13575_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIAMINE__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYCOGENSYN__45__RXN" name="Starch synthase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-622 , GLYCOGENSYNTH-PWY

GENE_ASSOCIATION: (CHC_T00009277001_1) or (CHC_T00009277001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADP__45__D__45__GLUCOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__14__46__21__46__6__45__RXN" name="1.14.21.6-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3 , PWY66-341

GENE_ASSOCIATION: (CHC_T00006481001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4186_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__4187_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__1__46__1__46__145__45__RXN" name="1.1.1.145-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003646001_1) or (CHC_T00007359001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3b__45__hydroxy__45__D5__45__steroids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__D5__45__steroids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ORNITHINE__45__GLU__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-glutarate aminotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-3341 , ARG-PRO-PWY , PWY-6344 , PWY-4981 , ARGININE-SYN4-PWY , CITRULBIO-PWY , ARGASEDEG-PWY , PWY-6922

GENE_ASSOCIATION: (CHC_T00002893001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ORNITHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4142" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2724 , PWY-2501

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Fatty__45__Aldehydes_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__6__46__3__46__16__45__RXN" name="probable arsenite translocating ATPase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4621

GENE_ASSOCIATION: (CHC_T00006022001_1) or (CHC_T00006037001_1) or (CHC_T00009174001_1) or (CHC_T00009174001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__763_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__763_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SPONTPRO__45__RXN" name="SPONTPRO-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-3341 , PWY-6853 , ARG-PRO-PWY , PROUT-PWY , PWY-6344 , PWY-4981 , CITRULBIO-PWY , PWY-6922 , PROSYN-PWY , PWY-7770

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MYO__45__INOSITOL__45__2__45__DEHYDROGENASE__45__RXN" name="myo-inositol dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7241 , PWY-7237 , PWY-5940 , P562-PWY

GENE_ASSOCIATION: (CHC_T00009082001_1) or (CHC_T00008315001_1) or (CHC_T00007975001_1) or (CHC_T00009290001_1) or (CHC_T00008315001) or (CHC_T00009290001) or (CHC_T00009082001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14808_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__13__46__4__45__RXN" name="3.1.13.4-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007271001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_mRNAs__45__With__45__PolyA__45__Tails_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_mRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HEME__45__OXYGENASE__45__DECYCLIZING__45__RXN" name="HEME-OXYGENASE-DECYCLIZING-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5874

GENE_ASSOCIATION: (CHC_T00006260001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTOHEME_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FE__43__2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__MONOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_BILIVERDINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTIDINE__45____45__TRNA__45__LIGASE__45__RXN" name="histidine tRNA synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_255) or (CHC_T00004806001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HIS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HIS__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Charged__45__HIS__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_OXYGEN__45__MOLECULE" name="ExchangeSeed_OXYGEN-MOLECULE" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OXYGEN__45__MOLECULE_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ARGININE__45__2__45__MONOOXYGENASE__45__RXN" name="ARGININE-2-MONOOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

SUBSYSTEM: ARGDEG-V-PWY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ARG_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__GUANIDO__45__BUTYRAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRNA__45__URACIL__45__5__45____45__METHYLTRANSFERASE__45__RXN" name="TRNA-URACIL-5--METHYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008089001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Uracil__45__54__45__in__45__tRNA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNA__45__containing__45__5Me__45__uridine54_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DCMP__45__DEAMINASE__45__RXN" name="DCMP-DEAMINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7210

GENE_ASSOCIATION: (CHC_T00004709001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DCMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DUMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__708" name="RXN-708" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2541

GENE_ASSOCIATION: (CHC_T00002789001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4141_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__707_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOMOCYSMETB12__45__RXN" name="HOMOCYSMETB12-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HOMOSER-METSYN-PWY , 1CMET2-PWY , PWY-2201 , PWY-3841 , ADENOSYLHOMOCYSCAT-PWY , HSERMETANA-PWY

GENE_ASSOCIATION: (CHC_T00005524001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__METHYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__27__46__9__45__RXN" name="3.1.27.9-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7803 , PWY-6689

GENE_ASSOCIATION: (CHC_T00001110001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2350_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNA__45__Introns_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pre__45__tRNA__45__5__45__prime__45__half__45__molecules_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pre__45__tRNA__45__3__45__prime__45__half__45__molecules_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14957" name="Lipoate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7382

GENE_ASSOCIATION: (CHC_T00008509001) or (CHC_T00008509001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_a__45__pyruvate__45__dehydrogenase__45__E2__45__protein__45__Nsup_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pyruvate__45__dehydrogenase__45__lipoate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Oxidized__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSPHOGLUCMUT__45__RXN" name="phosphoglucomutase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5941 , PWY-2723 , PWY-5940 , PWY66-422 , PWY-3801 , PWY-6317 , PWY-622 , PWY-6731 , PWY-6737 , GLUCOSE1PMETAB-PWY , PWY-5384 , GLYCOCAT-PWY , PWY-5661 , PWY-7343 , PWY-7238 , GLYCOGENSYNTH-PWY

GENE_ASSOCIATION: (CHC_T00005896001_1) or (CHC_T00008779001_1) or (CHC_T00008779001) or (CHC_T00003000001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__glucopyranose__45__6__45__phosphate_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_S__45__2__45__HYDROXY__45__ACID__45__OXIDASE__45__RXN" name="S-2-HYDROXY-ACID-OXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004702001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__2__45__Hydroxyacids1_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__Oxo__45__carboxylates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GPPSYN__45__RXN" name="GPPSYN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7141 , PWY-5122 , PWY-5123 , PWY-7182 , PWY-6383 , PWY-7410 , PWY-6859 , PWY-7736 , PWY-7709 , PWY-7102 , PWY-7659

GENE_ASSOCIATION: (CHC_T00003042001_1) or (CHC_T00004833001_1) or (CHC_T00008265001_1) or (CHC_T00008377001_1) or (CHC_T00006851001_1) or (CHC_T00002324001_1) or (CHC_T00002263001_1) or (CHC_T00000930001_1) or (CHC_T00005639001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4211_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GERANYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MALEYLACETOACETATE__45__ISOMERASE__45__RXN" name="MALEYLACETOACETATE-ISOMERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TYRFUMCAT-PWY

GENE_ASSOCIATION: (CHC_T00008425001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4__45__MALEYL__45__ACETOACETATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_4__45__FUMARYL__45__ACETOACETATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__26__46__11__45__RXN" name="3.1.26.11-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005540001_1) or (CHC_T00008119001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNA__45__precursors_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_mature__45__tRNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SS__45__Oligoribonucleotides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DEPHOSPHOCOAKIN__45__RXN" name="DEPHOSPHOCOAKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: COA-PWY-1 , COA-PWY

GENE_ASSOCIATION: (CHC_T00006507001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DEPHOSPHO__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__462" name="RXN1F-462" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5321 , PWY-7173 , PWY-5390 , PWY-7172 , PWY-7129 , PWY-7137

GENE_ASSOCIATION: (CHC_T00001656001_1) or (CHC_T00000989001_1) or (CHC_T00003244001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__520_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__437_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13426" name="&alpha;-linolenoyl-CoA &Delta;6-desaturase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7049

GENE_ASSOCIATION: (CHC_T00008879001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LINOLENOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__14392_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__1__46__139__45__RXN" name="2.7.1.139-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6554

GENE_ASSOCIATION: (CHC_T00001462001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__506_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11244" name="RXN-11244" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7046 , PWY-6435

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__COUMAROYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12199_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1882" name="RXN-1882" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-882 , PWY-5115 , PWY4FS-12 , PWY4FS-13

GENE_ASSOCIATION: (CHC_T00009453001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GDP__45__L__45__GALACTOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANSALDOL__45__RXN" name="TRANSALDOL-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , PWY-5723 , PWY-1861 , P185-PWY , NONOXIPENT-PWY

GENE_ASSOCIATION: (CHC_T00000120001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__SEDOHEPTULOSE__45__7__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ERYTHROSE__45__4P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7706" name="RXN-7706" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5082

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7036_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7037_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_PHOSPHASERDECARB__45__RXN_PORPHYRA__45__334" name="extended_PHOSPHASERDECARB-RXN_PORPHYRA-334" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008892001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PORPHYRA__45__334_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MAA2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7952__45__CPD66__45__43__47__WATER__47____47__GLYCEROL__47__PALMITATE__47__PROTON__46__42__46__" name="RXN-7952-CPD66-43/WATER//GLYCEROL/PALMITATE/PROTON.42." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD66__45__43_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIOHBUTANONEPSYN__45__RXN" name="DIOHBUTANONEPSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6168 , PWY-6167 , RIBOSYN2-PWY

GENE_ASSOCIATION: (CHC_T00001056001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RIBULOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROXY__45__BUTANONE__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11478" name="RXN-11478" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6519

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Enoylglutaryl__45__ACP__45__methyl__45__esters_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glutaryl__45__ACP__45__methyl__45__esters_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FRUCTOKINASE__45__RXN" name="FRUCTOKINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6531 , PWY-4101 , SUCUTIL-PWY , PWY-3801 , P122-PWY , PWY-621 , PWY-5384 , SUCROSEUTIL2-PWY

GENE_ASSOCIATION: (CHC_T00007969001_1) or (CHC_T00008037001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BETA__45__D__45__FRUCTOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENYL__45__KIN__45__RXN" name="ADENYL-KIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7219

GENE_ASSOCIATION: (CHC_T00000884001_1) or (CHC_T00006303001_1) or (CHC_T00004355001_1) or (CHC_T00002564001_1) or (CHC_T00008779001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRNUTRANSHYDROGEN__45__RXN" name="NAD(P) transhydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5083

GENE_ASSOCIATION: (CHC_T00008930001) or (CHC_T00008930001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12263" name="RXN-12263" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5875 , PWY-6767 , PWY-7072 , PWY-6105

GENE_ASSOCIATION: (CHC_T00001581001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__465_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__7239" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OLEATE__45__CPD_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__46__2__46__99__46__18__45__RXN" name="4.2.99.18-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000985001_1) or (CHC_T00000546001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DNA__45__containing__45__abasic__45__Sites_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__Phospho__45__terminated__45__DNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__terminal__45__unsaturated__45__sugars_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FERRIC__45__CHELATE__45__REDUCTASE__45__RXN" name="FERRIC-CHELATE-REDUCTASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5934 , PWY-6854

GENE_ASSOCIATION: (CHC_T00003126001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Fe3__45__siderophores_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Fe2__45__siderophores_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2002" name="RXN-2002" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6443 , PWY-6458 , PWY-6446

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CINNAMOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__513_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HEXADECANOL__45__DEHYDROGENASE__45__RXN" name="HEXADECANOL-DEHYDROGENASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__348_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THREONINE__45____45__TRNA__45__LIGASE__45__RXN" name="threonine--tRNA ligase, cytoplasmic" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00008771001_1) or (CHC_T00009393001_1) or (CHC_T00008771001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THR__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__THR__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17373" name="probable 2-epi-valiolone synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009338001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__SEDOHEPTULOSE__45__7__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18780_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10915" name="3,4-dihydroxyphenylglycol dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6342

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11497_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11876_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__20" name="magnesium chelatase subunit H" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7159 , PWY-5531 , CHLOROPHYLL-SYN

GENE_ASSOCIATION: (CHC_T00008429001_1) or (CHC_T00008422001_1) or (CHC_T00000990001_1) or (CHC_T00008032001_1) or (CHC_T00008422001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MG__43__2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTOPORPHYRIN_IX_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MG__45__PROTOPORPHYRIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4231" name="RXN-4231" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2582

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__698_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__3945_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_IPPISOM__45__RXN" name="IPPISOM-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NONMEVIPP-PWY , PWY-7560 , PWY-5123 , PWY-7524 , PWY-7391 , PWY-6383 , PWY-6859 , PWY-922 , PWY-7102 , PWY-6174

GENE_ASSOCIATION: (CHC_T00001581001_1) or (CHC_T00006126001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4211_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9658" name="trans hex-2-enoyl-[acp]-reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Hex__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Hexanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11057" name="RXN-11057" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6398

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__ACETYL__45__5__45__METHOXY__45__TRYPTAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FORMALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__ACETYL__45__SEROTONIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6305 , ORNDEG-PWY , PWY-46

GENE_ASSOCIATION: (CHC_T00010074001) or (CHC_T00010074001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__ORNITHINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PUTRESCINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CELLULOSE__45__SYNTHASE__45__UDP__45__FORMING__45__RXN" name="CELLULOSE-SYNTHASE-UDP-FORMING-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1001

GENE_ASSOCIATION: (CHC_T00008534001_1) or (CHC_T00009525001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CELLULOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CELLULOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__3__46__57__45__RXN" name="3.1.3.57-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6363

GENE_ASSOCIATION: (CHC_T00008808001_1) or (CHC_T00008454001_1) or (CHC_T00001291001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INOSITOL__45__1__45__4__45__BISPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__MYO__45__INOSITOL__45__4__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_FE__43__3" name="ExchangeSeed_FE+3" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FE__43__3_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FE__43__3_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9674" name="RXN-9674" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6002 , PWY-7092

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10277_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12699_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7745" name="RXN-7745" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5101

GENE_ASSOCIATION: (CHC_T00009293001_1) or (CHC_T00009162001_1) or (CHC_T00008852001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7066_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__OXOBUTANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__317" name="4&alpha;-formyl-5&alpha;-cholesta-8,24-dien-3&beta;-ol 4-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074 , PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4580_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4702_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8674" name="RXN-8674" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001330001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10490_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYOX_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETHANAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYTOCHROME__45__C__45__OXIDASE__45__RXN" name="CYTOCHROME-C-OXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7279 , PWY-3781 , PWY-4521

GENE_ASSOCIATION: (CHC_T00009022001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cytochromes__45__C__45__Reduced_e" stoichiometry="4" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="8" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_e" stoichiometry="4" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Cytochromes__45__C__45__Oxidized_e" stoichiometry="4" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_NITRATE" name="TransportSeed_NITRATE" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NITRATE_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NITRATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__46__3__46__1__46__17__45__RXN" name="similar to serine dehydratase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009480001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__773" name="RXN-773" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2582 , PWY-699

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__710_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__712_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBONUCLEOSIDE__45__DIP__45__REDUCTI__45__RXN" name="ribonucleoside-diphosphate reductase beta chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008864001_1) or (CHC_T00008926001_1) or (CHC_T00008864001) or (CHC_T00008926001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ribonucleoside__45__Diphosphates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Deoxy__45__Ribonucleoside__45__Diphosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__3__46__74__45__RXN" name="Pyridoxal phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7204

GENE_ASSOCIATION: (CHC_T00008718001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXAL_PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXAL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14394" name="RXN-14394" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15244_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7221_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_OHBUTYRYL__45__COA__45__EPIM__45__RXN" name="OHBUTYRYL-COA-EPIM-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: FAO-PWY , PWY-5138

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__3__45__HYDROXYACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__3__45__HYDROXYACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RETINOL__45__DEHYDROGENASE__45__RXN" name="all-trans-retinol dehydrogenase (NAD)" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009571001_1) or (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13524_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_RETINAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PEPTIDYLPROLYL__45__ISOMERASE__45__RXN" name="Peptidyl-prolyl cis-trans isomerase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005215001_1) or (CHC_T00008963001_1) or (CHC_T00007958001_1) or (CHC_T00007696001_1) or (CHC_T00009116001_1) or (CHC_T00001971001_1) or (CHC_T00008322001_1) or (CHC_T00006404001_1) or (CHC_T00003821001_1) or (CHC_T00010100001_1) or (CHC_T00007310001_1) or (CHC_T00006996001_1) or (CHC_T00003429001_1) or (CHC_T00000384001_1) or (CHC_T00006888001_1) or (CHC_T00002787001_1) or (CHC_T00009552001_1) or (CHC_T00009539001_1) or (CHC_T00007913001_1) or (CHC_T00004338001_1) or (CHC_T00006154001_1) or (CHC_T00001335001_1) or (CHC_T00006301001_1) or (CHC_T00008599001) or (CHC_T00010100001) or (CHC_T00008726001) or (CHC_T00008963001) or (CHC_T00009552001) or (CHC_T00009539001) or (CHC_T00008420001) or (CHC_T00009116001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8624_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8625_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GPH__45__RXN" name="Phosphoglycolate phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-181

GENE_ASSOCIATION: (CHC_T00008946001_1) or (CHC_T00008678001) or (CHC_T00008858001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__67_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCOLLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_METHIONYL__45__TRNA__45__FORMYLTRANSFERASE__45__RXN" name="METHIONYL-TRNA-FORMYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003453001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__methionyl__45__tRNAfmet_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__formyl__45__L__45__methionyl__45__tRNAfmet_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12614" name="RXN-12614" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6891

GENE_ASSOCIATION: (CHC_T00001330001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12279_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7676" name="chlorophyllide-a monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5068

GENE_ASSOCIATION: (CHC_T00000246001_1) or (CHC_T00006958001_1) or (CHC_T00004024001_1) or (CHC_T00003882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7015_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14200" name="RXN-14200" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_TTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_TMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BETA__45__UREIDOPROPIONASE__45__RXN" name="BETA-UREIDOPROPIONASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-3982

GENE_ASSOCIATION: (CHC_T00006316001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_3__45__UREIDO__45__PROPIONATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_B__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4OHBENZOATE__45__OCTAPRENYLTRANSFER__45__RXN" name="4OHBENZOATE-OCTAPRENYLTRANSFER-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6708 , PWY-5870

GENE_ASSOCIATION: (CHC_T00002263001_1) or (CHC_T00003042001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OCTAPRENYL__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__hydroxybenzoate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_Exchange_BIOMASS" name="Exchange_BIOMASS" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BIOMASS_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BIOMASS_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_QUEUOSINE__45__TRNA__45__RIBOSYLTRANSFERASE__45__RXN" name="QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008743001_1) or (CHC_T00008745001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_QUEUINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Guanine34__45__in__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNAs__45__with__45__queuine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GUANINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15479" name="photosystem I subunit II" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-101

GENE_ASSOCIATION: (CHC_665) or (CHC_25) or (CHC_420) or (CHC_1075) or (CHC_1150)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Oxidized__45__ferredoxins_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Plastocyanin__45__Reduced_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Light_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__Plastocyanins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__9__46__3__45__RXN" name="2.7.9.3-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-901 , PWY-6281

GENE_ASSOCIATION: (CHC_T00005216001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SE__45__2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SEPO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14480" name="RXN-14480" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000153001_1) or (CHC_T00003933001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_6__45__Dimethylallyladenosine37__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15360_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__24__45__RXN" name="alpha-mannosidase type II manG" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008655001_1) or (CHC_T00008655001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alpha__45__D__45__Mannosides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13559_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Non__45__Glycosylated__45__sugar__45__Acceptors_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__151" name="RXN1F-151" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5943

GENE_ASSOCIATION: (CHC_T00009303001_1) or (CHC_T00003979001_1) or (CHC_T00002318001_1) or (CHC_T00009401001_1) or (CHC_T00009131001_1) or (CHC_T00008663001_1) or (CHC_T00009499001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008616001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1F__45__126_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1F__45__129_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6__46__3__46__4__46__9__45__RXN" name="6.3.4.9-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001081001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_apo__45__Transcarboxylases_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_holo__45__Transcarboxylases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7668" name="RXN-7668" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5067

GENE_ASSOCIATION: (CHC_T00009277001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_POLY__45__GLUCOSYLATED__45__GLYCOGENINS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_POLY__45__GLUCOSYLATED__45__GLYCOGENINS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__353" name="RXN66-353" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7299

GENE_ASSOCIATION: (CHC_T00007359001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PREGNENOLONE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD66__45__28_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7647" name="RXN-7647" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5059

GENE_ASSOCIATION: (CHC_T00008856001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__6993_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__6991_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__113__45__RXN" name="mannosyl-oligosaccharide1,2-alpha-mannosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008848001_1) or (CHC_T00009079001_1) or (CHC_T00008364001) or (CHC_T00009079001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Mannosyl9__45__Nacetylglucosaminyl2_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Mannosyl8__45__Nacetylglucosaminyl2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MANNOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GST__45__RXN" name="Glutathione S-transferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009287001_1) or (CHC_T00006560001_1) or (CHC_T00008810001_1) or (CHC_T00009444001_1) or (CHC_T00008274001_1) or (CHC_T00009312001_1) or (CHC_T00008791001_1) or (CHC_T00003419001_1) or (CHC_T00009287001) or (CHC_T00008791001) or (CHC_T00008724001) or (CHC_T00008766001) or (CHC_T00009444001) or (CHC_T00008810001) or (CHC_T00008274001) or (CHC_T00009312001) or (CHC_T00008331001) or (CHC_T00008425001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__CHLORO__45__24__45__DINITROBENZENE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CL__45___c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__24__45__DINITROPHENYLGLUTATHIONE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3PGAREARR__45__RXN" name="3PGAREARR-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , PWY-5484 , PWY-1042 , PWY-5723 , GLYCOLYSIS , PWY-6901 , PWY-6142 , PWY-7003 , PWY-7218 , PWY-7124 , PWY-2221 , GLUCONEO-PWY , PWY-6886 , P341-PWY

GENE_ASSOCIATION: (CHC_T00001519001_1) or (CHC_T00004201001_1) or (CHC_T00007707001_1) or (CHC_T00000449001_1) or (CHC_T00001241001_1) or (CHC_T00004490001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__PG_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_G3P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2142" name="beta-ketoacyl reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-862

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_b__45__Keto__45__cis__45__D5__45__dodecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_b__45__Hydroxy__45__cis__45__D5__45__dodecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__45__PHOSPHATIDYLINOSITOL__45__KINASE__45__RXN" name="1-PHOSPHATIDYLINOSITOL-KINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6351 , PWY-6352

GENE_ASSOCIATION: (CHC_T00000531001_1) or (CHC_T00004060001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__1__45__phosphatidyl__45__inositols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1108_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__5__46__1__46__58__45__RXN" name="2.5.1.58-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003446001_1) or (CHC_T00003240001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROT__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__S__45__farnesyl__45__L__45__cysteines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8228" name="delphinidin 3-O-glucoside 5-O-glucosyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5307

GENE_ASSOCIATION: (CHC_T00001656001_1) or (CHC_T00000989001_1) or (CHC_T00003244001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7117_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7139_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RETINYL__45__PALMITATE__45__ESTERASE__45__RXN" name="retinyl-palmitate esterase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003680001_1) or (CHC_T00000998001_1) or (CHC_T00008784001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHOCOLA_A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PALMITATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Retinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PREPHENATEDEHYDRAT__45__RXN" name="PREPHENATEDEHYDRAT-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7432 , PHESYN

GENE_ASSOCIATION: (CHC_T00003465001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PREPHENATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHENYL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11484" name="RXN-11484" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7147 , PWY-6519

GENE_ASSOCIATION: (CHC_T00004094001_1) or (CHC_T00004096001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pimeloyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_8__45__AMINO__45__7__45__OXONONANOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_PROTON" name="TransportSeed_PROTON" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__11__46__18__45__RXN" name="methionyl aminopeptidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008747001_1) or (CHC_T00006524001_1) or (CHC_T00005764001_1) or (CHC_T00008747001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__With__45__N__45__Terminal__45__Met_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__24__46__56__45__RXN" name="3.4.24.56-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006291001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_POLYPEPTIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_MN__43__2" name="ExchangeSeed_MN+2" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MN__43__2_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MN__43__2_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__905" name="RXN-905" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-81

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBOXYMETHYL__45__HYDROXYPHENYLPROPCOA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BENZOYLSUCCINYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1382" name="RXN-1382" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7506 , PHOSLIPSYN2-PWY , PWY-6273

GENE_ASSOCIATION: (CHC_T00000039001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__1__45__PHOSPHATIDYL__45__SERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETHANOL__45__AMINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__29" name="TRANS-RXN1HP7-29" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007225001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Anions_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NA__43___e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Anions_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NA__43___c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLY3KIN__45__RXN" name="GLY3KIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-181

GENE_ASSOCIATION: (CHC_T00002505001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCERATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_G3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9281" name="nonaprenyldihydroxybenzoate methyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5871

GENE_ASSOCIATION: (CHC_T00007491001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9896_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__9898_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYSTEINE__45____45__TRNA__45__LIGASE__45__RXN" name="Cysteinyl-tRNA Synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00002892001_1) or (CHC_T00009398001_1) or (CHC_T00009398001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__CYS__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_CPD__45__315" name="TransportSeed_CPD-315" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__315_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__315_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__445" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Arachidoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__behenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTOLDEHYD__45__RXN" name="histidinol dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HISTSYN-PWY

GENE_ASSOCIATION: (CHC_T00008451001) or (CHC_T00008451001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HISTIDINOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HISTIDINAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_COB__45__I__45__ALAMIN" name="ExchangeSeed_COB-I-ALAMIN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_COB__45__I__45__ALAMIN_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_COB__45__I__45__ALAMIN_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12392" name="Starch phosphorylase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Linear__45__Malto__45__Oligosaccharides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Linear__45__Malto__45__Oligosaccharides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4209" name="RXN-4209" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2541

GENE_ASSOCIATION: (CHC_T00006481001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4125_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__4126_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4210" name="RXN-4210" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2541

GENE_ASSOCIATION: (CHC_T00006493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4126_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4127_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTAMINOTRANS__45__RXN" name="probable histidinol-phosphate aminotransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HISTSYN-PWY

GENE_ASSOCIATION: (CHC_T00008605001_1) or (CHC_T00009141001_1) or (CHC_T00008605001) or (CHC_T00009141001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_IMIDAZOLE__45__ACETOL__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__HISTIDINOL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__482" name="trans-2-enoyl-CoA reductase (NADPH)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-389

GENE_ASSOCIATION: (CHC_T00008594001_1) or (CHC_T00008438001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14928_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__206_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11356" name="RXN-11356" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6475

GENE_ASSOCIATION: (CHC_T00008407001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7526_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETR__45__Quinones_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7524_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETR__45__Quinols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5098" name="RXN0-5098" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1275

GENE_ASSOCIATION: (CHC_T00006203001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Lipoyl__45__Protein__45__L__45__Lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__195_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Octanoylated__45__domains_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GAMMA__45__GLUTAMYLCYCLOTRANSFERASE__45__RXN" name="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4041

GENE_ASSOCIATION: (CHC_T00003336001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__OXOPROLINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11195" name="RXN-11195" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007556001_1) or (CHC_T00008899001_1) or (CHC_T00003369001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ferrihemoglobins_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ferrohemoglobins_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10781" name="5-hydroxytryptophol dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6313

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__HYDROXYINDOLE_ACETALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11671_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8999" name="RXN-8999" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5785

GENE_ASSOCIATION: (CHC_T00001389001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="8" constant="false"/>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UNDECAPRENYL__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="8" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYTOCHROME__45__C__45__PEROXIDASE__45__RXN" name="CYTOCHROME-C-PEROXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010263001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cytochromes__45__C__45__Reduced_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Cytochromes__45__C__45__Oxidized_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13163" name="3-isopropylmalate dehydratase small subunit" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009087001_1) or (CHC_T00009184001_1) or (CHC_T00009184001) or (CHC_T00009087001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LINOLEOYL__45__RXN" name="LINOLEOYL-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6917

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LINOLEIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13603" name="neolinustatin &beta;-diglucosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7092

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14596_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__10277_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GUANIDINOBUTYRASE__45__RXN" name="GUANIDINOBUTYRASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

SUBSYSTEM: ARGDEG-IV-PWY , PWY-7523 , ARGDEG-V-PWY , PWY-5742

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__592_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UREA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__AMINO__45__BUTYRATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETOLACTREDUCTOISOM__45__RXN" name="ketol-acid reductoisomerase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7111 , VALSYN-PWY

GENE_ASSOCIATION: (CHC_T00008929001) or (CHC_T00008929001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13357_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__ACETO__45__LACTATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RNA__45__DIRECTED__45__DNA__45__POLYMERASE__45__RXN" name="RNA-dependent DNA polymerase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010272001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Deoxy__45__Ribonucleoside__45__Triphosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DNA__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DNA__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11845" name="RXN-11845" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000312001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_23S__45__rRNA__45__uridine__45__2552_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_23S__45__rRNA__45__2__45__O__45__methyluridine2552_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9336" name="RXN-9336" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5883

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__674_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BENZOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__46__99__46__1__46__3__45__RXN" name="4.99.1.3-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7377

GENE_ASSOCIATION: (CHC_T00007728001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__43__2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SIROHYDROCHLORIN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_COBALT__45__SIROHYDROCHLORIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYSTEINE__45__AMINOTRANSFERASE__45__RXN" name="CYSTEINE-AMINOTRANSFERASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5329 , PWY0-1534

GENE_ASSOCIATION: (CHC_T00005085001_1) or (CHC_T00009477001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__MERCAPTO__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_D__45__AMINO__45__ACID__45__OXIDASE__45__RXN" name="D-AMINO-ACID-OXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003782001_1) or (CHC_T00003785001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__Oxo__45__carboxylates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_KETOLACTOSE__45__RXN" name="KETOLACTOSE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: LACTOSEUTIL-PWY

GENE_ASSOCIATION: (CHC_T00008905001_1) or (CHC_T00008606001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__KETOLACTOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1242_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14325" name="RXN-14325" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007798001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DAHPSYN__45__RXN" name="3-deoxy-7-phosphoheptulonate synthase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6164

GENE_ASSOCIATION: (CHC_T00009474001_1) or (CHC_T00009382001_1) or (CHC_T00009474001) or (CHC_T00009382001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ERYTHROSE__45__4P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12624" name="chitinase-domain containing protein" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004415001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Chitodextrins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13227_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ENOYL__45__COA__45__DELTA__45__ISOM__45__RXN" name="Enoyl-CoA hydratase/isomerase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: FAO-PWY , PWY-5137

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1) or (CHC_T00008882001) or (CHC_T00009422001) or (CHC_T00008307001_1) or (CHC_T00009238001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CIS__45__DELTA3__45__ENOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TRANS__45__D2__45__ENOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_N__45__ACETYLGLUTPREDUCT__45__RXN" name="N-acetyl-gamma-glutamyl-phosphate reductase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ARGSYNBSUB-PWY , PWY-5154 , GLUTORN-PWY

GENE_ASSOCIATION: (CHC_T00009278001_1) or (CHC_T00009278001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__469_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__ACETYL__45__GLUTAMYL__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__18229" name="nitrilase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008379001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14673_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__PHENYLPROPIONATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FADSYN__45__RXN" name="FADSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6168 , PWY66-366 , PWY-6167 , RIBOSYN2-PWY

GENE_ASSOCIATION: (CHC_T00002523001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FMN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_CU__43__2" name="TransportSeed_CU+2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CU__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CU__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRAMKIN__45__RXN" name="PYRAMKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PLPSAL-PWY , PWY-7204

GENE_ASSOCIATION: (CHC_T00004634001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRIDOXAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PYRIDOXAMINE__45__5P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9601" name="RXN-9601" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6001

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__161" name="GA12-aldehyde monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5034 , PWY-5047

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__138_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__95_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1081" name="RXN0-1081" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003682001_1) or (CHC_T00005491001_1) or (CHC_T00001334001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNA__45__Arg__45__adenosine34_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNA__45__Arg__45__inosine34_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7700" name="RXN-7700" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5751 , PWY-5079

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHENYLACETALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7035_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTAMIDOTRANS__45__RXN" name="GLUTAMIDOTRANS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HISTSYN-PWY

GENE_ASSOCIATION: (CHC_T00001287001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AICAR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PGLUCONDEHYDRAT__45__RXN" name="PGLUCONDEHYDRAT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ENTNER-DOUDOROFF-PWY

GENE_ASSOCIATION: (CHC_T00009385001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__2961_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6478" name="ribonuclease E" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1479

GENE_ASSOCIATION: (CHC_120)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2350_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__2350_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2351_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDROOROT__45__RXN" name="Glutamine-dependent carbamoyl-phosphate synthase, Aspartate carbamoyltransferase, Dihydroorotase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7791 , PWY-7790 , PWY-5686

GENE_ASSOCIATION: (CHC_T00006412001_1) or (CHC_T00008596001_1) or (CHC_T00010056001_1) or (CHC_T00005381001_1) or (CHC_T00010056001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DI__45__H__45__OROTATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBAMYUL__45__L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__5__46__1__46__19__45__RXN" name="1.5.1.19-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000412001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ARG_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__308_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__469" name="3-methyl-branched fatty acyl-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-387

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Methyl__45__Saturated__45__Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Methyl__45__Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__13__46__9__45__RXN" name="3.4.13.9-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005156001_1) or (CHC_T00001494001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Dipeptides__45__With__45__Proline__45__Carboxy_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Amino__45__Acids__45__20_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRO_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15045" name="glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7411

GENE_ASSOCIATION: (CHC_T00008773001) or (CHC_T00008773001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__1__45__LYSOPHOSPHATIDATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYSTINE__45__REDUCTASE__45__NADH__45__RXN" name="CYSTINE-REDUCTASE-NADH-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CYSTINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ATPSYN__45__RXN" name="V-type ATP synthase, Subunit G" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7219

GENE_ASSOCIATION: (CHC_T00004901001_1) or (CHC_T00006181001_1) or (CHC_T00005161001_1) or (CHC_T00008719001_1) or (CHC_T00008404001_1) or (CHC_T00006782001_1) or (CHC_T00005903001_1) or (CHC_T00006891001_1) or (CHC_T00007788001_1) or (CHC_T00010194001_1) or (CHC_T00006631001_1) or (CHC_T00010260001_1) or (CHC_T00010053001_1) or (CHC_T00009073001_1) or (CHC_T00009194001_1) or (CHC_T00010175001_1) or (CHC_T00010124001_1) or (CHC_T00005827001_1) or (CHC_T00010260001) or (CHC_840) or (CHC_T00010194001) or (CHC_T00010146001) or (CHC_T00009194001) or (CHC_760)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_e" stoichiometry="4" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17428" name="RXN-17428" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__7005_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CHLOROPHYLL__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5217" name="RXN0-5217" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1303

GENE_ASSOCIATION: (CHC_T00009140001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CADAVERINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__METHYLTHIOADENOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__1065_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ORNITHINE__45____45__OXO__45__ACID__45__AMINOTRANSFERASE__45__RXN" name="ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002893001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__Oxo__45__carboxylates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ORNITHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Amino__45__Acids__45__20_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1602__45__CPD__45__17271__47__WATER__47____47__CPD66__45__43__47__STEARIC_ACID__47__PROTON__46__46__46__" name="RXN-1602-CPD-17271/WATER//CPD66-43/STEARIC_ACID/PROTON.46." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17271_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_STEARIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD66__45__43_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14354" name="Disproportionating Enzyme type 2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7238

GENE_ASSOCIATION: (CHC_T00009120001_1) or (CHC_T00009120001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Soluble__45__Heteroglycans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Soluble__45__Heteroglycans_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4301" name="RXN-4301" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2661

GENE_ASSOCIATION: (CHC_T00009540001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycogens_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Maltodextrins_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8443" name="RXN-8443" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5381

GENE_ASSOCIATION: (CHC_T00008019001_1) or (CHC_T00009119001_1) or (CHC_T00008932001_1) or (CHC_T00007870001_1) or (CHC_T00009267001_1) or (CHC_T00009300001_1) or (CHC_T00008702001_1) or (CHC_T00008503001_1) or (CHC_T00008731001_1) or (CHC_T00009344001_1) or (CHC_T00008716001_1) or (CHC_T00009299001_1) or (CHC_T00008700001_1) or (CHC_T00008284001_1) or (CHC_T00008711001_1) or (CHC_T00009481001_1) or (CHC_T00008310001_1) or (CHC_T00008964001_1) or (CHC_T00008904001_1) or (CHC_T00000777001_1) or (CHC_T00006889001_1) or (CHC_T00004793001_1) or (CHC_T00000891001_1) or (CHC_T00008508001_1) or (CHC_T00009163001_1) or (CHC_T00008949001_1) or (CHC_T00008979001_1) or (CHC_T00008548001_1) or (CHC_T00008793001_1) or (CHC_T00008885001_1) or (CHC_T00009536001_1) or (CHC_T00009092001_1) or (CHC_T00009038001_1) or (CHC_T00008708001_1) or (CHC_T00008638001_1) or (CHC_T00009315001_1) or (CHC_T00009573001_1) or (CHC_T00008817001_1) or (CHC_T00009203001_1) or (CHC_T00008462001_1) or (CHC_T00008959001_1) or (CHC_T00008833001_1) or (CHC_T00009242001_1) or (CHC_T00009439001_1) or (CHC_T00010324001_1) or (CHC_T00008532001_1) or (CHC_T00008435001_1) or (CHC_T00002425001_1) or (CHC_T00008541001_1) or (CHC_T00008388001_1) or (CHC_T00009317001_1) or (CHC_T00008625001_1) or (CHC_T00009286001_1) or (CHC_T00008682001_1) or (CHC_T00008925001_1) or (CHC_T00003488001_1) or (CHC_T00009517001_1) or (CHC_T00008389001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8259_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NICOTINATE_NUCLEOTIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYOHMETRANS__45__RXN__45__SER__47__THF__47____47__GLY__47__METHYLENE__45__THF__47__WATER__46__33__46__" name="GLYOHMETRANS-RXN-SER/THF//GLY/METHYLENE-THF/WATER.33." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_THF_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLENE__45__THF_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_RXN3O__45__218" name="extended_RXN3O-218" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: late_SSR , early_SSR

GENE_ASSOCIATION: (CHC_T00006492-3001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_7__45__DEHYDROCHOLESTEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CHOLESTEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLYSYN-ALA-PWY

GENE_ASSOCIATION: (CHC_T00008340001_1) or (CHC_T00002893001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYOX_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12567" name="RXN-12567" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6863

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OH__45__HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__2121_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11919" name="(2E)-5-methylhexa-2,4-dienoyl-CoA hydratase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6672

GENE_ASSOCIATION: (CHC_T00009110001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12904_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12905_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__71__45__RXN" name="2.1.1.71-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY4FS-3 , PWY-6825

GENE_ASSOCIATION: (CHC_T00007321001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__405_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__160_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2762" name="RXN-2762" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1581 , PWY-6978

GENE_ASSOCIATION: (CHC_T00009101001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__METHYL__45__6__45__SOLANYL__45__14__45__BENZOQUINONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12829_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__3__46__1__46__97__45__RXN" name="2.3.1.97-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003589001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYCYL__45__PEPTIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TETRADECANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__TETRADECANOYLGLYCYL__45__PEPTIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17897" name="Ferredoxin-NADP+ oxidoreductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008519001) or (CHC_T00008519001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9659" name="trans oct-2-enoyl-[acp] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__Octenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14972" name="RXN-14972" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7388

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__oxo__45__hexanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Oxo__45__octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__14__45__RXN" name="3.2.1.14-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6902 , PWY-7822 , PWY-6855

GENE_ASSOCIATION: (CHC_T00004415001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHITIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Chitodextrins_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_NA__43__" name="ExchangeSeed_NA+" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NA__43___C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NA__43___e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12503" name="RXN-12503" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007905001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_p__45__his__45__tRNAS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_App__45__his__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_CARBON__45__DIOXIDE" name="TransportSeed_CARBON-DIOXIDE" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CARBON__45__DIOXIDE_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYFLAVOXRE__45__RXN" name="PYFLAVOXRE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008442001_1) or (CHC_T00003376001_1) or (CHC_T00001730001_1) or (CHC_T00008758001_1) or (CHC_T00001454001_1) or (CHC_T00000866001_1) or (CHC_T00000865001_1) or (CHC_T00003402001_1) or (CHC_T00009061001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__flavodoxins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Reduced__45__flavodoxins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15036" name="RXN-15036" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7409

GENE_ASSOCIATION: (CHC_T00008526001_1) or (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8355_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8291_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17878" name="methionyl aminopeptidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7800

GENE_ASSOCIATION: (CHC_T00008747001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__methionyl__45__L__45__valyl__45__Protein_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__terminal__45__L__45__valine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__476__45__CPD__45__14719__47__NAD__47__WATER__47____47__CPD__45__7830__47__NADH__47__PROTON__46__42__46__" name="RXN66-476-CPD-14719/NAD/WATER//CPD-7830/NADH/PROTON.42." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14719_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7830_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRIDOXKIN__45__RXN" name="PYRIDOXKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7282 , PLPSAL-PWY , PWY-7204

GENE_ASSOCIATION: (CHC_T00004634001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXAL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXAL_PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_IMIDPHOSDEHYD__45__RXN" name="imidazoleglycerol-phosphate dehydratase (IGPD)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HISTSYN-PWY

GENE_ASSOCIATION: (CHC_T00008556001) or (CHC_T00008556001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_IMIDAZOLE__45__ACETOL__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9279" name="RXN-9279" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5872

GENE_ASSOCIATION: (CHC_T00006372001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9864_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9895_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__3__46__7__46__2__45__RXN" name="1.3.7.2-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7579 , PWY-5915

GENE_ASSOCIATION: (CHC_T00008004001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BILIVERDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_1516__45__DIHYDROBILIVERDIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__2__46__21__45__RXN" name="3.1.2.21-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5994 , PWY-5971

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Dodecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DODECANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7682" name="RXN-7682" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SALVADEHYPOX-PWY , PWY-6596 , P164-PWY

GENE_ASSOCIATION: (CHC_T00006932001_1) or (CHC_T00000194001_1) or (CHC_T00006216001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYPOXANTHINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_XANTHINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14274" name="decanoyl-CoA C-acyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10267_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__2105_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSACETYLGLUCOSAMINEMUT__45__RXN" name="PHOSACETYLGLUCOSAMINEMUT-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5514 , UDPNACETYLGALSYN-PWY , PWY-6906

GENE_ASSOCIATION: (CHC_T00001867001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN0__45__470" name="TRANS-RXN0-470" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007015001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__3__46__1__46__179__45__RXN" name="2.3.1.179-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5973

GENE_ASSOCIATION: (CHC_T00009465001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Palmitoleoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__cis__45__vaccenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__748" name="ribonucleoside-diphosphate reductase beta chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7222

GENE_ASSOCIATION: (CHC_T00008864001_1) or (CHC_T00008926001_1) or (CHC_T00008864001) or (CHC_T00008926001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__NrdH__45__Proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DGDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__NrdH__45__Proteins_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17368" name="RXN-17368" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7751

GENE_ASSOCIATION: (Scaffold115_51547_52668)

CATEGORIES: MANUAL and GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18779_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18777_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_POLYNUCLEOTIDE__45__5__45__HYDROXYL__45__KINASE__45__RXN" name="POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002174001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__Dephospho__45__DNA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__Phospho__45__DNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__21__46__83__45__RXN" name="3.4.21.83-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006531001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OLIGOPEPTIDES_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14195" name="RXN-14195" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_DATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_DAMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOMOSERDEAM__45__RXN" name="HOMOSERDEAM-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMO__45__SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__OXOBUTANOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HYPOXANPRIBOSYLTRAN__45__RXN" name="HYPOXANPRIBOSYLTRAN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6609 , PWY-6610

GENE_ASSOCIATION: (CHC_T00004960001_1) or (CHC_T00004428001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYPOXANTHINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_IMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8348" name="RXN-8348" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6823

GENE_ASSOCIATION: (CHC_T00005714001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8122_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8123_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5398" name="RXN0-5398" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6019

GENE_ASSOCIATION: (CHC_T00001369001_1) or (CHC_T00003056001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_URACIL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15317_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PSEUDOURIDINE__45__5__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15561" name="RXN-15561" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7511

GENE_ASSOCIATION: (CHC_T00002417001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__L__45__lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ubiquitinyl__45__UCP__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTEIN__45__N__45__UBIQUITYL__45__LYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquitin__45__carrier__45__protein__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10952" name="RXN-10952" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6363

GENE_ASSOCIATION: (CHC_T00002260001_1) or (CHC_T00001291001_1) or (CHC_T00007726001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__MYO__45__INOSITOL__45__4__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10911" name="RXN-10911" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6342

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROXYPHENYLGLYCOLALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11878_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10059" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321 , PWY-6113

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Lignoceroyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__cerotoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14272" name="(E)-hexadec-2-enoyl-CoA hydratase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7656 , PWY-7654

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2117_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__2232_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTIDPHOS__45__RXN__91__CCO__45__CYTOSOL__93____45__L__45__HISTIDINOL__45__P__47__WATER__47____47__HISTIDINOL__47__Pi__46__49__46__" name="HISTIDPHOS-RXN[CCO-CYTOSOL]-L-HISTIDINOL-P/WATER//HISTIDINOL/Pi.49." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__HISTIDINOL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HISTIDINOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10089" name="imidazole acetaldehyde reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6181

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_IMIDAZOLE_ACETALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__IMIDAZOLEACETATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ASNSYNA__45__RXN" name="ASNSYNA-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ASPARAGINESYN-PWY

GENE_ASSOCIATION: (CHC_T00000667001_1) or (CHC_T00004458001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9546" name="trans-2,3-stearoyl-CoA-reductase (NADPH, B-specific)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5972

GENE_ASSOCIATION: (CHC_T00008438001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10262_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_STEAROYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17877" name="methionyl aminopeptidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7800

GENE_ASSOCIATION: (CHC_T00008747001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__methionyl__45__L__45__threonyl__45__Protein_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__N__45__terminal__45__L__45__threonine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7669" name="1,4-alpha-Glucan branching enzyme" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5067

GENE_ASSOCIATION: (CHC_T00008662001) or (CHC_T00008662001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_POLY__45__GLUCOSYLATED__45__GLYCOGENINS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glycogens_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17016" name="glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008773001) or (CHC_T00008773001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cis__45__vaccenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18348_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14049" name="RXN-14049" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMO__45__SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15056_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__27" name="RXN66-27" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-4

GENE_ASSOCIATION: (CHC_T00006493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8646_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DESMOSTEROL__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_R83__45__RXN" name="E1 enzyme family" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4361

GENE_ASSOCIATION: (CHC_T00010198001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__HYDROXY__45__3__45__KETO__45__5__45__METHYLTHIO__45__1__45__PHOSPHOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__85_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NARINGENIN__45__CHALCONE__45__SYNTHASE__45__RXN" name="NARINGENIN-CHALCONE-SYNTHASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5135 , PWY-6787 , PWY-6316 , PWY1F-FLAVSYN , PWY-7397

GENE_ASSOCIATION: (CHC_T00009104001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_P__45__COUMAROYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_APIGENIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_CPD__45__3" name="TransportSeed_CPD-3" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__3_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__3_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__45__OCTAPRENYL__45__METHOXY__45__BENZOQ__45__METH__45__RXN" name="2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6708 , PWY-5870

GENE_ASSOCIATION: (CHC_T00005416001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OCTAPRENYL__45__METHOXY__45__BENZOQUINONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11575" name="RXN-11575" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5434

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8843_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9648" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Butanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__hexanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16157" name="RXN-16157" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6433

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15367_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17399_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__6" name="TRANS-RXN1HP7-6" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007150001_1) or (CHC_T00008463001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Anions_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Anions_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ETHANOLAMINE__45__KINASE__45__RXN" name="Choline/ethanolamine kinase, putative" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7782 , PWY4FS-6 , PWY-3385

GENE_ASSOCIATION: (CHC_T00008383001) or (CHC_T00008383001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETHANOL__45__AMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHORYL__45__ETHANOLAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16132" name="RXN-16132" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7606

GENE_ASSOCIATION: (CHC_T00008879001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17331_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17385_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10698" name="RXN-10698" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11519_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11520_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__884" name="RXN0-884" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NONMEVIPP-PWY , PWY-7560

GENE_ASSOCIATION: (CHC_T00008841001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_HYDROXY__45__METHYL__45__BUTENYL__45__DIP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__4211_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15510" name="RXN-15510" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001241001_1) or (CHC_T00007707001_1) or (CHC_T00000449001_1) or (CHC_T00001519001_1) or (CHC_T00004201001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__PG_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__pi__45__phospho__45__L__45__histidines_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__Histidines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_23__45__DIPHOSPHOGLYCERATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__46__99__46__1__46__3__45__RXN" name="Type II DNA topoisomerase VI subunit B" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006305001_1) or (CHC_T00007354001_1) or (CHC_T00002053001_1) or (CHC_T00006880001_1) or (CHC_T00008288001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Double__45__Stranded__45__DNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Negatively__45__super__45__coiled__45__DNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__8__46__15__45__RXN" name="2.7.8.15-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00007237001_1) or (CHC_T00006227001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__190_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13405" name="RXN-13405" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006195001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_SARCOSINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_BETAINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__6__46__4__46__6__45__RXN" name="3.6.4.6-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006591001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Membrane__45__Compartments_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Membrane__45__Compartments_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__477" name="straight chain fatty acyl-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-388

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Odd__45__Straight__45__Chain__45__234__45__Sat__45__FA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Odd__45__Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9680" name="RXN-9680" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6004 , P541-PWY

GENE_ASSOCIATION: (CHC_T00006195001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIMETHYL__45__GLYCINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BETAINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETYLGLUTKIN__45__RXN" name="acetylglutamate kinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ARGSYNBSUB-PWY , GLUTORN-PWY , PWY-5154

GENE_ASSOCIATION: (CHC_T00008357001_1) or (CHC_395)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__GLU_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__ACETYL__45__GLUTAMYL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10780" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6313

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__HYDROXYINDOLE_ACETALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__HYDROXYINDOLE_ACETATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTDEHYD__45__RXN" name="Glutamate dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY490-3 , GLUTSYNIII-PWY , PWY-5675 , PWY-5913

GENE_ASSOCIATION: (CHC_T00010235001) or (CHC_T00010235001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11482" name="RXN-11482" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6519

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Enoylpimeloyl__45__ACP__45__methyl__45__esters_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pimeloyl__45__ACP__45__methyl__45__esters_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14481" name="RXN-14481" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000153001_1) or (CHC_T00003933001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15360_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11592_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8038" name="RXN-8038" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009303001_1) or (CHC_T00009401001_1) or (CHC_T00003979001_1) or (CHC_T00009131001_1) or (CHC_T00008663001_1) or (CHC_T00009499001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008616001_1) or (CHC_T00002318001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NEUROSPORENE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7419_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THREDEHYD__45__RXN" name="THREDEHYD-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-428

GENE_ASSOCIATION: (CHC_T00007475001_1) or (CHC_T00005128001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_THR_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__OXOBUTANOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11246" name="RXN-11246" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6435

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10600_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__201_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__349" name="3-oxoacyl-(acyl-carrier-protein) reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__arachidoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_R__45__3__45__hydroxyarachidoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ISOCHORSYN__45__RXN" name="ISOCHORSYN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6406 , PWY-5837 , PWY-5901

GENE_ASSOCIATION: (CHC_T00002409001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHORISMATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ISOCHORISMATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_METBALT__45__RXN" name="METBALT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_O__45__SUCCINYL__45__L__45__HOMOSERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__OXOBUTANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_XANTHINE__45__OXIDASE__45__RXN" name="XANTHINE-OXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6538 , PWY-6999

GENE_ASSOCIATION: (CHC_T00006932001_1) or (CHC_T00000194001_1) or (CHC_T00006216001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_XANTHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_URATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_QUERCETIN__45__3__45__O__45__METHYLTRANSFERASE__45__RXN" name="QUERCETIN-3-O-METHYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6064 , PWY-7161

GENE_ASSOCIATION: (CHC_T00007625001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__520_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3457__45__TETRAHYDROXY__45__3__45__METHOXYFLAVONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__46__1__46__2__46__3__45__RXN" name="5.1.2.3-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__3__45__HYDROXYBUTANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__650_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__1__46__64__45__RXN" name="all-trans-retinyl-palmitate hydrolase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003680001_1) or (CHC_T00000998001_1) or (CHC_T00008784001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHOCOLA_A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13524_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LYSOPHOSPHOLIPASE__45__RXN" name="Putative lysophospholipase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009177001_1) or (CHC_T00008581001_1) or (CHC_T00008784001_1) or (CHC_T00005231001_1) or (CHC_T00003275001_1) or (CHC_T00009450001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__Lysophosphatidylcholines_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Carboxylates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYOXII__45__RXN" name="GLYOXII-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5386

GENE_ASSOCIATION: (CHC_T00008108001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__LACTOYL__45__GLUTATHIONE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__LACTATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16624" name="RXN-16624" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7664

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2E__45__7Z__45__hexadeca__45__2__45__7__45__dienoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_7Z__45__hexadec__45__7__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5283" name="Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CHLOROPHYLL-SYN , PWY-7159

GENE_ASSOCIATION: (CHC_670)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__315" name="4&alpha;-methyl-zymosterol 4-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074 , PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4__45__METHYL__45__824__45__CHOLESTADIENOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4579_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16378" name="RXN-16378" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006481001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Delta7__45__Steroids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Delta5__45__Delta7__45__Steroids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NADPYROPHOSPHAT__45__RXN" name="NADPYROPHOSPHAT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PYRIDNUCSAL-PWY , NAD-BIOSYNTHESIS-II , PWY-5381 , PWY-7761

GENE_ASSOCIATION: (CHC_T00000276001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NICOTINAMIDE_NUCLEOTIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THI__45__P__45__SYN__45__RXN" name="THI-P-SYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6908 , PWY-7356 , PWY-6897 , PWY-7357

GENE_ASSOCIATION: (CHC_T00006163001_1) or (CHC_T00006435001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THZ__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIAMINE__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8014" name="RXN-8014" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5168

GENE_ASSOCIATION: (CHC_T00008575001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SINAPALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SINAPATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9539" name="3-oxo-palmitoyl-[acyl-carrier protein] synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN3O__45__203" name="RXN3O-203" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6075

GENE_ASSOCIATION: (CHC_T00001257001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FECOSTEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_EPISTEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13805" name="glycerol-3-phosphate acyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008773001) or (CHC_T00008773001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14772_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14828_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_2__46__1__46__1__46__143__45__RXN_CPD__45__707" name="extended_2.1.1.143-RXN_CPD-707" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009101001) or (CHC_T00000837001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__707_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4162_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__706_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AMINOACYLASE__45__RXN" name="AMINOACYLASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000215001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__Acylated__45__Aliphatic__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Aliphatic__45__L__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Carboxylates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADCLY__45__RXN" name="ADCLY-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6543

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4__45__AMINO__45__4__45__DEOXYCHORISMATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__AMINO__45__BENZOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5861" name="RXN-5861" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6133 , PWY-5399 , PWY-3581 , PWY-6955

GENE_ASSOCIATION: (CHC_T00005217001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TYR_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__DIHYDROXY__45__PHENYLALANINE_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__14__46__13__46__72__45__RXN" name="methylsterol monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_44__45__DIMETHYL__45__5ALPHA__45__CHOLEST__45__7__45__EN__45__3BET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5847_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16655" name="aldehyde dehydrogenase, (NAD) activity" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PALMITATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11361" name="Adenylyltransferase and sulfurtransferase, MOCS3" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6823

GENE_ASSOCIATION: (CHC_T00009205001) or (CHC_T00009205001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MPT__45__Synthases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Carboxyadenylated__45__MPT__45__synthases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2OXOGLUTARATEDEH__45__RXN" name="2-oxoglutarate dehydrogenase complex" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5690 , TCA , PWY-7254

GENE_ASSOCIATION: (CHC_T00008441001_1) or (CHC_T00010287001_1) or (CHC_T00008312001_1) or (CHC_T00008312001) or (CHC_T00008441001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1125" name="RXN-1125" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-361

GENE_ASSOCIATION: (CHC_T00009372001_1) or (CHC_T00007340001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SINAPALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SINAPYL__45__ALCOHOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__10" name="TRANS-RXN1HP7-10" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002313001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TYR_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRP_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TYR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__1" name="TRANS-RXN1HP7-1" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004267001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MG__43__2_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MG__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12460" name="L-asparaginyl-tRNAasn hydrolase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY490-4

GENE_ASSOCIATION: (CHC_T00006238001_1) or (CHC_T00008495001_1) or (CHC_T00008495001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__ASN__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ASN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASN__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_IMPCYCLOHYDROLASE__45__RXN" name="IMPCYCLOHYDROLASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6124 , PWY-6123 , PWY-7234

GENE_ASSOCIATION: (CHC_T00009056001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_IMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15733" name="RXN-15733" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6148

GENE_ASSOCIATION: (CHC_T00003007001_1) or (CHC_T00007059001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__16953_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__16954_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14179" name="RXN-14179" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SCOPOLIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SCOPOLETIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUCOSAMINEPNACETYLTRANS__45__RXN" name="GLUCOSAMINEPNACETYLTRANS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5514 , UDPNACETYLGALSYN-PWY

GENE_ASSOCIATION: (CHC_T00003842001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__GLUCOSAMINE__45__6__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12507" name="RXN-12507" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7654

GENE_ASSOCIATION: (CHC_T00008882001_1) or (CHC_T00009349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2171_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10284_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12391" name="Disproportionating Enzyme type 2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6724

GENE_ASSOCIATION: (CHC_T00009120001_1) or (CHC_T00009120001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALTOTRIOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucans_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALDOSE1EPIM__45__RXN" name="ALDOSE1EPIM-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-422 , PWY-6317

GENE_ASSOCIATION: (CHC_T00007315001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GALACTOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ALPHA__45__D__45__GALACTOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1147" name="2-oxoglutarate dehydrogenase, E1 component" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-398 , PWY-5084

GENE_ASSOCIATION: (CHC_T00010287001_1) or (CHC_T00008441001_1) or (CHC_T00010023001_1) or (CHC_T00008312001_1) or (CHC_T00008441001) or (CHC_T00008312001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Oxo__45__glutarate__45__dehydrogenase__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxo__45__glutarate__45__dehydro__45__suc__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALLANTOINASE__45__RXN" name="ALLANTOINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5697 , PWY-5698

GENE_ASSOCIATION: (CHC_T00005381001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ALLANTOIN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALLANTOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15117" name="RXN-15117" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7817

GENE_ASSOCIATION: (CHC_T00008565001_1) or (CHC_T00003861001_1) or (CHC_T00000791001_1) or (CHC_T00007099001_1) or (CHC_T00009383001_1) or (CHC_T00009283001_1) or (CHC_T00010015001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__Glucosyl__45__12__45__diacyl__45__glycerols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_diacyl__45__3__45__O__45__glucl__45__1__45__6__45__gluc__45__sn__45__glycerol_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_KDOTRANS__45__RXN" name="KDOTRANS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: KDOSYN-PWY , PWY-7675

GENE_ASSOCIATION: (CHC_T00003262001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LIPID__45__IV__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP__45__KDO_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_KDO__45__LIPID__45__IVA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12558" name="crotonyl-CoA reductase (NAD+)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6863 , PWY-6883

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CROTONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2PGADEHYDRAT__45__RXN" name="enolase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , PWY-5484 , PWY66-399 , PWY-1042 , PWY-1622 , GLYCOLYSIS , PWY-5723 , PWY-6901 , P122-PWY , PWY-6142 , PWY-7003 , ANAGLYCOLYSIS-PWY , PWY-7124 , PWY-2221 , GLUCONEO-PWY , NPGLUCAT-PWY , PWY-6886 , P341-PWY , PWY-7218

GENE_ASSOCIATION: (CHC_T00008696001_1) or (CHC_T00009127001_1) or (CHC_T00009127001) or (CHC_T00008696001) or (CHC_T00008490001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__PG_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GALACTOSYLCERAMIDE__45__SULFOTRANSFERASE__45__RXN" name="Glycolipid sulfotransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008551001) or (CHC_T00009336001) or (CHC_T00008762001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PAPS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cerebrosides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__5__45__ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GALACTOSYLCERAMIDE__45__SULFATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_NITRATE" name="ExchangeSeed_NITRATE" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NITRATE_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NITRATE_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7651" name="RXN-7651" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5060

GENE_ASSOCIATION: (CHC_T00009499001_1) or (CHC_T00008616001_1) or (CHC_T00009131001_1) or (CHC_T00010004001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00008672001_1) or (CHC_T00009062001_1) or (CHC_T00008663001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__431_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5734__45__TETRAHYDROXYFLAVONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACECOATRANS__45__RXN__45__CPD__45__14717__47__ACET__47____47__R__45__2__45__HYDROXYSTEARATE__47__ACETYL__45__COA__46__47__46__" name="ACECOATRANS-RXN-CPD-14717/ACET//R-2-HYDROXYSTEARATE/ACETYL-COA.47." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14717_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_R__45__2__45__HYDROXYSTEARATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11820__45__STEARIC_ACID__47__HYDROGEN__45__PEROXIDE__47____47__R__45__2__45__HYDROXYSTEARATE__47__WATER__46__58__46__" name="RXN-11820-STEARIC_ACID/HYDROGEN-PEROXIDE//R-2-HYDROXYSTEARATE/WATER.58." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_STEARIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_R__45__2__45__HYDROXYSTEARATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="BRANCHED-CHAINAMINOTRANSFERLEU-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5076 , LEU-DEG2-PWY , LEUSYN-PWY , PWY-7767

GENE_ASSOCIATION: (CHC_T00003864001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LEU_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2K__45__4CH3__45__PENTANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16076" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2113_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Stearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__1423_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__161" name="RXN66-161" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-221

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__2742_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__2750_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__901" name="RXN0-901" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5497 , PWY-6596 , PWY-6538 , PWY-6999 , PWY-6606 , PWY-6608 , SALVADEHYPOX-PWY , PWY-5695 , PWY-6607 , P164-PWY

GENE_ASSOCIATION: (CHC_T00006932001_1) or (CHC_T00000194001_1) or (CHC_T00006216001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_XANTHINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_URATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13445" name="RXN-13445" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7606 , PWY-7727 , PWY-7053

GENE_ASSOCIATION: (CHC_T00001929001_1) or (CHC_T00000757001_1) or (CHC_T00006026001_1) or (CHC_T00003552001_1) or (CHC_T00006926001_1) or (CHC_T00004718001_1) or (CHC_T00005019001_1) or (CHC_T00001951001_1) or (CHC_T00000701001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14425_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14426_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12195" name="RXN-12195" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7210 , PWY-7184 , PWY-6545 , PWY-7198

GENE_ASSOCIATION: (CHC_T00006198001_1) or (CHC_T00000060001_1) or (CHC_T00007176001_1) or (CHC_T00010157001_1) or (CHC_T00004941001_1) or (CHC_T00005746001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12693" name="RXN-12693" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6946

GENE_ASSOCIATION: (CHC_T00003646001_1) or (CHC_T00007359001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHOLESTEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13684_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__2" name="TRANS-RXN1HP7-2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007330001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Sugar_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Sugar_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__13" name="4,4-dimethyl-14&alpha;-formyl-5&alpha;-cholesta-8-en-3&beta;-ol deformylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8608_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8609_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AMIDASE__45__RXN" name="AMIDASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009018001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Monocarboxylic__45__Acid__45__Amides_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Monocarboxylates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16621" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7664

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5Z__45__tetradec__45__5__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_7Z__45__3__45__oxo__45__hexadec__45__7__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9366" name="RXN-9366" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5895

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12122_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12130_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7919" name="RXN-7919" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008108001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__hydroxyacyl__45__glutathiones_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__Hydroxy__45__carboxylates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UROGENIIISYN__45__RXN" name="UROGENIIISYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5188 , PWY-5189

GENE_ASSOCIATION: (CHC_T00007253001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROXYMETHYLBILANE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UROPORPHYRINOGEN__45__III_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTALDEHYD__45__RXN" name="histidinol dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HISTSYN-PWY

GENE_ASSOCIATION: (CHC_T00008451001) or (CHC_T00008451001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HISTIDINAL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_HIS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9549" name="RXN-9549" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5994 , PWY-5971 , PWY-7746

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14215" name="RXN-14215" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DAMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UROGENDECARBOX__45__RXN" name="UROGENDECARBOX-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7766 , PWY-5531 , HEME-BIOSYNTHESIS-II , HEMESYN2-PWY , CHLOROPHYLL-SYN , PWY0-1415 , PWY-7159

GENE_ASSOCIATION: (CHC_T00008531001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_UROPORPHYRINOGEN__45__III_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_COPROPORPHYRINOGEN_III_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="4" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SEDOHEPTULOSE__45__BISPHOSPHATASE__45__RXN__45__D__45__SEDOHEPTULOSE__45__1__45__7__45__P2__47__WATER__47____47__CPD__45__19339__47__Pi__46__43__46__" name="SEDOHEPTULOSE-BISPHOSPHATASE-RXN-D-SEDOHEPTULOSE-1-7-P2/WATER//CPD-19339/Pi.43." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__SEDOHEPTULOSE__45__1__45__7__45__P2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19339_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_KETOACYLCOATHIOL__45__RXN" name="KETOACYLCOATHIOL-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5136 , FAO-PWY , PWY66-391 , PWY-7288

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__KETOACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PMPOXI__45__RXN" name="PMPOXI-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PLPSAL-PWY , PWY-7204

GENE_ASSOCIATION: (CHC_T00008142001_1) or (CHC_T00006254001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXAMINE__45__5P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXAL_PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_ZN__43__2" name="ExchangeSeed_ZN+2" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ZN__43__2_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ZN__43__2_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GSAAMINOTRANS__45__RXN" name="glutamate-1-semialdehyde 2,1-aminomutase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5188

GENE_ASSOCIATION: (CHC_T00008868001_1) or (CHC_T00008868001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLUTAMATE__45__1__45__SEMIALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__AMINO__45__LEVULINATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9623" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971 , PWY-5972

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__46" name="TRANS-RXN1HP7-46" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004666001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GTP_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13443" name="3-oxoacyl-[acyl-carrier-protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7606 , PWY-7727 , PWY-7053

GENE_ASSOCIATION: (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008557001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14423_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14424_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1602" name="RXN0-1602" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DITP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__484" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PRISTANATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14675_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4243" name="RXN-4243" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

SUBSYSTEM: PWY-2541

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4143_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4162_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__3__46__1__46__41__45__RXN" name="3-oxoacyl-[acyl-carrier-protein] reductase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_B__45__KETOACYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__3__46__1__46__176__45__RXN" name="2.3.1.176-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6061

GENE_ASSOCIATION: (CHC_T00009349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7257_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__202_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROPIONYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_C__45__22_sterol_desaturase" name="C-22_sterol_desaturase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CYP) or (FMO)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHOLESTEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_22__45__DEHYDROCHOLESTEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13710" name="4&alpha;-methyl-cholesta-8-enol 4- monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4184_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8619_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14803" name="RXN-14803" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7340

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15691_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15692_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UNDECAPRENYL__45__DIPHOSPHATASE__45__RXN" name="UNDECAPRENYL-DIPHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5785

GENE_ASSOCIATION: (CHC_T00000153001_1) or (CHC_T00003933001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UNDECAPRENYL__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9646_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6883" name="RXN-6883" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4302

GENE_ASSOCIATION: (CHC_T00000162001_1) or (CHC_T00008174001_1) or (CHC_T00008172001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquinols_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Ubiquinones_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14959" name="Lipoate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7382

GENE_ASSOCIATION: (CHC_T00008509001) or (CHC_T00008509001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_a__45__2__45__oxoglutarate__45__dehydrogenase__45__E2__45__protei_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Oxo__45__glutarate__45__dehydrogenase__45__lipoyl_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DISULFOXRED__45__RXN" name="DISULFOXRED-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010347001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__Red__45__Disulfides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__Ox__45__Disulfides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16042" name="RXN-16042" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6958

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14394_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17281_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16558" name="RXN-16558" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7656

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17813_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17814_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14906" name="RXN-14906" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006367001_1) or (CHC_T00008683001_1) or (CHC_T00008396001_1) or (CHC_T00009392001_1) or (CHC_T00008654001_1) or (CHC_T00009394001_1) or (CHC_T00008906001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Proteins__45__L__45__Threonines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__Phosphothreonines_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13039" name="RXN-13039" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6984

GENE_ASSOCIATION: (CHC_T00006203001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Gcv__45__H_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LIPOYL__45__AMP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTEIN__45__LIPOYLLYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_RXN3O__45__203" name="extended_RXN3O-203" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: late_SSR , early_SSR

GENE_ASSOCIATION: (CHC_T00001257001_1)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ZYMOSTEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5A_CHOLESTA__45__7__44__24__45__DIENOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12473" name="Adenylyltransferase and sulfurtransferase, MOCS3" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6823

GENE_ASSOCIATION: (CHC_T00009205001) or (CHC_T00009205001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Carboxyadenylated__45__MPT__45__synthases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__Cysteine__45__Desulfurase__45__persulfide_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cysteine__45__Desulfurase__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Thiocarboxylated__45__MPT__45__synthases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16616" name="beta-ketoacyl reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7664

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5Z__45__3__45__oxo__45__tetradec__45__5__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3R__45__5Z__45__3__45__hydroxy__45__tetradec__45__5__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_FE__43__2" name="ExchangeSeed_FE+2" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FE__43__2_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FE__43__2_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11667" name="(S)-3-hydroxybutanoyl-CoA dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6883 , PWY-6583 , PWY-7401 , P162-PWY , CENTFERM-PWY , PWY-5177 , PWY-5789 , P3-PWY , PWY-6863

GENE_ASSOCIATION: (CHC_T00009110001_1) or (CHC_T00008882001_1) or (CHC_T00009349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__3__45__HYDROXYBUTANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CROTONYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_APYRASE__45__RXN" name="APYRASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10954" name="RXN-10954" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002260001_1) or (CHC_T00001291001_1) or (CHC_T00007726001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__6702_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17788" name="Putative Acyl-COA dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009166001) or (CHC_T00009166001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10269_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19162_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5114" name="RXN0-5114" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SERSYN-PWY

GENE_ASSOCIATION: (CHC_T00005163001_1) or (CHC_T00006166001_1) or (CHC_T00007222001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__P__45__SERINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5464" name="RXN-5464" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00000791001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__5162_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__5164_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthase (glutamine-hydrolysing)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7221

GENE_ASSOCIATION: (CHC_T00009427001_1) or (CHC_T00009427001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_XANTHOSINE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GAPOXNPHOSPHN__45__RXN" name="GAPOXNPHOSPHN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , PWY-5484 , PWY66-399 , PWY-1042 , PWY-6901 , P122-PWY , GLYCOLYSIS , PWY-7003 , ANAGLYCOLYSIS-PWY , GLUCONEO-PWY , P185-PWY , SUCSYN-PWY

GENE_ASSOCIATION: (CHC_T00009438001_1) or (CHC_T00009523001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DPG_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14919" name="RXN-14919" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7436

GENE_ASSOCIATION: (CHC_T00000837001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15839_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15837_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DXPREDISOM__45__RXN" name="DXPREDISOM-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NONMEVIPP-PWY , PWY-7560

GENE_ASSOCIATION: (CHC_T00009191001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEOXYXYLULOSE__45__5P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__181" name="RXN66-181" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-241

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__3481_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__3483_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13061" name="RXN-13061" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5399

GENE_ASSOCIATION: (CHC_T00005217001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__DIHYDROXY__45__PHENYLALANINE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_DOPAQUINONE_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7825" name="RXN-7825" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009104001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ISOVALERYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__7146_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1342" name="RXN0-1342" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6700

GENE_ASSOCIATION: (CHC_T00006545001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNA__45__with__45__7__45__aminomethyl__45__7__45__deazaguanine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNAs__45__containing__45__epoxy__45__quenosine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6705" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__PALMITOYLGLYCEROL__45__3__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__1422_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13191" name="Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_670)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_MG__45__PROTOPORPHYRIN__45__MONOMETHYL__45__ESTER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="5" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__3541" name="ascorbate oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009050001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ASCORBATE_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="4" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__318_c" stoichiometry="4" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5240" name="RXN0-5240" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009460001_1) or (CHC_T00008323001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRIDOXAL_PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__ALANINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXAMINE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PORPHOBILSYNTH__45__RXN" name="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5188 , PWY-5189

GENE_ASSOCIATION: (CHC_T00008491001_1) or (CHC_T00008491001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__AMINO__45__LEVULINATE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PORPHOBILINOGEN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_CO__43__2" name="TransportSeed_CO+2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__12__46__2__45__RXN" name="Mitogen-activated protein kinase kinase 6, MPKK6" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008752001) or (CHC_T00008994001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Mitogen__45__Activated__45__Protein__45__Kinase__45__L__45__Thr_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MAP__45__Kinase__45__L__45__Phosphothreonine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__3__46__7__46__3__45__RXN" name="1.3.7.3-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7579 , PWY-5915

GENE_ASSOCIATION: (CHC_T00003760001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_1516__45__DIHYDROBILIVERDIN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_3Z__45__PHYCOERYTHROBILIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__46__1__46__1__46__72__45__RXN" name="branched-chain alpha-keto acid decarboxylase E1 beta subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5078

GENE_ASSOCIATION: (CHC_T00008584001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETO__45__3__45__METHYL__45__VALERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLBUT__45__CPD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14386" name="RXN-14386" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7250

GENE_ASSOCIATION: (CHC_T00008053001_1) or (CHC_T00000657001_1) or (CHC_T00009510001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__CD__45__S__45__SP__45__Complex_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CD__45__2S__45__SP__45__Complex_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__SULFINOALANINE__45__AMINOTRANSFERASE__45__RXN" name="3-SULFINOALANINE-AMINOTRANSFERASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CYSTEINE-DEG-PWY

GENE_ASSOCIATION: (CHC_T00005085001_1) or (CHC_T00009477001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__SULFINOALANINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__SULFINYL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9952" name="RXN-9952" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: OXIDATIVEPENT-PWY

GENE_ASSOCIATION: (CHC_T00008023001_1) or (CHC_T00008523001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__2961_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RIBULOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5408" name="RXN0-5408" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4702

GENE_ASSOCIATION: (CHC_T00008808001_1) or (CHC_T00008454001_1) or (CHC_T00008597001_1) or (CHC_T00003382001_1) or (CHC_T00001291001_1) or (CHC_T00007726001_1) or (CHC_T00002260001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__MYO__45__INOSITOL__45__1__45__MONOPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10441" name="RXN-10441" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6668

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GERANYLGERANYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8848_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ATP__45__CITRATE__45__PRO__45__S__45____45__LYASE__45__RXN" name="ATP citrate lyase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P23-PWY , PWY-5172

GENE_ASSOCIATION: (CHC_T00009158001_1) or (CHC_T00009045001_1) or (CHC_T00009045001) or (CHC_T00009158001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CIT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OXALACETIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PLASTOQUINOL__45____45__PLASTOCYANIN__45__REDUCTASE__45__RXN" name="Cytochrome b6-f complex subunit IV" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-101

GENE_ASSOCIATION: (CHC_675) or (CHC_T00007954001_1) or (CHC_680) or (CHC_620) or (CHC_310) or (CHC_645) or (CHC_920)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Plastoquinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__Plastocyanins_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Plastocyanin__45__Reduced_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_PLASTOQUINONE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14917" name="RXN-14917" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7436

GENE_ASSOCIATION: (CHC_T00009101001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11712_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15834_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__22__46__68__45__RXN" name="3.4.22.68-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000003001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SUMO__45__propeptides_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SUMO__45__peptides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRUVATEORTHOPHOSPHATE__45__DIKINASE__45__RXN" name="PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6549 , PWY-241 , PWY-7117 , PWY-7115

GENE_ASSOCIATION: (CHC_T00008992001_1) or (CHC_T00008789001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PGLYCDEHYDROG__45__RXN" name="PGLYCDEHYDROG-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SERSYN-PWY

GENE_ASSOCIATION: (CHC_T00003586001_1) or (CHC_T00009221001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_G3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__P__45__HYDROXYPYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12252" name="Carboxylesterase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003680001_1) or (CHC_T00000998001_1) or (CHC_T00008784001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13174_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13172_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__173_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__4" name="TRANS-RXN1HP7-4" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009508001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Amino__45__Acids_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__2__46__4__46__4__45__RXN" name="1.2.4.4-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5046

GENE_ASSOCIATION: (CHC_T00006349001_1) or (CHC_T00008584001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETO__45__ISOVALERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__lipoyl_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__2MP__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16314" name="RXN-16314" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7511

GENE_ASSOCIATION: (CHC_T00002999001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_E3__45__independent__45__Ubiquitin__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ubiquitinyl__45__UAP__45__E1__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ubiquitin__45__activating__45__protein__45__E1__45__L__45__cys_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ubiquitinyl__45__E3__45__independent__45__E2__45__Cys_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__961" name="D-ribulose-1,5-bisphosphate cleaving dioxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-181

GENE_ASSOCIATION: (CHC_955) or (CHC_950)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__RIBULOSE__45__15__45__P2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__67_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_G3P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYCOLATE__45__REDUCTASE__45__RXN" name="GLYCOLATE-REDUCTASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7295 , PWY-7294

GENE_ASSOCIATION: (CHC_T00009559001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYCOLLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYOX_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16637" name="Peptidyl-tRNA hydrolase 2, mitochondrial" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6308

GENE_ASSOCIATION: (CHC_T00006238001_1) or (CHC_T00008495001_1) or (CHC_T00008495001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__CYS__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7163" name="RXN-7163" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6372 , PWY-6362 , PWY-6554 , PWY-6361 , PWY-4661 , PWY-6369

GENE_ASSOCIATION: (CHC_T00004985001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1107_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MI__45__HEXAKISPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6PFRUCTPHOS__45__RXN" name="6-phosphofructokinase (pseudogenised)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5484 , PWY-7385 , PWY-1042 , PWY-1861 , GLYCOLYSIS , ANAGLYCOLYSIS-PWY

GENE_ASSOCIATION: (CHC_T00009387001_1) or (CHC_T00007415001_1) or (CHC_T00008955001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FRUCTOSE__45__16__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14391" name="RXN-14391" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7250

GENE_ASSOCIATION: (CHC_T00008003001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Chap__45__ADP__45__apo__45__SP__45__Complex_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FeS__45__Cluster__45__Chaperones__45__ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__form__45__FeS__45__Cluster__45__Scaffold__45__Proteins_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_VALINE__45____45__TRNA__45__LIGASE__45__RXN" name="VALINE--TRNA-LIGASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00001234001_1) or (CHC_T00005897001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_VAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_VAL__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__VAL__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15830" name="RXN-15830" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6692

GENE_ASSOCIATION: (CHC_T00009022001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="8" constant="false"/>
         <speciesReference species="M_Cytochromes__45__C__45__Reduced_e" stoichiometry="4" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Cytochromes__45__C__45__Oxidized_e" stoichiometry="4" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="4" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8040" name="RXN-8040" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009303001_1) or (CHC_T00009401001_1) or (CHC_T00003979001_1) or (CHC_T00009131001_1) or (CHC_T00008663001_1) or (CHC_T00009499001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008616001_1) or (CHC_T00002318001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NEUROSPORENE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7422_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13697" name="Aspartate aminotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7117 , PWY-7115

GENE_ASSOCIATION: (CHC_T00003344001_1) or (CHC_T00009477001_1) or (CHC_T00006498001_1) or (CHC_T00005085001_1) or (CHC_T00010197001) or (CHC_T00008432001) or (CHC_T00010017001) or (CHC_T00009477001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OXALACETIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYTIDEAM__45__RXN" name="CYTIDEAM-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7199 , PWY-7181

GENE_ASSOCIATION: (CHC_T00000921001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEOXYCYTIDINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DEOXYURIDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_EDTA" name="ExchangeSeed_EDTA" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_EDTA_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_EDTA_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11056" name="RXN-11056" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6398

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__ACETYL__45__5__45__METHOXY__45__TRYPTAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12014_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1381" name="glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRIGLSYN-PWY , PWY-5667

GENE_ASSOCIATION: (CHC_T00008773001) or (CHC_T00008773001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Long__45__Chain__45__Acyl__45__CoAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACYL__45__SN__45__GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FATTY__45__ACYL__45__COA__45__SYNTHASE__45__RXN" name="FATTY-ACYL-COA-SYNTHASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5970

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Long__45__Chain__45__Acyl__45__CoAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15129" name="RXN-15129" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: LCYSDEG-PWY

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__AMINOACRYLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_K__43__" name="TransportSeed_K+" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_K__43___e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_K__43___c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1134" name="pyruvate dehydrogenase E1 alpha subunit, mitochondrial precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PYRUVDEHYD-PWY

GENE_ASSOCIATION: (CHC_T00008442001_1) or (CHC_T00008732001_1) or (CHC_T00008732001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pyruvate__45__dehydrogenase__45__lipoate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pyruvate__45__dehydrogenase__45__acetylDHlipoyl_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DEOXYHYPUSINE__45__MONOOXYGENASE__45__RXN" name="DEOXYHYPUSINE-MONOOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5905

GENE_ASSOCIATION: (CHC_T00000296001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9973_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_EIF5A__45__HYPUSINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDROKAEMPFEROL__45__4__45__REDUCTASE__45__RXN" name="DIHYDROKAEMPFEROL-4-REDUCTASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY1F-823

GENE_ASSOCIATION: (CHC_T00009538001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIHYDROKAEMPFEROL__45__CMPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_LEUCOPELARGONIDIN__45__CMPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16909" name="carbamoyl phosphate synthase small subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7693

GENE_ASSOCIATION: (CHC_T00008596001_1) or (CHC_T00010056001_1) or (CHC_70)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HCO3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18238_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LIPOXYGENASE__45__RXN" name="LIPOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5409 , PWY-5410

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LINOLEIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_13__45__HYDROPEROXYOCTADECA__45__911__45__DIENOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MYRPALMTRAN__45__RXN" name="MYRPALMTRAN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: KDO-NAGLIPASYN-PWY

GENE_ASSOCIATION: (CHC_T00003589001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_KDO2__45__PALMITOLEOYL__45__LIPID__45__IVA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_KDO2__45__LIPID__45__IVA__45__COLD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__8" name="TRANS-RXN1HP7-8" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007330001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MYO__45__INOSITOL_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__77__45__RXN" name="2.1.1.77-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003310001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTEIN__45__L__45__BETA__45__ISOASPARTATES_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ISOLEUCINE__45____45__TRNA__45__LIGASE__45__RXN" name="isoleucine--tRNA ligase, cytoplasmic" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00009388001_1) or (CHC_T00005914001_1) or (CHC_T00009388001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ILE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ILE__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__ILE__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7693" name="RXN-7693" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6871 , PWY-5076

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7032_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7031_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5472" name="RXN-5472" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00009283001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__166_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5170_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18076_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__DEHYDROQUINATE__45__DEHYDRATASE__45__RXN" name="3-DEHYDROQUINATE-DEHYDRATASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6416 , QUINATEDEG-PWY , PWY-6707 , PWY-6163

GENE_ASSOCIATION: (CHC_T00007254001_1) or (CHC_T00008696001_1) or (CHC_T00009127001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DEHYDROQUINATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__DEHYDRO__45__SHIKIMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DUTP__45__PYROP__45__RXN" name="DUTP-PYROP-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7184 , PWY-7187 , PWY0-166 , PWY-6545 , PWY-7206

GENE_ASSOCIATION: (CHC_T00002427001_1) or (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DUTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DUMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CHD__45__RXN" name="CHD-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CHOLINE-BETAINE-ANA-PWY , BETSYN-PWY

GENE_ASSOCIATION: (CHC_T00008591001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHOLINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BETAINE_ALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7677" name="71-hydroxychlorophyllide a monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5068

GENE_ASSOCIATION: (CHC_T00000246001_1) or (CHC_T00006958001_1) or (CHC_T00004024001_1) or (CHC_T00003882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7015_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7014_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ENZRXN__45__201__45__RXN" name="ENZRXN-201-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6583

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BUTANOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BUTANAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11468" name="RXN-11468" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6515

GENE_ASSOCIATION: (CHC_T00009104001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__12449_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_PHLORETIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__4961" name="DNA polymerase zeta catalytic subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007205001_1) or (CHC_T00000882001_1) or (CHC_T00008362001_1) or (CHC_T00002866001_1) or (CHC_T00009322001_1) or (CHC_T00003762001_1) or (CHC_T00008124001_1) or (CHC_T00009322001) or (CHC_T00008362001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DNA__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Nucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NAPHTHOATE__45__SYN__45__RXN" name="naphthoate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5837

GENE_ASSOCIATION: (CHC_T00008821001_1) or (CHC_T00008821001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__6972_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9925_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__152" name="RXN1F-152" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD1F__45__129_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD1F__45__130_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_P__45__PANTOCYSDECARB__45__RXN" name="P-PANTOCYSDECARB-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: COA-PWY-1 , COA-PWY

GENE_ASSOCIATION: (CHC_T00003170001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PANTETHEINE__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9558" name="RXN-9558" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5973

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_cis__45__vaccen__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cis__45__vaccenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTIDPHOS__45__RXN" name="HISTIDPHOS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: HISTSYN-PWY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__HISTIDINOL__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HISTIDINOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PGLUCISOM__45__RXN" name="glucose-6-phosphate isomerase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-399 , PWY-3801 , GLYCOLYSIS , UDPNAGSYN-PWY , PWY-6981 , PWY-7238 , PWY-7347 , PWY-5659 , PWY-622 , P122-PWY , ANAGLYCOLYSIS-PWY , PWY-621 , PWY-5384 , PWY-6992 , SUCSYN-PWY , RUMP-PWY , PWY-6142 , PWY-5054 , GLUCONEO-PWY , PWY-5514 , P341-PWY , P124-PWY , PWY-7385

GENE_ASSOCIATION: (CHC_T00008268001_1) or (CHC_T00009370001_1) or (CHC_T00009370001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__glucopyranose__45__6__45__phosphate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10706" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00008400001_1) or (CHC_T00007910001_1) or (CHC_T00008478001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00009142001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11521_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11522_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14353" name="Starch phosphorylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7238

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Soluble__45__Heteroglycans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Soluble__45__Heteroglycans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__26__46__3__45__RXN" name="3.1.26.3-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004988001_1) or (CHC_T00003182001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_RNASE__45__III__45__MRNA__45__PROCESSING__45__SUBSTRATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_mRNA__45__Fragments_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_RNASE__45__III__45__PROCESSING__45__PRODUCT__45__MRNA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_XANPRIBOSYLTRAN__45__RXN" name="XANPRIBOSYLTRAN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SALVPURINE2-PWY

GENE_ASSOCIATION: (CHC_T00004960001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_XANTHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_XANTHOSINE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIACYLGLYKIN__45__RXN" name="DIACYLGLYKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7039 , PWY-7817

GENE_ASSOCIATION: (CHC_T00008540001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__PHOSPHATIDATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__472" name="fatty aldehyde dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-387

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__Me__45__Branched__45__234__45__Sat__45__FALD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_2__45__Me__45__Branched__45__234__45__Sat__45__FA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1106" name="RXN-1106" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6027 , PWY-361

GENE_ASSOCIATION: (CHC_T00009538001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FERULOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CONIFERYL__45__ALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14047" name="Aconitate hydratase, mitochondrial" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008781001_1) or (CHC_T00009087001_1) or (CHC_T00008781001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CIT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_THREO__45__DS__45__ISO__45__CITRATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8672" name="RXN-8672" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001330001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LCYSDESULF__45__RXN" name="LCYSDESULF-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17229" name="hexose oxidase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009130001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLC__45__D__45__LACTONE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12554" name="chitinase-domain containing protein" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004415001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHITIN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CHITOBIOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__8__46__3__46__5__45__RXN" name="1.8.3.5-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001248001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__PRENYL__45__L__45__CYSTEINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRENAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9527" name="3-oxo-decanoyl-[acyl-carrier protein] synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__decanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8975" name="RXN-8975" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6471 , PWY-5265

GENE_ASSOCIATION: (CHC_T00007237001_1) or (CHC_T00006227001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9646_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_C3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_C4_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="BRANCHED-CHAINAMINOTRANSFERILEU-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5078 , ILEUSYN-PWY , ILEUDEG-PWY , PWY-5108 , PWY-5104 , PWY-5101 , PWY-5103

GENE_ASSOCIATION: (CHC_T00003864001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ILE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETO__45__3__45__METHYL__45__VALERATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1603" name="RXN0-1603" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_XTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_XANTHOSINE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__470" name="3-methyl-branched fatty acyl-CoA 2-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-387

GENE_ASSOCIATION: (CHC_T00003462001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__Methyl__45__Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__OH__45__3__45__Methyl__45__Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AIRCARBOXY__45__RXN" name="AIRCARBOXY-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6124

GENE_ASSOCIATION: (CHC_T00009497001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBULOSE__45__BISPHOSPHATE__45__CARBOXYLASE__45__RXN" name="ribulose bisphosphate carboxylase, small chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5532 , PWY-5723 , CALVIN-PWY

GENE_ASSOCIATION: (CHC_955) or (CHC_950) or (CHC_T00006620001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__RIBULOSE__45__15__45__P2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_G3P_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTCYCLOHYD__45__RXN" name="HISTCYCLOHYD-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HISTSYN-PWY

GENE_ASSOCIATION: (CHC_T00008128001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHOSPHORIBOSYL__45__AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__546" name="RXN66-546" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001376001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRROLINE__45__HYDROXY__45__CARBOXYLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__HYDROXY__45__L__45__PROLINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13741" name="D-mannose oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009130001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__mannopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14780_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__483" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-387

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__Me__45__Branched__45__234__45__Sat__45__FA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__Me__45__Branched__45__234__45__Sat__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__303" name="lanosterol 14-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LANOSTEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4568_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12568__45__HEXANAL__47__CO__45__A__47__NAD__47____47__HEXANOYL__45__COA__47__NADH__47__PROTON__46__43__46__" name="RXN-12568-HEXANAL/CO-A/NAD//HEXANOYL-COA/NADH/PROTON.43." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HEXANAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11480" name="3-oxoacyl-(acyl-carrier-protein) reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6519

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Ketopimeloyl__45__ACP__45__methyl__45__esters_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__hydroxypimeloyl__45__ACP__45__methyl__45__esters_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15680" name="3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine glutathione S-transferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7533

GENE_ASSOCIATION: (CHC_T00009287001_1) or (CHC_T00006560001_1) or (CHC_T00008810001_1) or (CHC_T00009444001_1) or (CHC_T00008274001_1) or (CHC_T00009312001_1) or (CHC_T00008791001_1) or (CHC_T00003419001_1) or (CHC_T00009287001) or (CHC_T00008791001) or (CHC_T00008724001) or (CHC_T00008766001) or (CHC_T00009444001) or (CHC_T00008810001) or (CHC_T00008274001) or (CHC_T00009312001) or (CHC_T00008331001) or (CHC_T00008425001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__17045_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17046_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16415" name="long-chain-fatty-acid-CoA ligase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Very__45__long__45__chain__45__fatty__45__acids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_VERY__45__LONG__45__CHAIN__45__FATTY__45__ACYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DOPAMINE__45__BETA__45__MONOOXYGENASE__45__RXN" name="DOPAMINE-BETA-MONOOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-301

GENE_ASSOCIATION: (CHC_T00003620001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASCORBATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DOPAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__DEHYDRO__45__ASCORBATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NOREPINEPHRINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1826" name="Starch phosphorylase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Long__45__linear__45__glucans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Long__45__linear__45__glucans_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIACYLGLYCEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Diacylglycerol O-acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRIGLSYN-PWY

GENE_ASSOCIATION: (CHC_T00007755001_1) or (CHC_T00010127001_1) or (CHC_T00009240001_1) or (CHC_T00010104001) or (CHC_T00010127001) or (CHC_T00009240001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Triacylglycerols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__1__46__149__45__RXN" name="2.7.1.149-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6351 , PWY-6367

GENE_ASSOCIATION: (CHC_T00002812001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__PHOSPHATIDYL__45__1D__45__MYO__45__INOSITOL__45__5__45__PHOSPHA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__5__46__2__46__17__45__RXN" name="3.5.2.17-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5691 , PWY-7394

GENE_ASSOCIATION: (CHC_T00004512001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__HYDROXYISOURATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5821_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10711" name="Carboxylesterase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6303

GENE_ASSOCIATION: (CHC_T00003680001_1) or (CHC_T00000998001_1) or (CHC_T00008784001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10546_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METOH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INDOLE_ACETATE_AUXIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17775" name="Putative Acyl-COA dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009166001) or (CHC_T00009166001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19172_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15068" name="phospholipase A2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7417

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8268_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OLEATE__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__1__45__LYSOPHOSPHATIDATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15910" name="alpha-glucosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-842

GENE_ASSOCIATION: (CHC_T00000021001_1) or (CHC_T00008497001_1) or (CHC_T00009379001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8673" name="RXN-8673" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001330001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SARCOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYOX_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__16__45__RXN" name="2.1.1.16-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009046001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phospholipid__45__Olefinic__45__Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8190_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5468" name="RXN-5468" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00009519001_1) or (CHC_T00009193001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__171_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5166_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__5167_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5467" name="RXN-5467" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00009519001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__171_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5165_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5166_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17366" name="RXN-17366" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7751

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18773_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18776_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PANTOATE__45__BETA__45__ALANINE__45__LIG__45__RXN" name="PANTOATE-BETA-ALANINE-LIG-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PANTO-PWY

GENE_ASSOCIATION: (CHC_T00001099001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_B__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__PANTOATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PANTOTHENATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRUVATE__45__CARBOXYLASE__45__RXN" name="PYRUVATE-CARBOXYLASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5750 , P42-PWY , PWY-6146 , PWY-6142 , PWY66-399

GENE_ASSOCIATION: (CHC_T00009426001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HCO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXALACETIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16654" name="aldehyde dehydrogenase, (NAD) activity" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7880_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DODECANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17784" name="Putative Acyl-COA dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009166001) or (CHC_T00009166001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18346_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19163_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9634" name="RXN-9634" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5989 , PWY3O-355

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_R__45__3__45__hydroxystearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Octadec__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__13__46__1__45__RXN" name="3.1.13.1-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003097001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RNASE__45__II__45__DEGRADATION__45__SUBSTRATE__45__MRNA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Nucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14024" name="RXN-14024" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Nucleoside__45__Triphosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Nucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11519" name="RXN-11519" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6632

GENE_ASSOCIATION: (CHC_T00006932001_1) or (CHC_T00000194001_1) or (CHC_T00006216001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__7__45__DIMETHYLXANTHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12482_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTPRATPHYD__45__RXN" name="HISTPRATPHYD-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HISTSYN-PWY

GENE_ASSOCIATION: (CHC_T00008128001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHOSPHORIBOSYL__45__ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHORIBOSYL__45__AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16016" name="RXN-16016" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7583

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="22" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="9" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="14" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="10" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="8" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="14" constant="false"/>
         <speciesReference species="M_ARACHIDONIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="9" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12496" name="RXN-12496" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003979001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Carotenoid__45__psi__45__end__45__group_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Carotenoid__45__beta__45__end__45__group_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LEUCINE__45____45__TRNA__45__LIGASE__45__RXN" name="leucine--tRNA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00009574001_1) or (CHC_T00004313001_1) or (CHC_T00009574001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LEU__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LEU_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Charged__45__LEU__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_H2NEOPTERINP3PYROPHOSPHOHYDRO__45__RXN" name="H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6147

GENE_ASSOCIATION: (CHC_T00000137001_1) or (CHC_T00007861001_1) or (CHC_T00010060001_1) or (CHC_T00001386001_1) or (CHC_T00007752001_1) or (CHC_T00003907001_1) or (CHC_T00003258001_1) or (CHC_T00010142001_1) or (CHC_T00003277001_1) or (CHC_T00002646001_1) or (CHC_T00009294001_1) or (CHC_T00008309001_1) or (CHC_T00000427001_1) or (CHC_T00008748001_1) or (CHC_T00002083001_1) or (CHC_T00005127001_1) or (CHC_T00003332001_1) or (CHC_T00008721001_1) or (CHC_T00009222001_1) or (CHC_T00010119001_1) or (CHC_T00010343001_1) or (CHC_T00000109001_1) or (CHC_T00010215001_1) or (CHC_T00002743001_1) or (CHC_T00009449001_1) or (CHC_T00010240001_1) or (CHC_T00010340001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDRONEOPTERIN__45__P3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDRONEOPTERIN__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5341" name="RXN-5341" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7091 , PWY-3121

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LINAMARIN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__HYDROXY__45__2__45__METHYLPROPANENITRILE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10814" name="aspartate aminotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6318

GENE_ASSOCIATION: (CHC_T00006498001_1) or (CHC_T00005085001_1) or (CHC_T00003344001_1) or (CHC_T00009477001_1) or (CHC_T00010197001) or (CHC_T00008432001) or (CHC_T00010017001) or (CHC_T00009477001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHENYL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7904" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6803 , PWY-6873 , PWY-5143 , PWY-5885 , PWY-7033

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Long__45__Chain__45__Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Long__45__Chain__45__Acyl__45__CoAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBULP3EPIM__45__RXN" name="similar to Ribulose-phosphate 3-epimerase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , NONOXIPENT-PWY , PWY-1861 , PWY-5723 , P122-PWY , P21-PWY , CALVIN-PWY , P185-PWY

GENE_ASSOCIATION: (CHC_T00006121001_1) or (CHC_T00008270001_1) or (CHC_T00008270001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RIBULOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_XYLULOSE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PRIBFAICARPISOM__45__RXN" name="PRIBFAICARPISOM-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HISTSYN-PWY

GENE_ASSOCIATION: (CHC_T00001580001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALDHDEHYDROG__45__RXN" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7269

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Aldehydes_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Carboxylates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__5__46__1__46__88__45__RXN" name="3.5.1.88-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FORMYL__45__L__45__METHIONYL__45__PEPTIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_METHIONYL__45__PEPTIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8497" name="linolenate 9S-lipoxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5406 , PWY-6917 , PWY-5408 , PWY-5407

GENE_ASSOCIATION: (CHC_T00008739001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LINOLENIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8678_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2161" name="serine--tRNA ligase, cytoplasmic" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-901 , PWY-6281

GENE_ASSOCIATION: (CHC_T00009366001_1) or (CHC_T00009407001_1) or (CHC_T00009407001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNA__45__Sec_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__seryl__45__SEC__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14117" name="pyruvate kinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008482001_1) or (CHC_T00008652001_1) or (CHC_T00008530001_1) or (CHC_T00008482001) or (CHC_T00008530001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16313" name="RXN-16313" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7511

GENE_ASSOCIATION: (CHC_T00002999001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__L__45__lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ubiquitinyl__45__E3__45__independent__45__E2__45__Cys_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTEIN__45__N__45__UBIQUITYL__45__LYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_E3__45__independent__45__Ubiquitin__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENOSYLHOMOCYSTEINASE__45__RXN" name="S-adenosyl-L-homocysteine hydrolase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: METHIONINE-DEG1-PWY , PWY-5041

GENE_ASSOCIATION: (CHC_T00009343001_1) or (CHC_T00009343001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11026" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5136 , PWY66-391 , PWY-7288

GENE_ASSOCIATION: (CHC_T00008478001_1) or (CHC_T00009142001_1) or (CHC_T00007910001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00008400001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TRANS__45__D2__45__ENOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11269" name="RXN-11269" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6444

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__674_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12218_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_CARBON__45__DIOXIDE" name="ExchangeSeed_CARBON-DIOXIDE" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CARBON__45__DIOXIDE_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUCONOKIN__45__RXN" name="GLUCONOKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: IDNCAT-PWY , GLUCONSUPER-PWY , PWY-5530

GENE_ASSOCIATION: (CHC_T00003912001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUCONATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__2961_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DADPKIN__45__RXN" name="nucleoside-diphosphate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7227 , PWY-7224 , PWY-7220

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__308" name="cysteine desulfurase IscS, mitochondrial precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6891 , PWY0-1021 , PWY-6823 , PWY-6892

GENE_ASSOCIATION: (CHC_T00009510001_1) or (CHC_T00008053001_1) or (CHC_T00000657001_1) or (CHC_T00009510001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cysteine__45__Desulfurase__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__Cysteine__45__Desulfurase__45__persulfide_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__14__46__11__46__18__45__RXN" name="1.14.11.18-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003462001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__206_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__HYDROXYPHYTANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12878" name="ferredoxin-dependent glutamate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_1080)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_IMP__45__DEHYDROG__45__RXN" name="Inosine-5'-monophosphate dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7221 , PWY-6596 , PWY-5695

GENE_ASSOCIATION: (CHC_T00003368001_1) or (CHC_T00009518001_1) or (CHC_T00009518001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_IMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_XANTHOSINE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12279" name="RXN-12279" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6724

GENE_ASSOCIATION: (CHC_T00008493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13198_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Branched__45__Unphos__45__Amylopectin__45__Tails_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HYDROG__45__RXN" name="HYDROG-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6780 , GLUDEG-II-PWY , PWY-6785 , PWY4LZ-257 , PWY-6759

GENE_ASSOCIATION: (CHC_T00004440001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6948" name="glutamate N-acetyltransferase / amino-acid N-acetyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008260001_1) or (CHC_T00008357001_1) or (CHC_T00008260001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__2015_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1121" name="RXN-1121" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2181

GENE_ASSOCIATION: (CHC_T00006372001_1) or (CHC_T00009131001_1) or (CHC_T00008663001_1) or (CHC_T00009499001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008616001_1) or (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERULIC__45__ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__HYDROXY__45__FERULIC__45__ACID_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__18" name="TRANS-RXN1HP7-18" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008996001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RS__45__Malate_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RS__45__Malate_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBONUCLEOSIDE__45__DIP__45__REDUCTII__45__RXN" name="ribonucleoside-diphosphate reductase beta chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-166

GENE_ASSOCIATION: (CHC_T00008926001_1) or (CHC_T00008864001_1) or (CHC_T00008864001) or (CHC_T00008926001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__NrdH__45__Proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__NrdH__45__Proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DCDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACYLAMINOACYL__45__PEPTIDASE__45__RXN" name="ACYLAMINOACYL-PEPTIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001116001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__Acetyl__45__Peptides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__Acylated__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__10__46__2__46__2__45__RXN" name="Ubiquinol-cytochrome c reductase iron-sulfur subunit" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7279 , PWY-7082 , PWY-3781

GENE_ASSOCIATION: (CHC_T00009218001_1) or (CHC_T00008759001_1) or (CHC_T00007973001_1) or (CHC_T00008759001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cytochromes__45__C__45__Oxidized_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Ubiquinols_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Cytochromes__45__C__45__Reduced_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Ubiquinones_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12002" name="RXN-12002" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7176

GENE_ASSOCIATION: (CHC_T00004355001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__46__2__46__1__46__58__45__RXN" name="(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994 , PWY-5971 , PWY-7388

GENE_ASSOCIATION: (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Beta__45__3__45__hydroxybutyryl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Crotonyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_BIOTIN" name="ExchangeSeed_BIOTIN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BIOTIN_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BIOTIN_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10067" name="RXN-10067" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6174

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__499_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10818_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__16" name="TRANS-RXN1HP7-16" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007970001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cations_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Anions_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Cations_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Anions_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__40" name="TRANS-RXN1HP7-40" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005840001_1) or (CHC_T00002066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NI__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NI__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__45__OXOPROLINASE__45__ATP__45__HYDROLYSING__45__RXN" name="5-oxo-L-prolinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4041

GENE_ASSOCIATION: (CHC_T00008487001_1) or (CHC_T00008487001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__OXOPROLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17786" name="RXN-17786" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008557001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19159_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19160_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5668 , PWY4FS-7 , PWY-7817 , PWY4FS-8 , PWY-5269 , PWY0-1545

GENE_ASSOCIATION: (CHC_T00009507001_1) or (CHC_T00008428001_1) or (CHC_T00009507001) or (CHC_T00008428001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CDPDIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTATHIONE__45__PEROXIDASE__45__RXN" name="GLUTATHIONE-PEROXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4081 , DETOX1-PWY-1

GENE_ASSOCIATION: (CHC_T00001518001_1) or (CHC_T00003751001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXIDIZED__45__GLUTATHIONE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9725" name="RXN-9725" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6035

GENE_ASSOCIATION: (CHC_T00009538001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__591_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__7630_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15559" name="RXN-15559" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7511

GENE_ASSOCIATION: (CHC_T00007701001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ubiquitinyl__45__UCP__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HECT__45__Ubiquitin__45__carrier__45__protein__45__E3__45__L__45__cys_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_S__45__ubiquitinyl__45__HECT__45__E3__45__UCP__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquitin__45__carrier__45__protein__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2044" name="RXN0-2044" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1361 , PWY0-321

GENE_ASSOCIATION: (CHC_T00008557001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__HYDROXYADIPYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__KETO__45__ADIPYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11270" name="RXN-11270" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6444

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12218_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BENZALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9531" name="3-oxo-dodecanoyl-[acyl-carrier protein] synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Decanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__dodecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXNN__45__404" name="RXNN-404" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5025 , PWY-3161 , PWY-581

GENE_ASSOCIATION: (CHC_T00009018001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__237_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_INDOLE_ACETATE_AUXIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENODEAMIN__45__RXN" name="ADENODEAMIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6611 , PWY-6609 , PWY0-1296 , SALVADEHYPOX-PWY

GENE_ASSOCIATION: (CHC_T00001501001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_INOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17896" name="RXN-17896" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7751

GENE_ASSOCIATION: (CHC_T00001829001)

CATEGORIES: GAP-FILLING and MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19220_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18779_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__476__45__CPD__45__388__47__NAD__47__WATER__47____47__CPD__45__8462__47__NADH__47__PROTON__46__40__46__" name="RXN66-476-CPD-388/NAD/WATER//CPD-8462/NADH/PROTON.40." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__388_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8462_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9282" name="RXN-9282" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5872

GENE_ASSOCIATION: (CHC_T00007491001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9895_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9897_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14140" name="RXN-14140" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13297" name="RXN-13297" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7036

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10279_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14273_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14796" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7340

GENE_ASSOCIATION: (CHC_T00008400001_1) or (CHC_T00007910001_1) or (CHC_T00008478001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00009142001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15684_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15685_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16044" name="RXN-16044" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5353

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14407_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17283_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__20" name="4&alpha;-methyl-cholesta-8-enol 4-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4184_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8617_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14139" name="RXN-14139" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7821

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15128" name="RXN-15128" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYSTINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__AMINOACRYLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIOCYSTEINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14950" name="Lipoate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7382

GENE_ASSOCIATION: (CHC_T00008509001_1) or (CHC_T00008509001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Reduced__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Octanoylated__45__Gcv__45__H_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CH33ADO_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Oxidized__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTEIN__45__LIPOYLLYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14220" name="RXN-14220" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DUDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DUMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AMP__45__DEPHOSPHORYLATION__45__RXN" name="AMP-DEPHOSPHORYLATION-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SALVADEHYPOX-PWY

GENE_ASSOCIATION: (CHC_T00000267001_1) or (CHC_T00008300001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SUPEROX__45__DISMUT__45__RXN" name="SUPEROX-DISMUT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: DETOX1-PWY , DETOX1-PWY-1 , PWY-6854

GENE_ASSOCIATION: (CHC_T00005214001_1) or (CHC_T00003067001_1) or (CHC_T00010182001_1) or (CHC_T00008473001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SUPER__45__OXIDE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1321" name="RXN0-1321" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6700

GENE_ASSOCIATION: (CHC_T00008743001_1) or (CHC_T00008745001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_7__45__AMINOMETHYL__45__7__45__DEAZAGUANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Guanine34__45__in__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNA__45__with__45__7__45__aminomethyl__45__7__45__deazaguanine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GUANINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__16" name="4&alpha;-hydroxymethyl-4&beta;-methyl-5&alpha;-cholesta-8-en-3&beta;-ol 4-dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8611_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8612_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9528" name="3-oxo-decanoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994 , PWY-5971

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__decanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Beta__45__hydroxydecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12197" name="RXN-12197" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__HYDROXY__45__KYNURENINASE__45__RXN" name="3-HYDROXY-KYNURENINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6309 , PWY-5651

GENE_ASSOCIATION: (CHC_T00002784001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__HYDROXY__45__L__45__KYNURENINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__HYDROXY__45__ANTHRANILATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN3O__45__1803" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY3O-355

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__stearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15043" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7417 , PWY-7411

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__1__45__LYSOPHOSPHATIDATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8268_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14192" name="pyruvate kinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008482001_1) or (CHC_T00008652001_1) or (CHC_T00008530001_1) or (CHC_T00008482001) or (CHC_T00008530001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16998" name="phosphoglucomutase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005896001_1) or (CHC_T00008779001_1) or (CHC_T00008779001) or (CHC_T00003000001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Phosphoglucomutase_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALPHA__45__GLUCOSE__45__16__45__BISPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__glucopyranose__45__6__45__phosphate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phosphorylated__45__phosphoglucomutase_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALKANE__45__1__45__MONOOXYGENASE__45__RXN" name="Alkane hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P221-PWY

GENE_ASSOCIATION: (CHC_T00010276001) or (CHC_T00010276001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__Rubredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__148_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OCTANOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__Rubredoxins_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17799" name="RXN-17799" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19153_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14925_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7691" name="RXN-7691" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5075

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7030_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ISOBUTYRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8036" name="RXN-8036" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5176

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7417_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7418_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12448" name="RXN-12448" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Secondary__45__Alcohols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_LONG__45__CHAIN__45__KETONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_OHACYL__45__COA__45__DEHYDROG__45__RXN" name="OHACYL-COA-DEHYDROG-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5136 , PWY-7007 , FAO-PWY , PWY66-391

GENE_ASSOCIATION: (CHC_T00008557001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__3__45__HYDROXYACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__KETOACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOMOCYSMETB12__45__RXN__45__HOMO__45__CYS__47__5__45__METHYL__45__THF__47____47__MET__47__THF__46__31__46__" name="HOMOCYSMETB12-RXN-HOMO-CYS/5-METHYL-THF//MET/THF.31." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__METHYL__45__THF_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_THF_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__15" name="4,4-dimethyl-5&alpha;-cholesta-8-en-3-&beta;-ol 4-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8610_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8611_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__56__45__RXN" name="2.4.1.56-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010280001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Lipopolysaccharides_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__ACETYL__45__ETCETERA__45__LIPOPOLYSACCHARIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_H2PTEROATESYNTH__45__RXN" name="H2PTEROATESYNTH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6614

GENE_ASSOCIATION: (CHC_T00003007001_1) or (CHC_T00007059001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIHYDROPTERIN__45__CH2OH__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__AMINO__45__BENZOATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_7__45__8__45__DIHYDROPTEROATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__23" name="TRANS-RXN1HP7-23" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001067001_1) or (CHC_T00008887001_1) or (CHC_T00009208001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NA__43___e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NA__43___c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__1__46__1__46__39__45__RXN" name="1.1.1.39-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7384 , PWY-7686 , PWY-7115 , GLUCONEO-PWY , PWY-3641 , PWY-7118

GENE_ASSOCIATION: (CHC_T00009563001_1) or (CHC_T00008878001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PANTOTHENATE__45__KIN__45__RXN" name="PANTOTHENATE-KIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PANTO-PWY , COA-PWY-1 , PWY-3961

GENE_ASSOCIATION: (CHC_T00002103001_1) or (CHC_T00002958001_1) or (CHC_T00006632001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PANTOTHENATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_4__45__P__45__PANTOTHENATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ISPH2__45__RXN" name="ISPH2-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NONMEVIPP-PWY , PWY-7560

GENE_ASSOCIATION: (CHC_T00008841001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROXY__45__METHYL__45__BUTENYL__45__DIP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16332" name="RXN-16332" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY3DJ-12

GENE_ASSOCIATION: (CHC_T00009401001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD3DJ__45__82_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_N__45__Acylsphingosine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17754" name="alpha-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008413001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__3801_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLUCONATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALPHA__45__D__45__GALACTOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDROFOLATEREDUCT__45__RXN" name="DIHYDROFOLATEREDUCT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: 1CMET2-PWY , PWY-6614 , PWY-3841

GENE_ASSOCIATION: (CHC_T00010030001_1) or (CHC_T00008680001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROFOLATE__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6384" name="3-hydroxyisobutyryl-CoA hydrolase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7574 , PWY-3941

GENE_ASSOCIATION: (CHC_T00008307001_1) or (CHC_T00008307001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__HYDROXY__45__PROPIONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__HYDROXY__45__PROPIONATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__7238" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9247_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18346_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SHIKIMATE__45__5__45__DEHYDROGENASE__45__RXN" name="SHIKIMATE-5-DEHYDROGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6163

GENE_ASSOCIATION: (CHC_T00007254001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__DEHYDRO__45__SHIKIMATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SHIKIMATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17728" name="acyl/alkyl-DHAP reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7782

GENE_ASSOCIATION: (CHC_T00004694001_1) or (CHC_T00000399001_1) or (CHC_T00008374001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__ALKYL__45__GLYCERONE__45__3__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__Alkyl__45__glycerol__45__3__45__phosphate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10062" name="trans-hexacos-2-enoyl-[acp] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321 , PWY-6113

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Trans__45__D2__45__hexacos__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cerotoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CDPKIN__45__RXN" name="nucleoside-diphosphate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7205

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDRODIPICSYN__45__RXN" name="DIHYDRODIPICSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: DAPLYSINESYN-PWY , PWY-5097 , PWY-2942 , PWY-2941

GENE_ASSOCIATION: (CHC_T00006235001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE__45__SEMIALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14443_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_CL__45__" name="TransportSeed_CL-" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CL__45___e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CL__45___c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYOXI__45__RXN" name="Lactoylglutathione lyase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5386

GENE_ASSOCIATION: (CHC_T00009567001_1) or (CHC_T00000393001_1) or (CHC_T00009136001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__LACTOYL__45__GLUTATHIONE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYL__45__GLYOXAL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ASPARTATE__45____45__TRNA__45__LIGASE__45__RXN" name="aspartyl-tRNA synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00009433001_1) or (CHC_T00004955001_1) or (CHC_T00003476001_1) or (CHC_T00004944001_1) or (CHC_T00010226001) or (CHC_T00010226001_1) or (CHC_T00009433001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASP__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__ASP__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__9__46__4__45__RXN" name="Alpha-glucan water dikinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008789001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alpha__45__D__45__Glucans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Phospho__45__alpha__45__glucans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14023" name="RXN-14023" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7178

GENE_ASSOCIATION: (CHC_T00009372001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCOLALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14570" name="RXN-14570" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1587

GENE_ASSOCIATION: (CHC_T00000321001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15435_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNA__45__adenine__45__37_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N6__45__L__45__threonylcarbamoyladenine37__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANSENOYLCOARED__45__RXN__45__HEXANOYL__45__COA__47__NADP__47____47__CPD0__45__2121__47__NADPH__47__PROTON__46__42__46__" name="TRANSENOYLCOARED-RXN-HEXANOYL-COA/NADP//CPD0-2121/NADPH/PROTON.42." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2121_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TREHALOSEPHOSPHA__45__RXN" name="Trehalose 6-phosphate synthase, family GT20 / Trehalose 6-phosphate phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-881 , TREHALOSESYN-PWY , TRESYN-PWY

GENE_ASSOCIATION: (CHC_T00010201001_1) or (CHC_T00002090001_1) or (CHC_T00009495001_1) or (CHC_T00008273001) or (CHC_T00010201001) or (CHC_T00009495001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TREHALOSE__45__6P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TREHALOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1225" name="RXN-1225" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-401 , PWY-7666

GENE_ASSOCIATION: (CHC_T00008344001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__Galactosyl__45__12__45__diacyl__45__glycerols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14553_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Galactosyl__45__galactosyl__45__diacyl__45__glycerols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYSPH__45__RXN" name="CYSPH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-702

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_O__45__PHOSPHO__45__L__45__HOMOSERINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__CYSTATHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FUMARYLACETOACETASE__45__RXN" name="fumarylacetoacetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TYRFUMCAT-PWY

GENE_ASSOCIATION: (CHC_T00005558001_1) or (CHC_T00010274001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4__45__FUMARYL__45__ACETOACETATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__KETOBUTYRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NACGLCTRANS__45__RXN" name="UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-&beta;-N-acetylglucosaminlytransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PEPTIDOGLYCANSYN-PWY

GENE_ASSOCIATION: (CHC_T00009362001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_C5_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_C6_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2141" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-862

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cis__45__delta__45__3__45__decenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_b__45__Keto__45__cis__45__D5__45__dodecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIAMINOPIMEPIM__45__RXN" name="DIAMINOPIMEPIM-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: DAPLYSINESYN-PWY , PWY-2941 , PWY-5097

GENE_ASSOCIATION: (CHC_T00004852001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LL__45__DIAMINOPIMELATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MESO__45__DIAMINOPIMELATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14196" name="carbamoyl phosphate synthase small subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7693

GENE_ASSOCIATION: (CHC_T00008596001_1) or (CHC_T00010056001_1) or (CHC_70)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CARBAMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBAMOYL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__13__46__3__45__RXN" name="2.7.13.3-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006736001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__Histidines_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__phospho__45__L__45__histidines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__2__46__1__46__25__45__RXN" name="1.2.1.25-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: VALDEG-PWY

GENE_ASSOCIATION: (CHC_T00006349001_1) or (CHC_T00008584001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETO__45__ISOVALERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ISOBUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__4401" name="RXN0-4401" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000276001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NMNH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ARGININE__45____45__TRNA__45__LIGASE__45__RXN" name="Arginyl-tRNA synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00010186001) or (CHC_T00010186001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ARG__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ARG_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__ARG__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN0__45__623" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD66__45__39_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17112" name="RXN-17112" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7726

GENE_ASSOCIATION: (CHC_T00008879001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__17328_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__18491_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13396" name="RXN-13396" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7126

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ARG_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__1470_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SQUALENE__45__MONOOXYGENASE__45__RXN" name="SQUALENE-MONOOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6098 , PWY-5670

GENE_ASSOCIATION: (Scaffold90_7511_6165) or (scaffold20_461442_460650) or (scaffold57_152407_364140)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SQUALENE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_EPOXYSQUALENE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17688" name="RXN-17688" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7053

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17282_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14018_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14224" name="aldehyde dehydrogenase, (NAD) activity" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15163_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__661_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__6__46__3__46__6__45__RXN" name="3.6.3.6-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004901001_1) or (CHC_T00010194001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__3__46__77__45__RXN" name="E1 enzyme family" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010198001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8999_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__85_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__45__DEHYDROPANTOATE__45__REDUCT__45__RXN" name="2-DEHYDROPANTOATE-REDUCT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PANTO-PWY , PWY-6654

GENE_ASSOCIATION: (CHC_T00002917001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__DEHYDROPANTOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__PANTOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN3O__45__581" name="inositol phosphoceramide synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SPHINGOLIPID-SYN-PWY

GENE_ASSOCIATION: (CHC_T00008908001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Alpha__45__hydroxyphytoceramides_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__1__45__phosphatidyl__45__inositols_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_IPC_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_MG__43__2" name="ExchangeSeed_MG+2" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MG__43__2_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MG__43__2_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DNA__45__LIGASE__45__ATP__45__RXN" name="DNA-LIGASE-ATP-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002554001_1) or (CHC_T00010250001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__Phospho__45__terminated__45__DNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Hydroxy__45__Terminated__45__DNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DNA__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_IGPSYN__45__RXN" name="indole-3-glycerol phosphate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRPSYN-PWY

GENE_ASSOCIATION: (CHC_T00008561001_1) or (CHC_T00004489001_1) or (CHC_T00000220001_1) or (CHC_T00008561001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_INDOLE__45__3__45__GLYCEROL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRIACYLGLYCEROL__45__LIPASE__45__RXN" name="TRIACYLGLYCEROL-LIPASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: LIPAS-PWY

GENE_ASSOCIATION: (CHC_T00009452001_1) or (CHC_T00005737001_1) or (CHC_T00000197001_1) or (CHC_T00000198001_1) or (CHC_T00009491001_1) or (CHC_T00008615001_1) or (CHC_T00002434001_1) or (CHC_T00000853001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Triacylglycerides_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__2__45__Diglycerides_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6PGLUCONDEHYDROG__45__RXN" name="phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P122-PWY

GENE_ASSOCIATION: (CHC_T00008023001_1) or (CHC_T00008523001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__2961_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_RIBULOSE__45__5P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__7__46__8__45__RXN" name="2.7.7.8-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000588001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ssRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ssRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Nucleoside__45__Diphosphates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__23" name="RXN66-23" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00003646001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8619_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8620_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__82__45__RXN" name="Probable galactinol--sucrose galactosyltransferase 4" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5337 , PWY-6525 , PWY-6524

GENE_ASSOCIATION: (CHC_T00008780001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__458_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUCROSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__1099_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYSTHIOCYS__45__RXN" name="CYSTHIOCYS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYSTINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIOCYSTEINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10" name="Argininosuccinate synthase (fragment)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5

GENE_ASSOCIATION: (CHC_T00010073001) or (CHC_T00010073001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_O__45__UREIDOHOMOSERINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CANAVANINOSUCCINATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__311" name="4&alpha;-hydroxymethyl-4&beta;-methyl-5&alpha;-cholesta-8,24-dien-3&beta;-ol dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074 , PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4575_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4576_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__18301" name="Glycolipid sulfotransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7840

GENE_ASSOCIATION: (CHC_T00008551001) or (CHC_T00009336001) or (CHC_T00008762001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_A__45__GALACTOSYLCERAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PAPS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_galactosylceramide__45__sulfate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__5__45__ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__83__45__RXN" name="probable dolichyl-phosphate mannosyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00009153001) or (CHC_T00009153001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__171_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUC1PADENYLTRANS__45__RXN" name="GLUC1PADENYLTRANS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-622 , GLYCOGENSYNTH-PWY

GENE_ASSOCIATION: (CHC_T00000775001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP__45__D__45__GLUCOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AIRS__45__RXN" name="phosphoribosylformylglycinamidine cyclo-ligase (phosphoribosyl-aminoimidazole synthetase) (AIR synthase)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6121 , PWY-6277 , PWY-6122

GENE_ASSOCIATION: (CHC_T00008410001) or (CHC_T00008410001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9220" name="RXN-9220" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5849

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12116_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12124_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PRAISOM__45__RXN" name="PRAISOM-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRPSYN-PWY

GENE_ASSOCIATION: (CHC_T00003361001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MEVALONATE__45__KINASE__45__RXN" name="MEVALONATE-KINASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6174 , PWY-922 , PWY-7391

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MEVALONATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__499_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__35" name="TRANS-RXN1HP7-35" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003221001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CA__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CA__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__79__45__RXN" name="Cyclopropane-fatty-acyl-phospholipid synthase family" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-541

GENE_ASSOCIATION: (CHC_T00005488001_1) or (CHC_T00003092001_1) or (CHC_T00006042001_1) or (CHC_T00009019001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Phospholipid__45__Olefinic__45__Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phospholipid__45__Cyclopropane__45__Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14385" name="RXN-14385" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7250

GENE_ASSOCIATION: (CHC_T00008053001_1) or (CHC_T00000657001_1) or (CHC_T00009510001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CD__45__S__45__SP__45__Complex_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_S__45__CD__45__S__45__SP__45__Complex_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AMPSYN__45__RXN" name="AMPSYN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7219

GENE_ASSOCIATION: (CHC_T00008097001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADENYLOSUCC_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__2__45__ENOYL__45__COA__45__REDUCTASE__45__NAD__43____45__RXN__45__CPD__45__10280__47__NAD__47____47__CPD__45__14282__47__NADH__47__PROTON__46__37__46__" name="TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN-CPD-10280/NAD//CPD-14282/NADH/PROTON.37." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14282_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10280_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_R163__45__RXN" name="R163-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008808001_1) or (CHC_T00008454001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PAPS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_APS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16152" name="RXN-16152" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6433

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15366_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17400_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_CU__43__2" name="ExchangeSeed_CU+2" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CU__43__2_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CU__43__2_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14372" name="1,4-alpha-Glucan branching enzyme" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-622

GENE_ASSOCIATION: (CHC_T00008662001) or (CHC_T00008662001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Alpha__45__Amyloses_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7043_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NITRATE__45__REDUCTASE__45__NADPH__45__RXN" name="NITRATE-REDUCTASE-NADPH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5675

GENE_ASSOCIATION: (CHC_T00008899001_1) or (CHC_T00003369001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRITE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__6__46__1__46__19__45__RXN" name="3.6.1.19-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Nucleoside__45__Triphosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Nucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DETHIOBIOTIN__45__SYN__45__RXN" name="DETHIOBIOTIN-SYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7380 , PWY0-1507

GENE_ASSOCIATION: (CHC_T00002287001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIAMINONONANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_DETHIOBIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__21__46__89__45__RXN" name="3.4.21.89-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005406001_1) or (CHC_T00000271001_1) or (CHC_T00001989001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__with__45__Leader__45__Sequence_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Leader__45__Sequences_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9548" name="RXN-9548" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5989

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Stearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_STEARIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2921" name="RXN0-2921" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2161

GENE_ASSOCIATION: (CHC_T00000400001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLENE__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METHYLENE__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14208" name="RXN-14208" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_DGTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DGMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11501" name="alpha-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6527

GENE_ASSOCIATION: (CHC_T00008413001) or (CHC_T00008413001_1) or (CHC_T00008780001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__170_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__1099_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALPHA__45__D__45__GALACTOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15035" name="Putative lysophospholipase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7409

GENE_ASSOCIATION: (CHC_T00005231001_1) or (CHC_T00008581001_1) or (CHC_T00003275001_1) or (CHC_T00009177001_1) or (CHC_T00008784001_1) or (CHC_T00009450001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8355_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__1__45__GLYCEROPHOSPHORYLETHANOL__45__AMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OLEATE__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_CO__43__2" name="ExchangeSeed_CO+2" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__43__2_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__43__2_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_H2NEOPTERINALDOL__45__RXN" name="H2NEOPTERINALDOL-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6147 , PWY-7539 , PWY-6148 , PWY-6797

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIHYDRO__45__NEO__45__PTERIN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCOLALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9230" name="RXN-9230" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5857 , PWY-5872

GENE_ASSOCIATION: (CHC_T00002263001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9610_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__hydroxybenzoate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9864_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12400" name="xyloglucan XLLG oligosaccharide &beta;-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6807

GENE_ASSOCIATION: (CHC_T00008905001_1) or (CHC_T00008606001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__13378_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13375_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__galactopyranose_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11502" name="alpha-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6527

GENE_ASSOCIATION: (CHC_T00008413001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__1099_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ALPHA__45__D__45__GALACTOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUCROSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACONITATEHYDR__45__RXN" name="cis-aconitate hydratase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6549 , P23-PWY , REDCITCYC , PWY-5392 , PWY-5913 , PWY-5690 , P105-PWY , PWY-6969 , PWY-7124 , TCA , PWY66-398 , GLYOXYLATE-BYPASS , PWY-6728 , PWY-7254 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00008781001_1) or (CHC_T00009087001_1) or (CHC_T00008781001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CIS__45__ACONITATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_THREO__45__DS__45__ISO__45__CITRATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11834" name="RXN-11834" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006820001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_23S__45__rRNA__45__uridine2457_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_23S__45__rRNA__45__pseudouridine2457_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11329" name="RXN-11329" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008578001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RH__45__Group_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12287_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Bromide_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14266" name="3-hydroxyisovaleryl-CoA hydratase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009190001_1) or (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__HYDROXY__45__ISOVALERYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__1083_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_F16BDEPHOS__45__RXN" name="fructose-1,6-bisphosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5484 , PWY66-399 , GLYCOLYSIS , CALVIN-PWY , GLUCONEO-PWY , P185-PWY , SUCSYN-PWY

GENE_ASSOCIATION: (CHC_T00008537001_1) or (CHC_T00008570001_1) or (CHC_T00008369001_1) or (CHC_T00002260001_1) or (CHC_T00008570001) or (CHC_T00008537001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FRUCTOSE__45__16__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_COB__45__I__45__ALAMIN" name="TransportSeed_COB-I-ALAMIN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_COB__45__I__45__ALAMIN_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_COB__45__I__45__ALAMIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRYPTOPHAN__45____45__TRNA__45__LIGASE__45__RXN" name="Tryptophan--tRNA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00010058001_1) or (CHC_T00002342001_1) or (CHC_T00010058001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TRP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRP__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__TRP__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UROPORIIIMETHYLTRANSA__45__RXN" name="UROPORIIIMETHYLTRANSA-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5194 , PWY-7377 , PWY-7376 , PWY-5196

GENE_ASSOCIATION: (CHC_T00000927001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UROPORPHYRINOGEN__45__III_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__9038_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13482" name="RXN-13482" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005123001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CARBAMOYL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ORNITHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__CITRULLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17252" name="RXN-17252" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5098 , PWY-6927

GENE_ASSOCIATION: (CHC_T00003882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__7061_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18666_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__46__1__46__1__46__18__45__RXN" name="5.1.1.18-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6455 , PWY-6196

GENE_ASSOCIATION: (CHC_T00008746001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__SERINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11109" name="DEAD box RNA helicase, putative" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002773001_1) or (CHC_T00008647001_1) or (CHC_T00006787001_1) or (CHC_T00010189001_1) or (CHC_T00007274001_1) or (CHC_T00003761001_1) or (CHC_T00006912001_1) or (CHC_T00010240001_1) or (CHC_T00005385001_1) or (CHC_T00010296001_1) or (CHC_T00000427001_1) or (CHC_T00010115001_1) or (CHC_T00010215001_1) or (CHC_T00008748001_1) or (CHC_T00002063001_1) or (CHC_T00010142001_1) or (CHC_T00009449001_1) or (CHC_T00004762001_1) or (CHC_T00010014001_1) or (CHC_T00010060001_1) or (CHC_T00004041001_1) or (CHC_T00010340001_1) or (CHC_T00010233001_1) or (CHC_T00010236001_1) or (CHC_T00010264001_1) or (CHC_T00010310001_1) or (CHC_T00010221001_1) or (CHC_T00010308001_1) or (CHC_T00010142001) or (CHC_T00010236001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Wound__45__RNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Unwound__45__RNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FGAMSYN__45__RXN" name="phosphoribosylformylglycinamidine synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6121 , PWY-6277 , PWY-6122

GENE_ASSOCIATION: (CHC_T00008585001) or (CHC_T00008585001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__7230" name="RXN0-7230" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008591001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ETR__45__Quinones_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHOLINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ETR__45__Quinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BETAINE_ALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7609" name="RXN-7609" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6608 , PWY-6606 , PWY-6607

GENE_ASSOCIATION: (CHC_T00000267001_1) or (CHC_T00008300001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GMP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GUANOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__3221" name="RXN-3221" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6325 , PWY-2002

GENE_ASSOCIATION: (CHC_T00008856001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__3041_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__3061_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETALD__45__DEHYDROG__45__RXN" name="ACETALD-DEHYDROG-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5480 , PHOSPHONOTASE-PWY , PWY-6587 , P122-PWY , PWY-5436 , P161-PWY , PWY-7180 , ETOH-ACETYLCOA-ANA-PWY , PWY-5162 , PWY-7085 , PWY4LZ-257 , FERMENTATION-PWY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETALD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6__45__PHOSPHOFRUCTO__45__2__45__KINASE__45__RXN" name="6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-423

GENE_ASSOCIATION: (CHC_T00009308001_1) or (CHC_T00009308001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__535_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13304" name="RXN-13304" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7036

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14277_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14282_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__646" name="RXN-646" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6993 , PWY-722 , PWY-5033 , PWY-7128

GENE_ASSOCIATION: (CHC_T00002303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALEAMATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALEATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6501" name="D-inositol-3-phosphate glycosyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY1G-0

GENE_ASSOCIATION: (CHC_T00009320001) or (CHC_T00010280001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__L__45__MYO__45__INOSITOL__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11975_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SERINE__45__O__45__ACETTRAN__45__RXN" name="SERINE-O-ACETTRAN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CYSTSYN-PWY , PWY-7274 , PWY-6936

GENE_ASSOCIATION: (CHC_T00008894001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYLSERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBOFLAVINKIN__45__RXN" name="RIBOFLAVINKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6168 , PWY-5523 , PWY66-366 , RIBOSYN2-PWY

GENE_ASSOCIATION: (CHC_T00009043001_1) or (CHC_T00000009001_1) or (CHC_T00002338001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RIBOFLAVIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FMN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GCVMULTI__45__RXN__45__GLY__47__THF__47__NAD__47____47__METHYLENE__45__THF__47__AMMONIUM__47__CARBON__45__DIOXIDE__47__NADH__46__56__46__" name="GCVMULTI-RXN-GLY/THF/NAD//METHYLENE-THF/AMMONIUM/CARBON-DIOXIDE/NADH.56." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_METHYLENE__45__THF_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ENOYL__45__ACP__45__REDUCT__45__NADH__45__RXN" name="2,3,4-saturated-fatty-acid-[acp] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: FASYN-ELONG-PWY

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRANS__45__D2__45__ENOYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Saturated__45__Fatty__45__Acyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1824" name="Pullulanase, Pul1" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008915001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Large__45__branched__45__glucans_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Long__45__linear__45__glucans_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15881" name="RXN-15881" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7250

GENE_ASSOCIATION: (CHC_T00009510001_1) or (CHC_T00008053001_1) or (CHC_T00000657001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__Cysteine__45__Desulfurases_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Persulfurated__45__L__45__cysteine__45__desulfurases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CHOLINE__45__KINASE__45__RXN" name="Choline/ethanolamine kinase, putative" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY3O-450 , PWY-7818 , PWY-7782

GENE_ASSOCIATION: (CHC_T00008383001) or (CHC_T00008383001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHOLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHORYL__45__CHOLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CARBONYL__45__REDUCTASE__45__NADPH__45__RXN" name="CARBONYL-REDUCTASE-NADPH-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006708001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Secondary__45__Alcohols_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_LONG__45__CHAIN__45__KETONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17795" name="RXN-17795" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19157_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19148_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BENZALDEHYDE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6766 , PWY-6763 , PWY-1501 , PWY-6444 , TOLUENE-DEG-CATECHOL-PWY , PWY-6446

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BENZALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BENZOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6397 , COLANSYN-PWY , PWY66-422 , PWY-3821 , PWY-6317 , PWY-6527 , PWY-7344 , PWY-7328

GENE_ASSOCIATION: (CHC_T00006828001_1) or (CHC_T00007304001_1) or (CHC_T00009498001_1) or (CHC_T00006831001_1) or (CHC_T00009498001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14553_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8629" name="lipoamide dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLYCLEAV-PWY

GENE_ASSOCIATION: (CHC_T00008441001_1) or (CHC_T00010287001_1) or (CHC_T00008441001) or (CHC_T00010287001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIHYDROLIPOYL__45__GCVH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTEIN__45__LIPOYLLYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__45__NUCLEOTID__45__RXN" name="5-NUCLEOTID-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008300001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Ribonucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ribonucleosides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17797" name="RXN-17797" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19150_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19151_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__8__46__1__46__6__45__RXN" name="biotin synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7380 , PWY0-1507

GENE_ASSOCIATION: (CHC_T00009361001_1) or (CHC_T00009361001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_DETHIOBIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_BIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12587" name="RXN-12587" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009510001_1) or (CHC_T00008053001_1) or (CHC_T00000657001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__Cysteine__45__Desulfurase__45__persulfide_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cysteine__45__Desulfurase__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_R311__45__RXN" name="Acrylamidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7308

GENE_ASSOCIATION: (CHC_T00009018001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACRYLAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACRYLATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5669

GENE_ASSOCIATION: (CHC_T00008892001_1) or (CHC_T00008892001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__1__45__PHOSPHATIDYL__45__SERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17371" name="RXN-17371" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (Scaffold115_53074_54093)

CATEGORIES: GAP-FILLING and MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18777_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__18778_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1404" name="nitrilase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5026 , PWY-581 , PWYQT-4476

GENE_ASSOCIATION: (CHC_T00008379001_1) or (CHC_T00008379001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_INDOLEYL__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INDOLE_ACETATE_AUXIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14225" name="aldehyde dehydrogenase, (NAD) activity" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__GLUCURONOLACTONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__GLUCARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__1__46__133__45__RXN" name="2.7.1.133-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6362 , PWY-6366 , PWY-6365 , PWY-6554

GENE_ASSOCIATION: (CHC_T00001462001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__505_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5183" name="alpha-glucosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLYCOCAT-PWY

GENE_ASSOCIATION: (CHC_T00000021001_1) or (CHC_T00009379001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALTOTRIOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11370" name="RXN-11370" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008650001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__3__45__CARBOXY__45__3__45__AMINOPROPYL__45__L__45__HISTIDINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__3__45__CARBOXY__45__3__45__METHYLAMMONIOPROPYL__45__L__45___c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ISOBUTYRYL__45__COA__45__MUTASE__45__RXN" name="ISOBUTYRYL-COA-MUTASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ISOBUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7710" name="1,4-alpha-Glucan branching enzyme" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008662001) or (CHC_T00008662001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Starch_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FLAVONADPREDUCT__45__RXN" name="FLAVONADPREDUCT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008519001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Oxidized__45__flavodoxins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Reduced__45__flavodoxins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13299" name="RXN-13299" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7036

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10283_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14276_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOMOSERKIN__45__RXN" name="HOMOSERKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-702 , HOMOSER-THRESYN-PWY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMO__45__SER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_O__45__PHOSPHO__45__L__45__HOMOSERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8872" name="RXN-8872" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5665 , PWY-7826

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__HYDROXYBENZALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7616_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CTPSYN__45__RXN" name="CTPSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7177 , PWY-7176 , PWY-7185

GENE_ASSOCIATION: (CHC_T00007798001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7674" name="RXN-7674" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5068

GENE_ASSOCIATION: (CHC_T00008377001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHYTYL__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__7014_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHLOROPHYLL__45__B_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_S__45__FORMYLGLUTATHIONE__45__HYDROLASE__45__RXN" name="probable S-formylglutathione hydrolase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1801

GENE_ASSOCIATION: (CHC_T00009148001_1) or (CHC_T00009148001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__548_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14201" name="RXN-14201" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9236" name="RXN-9236" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5857 , PWY-5872

GENE_ASSOCIATION: (CHC_T00003410001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9871_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9873_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__7248" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9245_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10269_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADPREDUCT__45__RXN" name="ADP reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7227 , PWY-7220

GENE_ASSOCIATION: (CHC_T00008926001_1) or (CHC_T00008864001_1) or (CHC_T00008864001) or (CHC_T00008926001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12978" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5Z8Z11Z14Z17Z__45__EICOSAPENTAENOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14018_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14284" name="Starch phosphorylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOPENTAOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOTETRAOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__969" name="RXN-969" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-181

GENE_ASSOCIATION: (CHC_T00004702001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCOLLATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYOX_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TREHALA__45__RXN" name="Trehalase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1466 , PWY0-1182

GENE_ASSOCIATION: (CHC_T00009196001) or (CHC_T00009196001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TREHALOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALPHA__45__GLUCOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14216" name="RXN-14216" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DCTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DCDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8655" name="RXN-8655" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-522

GENE_ASSOCIATION: (CHC_T00006203001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Lipoyl__45__Protein__45__L__45__Lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LIPOYL__45__AMP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Lipoyl__45__Protein__45__N6__45__lipoyllysine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ORNITHINE__45__CYCLODEAMINASE__45__RXN" name="ORNITHINE-CYCLODEAMINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: ORN-AMINOPENTANOATE-CAT-PWY , ARG-GLU-PWY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__ORNITHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PRO_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NITRATE__45__REDUCTASE__45__NADPORNOPH__45__RXN" name="NITRATE-REDUCTASE-NADPORNOPH-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008899001_1) or (CHC_T00003369001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRITE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__14__46__13__46__70__45__RXN" name="1.14.13.70-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2541

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_OBTUSIFOLIOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14793" name="RXN-14793" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7339

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15678_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15663_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_XYLULOKIN__45__RXN" name="Xylulose Kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: DARABITOLUTIL-PWY , XYLCAT-PWY , LARABITOLUTIL-PWY

GENE_ASSOCIATION: (CHC_T00009225001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__XYLULOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_XYLULOSE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__8__46__24__45__RXN" name="Phosphatidylcholine synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6826

GENE_ASSOCIATION: (CHC_T00008854001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHOLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CDPDIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHATIDYLCHOLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__1__46__3__46__37__45__RXN" name="1.1.3.37-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY3O-6

GENE_ASSOCIATION: (CHC_T00000692001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__356_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1789_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTONE__45__ACETYLTRANSFERASE__45__RXN" name="probable histone acetyltransferase GCN5" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010337001_1) or (CHC_T00009270001_1) or (CHC_T00009566001_1) or (CHC_T00003519001_1) or (CHC_T00009270001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Histone__45__L__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Histone__45__Acetyl__45__Lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1223" name="RXN-1223" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYQT-4427

GENE_ASSOCIATION: (CHC_T00009188001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP__45__SULFOQUINOVOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6359" name="RXN0-6359" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008822001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HCN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HSCN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__2544" name="cis-cyclopropane-&Delta;19-37-hydroxy-38-methyl-C57:1-[acp] synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00005488001_1) or (CHC_T00003092001_1) or (CHC_T00006042001_1) or (CHC_T00009019001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_cis__45__D19__45__37__45__MOH__45__38__45__Me__45__C57__45__1__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_cis__45__19__45__CP__45__37__45__Mex__45__38__45__Me__45__C59__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__24__46__57__45__RXN" name="probable O-sialoglycoprotein endopeptidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008520001) or (CHC_T00008520001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_O__45__Sialoglycoproteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16043" name="RXN-16043" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5353

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Gamma__45__linolenoyl__45__groups_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GAMMA__45__LINOLENOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__5__46__1__46__87__45__RXN" name="3.5.1.87-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000417001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__Carbamoyl__45__L__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12242" name="RXN-12242" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008407001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ETR__45__Quinones_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__7526_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7496_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETR__45__Quinols_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10662" name="RXN-10662" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10269_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9245_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16121" name="RXN-16121" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6453

GENE_ASSOCIATION: (CHC_T00009530001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17373_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17375_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14973" name="RXN-14973" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7388

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_3__45__Oxo__45__octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13202" name="carbamoyl phosphate synthase small subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4984

GENE_ASSOCIATION: (CHC_T00008596001_1) or (CHC_T00010056001_1) or (CHC_70)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HCO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CARBAMOYL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ARGINYLTRANSFERASE__45__RXN" name="ARGINYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007865001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Charged__45__ARG__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ARG__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__N__45__terminal__45__L__45__Arginine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2541" name="RXN-2541" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1422

GENE_ASSOCIATION: (CHC_T00000930001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHYTYL__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HOMOGENTISATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MPBQ_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__1__46__68__45__RXN" name="2.7.1.68-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6351 , PWY-6352

GENE_ASSOCIATION: (CHC_T00002812001_1) or (CHC_T00007622001_1) or (CHC_T00001659001_1) or (CHC_T00005927001_1) or (CHC_T00003824001_1) or (CHC_T00006799001_1) or (CHC_T00003679001_1) or (CHC_T00005762001_1) or (CHC_T00007860001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1108_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__24__46__71__45__RXN" name="3.4.24.71-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004162001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_big__45__endothelin_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_endothelin__45__1_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7690" name="RXN-7690" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5075

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__2041_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7030_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9384" name="RXN-9384" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007345001_1) or (CHC_T00005639001_1) or (CHC_T00003042001_1) or (CHC_T00004833001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_O__45__SUCCINYL__45__L__45__HOMOSERINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYTOCHROME__45__B5__45__REDUCTASE__45__RXN" name="CYTOCHROME-B5-REDUCTASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007556001_1) or (CHC_T00008899001_1) or (CHC_T00003369001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_L__45__IDITOL__45__2__45__DEHYDROGENASE__45__RXN" name="L-IDITOL-2-DEHYDROGENASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007340001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__369_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15616_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_METHYLACETOACETYLCOATHIOL__45__RXN" name="acetyl-CoA acetyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ILEUDEG-PWY , PWY-5109

GENE_ASSOCIATION: (CHC_T00008981001_1) or (CHC_T00009349001_1) or (CHC_T00008981001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__METHYL__45__ACETO__45__ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROPIONYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_WATER" name="ExchangeSeed_WATER" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17018" name="glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008773001) or (CHC_T00008773001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__PALMITOYLGLYCEROL__45__3__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__12" name="TRANS-RXN1HP7-12" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008480001_1) or (CHC_T00004326001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Metal__45__Ions_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Metal__45__Ions_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__3701" name="Rab geranylgeranyltransferase, beta subunit" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006421001_1) or (CHC_T00003446001_1) or (CHC_T00009072001_1) or (CHC_T00009072001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GERANYLGERANYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROT__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__GERANYLGERANYL__45__PROTEIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__146" name="RXN66-146" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-201

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NICOTINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__3187_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8642" name="RXN-8642" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009580001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXALO__45__SUCCINATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6479" name="RXN0-6479" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1479

GENE_ASSOCIATION: (CHC_T00003097001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2351_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Nucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2352_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CARBODEHYDRAT__45__RXN" name="carbonic anhydrase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010062001_1) or (CHC_T00010311001_1) or (CHC_T00010321001_1) or (CHC_T00007098001_1) or (CHC_T00002086001_1) or (CHC_T00010321001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_H2CO3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7643" name="branched-chain alpha-keto acid decarboxylase E1 beta subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7396 , PWY-5057 , PWY-7111

GENE_ASSOCIATION: (CHC_T00008584001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETO__45__ISOVALERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7000_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CATAL__45__RXN" name="CATAL-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: DETOX1-PWY-1 , DETOX1-PWY , PWY-5506

GENE_ASSOCIATION: (CHC_T00007915001_1) or (CHC_T00005477001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12705" name="RXN-12705" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6946 , PWY-6945

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13694_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13695_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12721" name="RXN-12721" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6932

GENE_ASSOCIATION: (CHC_T00009224001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__13713_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_SELENITE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXIDIZED__45__GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13295" name="RXN-13295" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7036

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9965_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10283_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_RXN__45__4144" name="extended_RXN-4144" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: late_SSR , early_SSR

GENE_ASSOCIATION: (CHC_T00003466001_1)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4A__45__METHYLCHOLEST__45__8__40__9__41____44__14__44__24__45__TRIEN__45__3B__45__OL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_4alpha_METHYLZYMOSTEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17429" name="RXN-17429" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7758 , PWY-7759 , PWY-7760

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18841_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METOH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__141__45__RXN" name="2.4.1.141-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00004836001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__190_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NN__45__DIACETYLCHITOBIOSYLDIPHOSPHODOLICHO_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16656" name="aldehyde dehydrogenase, (NAD) activity" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__292_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9768_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17203" name="Glycolipid sulfotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008551001) or (CHC_T00009336001) or (CHC_T00008762001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PAPS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__Alkyl__45__2__45__acyl__45__3D__45__galactosyl__45__sn__45__glycerol_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__5__45__ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Seminolipids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_OROPRIBTRANS__45__RXN" name="OROPRIBTRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7791 , PWY-7790 , PWY-5686

GENE_ASSOCIATION: (CHC_T00002698001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OROTIDINE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OROTATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__28" name="RXN66-28" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-4

GENE_ASSOCIATION: (CHC_T00002789001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DESMOSTEROL__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CHOLESTEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AMINOCYL__45__TRNA__45__HYDROLASE__45__RXN" name="Peptidyl-tRNA hydrolase 2, mitochondrial" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006238001_1) or (CHC_T00008495001_1) or (CHC_T00008495001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__Substituted__45__Aminoacyl__45__tRNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__Substituted__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYC3PDEHYDROGBIOSYN__45__RXN" name="GLYC3PDEHYDROGBIOSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1319 , PWY-5667 , PWY-5981

GENE_ASSOCIATION: (CHC_T00009494001_1) or (CHC_T00008461001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIHYDROXY__45__ACETONE__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2381" name="tryptophan synthase alpha chain" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6949 , TRPSYN-PWY

GENE_ASSOCIATION: (CHC_T00008705001_1) or (CHC_T00007475001_1) or (CHC_T00009102001_1) or (CHC_T00008842001_1) or (CHC_T00008746001_1) or (CHC_T00008401001) or (CHC_1120)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_INDOLE__45__3__45__GLYCEROL__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INDOLE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12750" name="3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoate dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6944

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13757_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13758_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__11__46__1__45__RXN" name="3.4.11.1-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004445001_1) or (CHC_T00002840001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__With__45__N__45__Terminal__45__X__45__Pro_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Amino__45__Acids__45__20_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__With__45__N__45__Terminal__45__Pro_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__3__45__RXN" name="2.1.1.3-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000853001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIMETHYLSULFONIOACETATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_S__45__METHYLTHIOGLYCOLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5285" name="NADPH:protochlorophyllide oxidoreductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CHLOROPHYLL-SYN

GENE_ASSOCIATION: (CHC_T00009425001_1) or (CHC_T00009425001) or (CHC_T00010090001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIVINYLCHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9663" name="trans hexadecenoyl-[acp] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__Hexadecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10661" name="RXN-10661" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6282

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Trans__45__D3__45__cis__45__D9__45__hexadecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Palmitoleoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14286" name="Starch phosphorylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__1133_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOHEXAOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17785" name="RXN-17785" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19163_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19159_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15511" name="RXN-15511" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6405

GENE_ASSOCIATION: (CHC_T00001241001_1) or (CHC_T00007707001_1) or (CHC_T00000449001_1) or (CHC_T00001519001_1) or (CHC_T00004201001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_23__45__DIPHOSPHOGLYCERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__Histidines_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_G3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__pi__45__phospho__45__L__45__histidines_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PSERTRANSAMPYR__45__RXN" name="phosphoserine aminotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PYRIDOXSYN-PWY

GENE_ASSOCIATION: (CHC_T00009221001_1) or (CHC_T00009221001) or (CHC_T00000094001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__PHOSPHONOOXY__45__THREONINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CAFFEOYL__45__COA__45__O__45__METHYLTRANSFERASE__45__RXN" name="CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1121 , PWY-5710 , PWY-361 , PWY-6039 , PWY-7498 , PWY-7398 , PWY-6792

GENE_ASSOCIATION: (CHC_T00003825001_1) or (CHC_T00001696001_1) or (CHC_T00005475001_1) or (CHC_T00007618001_1) or (CHC_T00001829001_1) or (CHC_T00001053001_1) or (CHC_T00009338001_1) or (CHC_T00004504001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CAFFEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FERULOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SERINE__45____45__TRNA__45__LIGASE__45__RXN" name="serine--tRNA ligase, cytoplasmic" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00009407001_1) or (CHC_T00009366001_1) or (CHC_T00009407001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SER__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__SER__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13712" name="4,4-dimethylzymosterol 4-monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__4577_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__550" name="electron transfer flavoprotein-ubiquinone oxidoreductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008888001) or (CHC_T00008888001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquinones_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquinols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TYROSINE__45__AMINOTRANSFERASE__45__RXN" name="tyrosine aminotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TYRSYN , PWY3O-4108 , PWY-5048 , TYRFUMCAT-PWY , PWY-5151 , PWY-3581 , PWY-5886 , PWY-7518 , PWY-5754 , PWY-7514

GENE_ASSOCIATION: (CHC_T00008863001) or (CHC_T00008863001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TYR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__HYDROXY__45__PHENYLPYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17020" name="Lysophosphatidic acid acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Palmitoleoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18379_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18380_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12579" name="RXN-12579" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6857

GENE_ASSOCIATION: (CHC_T00009452001_1) or (CHC_T00005737001_1) or (CHC_T00000197001_1) or (CHC_T00000198001_1) or (CHC_T00009491001_1) or (CHC_T00008615001_1) or (CHC_T00002434001_1) or (CHC_T00000853001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Dietary__45__retinyl__45__esters_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13524_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Long__45__Chain__45__Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4144" name="4&alpha;-methyl-5&alpha;-ergosta-8,14,24(28)-trien-3&beta;-ol &Delta;14 reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2541

GENE_ASSOCIATION: (CHC_T00003466001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4081_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__36" name="TRANS-RXN1HP7-36" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006881001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__5_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14282" name="alpha-glucosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000021001_1) or (CHC_T00009379001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOHEXAOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOPENTAOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTCYSLIG__45__RXN" name="GLUTCYSLIG-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6840 , GLUTATHIONESYN-PWY , PWY-7255

GENE_ASSOCIATION: (CHC_T00006446001_1) or (CHC_T00006447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__GAMMA__45__GLUTAMYLCYSTEINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15288" name="luteolin-7-O-diglucuronide peroxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7445

GENE_ASSOCIATION: (CHC_T00002409001_1) or (CHC_T00009160001_1) or (CHC_T00008578001_1) or (CHC_T00000152001_1) or (CHC_T00010263001_1) or (CHC_T00002083001_1) or (CHC_T00010024001_1) or (CHC_T00008640001_1) or (CHC_T00010209001_1) or (CHC_T00010179001_1) or (CHC_T00009550001_1) or (CHC_T00008635001_1) or (CHC_T00009516001_1) or (CHC_T00010289001_1) or (CHC_T00010094001_1) or (CHC_T00010161001_1) or (CHC_T00009008001_1) or (CHC_T00007624001_1) or (CHC_T00008271001_1) or (CHC_T00008590001_1) or (CHC_T00009515001_1) or (CHC_T00009006001_1) or (CHC_T00009490001_1) or (CHC_T00010108001_1) or (CHC_T00004197001_1) or (CHC_T00010243001_1) or (CHC_T00010133001_1) or (CHC_T00008836001_1) or (CHC_T00009226001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LUTEOLIN__45__7__45__O__45__BETA__45__D__45__DIGLUCURONIDE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_a__45__radical__45__of__45__luteolin__45__7__45__iOi__45__diglucuronid_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOMOCYSMET__45__RXN" name="5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HOMOSER-METSYN-PWY , HSERMETANA-PWY , PWY-702 , PWY-5041 , PWY-6151

GENE_ASSOCIATION: (CHC_T00009326001_1) or (CHC_T00005524001_1) or (CHC_T00009326001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1302_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1301_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETOOHBUTREDUCTOISOM__45__RXN" name="ketol-acid reductoisomerase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ILEUSYN-PWY , PWY-5103

GENE_ASSOCIATION: (CHC_T00008929001) or (CHC_T00008929001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__KETO__45__2__45__METHYLVALERATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10655" name="3-oxoacyl-(acyl-carrier-protein) reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6282

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__cis__45__D7__45__tetradecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__hydroxy__45__cis__45__D7__45__tetraecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__1__46__152__45__RXN" name="2.7.1.152-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6369

GENE_ASSOCIATION: (CHC_T00003487001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MI__45__HEXAKISPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__DIPHOSPHO__45__1D__45__MYO__45__INOSITOL__45__12346P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13617" name="RXN-13617" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7094

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2123_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__196_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14207" name="pyruvate kinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008652001_1) or (CHC_T00008530001_1) or (CHC_T00008482001_1) or (CHC_T00008482001) or (CHC_T00008530001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DGTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DGDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__11__46__24__45__RXN" name="Mitogen-activated protein kinase 5 MPK5" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008430001) or (CHC_T00009267001_1) or (CHC_T00009504001) or (CHC_T00008310001) or (CHC_T00009267001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__Ser__45__or__45__L__45__Thr__45__L__45__Pro_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__Ser__45__or__45__L__45__Thr__45__P__45__L__45__Pro_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9615" name="RXN-9615" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000615001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMMONIUM_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__21__46__53__45__RXN" name="probable ATP-dependent protease Lon" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003469001_1) or (CHC_T00009404001_1) or (CHC_T00009404001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MANNPGUANYLTRANGDP__45__RXN" name="MANNPGUANYLTRANGDP-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009182001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MANNOSE__45__1P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13158" name="RXN-13158" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009293001_1) or (CHC_T00009162001_1) or (CHC_T00008852001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2K__45__4CH3__45__PENTANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UDPREDUCT__45__RXN" name="ribonucleoside-diphosphate reductase alpha chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7184 , PWY0-166 , PWY-6545

GENE_ASSOCIATION: (CHC_T00008926001_1) or (CHC_T00008864001_1) or (CHC_T00008864001) or (CHC_T00008926001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DUDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9514" name="acetoacetyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994 , PWY-5971 , PWY-7388

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Acetoacetyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Beta__45__3__45__hydroxybutyryl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13398" name="RXN-13398" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000246001_1) or (CHC_T00006958001_1) or (CHC_T00004024001_1) or (CHC_T00003882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__7014_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__508" name="3-oxo-lignoceroyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__oxo__45__lignoceroyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_R__45__3__45__hydroxylignoceroyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_S__45__ADENMETSYN__45__RXN" name="S-adenosylmethionine synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5041 , METHIONINE-DEG1-PWY , ETHYL-PWY , PWY-5912 , SAM-PWY

GENE_ASSOCIATION: (CHC_T00008826001) or (CHC_T00008826001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__469" name="3-oxobehenoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__behenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_R__45__3__45__hydroxybehenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12293" name="RXN-12293" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6786

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8847_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MEK_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8675" name="RXN-8675" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5194 , PWY-7377 , PWY-7376 , PWY-5196

GENE_ASSOCIATION: (CHC_T00000927001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9038_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROSIROHYDROCHLORIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_O__45__SUCCHOMOSERLYASE__45__RXN" name="O-SUCCHOMOSERLYASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HOMOSER-METSYN-PWY , PWY-I9

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_O__45__SUCCINYL__45__L__45__HOMOSERINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__CYSTATHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACYLCOASYN__45__RXN" name="2,3,4-saturated fatty acyl-CoA synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5136 , FAO-PWY , PWY66-391 , PWY-7288

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD66__45__39_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__114__45__RXN" name="3.2.1.114-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7426

GENE_ASSOCIATION: (CHC_T00008655001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Mannosyl5__45__N__45__acetyl__45__glucosamine2__45__R_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13559_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_2__45__N__45__linked__45__Glycan_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NADH__45__DEHYDROGENASE__45__RXN" name="NADH-DEHYDROGENASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008785001_1) or (CHC_T00004265001_1) or (CHC_T00007379001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ISOCITDEH__45__RXN" name="ISOCITDEH-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6549 , P23-PWY , REDCITCYC , PWY-5913 , P105-PWY , PWY-7124 , PWY-6969 , TCA , PWY-7268 , PWY-6728 , PWY-7254 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00009580001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THREO__45__DS__45__ISO__45__CITRATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__18303" name="Glycolipid sulfotransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7840

GENE_ASSOCIATION: (CHC_T00008551001) or (CHC_T00009336001) or (CHC_T00008762001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PAPS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Digalactosylceramides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Digalactosylceramide__45__sulfate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__5__45__ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13162" name="RXN-13162" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5670

GENE_ASSOCIATION: (CHC_T00001581001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SQUALENE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GMP__45__SYN__45__NH3__45__RXN" name="GMP synthase (glutamine-hydrolysing)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009427001) or (CHC_T00009427001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_XANTHOSINE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_GMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__HYDROXYISOBUTYRYL__45__COA__45__HYDROLASE__45__RXN" name="3-hydroxyisobutyryl-CoA hydrolase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: VALDEG-PWY

GENE_ASSOCIATION: (CHC_T00008307001_1) or (CHC_T00008307001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12173_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12175_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15005" name="acetylglutamate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7400

GENE_ASSOCIATION: (CHC_395)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LysW__45__L__45__glutamate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_LysW__45__L__45__glutamate__45__5__45__phosphate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_WATER" name="TransportSeed_WATER" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__CINNAMATE__45__4__45__MONOOXYGENASE__45__RXN" name="TRANS-CINNAMATE-4-MONOOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1121 , PWY1F-467

GENE_ASSOCIATION: (CHC_T00009499001_1) or (CHC_T00008616001_1) or (CHC_T00009131001_1) or (CHC_T00010004001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00008672001_1) or (CHC_T00009062001_1) or (CHC_T00008663001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__674_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_COUMARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14125" name="RXN-14125" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009376001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4__45__PHOSPHONOOXY__45__THREONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2189_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9520" name="RXN-9520" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5994 , PWY-5971

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_R__45__3__45__hydroxyhexanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Hex__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__45__COUMARATE__45____45__COA__45__LIGASE__45__RXN" name="4-COUMARATE--COA-LIGASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7046 , PWY-6435 , PWY-7397 , PWY-361 , PWY-5754 , PWY-6320 , PWY-6982 , PWY-5135 , PWY-7398 , PWY1F-FLAVSYN , PWY-6920

GENE_ASSOCIATION: (CHC_T00008160001_1) or (CHC_T00008472001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_COUMARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__COUMAROYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__24__46__59__45__RXN" name="3.4.24.59-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003664001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_mitochondrial__45__intermediate__45__protein_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_mature__45__protein_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Octapeptides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9662" name="trans tetradec-2-enoyl-[acp] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Tetradec__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SULFOCYS__45__RXN" name="Cysteine synthase CYS1" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008705001_1) or (CHC_T00008547001_1) or (CHC_T00008842001_1) or (CHC_T00008705001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYLSERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S2O3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SULFO__45__CYSTEINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LONG__45__CHAIN__45__ALCOHOL__45__DEHYDROGENASE__45__RXN__45__CPD__45__348__47__NAD__47__WATER__47____47__PALMITATE__47__NADH__47__PROTON__46__41__46__" name="LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN-CPD-348/NAD/WATER//PALMITATE/NADH/PROTON.41." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__348_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PALMITATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRYPSYN__45__RXN" name="tryptophan synthase alpha chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008401001_1) or (CHC_T00009102001_1) or (CHC_T00008705001_1) or (CHC_T00007475001_1) or (CHC_T00008842001_1) or (CHC_T00008746001_1) or (CHC_T00008401001) or (CHC_1120)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_INDOLE__45__3__45__GLYCEROL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TRP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BTUR2__45__RXN" name="BTUR2-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6269 , COBALSYN-PWY

GENE_ASSOCIATION: (CHC_T00002690001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_COBINAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_P3I_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYLCOBINAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13323" name="RXN-13323" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__1028_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12321_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__304" name="14-hydroxylanosterol 14-dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4568_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4573_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12484" name="RXN-12484" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009372001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETOH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETALD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__3__46__1__46__168__45__RXN" name="2.3.1.168-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5046

GENE_ASSOCIATION: (CHC_T00006349001_1) or (CHC_T00008584001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ISOBUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__2MP__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THIAMIN__45__PYROPHOSPHOKINASE__45__RXN" name="THIAMIN-PYROPHOSPHOKINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6908 , PWY-6907 , PWY-6898 , PWY-7356

GENE_ASSOCIATION: (CHC_T00001114001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIAMINE__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__3__46__16__45__RXN" name="3.1.3.16-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006530001_1) or (CHC_T00007644001_1) or (CHC_T00004176001_1) or (CHC_T00004298001_1) or (CHC_T00008956001_1) or (CHC_T00006477001_1) or (CHC_T00000279001_1) or (CHC_T00008536001_1) or (CHC_T00007021001_1) or (CHC_T00002485001_1) or (CHC_T00008508001_1) or (CHC_T00006835001_1) or (CHC_T00008630001_1) or (CHC_T00004777001_1) or (CHC_T00009030001_1) or (CHC_T00009328001_1) or (CHC_T00004449001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__Ser__45__or__45__Thr__45__phosphate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__L__45__serine__45__or__45__L__45__threonine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9654" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PEPCARBOX__45__RXN" name="PEPCARBOX-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P23-PWY , PWY-6549 , PWY-1622 , PWY-5913 , PWY-7117 , PWY-7124 , PWY-7115 , PWY-6142 , PWY-241 , PWYQT-4429 , PWY-6146 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00008437001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HCO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXALACETIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7580" name="ent-kaurenal 19-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5034 , PWY-5047

GENE_ASSOCIATION: (CHC_T00009499001_1) or (CHC_T00008616001_1) or (CHC_T00009131001_1) or (CHC_T00010004001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00008672001_1) or (CHC_T00009062001_1) or (CHC_T00008663001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ENT__45__KAUR__45__16__45__EN__45__19__45__AL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1F__45__132_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_1__46__14__46__13__46__72__45__RXN_CYCLOARTENOL" name="extended_1.14.13.72-RXN_CYCLOARTENOL" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: early_SSR , late_SSR

GENE_ASSOCIATION: (scaffold212) or (CHC_T00010320001_1)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYCLOARTENOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_29__45__NORCYCLOARTENOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9524" name="3-oxo-octanoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994 , PWY-5971

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__Oxo__45__octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Hydroxy__45__octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6642" name="RXN-6642" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4061 , PWY-6842

GENE_ASSOCIATION: (CHC_T00002549001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__6262_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__Substituted__45__L__45__Cysteines_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_Light" name="ExchangeSeed_Light" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Light_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Light_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13403" name="RXN-13403" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000927001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UROPORPHYRINOGEN__45__III_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIHYDROSIROHYDROCHLORIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CHONDROITIN__45__GLUCURONATE__45__5__45__EPIMERASE__45__RXN" name="CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6568

GENE_ASSOCIATION: (CHC_T00005569001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Chondroitin__45__D__45__glucuronates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DERMATAN__45__L__45__IDURONATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MALONYL__45__COA__45__ACP__45__TRANSACYL__45__RXN" name="MALONYL-COA-ACP-TRANSACYL-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6799 , PWY-7388 , PWY-4381

GENE_ASSOCIATION: (CHC_T00008765001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SAICARSYN__45__RXN" name="SAICARSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6124 , PWY-6123 , PWY-7234

GENE_ASSOCIATION: (CHC_T00009497001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SULFATE__45__ADENYLYLTRANS__45__RXN" name="SULFATE-ADENYLYLTRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6683 , DISSULFRED-PWY , P224-PWY , SULFMETII-PWY , PWY-5278 , PWY-5340

GENE_ASSOCIATION: (CHC_T00008927001_1) or (CHC_T00008316001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SULFATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_APS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9003" name="RXN-9003" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7235 , PWY3O-19

GENE_ASSOCIATION: (CHC_T00004833001_1) or (CHC_T00003042001_1) or (CHC_T00007345001_1) or (CHC_T00005639001_1) or (CHC_T00002263001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__hydroxybenzoate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__HEXAPRENYL__45__4__45__HYDROXYBENZOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYCOPHOSPHORYL__45__RXN" name="Starch phosphorylase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5941 , GLYCOCAT-PWY

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycogens_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__971_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15816" name="Ubiquinol-cytochrome c reductase iron-sulfur subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008759001_1) or (CHC_T00009218001_1) or (CHC_T00007973001_1) or (CHC_T00008759001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cytochromes__45__C__45__Oxidized_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_ETR__45__Quinols_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Cytochromes__45__C__45__Reduced_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_ETR__45__Quinones_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="nucleoside-diphosphate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Nucleoside__45__Diphosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Nucleoside__45__Triphosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN4FS__45__2" name="RXN4FS-2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY4FS-3 , PWY-6825 , PWY4FS-4

GENE_ASSOCIATION: (CHC_T00007321001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__160_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHATIDYLCHOLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SAMDECARB__45__RXN" name="SAMDECARB-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: BSUBPOLYAMSYN-PWY , PWY-6834 , ARGSPECAT-PWY

GENE_ASSOCIATION: (CHC_T00002455001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__3__46__56__45__RXN" name="probable inosine triphosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6363

GENE_ASSOCIATION: (CHC_T00009365001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INOSITOL__45__1__45__4__45__BISPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__45__KETO__45__ADIPATE__45__DEHYDROG__45__RXN" name="2-KETO-ADIPATE-DEHYDROG-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-425 , LYSINE-DEG1-PWY , PWY-5652

GENE_ASSOCIATION: (CHC_T00010023001_1) or (CHC_T00008441001_1) or (CHC_T00010287001_1) or (CHC_T00008312001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2K__45__ADIPATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUTARYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14181" name="Pyridoxal phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7204

GENE_ASSOCIATION: (CHC_T00008718001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXINE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PYRIDOXINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXNQT__45__4142" name="RXNQT-4142" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-882

GENE_ASSOCIATION: (CHC_T00008808001_1) or (CHC_T00008454001_1) or (CHC_T00008597001_1) or (CHC_T00001291001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPDQT__45__4_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__Galactopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__147" name="RXN1F-147" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5946

GENE_ASSOCIATION: (CHC_T00009303001_1) or (CHC_T00009401001_1) or (CHC_T00003979001_1) or (CHC_T00009131001_1) or (CHC_T00008663001_1) or (CHC_T00009499001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008616001_1) or (CHC_T00002318001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1F__45__114_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1F__45__115_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__312" name="4&alpha;-formyl-4&beta;-methyl-5&alpha;-cholesta-8,24-dien-3&beta;-ol 4-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074 , PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4576_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4577_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_MG__43__2" name="TransportSeed_MG+2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MG__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MG__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__21" name="TRANS-RXN1HP7-21" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009029001_1) or (CHC_T00000031001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Bile__45__acids_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Bile__45__acids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THIOSULFATE__45__SULFURTRANSFERASE__45__RXN" name="THIOSULFATE-SULFURTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5350

GENE_ASSOCIATION: (CHC_T00008822001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S2O3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HCN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HSCN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__715" name="RXN-715" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-699

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__713_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__714_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__160" name="ent-7&alpha;-hydroxykaur-16-en-19-oate monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5034 , PWY-5047

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__136_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__138_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13600" name="RXN-13600" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7089

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1103_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HCN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__HYDROXYBENZALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBOKIN__45__RXN" name="RIBOKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: RIBOKIN-PWY

GENE_ASSOCIATION: (CHC_T00004774001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10330_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15318_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__114__45__RXN" name="hexaprenyldihydroxybenzoate methyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7235 , PWY3O-19 , PWY-7233

GENE_ASSOCIATION: (CHC_T00007491001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__HEXAPRENYL__45__45__45__DIHYDROXYBENZOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__HEXAPRENYL__45__4__45__HYDROXY__45__5__45__METHOXYBENZOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10707" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00008400001_1) or (CHC_T00007910001_1) or (CHC_T00008478001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00009142001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11525_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11526_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__11__46__1__46__15__45__RXN" name="peroxiredoxin, PRX3" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002035001_1) or (CHC_T00003196001_1) or (CHC_T00009369001) or (CHC_T00010097001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROT__45__CYS_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Alkyl__45__Hydro__45__Peroxides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__Disulfides_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alcohols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12200" name="RXN-12200" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7177 , PWY-7185

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12720" name="RXN-12720" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6932

GENE_ASSOCIATION: (CHC_T00008927001_1) or (CHC_T00008316001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SELENATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13713_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_1__46__14__46__13__46__72__45__RXN_4alpha_METHYLZYMOSTEROL" name="extended_1.14.13.72-RXN_4alpha_METHYLZYMOSTEROL" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: late_SSR , early_SSR

GENE_ASSOCIATION: (scaffold212) or (CHC_T00010320001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4alpha_METHYLZYMOSTEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ZYMOSTEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__13__46__11__46__6__45__RXN" name="1.13.11.6-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6309 , PWY-6505 , PWY-5647 , PWY-5651

GENE_ASSOCIATION: (CHC_T00004932001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__HYDROXY__45__ANTHRANILATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__AMINO__45__3__45__3__45__OXOPROP__45__2__45__ENYL__45__BUT__45__2__45__ENEDI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__4__46__3__46__19__45__RXN" name="1.4.3.19-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7396

GENE_ASSOCIATION: (CHC_T00001330001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYOX_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8635" name="RXN-8635" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5461

GENE_ASSOCIATION: (CHC_T00002409001_1) or (CHC_T00009160001_1) or (CHC_T00008578001_1) or (CHC_T00000152001_1) or (CHC_T00010263001_1) or (CHC_T00002083001_1) or (CHC_T00010024001_1) or (CHC_T00008640001_1) or (CHC_T00010209001_1) or (CHC_T00010179001_1) or (CHC_T00009550001_1) or (CHC_T00008635001_1) or (CHC_T00009516001_1) or (CHC_T00010289001_1) or (CHC_T00010094001_1) or (CHC_T00010161001_1) or (CHC_T00009008001_1) or (CHC_T00007624001_1) or (CHC_T00008271001_1) or (CHC_T00008590001_1) or (CHC_T00009515001_1) or (CHC_T00009006001_1) or (CHC_T00009490001_1) or (CHC_T00010108001_1) or (CHC_T00004197001_1) or (CHC_T00010243001_1) or (CHC_T00010133001_1) or (CHC_T00008836001_1) or (CHC_T00009226001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8653_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__8890_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_POLYPHOSPHATE__45__KINASE__45__RXN" name="Polyphosphate kinase (fragment)" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008740001) or (CHC_T00008740001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Long__45__Chain__45__Polyphosphate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Long__45__Chain__45__Polyphosphate_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_CYCLOEUCALENOL__45__CYCLOISOMERASE__45__RXN" name="extended_CYCLOEUCALENOL-CYCLOISOMERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: late_SSR , early_SSR

GENE_ASSOCIATION: (CHC_T00002985001_1)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_29__45__NORCYCLOARTENOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_29__45__NORLANOSTEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DTMPKI__45__RXN" name="DTMPKI-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7210 , PWY-7184 , PWY0-166 , PWY-7187 , PWY-7198 , PWY-7197 , PWY-6545

GENE_ASSOCIATION: (CHC_T00002059001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FORMYLTHFGLUSYNTH__45__RXN" name="FORMYLTHFGLUSYNTH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2161

GENE_ASSOCIATION: (CHC_T00000400001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FORMYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10642" name="RXN-10642" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008531001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_CPD__45__11444_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_COPROPORPHYRINOGEN_I_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="4" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__10__46__1__45__RXN" name="Tyrosine-protein kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009163001_1) or (CHC_T00008395001_1) or (CHC_T00004170001_1) or (CHC_T00009392001_1) or (CHC_T00008396001_1) or (CHC_T00008654001_1) or (CHC_T00009394001_1) or (CHC_T00008906001_1) or (CHC_T00008683001_1) or (CHC_T00009202001_1) or (CHC_T00009054001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__Tyrosines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__tyrosine__45__phosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="acetyl-CoA carboxylase biotin carboxyl carrier protein" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5743 , PWY-5744 , PWY-6679 , PWY-5789 , PWY-4381 , PWY-6722 , PWY-7388

GENE_ASSOCIATION: (CHC_T00009359001_1) or (CHC_T00007145001_1) or (CHC_T00008359001_1) or (CHC_T00009426001_1) or (CHC_640) or (CHC_T00008359001) or (CHC_T00009359001) or (CHC_55)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HCO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10953" name="RXN-10953" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002260001_1) or (CHC_T00001291001_1) or (CHC_T00007726001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__6701_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10658" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6282

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cis__45__Delta7__45__tetradecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__cis__45__D9__45__hexadecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9363" name="RXN-9363" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5892

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12121_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12129_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__368" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Stearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__arachidoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13008" name="3-oxoacyl-[acyl-carrier-protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__OXO__45__EICOSAPENTAENOYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__HYDROXY__45__DOCOSAPENTAENOYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9205" name="RXN-9205" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5844

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12118_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12126_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14268" name="lauroyl-CoA acetyl-CoA acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7654

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10284_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LAUROYLCOA__45__CPD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9655" name="RXN-9655" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5994 , PWY0-862 , PWY-5971

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Beta__45__hydroxydecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Trans__45__D2__45__decenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__7__46__14__45__RXN" name="Ethanolamine-phosphate cytidylyltransferase, putative" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY4FS-6 , PWY-7782

GENE_ASSOCIATION: (CHC_T00008907001) or (CHC_T00008907001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHOSPHORYL__45__ETHANOLAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CDP__45__ETHANOLAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16626" name="beta-ketoacyl reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7664

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_9Z__45__3__45__oxo__45__octadec__45__9__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3R__45__9Z__45__3__45__hydroxy__45__octadec__45__9__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6480" name="RXN0-6480" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1479

GENE_ASSOCIATION: (CHC_T00004542001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2354_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNA__45__fragment_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1061" name="RXN0-1061" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010148001_1) or (CHC_T00009161001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Unfolded__45__Proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17783" name="Putative Acyl-COA dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009166001) or (CHC_T00009166001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15436_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__1162_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11368" name="RXN-11368" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002263001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4__45__hydroxybenzoate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Polyisoprenyl__45__Diphosphates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__Hydroxy__45__3__45__polyprenylbenzoates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10973" name="RXN-10973" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6369

GENE_ASSOCIATION: (CHC_T00003487001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11937_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11939_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14281" name="alpha-glucosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000021001_1) or (CHC_T00009379001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOPENTAOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOTETRAOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__3443" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2221

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_G3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THREODEHYD__45__RXN" name="THREODEHYD-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7378 , THRDLCTCAT-PWY , THREONINE-DEG2-PWY

GENE_ASSOCIATION: (CHC_T00007340001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THR_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMINO__45__OXOBUT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16620" name="RXN-16620" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7664

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2E__45__5Z__45__tetradeca__45__2__45__5__45__dienoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5Z__45__tetradec__45__5__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7719" name="lipoamide dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5046

GENE_ASSOCIATION: (CHC_T00008441001_1) or (CHC_T00006349001_1) or (CHC_T00008584001_1) or (CHC_T00010287001_1) or (CHC_T00008441001) or (CHC_T00010287001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__lipoyl_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12278" name="RXN-12278" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6724

GENE_ASSOCIATION: (CHC_T00008493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13198_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7043_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SEDOBISALDOL__45__RXN" name="SEDOBISALDOL-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1517 , CALVIN-PWY

GENE_ASSOCIATION: (CHC_T00008586001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIHYDROXY__45__ACETONE__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ERYTHROSE__45__4P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__SEDOHEPTULOSE__45__1__45__7__45__P2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15564" name="RXN-15564" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7511

GENE_ASSOCIATION: (CHC_T00006794001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__terminal__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ubi__45__N__45__term__45__specific__45__UCP__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__terminal__45__ubiquitinyl__45__proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__terminal__45__specific__45__UCP__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__385" name="RXN0-385" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DGTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DGMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__461" name="RXN1F-461" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7168 , PWY-7143 , PWY-5348 , PWY-5320

GENE_ASSOCIATION: (CHC_T00001656001_1) or (CHC_T00000989001_1) or (CHC_T00003244001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1F__45__90_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1F__45__453_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10862" name="RXN-10862" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13883" name="RXN-13883" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7154

GENE_ASSOCIATION: (CHC_T00006481001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14893_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14894_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13188" name="RXN-13188" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_44__45__DIMETHYL__45__5ALPHA__45__CHOLEST__45__7__45__EN__45__3BET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__5846_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHEAMINOTRANS__45__RXN" name="PHEAMINOTRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ANAPHENOXI-PWY , PWY-7432 , PWY-5079 , PHESYN

GENE_ASSOCIATION: (CHC_T00009141001_1) or (CHC_T00009477001_1) or (CHC_T00008863001_1) or (CHC_T00005085001_1) or (CHC_T00003344001_1) or (CHC_T00006498001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHENYL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BUTANAL__45__DEHYDROGENASE__45__RXN__45__BUTANAL__47__CO__45__A__47__NADP__47____47__BUTYRYL__45__COA__47__NADPH__47__PROTON__46__44__46__" name="BUTANAL-DEHYDROGENASE-RXN-BUTANAL/CO-A/NADP//BUTYRYL-COA/NADPH/PROTON.44." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BUTANAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DAPASYN__45__RXN" name="DAPASYN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1507

GENE_ASSOCIATION: (CHC_T00002287001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_8__45__AMINO__45__7__45__OXONONANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIAMINONONANOATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Methylacrylyl-CoA hydratase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: VALDEG-PWY

GENE_ASSOCIATION: (CHC_T00009190001_1) or (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1) or (CHC_T00008882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12173_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_METHACRYLYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12747" name="5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA 5-dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6944

GENE_ASSOCIATION: (CHC_T00003646001_1) or (CHC_T00007359001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13754_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13755_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ASPARTATEKIN__45__RXN" name="ASPARTATEKIN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2942 , PWY-7153 , P101-PWY , PWY-5097 , HOMOSERSYN-PWY , PWY-6559 , PWY-6562 , PWY-2941 , DAPLYSINESYN-PWY

GENE_ASSOCIATION: (CHC_T00002228001_1) or (CHC_T00008550001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__BETA__45__ASPARTYL__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_Palythene_hydrolysis" name="Palythene_hydrolysis" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALYTHENE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PALYTHINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11917" name="7-methyl-3-oxo-6-octenoyl-CoA:acetyl-CoA C-acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6672

GENE_ASSOCIATION: (CHC_T00009349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12897_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12902_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15684" name="FAD-dependent 3-benzyl-3,6 -dithio-6-(hydroxymethyl)-diketopiperazine dithiol oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7533

GENE_ASSOCIATION: (CHC_T00004505001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17049_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17050_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4225" name="RXN-4225" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2582

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__707_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__3943_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7810" name="RXN-7810" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5132

GENE_ASSOCIATION: (CHC_T00008265001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4211_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7109_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7105_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UGD__45__RXN" name="UDP-glucose dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7820 , PWY-7346

GENE_ASSOCIATION: (CHC_T00008869001_1) or (CHC_T00008869001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_UDP__45__GLUCURONATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2TRANSKETO__45__RXN" name="2TRANSKETO-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NONOXIPENT-PWY , PWY-1861 , PWY-6901 , PWY-5723 , P21-PWY , CALVIN-PWY , P185-PWY

GENE_ASSOCIATION: (CHC_T00005040001_1) or (CHC_T00009390001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_XYLULOSE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ERYTHROSE__45__4P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10974" name="RXN-10974" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6369

GENE_ASSOCIATION: (CHC_T00003487001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11700_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11938_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11521" name="RXN-11521" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6632

GENE_ASSOCIATION: (CHC_T00006932001_1) or (CHC_T00000194001_1) or (CHC_T00006216001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_7__45__METHYLXANTHINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12481_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5419" name="RXN0-5419" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002256001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Nonmethylated__45__Ribosomal__45__Protein__45__L11s_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Methylated__45__Ribosomal__45__Protein__45__L11s_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14199" name="RXN-14199" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DUTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_DUMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16030" name="RXN-16030" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009530001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17273_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17271_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11921" name="3-methylcrotonyl-CoA:acetyl-CoA C-acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6672

GENE_ASSOCIATION: (CHC_T00009349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12906_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__METHYL__45__CROTONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_FE__43__3" name="TransportSeed_FE+3" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FE__43__3_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FE__43__3_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15006" name="N-acetyl-gamma-glutamyl-phosphate reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7400

GENE_ASSOCIATION: (CHC_T00009278001_1) or (CHC_T00009278001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LysW__45__L__45__glutamate__45__5__45__phosphate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LysW__45__L__45__glutamate__45__5__45__semialdehyde_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__96__45__RXN" name="3.2.1.96-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009347001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_a__45__glycopeptide__45__D__45__mannosyl__45__Nsup4sup__45__N__45__ace_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14375_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__acetyl__45__D__45__glucosamine__45__asparagine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10715" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6307

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INDOLE_ACETALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_INDOLE_ACETATE_AUXIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1828" name="Disproportionating Enzyme type 2" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009120001_1) or (CHC_T00009120001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Long__45__linear__45__glucans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALPHA__45__GLUCOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Short__45__glucans_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__21__46__105__45__RXN" name="3.4.21.105-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004116001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Type__45__1__45__transmemberane__45__domains_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Cleaved__45__type__45__1__45__transmembrane__45__domains_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_CPD__45__3" name="ExchangeSeed_CPD-3" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__3_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__3_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CARBOXYPEPTIDASE__45__A__45__RXN" name="CARBOXYPEPTIDASE-A-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006197001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_KETOISOCAPROATE__45__RXN" name="4-methyl-2-oxopentanoate dehydrogenase (lipoamide)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006349001_1) or (CHC_T00008584001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__lipoyl_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2K__45__4CH3__45__PENTANOATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCAA__45__dehydrogenase__45__3MB__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9362" name="RXN-9362" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5891

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12120_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12128_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__1__46__23__45__RXN" name="3.1.1.23-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: LIPAS-PWY

GENE_ASSOCIATION: (CHC_T00001533001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__504_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Fatty__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8344" name="RXN-8344" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6823

GENE_ASSOCIATION: (CHC_T00005714001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8122_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBITOL__45__2__45__DEHYDROGENASE__45__RXN" name="RIBITOL-2-DEHYDROGENASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: RIBITOLUTIL-PWY

GENE_ASSOCIATION: (CHC_T00009325001_1) or (CHC_T00010090001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RIBITOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__RIBULOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MALTODEG__45__RXN" name="Disproportionating Enzyme type 2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009120001_1) or (CHC_T00009120001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALTOHEXAOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__1133_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16045" name="RXN-16045" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5995

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Linoleoyl__45__groups_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7740" name="RXN-7740" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7061_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7063_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15563" name="RXN-15563" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7511

GENE_ASSOCIATION: (CHC_T00006794001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__terminal__45__specific__45__UCP__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ubiquitinyl__45__UAP__45__E1__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ubiquitin__45__activating__45__protein__45__E1__45__L__45__cys_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ubi__45__N__45__term__45__specific__45__UCP__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13303" name="RXN-13303" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7036

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14276_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14281_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17874" name="methionyl aminopeptidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7800 , PWY-7799

GENE_ASSOCIATION: (CHC_T00008747001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__methionyl__45__L__45__cysteinyl__45__Protein_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__terminal__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__11__46__1__46__12__45__RXN" name="1.11.1.12-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4081

GENE_ASSOCIATION: (CHC_T00003751001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_A__45__LIPID__45__HYDROPEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXIDIZED__45__GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Lipid__45__hydroxy__45__fatty__45__acids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7645" name="RXN-7645" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5059

GENE_ASSOCIATION: (CHC_T00009104001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CINNAMOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__6993_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13307" name="RXN-13307" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7036

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14281_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__10279_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11837" name="RXN-11837" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006820001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_23S__45__rRNA__45__uridine1911__45__1915__45__1917_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_23S__45__rRNA__45__pseudouridine1911__45__1915__45__1917_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2OXOGLUTDECARB__45__RXN" name="dihydrolipoamide dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-398 , PWY-5084

GENE_ASSOCIATION: (CHC_T00008441001_1) or (CHC_T00010287001_1) or (CHC_T00008312001_1) or (CHC_T00008312001) or (CHC_T00008441001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxo__45__glutarate__45__dehydrogenase__45__lipoyl_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxo__45__glutarate__45__dehydro__45__suc__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1224" name="RXN-1224" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYQT-4427

GENE_ASSOCIATION: (CHC_T00003861001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP__45__SULFOQUINOVOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SULFOQUINOVOSYLDIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5184" name="Starch phosphorylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__72" name="RXN1F-72" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MONO__45__VINYL__45__PROTOCHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15509" name="RXN-15509" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001241001_1) or (CHC_T00007707001_1) or (CHC_T00000449001_1) or (CHC_T00001519001_1) or (CHC_T00004201001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_23__45__DIPHOSPHOGLYCERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__Histidines_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__16758_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__pi__45__phospho__45__L__45__histidines_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__26__46__4__45__RXN" name="3.1.26.4-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003815001_1) or (CHC_T00007240001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RNA__45__DNA__45__hybrids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Nucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DNA__45__Holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__67__45__RXN" name="2.4.1.67-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5337

GENE_ASSOCIATION: (CHC_T00008780001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__458_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1099_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__170_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PEPSYNTH__45__RXN" name="PEPSYNTH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P23-PWY , GLUCONEO-PWY , GLYCOLYSIS , PWY-5484

GENE_ASSOCIATION: (CHC_T00008992001_1) or (CHC_T00008789001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHO__45__ENOL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NADPH__45__DEHYDROGENASE__45__FLAVIN__45__RXN" name="NADPH-DEHYDROGENASE-FLAVIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005331001_1) or (CHC_T00007936001_1) or (CHC_T00008525001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RIBOFLAVIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__316_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6524" name="RXN0-6524" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003097001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RNASE__45__II__45__POLY__45__A__45__SUBSTRATE__45__MRNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_RNASE__45__II__45__SUBSTRATE__45__WITH__45__NO__45__POLY__45__A__45__TAIL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GALACTOKIN__45__RXN" name="GALACTOKIN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-422 , PWY-6527 , PWY-6317 , PWY-3821

GENE_ASSOCIATION: (CHC_T00006828001_1) or (CHC_T00007304001_1) or (CHC_T00006831001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALPHA__45__D__45__GALACTOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GALACTOSE__45__1P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDROXYMETVALDEHYDRAT__45__RXN" name="2,3-Dihydroxy-3-methylvalerate dehydratase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5104 , PWY-5101 , ILEUSYN-PWY , PWY-5103

GENE_ASSOCIATION: (CHC_T00009385001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__KETO__45__2__45__METHYLVALERATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__KETO__45__3__45__METHYL__45__VALERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AMP__45__DEAMINASE__45__RXN" name="AMP deaminase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6596

GENE_ASSOCIATION: (CHC_T00008583001_1) or (CHC_T00001501001_1) or (CHC_T00008583001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_IMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_F16ALDOLASE__45__RXN" name="fructose-1,6-biphosphate aldolase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5484 , PWY-7385 , PWY66-399 , PWY-1042 , PWY-1861 , GLYCOLYSIS , PWY-6142 , ANAGLYCOLYSIS-PWY , CALVIN-PWY , GLUCONEO-PWY , P185-PWY , SUCSYN-PWY , P341-PWY

GENE_ASSOCIATION: (CHC_T00008586001_1) or (CHC_T00008586001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FRUCTOSE__45__16__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIHYDROXY__45__ACETONE__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBOFLAVINSYNDEAM__45__RXN" name="RIBOFLAVINSYNDEAM-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: RIBOSYN2-PWY

GENE_ASSOCIATION: (CHC_T00006214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__602_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12457" name="RXN-12457" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007932001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Uracil47__45__in__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_56__45__Dihydrouracil47__45__in__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17352" name="RXN-17352" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5469 , PWY-6824 , PWY-5466

GENE_ASSOCIATION: (CHC_T00002409001_1) or (CHC_T00009160001_1) or (CHC_T00008578001_1) or (CHC_T00000152001_1) or (CHC_T00010263001_1) or (CHC_T00002083001_1) or (CHC_T00010024001_1) or (CHC_T00008640001_1) or (CHC_T00010209001_1) or (CHC_T00010179001_1) or (CHC_T00009550001_1) or (CHC_T00008635001_1) or (CHC_T00009516001_1) or (CHC_T00010289001_1) or (CHC_T00010094001_1) or (CHC_T00010161001_1) or (CHC_T00009008001_1) or (CHC_T00007624001_1) or (CHC_T00008271001_1) or (CHC_T00008590001_1) or (CHC_T00009515001_1) or (CHC_T00009006001_1) or (CHC_T00009490001_1) or (CHC_T00010108001_1) or (CHC_T00004197001_1) or (CHC_T00010243001_1) or (CHC_T00010133001_1) or (CHC_T00008836001_1) or (CHC_T00009226001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CONIFERYL__45__ALCOHOL_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18761_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17608" name="RXN-17608" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009018001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19042_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19014_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5962" name="RXN-5962" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5947

GENE_ASSOCIATION: (CHC_T00009499001_1) or (CHC_T00008616001_1) or (CHC_T00009131001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008663001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__5661_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__119_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16025" name="Lysophosphatidic acid acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2113_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17273_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MERCAPYSTRANS__45__RXN" name="3-mercaptopyruvate sulfurtransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5329

GENE_ASSOCIATION: (CHC_T00008822001) or (CHC_T00008822001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__MERCAPTO__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HCN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HSCN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13926" name="RXN-13926" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003646001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3beta__45__hydroxy__45__4alpha__45__carboxy__45__sterols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Oxosteroids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16562" name="RXN-16562" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7656

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_TETRADECANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7875_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14576" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7291

GENE_ASSOCIATION: (CHC_T00008478001_1) or (CHC_T00009142001_1) or (CHC_T00007910001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00008400001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15436_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__1162_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__1435" name="Trehalose 6-phosphate synthase, family GT20 / Trehalose 6-phosphate phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00002090001_1) or (CHC_T00009495001_1) or (CHC_T00010201001_1) or (CHC_T00008273001) or (CHC_T00010201001) or (CHC_T00009495001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD1G__45__768_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1G__45__1344_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17796" name="Putative Acyl-COA dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009166001) or (CHC_T00009166001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19148_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19150_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__22" name="TRANS-RXN1HP7-22" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002196001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FE__43__3_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FE__43__3_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14270" name="5-amino-4-imidazolecarboxamide phosphoribosyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005158001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AICAR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__3762_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__4941" name="RXN-4941" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6369

GENE_ASSOCIATION: (CHC_T00003487001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1107_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIPHOSPHO__45__1D__45__MYO__45__INOSITOL__45__TETRAKISPHOSPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GUANIDINOBUTANAMIDE__45__NH3__45__RXN" name="GUANIDINOBUTANAMIDE-NH3-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ARGDEG-V-PWY

GENE_ASSOCIATION: (CHC_T00009018001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4__45__GUANIDO__45__BUTYRAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__592_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5282" name="Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7159 , CHLOROPHYLL-SYN

GENE_ASSOCIATION: (CHC_670)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MG__45__PROTOPORPHYRIN__45__MONOMETHYL__45__ESTER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__MG__45__PROTOPORPHYRIN__45__METHYLESTER__45__SYN" name="RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7159 , PWY-5531 , CHLOROPHYLL-SYN

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MG__45__PROTOPORPHYRIN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MG__45__PROTOPORPHYRIN__45__MONOMETHYL__45__ESTER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1132" name="pyruvate dehydrogenase E1 alpha subunit, mitochondrial precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PYRUVDEHYD-PWY

GENE_ASSOCIATION: (CHC_T00008441001_1) or (CHC_T00010287001_1) or (CHC_T00008441001) or (CHC_T00008732001) or (CHC_T00010287001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pyruvate__45__dehydrogenase__45__dihydrolipoate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pyruvate__45__dehydrogenase__45__lipoate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6__46__3__46__4__46__10__45__RXN" name="6.3.4.10-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001081001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Apo__45__Propionyl__45__CoA__45__CO2__45__ligases_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Propionyl__45__CoA__45__CO2__45__ligases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7913" name="RXN-7913" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7197

GENE_ASSOCIATION: (CHC_T00004355001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DCMP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DCDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GDPREDUCT__45__RXN" name="ribonucleoside-diphosphate reductase alpha chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7226 , PWY-7222

GENE_ASSOCIATION: (CHC_T00008864001_1) or (CHC_T00008926001_1) or (CHC_T00008864001) or (CHC_T00008926001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DGDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16261" name="RXN-16261" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005154001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__1__45__phosphatidyl__45__inositols_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__MYO__45__INOSITOL__45__1__45__MONOPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7968" name="RXN-7968" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6163

GENE_ASSOCIATION: (CHC_T00007254001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SHIKIMATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__DEHYDRO__45__SHIKIMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__21__46__102__45__RXN" name="3.4.21.102-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002502001_1) or (CHC_T00006797001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__22" name="4&alpha;-formyl-5&alpha;-cholesta-8-en-3&beta;-ol 4-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8618_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8619_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENOSYLHOMOCYSTEINE__45__NUCLEOSIDASE__45__RXN" name="ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6151 , PWY-I9 , PWY-6153 , PWY-6154

GENE_ASSOCIATION: (CHC_T00009343001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__564_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17787" name="RXN-17787" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19160_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10269_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXNQT__45__4366" name="Carboxylesterase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003680001_1) or (CHC_T00000998001_1) or (CHC_T00008784001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__6442_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__110_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_METOH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10841" name="RXN-10841" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6857 , PWY-6861

GENE_ASSOCIATION: (CHC_T00009571001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13524_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_RETINAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__8__46__1__46__4__45__RXN" name="dihydrolipoamide dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010287001_1) or (CHC_T00008441001_1) or (CHC_T00008441001) or (CHC_T00010287001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Dihydro__45__Lipoyl__45__Proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Lipoyl__45__Protein__45__N6__45__lipoyllysine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__109__45__RXN" name="2.4.1.109-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010153001_1) or (CHC_T00009268001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__171_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__serine__45__or__45__L__45__threonine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_O__45__D__45__MANNOSYL__45__PROTEIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5581" name="RXN-5581" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-3162

GENE_ASSOCIATION: (CHC_T00008341001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_INDOLE_ACETALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_INDOLE_ACETATE_AUXIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_CU__43__" name="TransportSeed_CU+" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CU__43___e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CU__43___c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5463" name="RXN-5463" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00007099001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5161_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__5162_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRNA__45__PSEUDOURIDINE__45__SYNTHASE__45__I__45__RXN" name="TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007304001_1) or (CHC_T00005989001_1) or (CHC_T00006828001_1) or (CHC_T00004120001_1) or (CHC_T00001369001_1) or (CHC_T00001139001_1) or (CHC_T00006048001_1) or (CHC_T00006579001_1) or (CHC_T00009542001_1) or (CHC_T00006204001_1) or (CHC_T00006820001_1) or (CHC_T00003130001_1) or (CHC_T00001402001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_tRNA__45__uridine__45__38__45__40_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNA__45__pseudouridine__45__38__45__40_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DNA__45__DIRECTED__45__DNA__45__POLYMERASE__45__RXN" name="DNA polymerase zeta catalytic subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003644001_1) or (CHC_T00005408001_1) or (CHC_T00005704001_1) or (CHC_T00003199001_1) or (CHC_T00002866001_1) or (CHC_T00009248001_1) or (CHC_T00008362001_1) or (CHC_T00007205001_1) or (CHC_T00005598001_1) or (CHC_T00008124001_1) or (CHC_T00007271001_1) or (CHC_T00000882001_1) or (CHC_T00001061001_1) or (CHC_T00009322001_1) or (CHC_T00010052001_1) or (CHC_T00005795001_1) or (CHC_T00003762001_1) or (CHC_T00009322001) or (CHC_T00010052001) or (CHC_T00008362001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DNA__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Deoxy__45__Ribonucleoside__45__Triphosphates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DNA__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__3" name="TRANS-RXN1HP7-3" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003941001_1) or (CHC_T00006248001_1) or (CHC_T00008161001_1) or (CHC_T00005616001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cations_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Cations_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__22" name="RXN-22" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5

GENE_ASSOCIATION: (CHC_T00004007001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CANAVANINOSUCCINATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CANAVANINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSGLYPHOS__45__RXN" name="phosphoglycerate kinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , PWY-5484 , PWY66-399 , PWY-1042 , GLYCOLYSIS , PWY-7003 , P122-PWY , PWY-6901 , PWY-6886 , ANAGLYCOLYSIS-PWY , CALVIN-PWY , GLUCONEO-PWY , P185-PWY , SUCSYN-PWY

GENE_ASSOCIATION: (CHC_T00004105001_1) or (CHC_T00009179001_1) or (CHC_T00009179001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_G3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DPG_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PREPHENATE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="PREPHENATE-DEHYDROGENASE-NADP+-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PREPHENATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_P__45__HYDROXY__45__PHENYLPYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ATPASE__45__RXN" name="ATPASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007176001_1) or (CHC_T00007987001_1) or (CHC_T00010175001_1) or (CHC_T00010194001_1) or (CHC_T00010157001_1) or (CHC_T00000568001_1) or (CHC_T00000803001_1) or (CHC_T00005746001_1) or (CHC_T00008607001_1) or (CHC_T00005852001_1) or (CHC_T00009073001_1) or (CHC_T00007788001_1) or (CHC_T00006855001_1) or (CHC_T00002341001_1) or (CHC_T00009220001_1) or (CHC_T00007944001_1) or (CHC_T00008559001_1) or (CHC_T00006181001_1) or (CHC_T00008404001_1) or (CHC_T00010260001_1) or (CHC_T00005161001_1) or (CHC_T00008719001_1) or (CHC_T00006343001_1) or (CHC_T00006782001_1) or (CHC_T00004941001_1) or (CHC_T00009194001_1) or (CHC_T00008391001_1) or (CHC_T00009486001_1) or (CHC_T00006591001_1) or (CHC_T00004901001_1) or (CHC_T00006824001_1) or (CHC_T00010053001_1) or (CHC_T00001732001_1) or (CHC_T00009461001_1) or (CHC_T00002085001_1) or (CHC_T00006849001_1) or (CHC_T00003623001_1) or (CHC_T00001383001_1) or (CHC_T00000820001_1) or (CHC_T00006037001_1) or (CHC_T00009174001_1) or (CHC_T00003209001_1) or (CHC_T00006146001_1) or (CHC_T00009522001_1) or (CHC_T00007060001_1) or (CHC_T00006675001_1) or (CHC_T00000505001_1) or (CHC_T00004602001_1) or (CHC_T00010124001_1) or (CHC_T00005827001_1) or (CHC_T00004800001_1) or (CHC_T00000800001_1) or (CHC_T00002881001_1) or (CHC_T00002879001_1) or (CHC_T00004889001_1) or (CHC_T00005829001_1) or (CHC_T00000757001_1) or (CHC_T00001929001_1) or (CHC_T00003552001_1) or (CHC_T00004718001_1) or (CHC_T00005019001_1) or (CHC_T00000701001_1) or (CHC_T00006026001_1) or (CHC_T00001951001_1) or (CHC_T00006926001_1) or (CHC_T00000829001_1) or (CHC_T00000225001_1) or (CHC_T00000226001_1) or (CHC_T00000723001_1) or (CHC_T00003061001_1) or (CHC_T00004261001_1) or (CHC_T00004550001_1) or (CHC_T00001019001_1) or (CHC_T00006198001_1) or (CHC_T00000060001_1) or (CHC_T00001236001_1) or (CHC_T00001801001_1) or (CHC_T00005903001_1) or (CHC_T00006631001_1) or (CHC_T00004658001_1) or (CHC_T00006891001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16632" name="RXN-16632" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7663

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2E__45__11Z__45__icosa__45__2__45__11__45__dienoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_11Z__45__icos__45__11__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9657" name="crotonyl-[acp] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Crotonyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Butanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13721" name="3-hydroxyisobutyryl-CoA hydrolase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008307001_1) or (CHC_T00008307001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__HYDROXY__45__ISOBUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__HYDROXY__45__ISOBUTYRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_KYNURENINE__45__3__45__MONOOXYGENASE__45__RXN" name="KYNURENINE-3-MONOOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7765 , PWY-6309 , PWY-7717 , PWY-5651

GENE_ASSOCIATION: (CHC_T00006269001_1) or (CHC_T00004849001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14736_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__HYDROXY__45__L__45__KYNURENINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UTPHEXPURIDYLYLTRANS__45__RXN" name="UDPglucose pyrophosphorylase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6527 , PWY-3821

GENE_ASSOCIATION: (CHC_T00009281001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GALACTOSE__45__1P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14553_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__488" name="trans-docos-2-enoyl-[acyl-carrier protein] reductase (NADPH, B-specific)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_trans__45__delta2__45__behenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Behenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17021" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18379_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TETRADECANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__1425_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIBOFLAVINSYNREDUC__45__RXN" name="RIBOFLAVINSYNREDUC-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: RIBOSYN2-PWY

GENE_ASSOCIATION: (CHC_T00006214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__602_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__1086_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11881" name="4&alpha;,14&alpha;-dimethyl-5&alpha;-cholesta-8,24-dien-3&beta;-ol 14-demethylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__12852_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12853_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12398" name="xyloglucan XXLG oligosaccharide &beta;-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6807

GENE_ASSOCIATION: (CHC_T00008905001_1) or (CHC_T00008606001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13376_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__galactopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13375_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_RXN__45__4243" name="extended_RXN-4243" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CYP) or (FMO)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHOLESTEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_22__45__DEHYDROCHOLESTEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1A0__45__6303" name="RXN1A0-6303" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY1A0-6325

GENE_ASSOCIATION: (CHC_T00004133001_1) or (CHC_T00007631001_1) or (CHC_T00004232001_1) or (CHC_T00004134001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Hepta__45__oxo__45__hexadecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Actinorhodin__45__Intermediate__45__2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14918" name="RXN-14918" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7436

GENE_ASSOCIATION: (CHC_T00000837001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15838_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15836_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PRTRANS__45__RXN" name="PRTRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRPSYN-PWY

GENE_ASSOCIATION: (CHC_T00004022001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ANTHRANILATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16615" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7664

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3Z__45__dodec__45__3__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5Z__45__3__45__oxo__45__tetradec__45__5__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SEDOHEPTULOSE__45__BISPHOSPHATASE__45__RXN" name="sedoheptulose-1,7-bisphosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CALVIN-PWY

GENE_ASSOCIATION: (CHC_T00008369001_1) or (CHC_T00008570001_1) or (CHC_T00008537001_1) or (CHC_T00008369001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__SEDOHEPTULOSE__45__1__45__7__45__P2_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__SEDOHEPTULOSE__45__7__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__383" name="RXN0-383" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2145" name="RXN0-2145" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-862

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Trans__45__D3__45__cis__45__D5__45__dodecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cis__45__Delta5__45__dodecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17116" name="RXN-17116" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7726

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18494_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17365_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSMANMUT__45__RXN" name="phosphomannomutase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7456 , PWY-882 , PWY-5659 , PWY-7586

GENE_ASSOCIATION: (CHC_T00009219001_1) or (CHC_T00003000001_1) or (CHC_T00009219001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MANNOSE__45__1P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15979_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14205" name="RXN-14205" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__1905_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__12365_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12322" name="RXN-12322" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003680001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Phosphatase__45__2A__45__leucine__45__methyl__45__ester_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_METOH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phosphatase__45__2A__45__leucine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10919" name="RXN-10919" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008160001_1) or (CHC_T00008472001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SINAPATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SINAPOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13707" name="24,25-dihydrolanosterol 14-demethylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__8606_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8609_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__2__46__31__45__RXN" name="2.4.2.31-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003572001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__L__45__Arginines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__557_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NIACINAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13935" name="RXN-13935" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7163

GENE_ASSOCIATION: (CHC_T00007625001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__90_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14950_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__157" name="3-oxo-behenoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__behenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_R__45__3__45__hydroxybehenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14003" name="RXN-14003" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_IDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_IMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2KETO__45__4METHYL__45__PENTANOATE__45__DEHYDROG__45__RXN" name="4-methyl-2-oxopentanoate dehydrogenase (acylating)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: LEU-DEG2-PWY

GENE_ASSOCIATION: (CHC_T00010287001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2K__45__4CH3__45__PENTANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ISOVALERYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__OXOACYL__45__ACP__45__REDUCT__45__RXN" name="beta-ketoacyl reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: FASYN-ELONG-PWY

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_B__45__KETOACYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OH__45__ACYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13308" name="RXN-13308" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7036

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14282_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__10280_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CDPREDUCT__45__RXN" name="ribonucleoside-diphosphate reductase alpha chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7210 , PWY-7184 , PWY0-166 , PWY-6545 , PWY-7198

GENE_ASSOCIATION: (CHC_T00008926001_1) or (CHC_T00008864001_1) or (CHC_T00008864001) or (CHC_T00008926001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DCDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12203" name="Alpha-glucan water dikinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6724

GENE_ASSOCIATION: (CHC_T00008789001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Starch_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_6__45__Phosphogluco__45__Amylopectins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_POLYNUCLEOTIDE__45__ADENYLYLTRANSFERASE__45__RXN" name="Poly(A) polymerase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010036001_1) or (CHC_T00003995001_1) or (CHC_T00010036001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_mRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_mRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9651" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__decanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THIAZOLSYN3__45__RXN" name="THIAZOLSYN3-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7356 , PWY-6897 , PWY-7357

GENE_ASSOCIATION: (CHC_T00007093001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THZ_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_THZ__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9944" name="ferredoxin-thioredoxin reductase beta subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_1145)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__276" name="RXN0-276" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__HYDROXYMETHYLGLUTATHIONE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__548_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6383" name="RXN-6383" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5743 , PWY-5744 , PWY-5789 , PWY-7574 , PWY-3941

GENE_ASSOCIATION: (CHC_T00009110001_1) or (CHC_T00008882001_1) or (CHC_T00009349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__HYDROXY__45__PROPIONYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACRYLYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8163" name="RXN-8163" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5283

GENE_ASSOCIATION: (CHC_T00003782001_1) or (CHC_T00003785001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__219_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__KETO__45__6__45__AMINO__45__CAPROATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__8__46__4__46__12__45__RXN" name="1.8.4.12-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005364001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__L__45__methionine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__methionine__45__R__45__S__45__oxides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10815" name="2-oxo-3-phenylpropanoate dioxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6318

GENE_ASSOCIATION: (CHC_T00009321001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHENYL__45__PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11495_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUC1PURIDYLTRANS__45__RXN" name="UDPglucose pyrophosphorylase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7238 , PWY-3801 , PWY-6527 , PWY-7817 , PWY-7343

GENE_ASSOCIATION: (CHC_T00009281001_1) or (CHC_T00002564001_1) or (CHC_T00008779001_1) or (CHC_T00009281001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13322" name="3-ketoacyl-CoA synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6433

GENE_ASSOCIATION: (CHC_T00009104001_1) or (CHC_T00009104001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14300_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__5__46__5__46__1__45__RXN" name="nitrilase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008379001_1) or (CHC_T00008379001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Nitriles_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Carboxylates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DGDPKIN__45__RXN" name="nucleoside-diphosphate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7224 , PWY-7226 , PWY-7222

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DGDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DGTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17873" name="methionyl aminopeptidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7800

GENE_ASSOCIATION: (CHC_T00008747001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__methionyl__45__L__45__alanyl__45__Protein_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__terminal__45__L__45__alanine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12399" name="xyloglucan XLXG oligosaccharide &beta;-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6807

GENE_ASSOCIATION: (CHC_T00008905001_1) or (CHC_T00008606001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13377_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__galactopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13375_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LEUKOTRIENE__45__A4__45__HYDROLASE__45__RXN" name="LEUKOTRIENE-A4-HYDROLASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-375

GENE_ASSOCIATION: (CHC_T00007495001_1) or (CHC_T00002758001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8892_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_6Z8E10E14Z__45__5S12R__45__512__45__DIHYDROXYI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_XMPXAN__45__RXN" name="XMPXAN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6596 , PWY-5695

GENE_ASSOCIATION: (CHC_T00000267001_1) or (CHC_T00008300001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_XANTHOSINE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_XANTHOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__10" name="NADPH:protochlorophyllide oxidoreductase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009425001_1) or (CHC_T00009425001) or (CHC_T00010090001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MONO__45__VINYL__45__PROTOCHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5187" name="RXN0-5187" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005741001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FMN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RIBOFLAVIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12440" name="Ascorbate Peroxidase, APX2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6960 , PWY-6959 , PWY-6961

GENE_ASSOCIATION: (CHC_T00010024001_1) or (CHC_T00008640001_1) or (CHC_T00010024001) or (CHC_T00008640001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASCORBATE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_L__45__DEHYDRO__45__ASCORBATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASCORBATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17024" name="Lysophosphatidic acid acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__PALMITOYLGLYCEROL__45__3__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18390_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9523" name="3-oxo-octanoyl-[acyl-carrier protein] synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Hexanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Oxo__45__octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__223__45__RXN" name="2.4.1.223-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6558

GENE_ASSOCIATION: (CHC_T00010247001_1) or (CHC_T00010079001_1) or (CHC_T00008814001_1) or (CHC_T00008592001_1) or (CHC_T00005911001_1) or (CHC_T00000714001_1) or (CHC_T00009017001_1) or (CHC_T00008436001_1) or (CHC_T00008553001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GlcA__45__Gal__45__Gal__45__Xyl__45__Proteins_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GlcNAc__45__GlcA__45__Gal__45__Gal__45__Xyl__45__Protein_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1101" name="RXN-1101" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-361

GENE_ASSOCIATION: (CHC_T00009538001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__COUMAROYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_COUMARALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2761" name="RXN-2761" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1581

GENE_ASSOCIATION: (CHC_T00000930001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SOLANESYL__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HOMOGENTISATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__METHYL__45__6__45__SOLANYL__45__14__45__BENZOQUINONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17008" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__PALMITOYLGLYCEROL__45__3__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10269_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18350_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5330" name="RXN0-5330" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7269 , PWY0-1567 , PWY0-1573 , PWY-7279 , PWY0-1568

GENE_ASSOCIATION: (CHC_T00009457001_1) or (CHC_T00010112001_1) or (CHC_T00007379001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquinones_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ubiquinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_KDOTRANS2__45__RXN" name="KDOTRANS2-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: KDOSYN-PWY

GENE_ASSOCIATION: (CHC_T00003262001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_KDO__45__LIPID__45__IVA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP__45__KDO_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_KDO2__45__LIPID__45__IVA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15122" name="RXN-15122" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5437 , ILEUSYN-PWY , PWY-5826

GENE_ASSOCIATION: (CHC_T00007475001_1) or (CHC_T00005128001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_THR_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15056_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__24__46__64__45__RXN" name="mitochondrial processing peptidase beta subunit (Complex III core subunit 1), precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009305001) or (CHC_T00009305001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Mitochondrial__45__Preproteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Processed__45__Mitochondrial__45__Proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8001" name="histidinol dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008451001) or (CHC_T00008451001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HISTIDINOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_HIS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11999" name="RXN-11999" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6681

GENE_ASSOCIATION: (CHC_T00004955001_1) or (CHC_T00003476001_1) or (CHC_T00004944001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12932_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12936_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__395" name="trans-eicos-2-enoyl-[acyl-carrier protein] reductase (NADPH, B-specific)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_trans__45__delta2__45__arachidoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Arachidoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__46__99__46__1__46__2__45__RXN" name="DNA topoisomerase I Mitochondrial" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008579001_1) or (CHC_T00006880001_1) or (CHC_T00010204001_1) or (CHC_T00002964001_1) or (CHC_T00007354001_1) or (CHC_T00008867001) or (CHC_T00008579001) or (CHC_T00010204001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Negatively__45__super__45__coiled__45__DNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Relaxed__45__DNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1124" name="RXN-1124" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009538001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SINAPOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SINAPALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PROSTAGLANDIN__45__ENDOPEROXIDE__45__SYNTHASE__45__RXN" name="PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY66-374

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ARACHIDONIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROSTAGLANDIN__45__H2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2425" name="RXN-2425" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1361 , PWY0-321

GENE_ASSOCIATION: (CHC_T00009110001_1) or (CHC_T00008882001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__HYDROXYADIPYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TRANS__45__23__45__DEHYDROADIPYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11662" name="RXN-11662" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6883 , PWY-6583 , PWY-7401 , P162-PWY , CENTFERM-PWY , PWY-5177 , PWY-6863 , PWY-5789 , PWY-7216 , PWY-7778 , PWY-7779

GENE_ASSOCIATION: (CHC_T00008557001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1) or (CHC_T00008882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__3__45__HYDROXYBUTANOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETOACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MYO__45__INOSITOL__45__1__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="myo-inositol 1-phosphate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6372 , PWY-6664 , PWY-2301 , PWY-4661 , PWY1G-0 , PWY-6580

GENE_ASSOCIATION: (CHC_T00008380001_1) or (CHC_T00009031001_1) or (CHC_T00008380001) or (CHC_T00009031001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__glucopyranose__45__6__45__phosphate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__L__45__MYO__45__INOSITOL__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__11__46__2__45__RXN" name="probable pyruvate dehydrogenase kinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006845001_1) or (CHC_T00008298001_1) or (CHC_T00008298001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pyruvate__45__dehydrogenases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phosphorylated__45__pyruvate__45__dehydrogenases_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__31" name="TRANS-RXN1HP7-31" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002450001_1) or (CHC_T00002441001_1) or (CHC_T00004333001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SUCROSE_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SUCROSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__232__45__RXN" name="2.4.1.232-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009519001_1) or (CHC_T00009193001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Lipid__45__linked__45__mannosyl__45__oligos_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Lipid__45__linked__45__16__45__mannosyl__45__mannose__45__oligos_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PRPPSYN__45__RXN" name="Ribose-phosphate pyrophosphokinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-662

GENE_ASSOCIATION: (CHC_T00008865001_1) or (CHC_T00007508001_1) or (CHC_T00008613001_1) or (CHC_T00008865001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RIBOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9673" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6000

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LINOLEIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GTP__45__CYCLOHYDRO__45__II__45__RXN" name="GTP-CYCLOHYDRO-II-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6168 , PWY-7539 , RIBOSYN2-PWY

GENE_ASSOCIATION: (CHC_T00001056001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6622" name="RXN-6622" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7559 , PWY-4041

GENE_ASSOCIATION: (CHC_T00002840001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS__45__GLY_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16602" name="probable dolichyl-phosphate mannosyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7661

GENE_ASSOCIATION: (CHC_T00009153001) or (CHC_T00009153001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17858_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17894_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__45__NITROPHENYLPHOSPHATASE__45__RXN" name="probable 4-nitrophenyl phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010038001_1) or (CHC_T00005928001_1) or (CHC_T00008718001_1) or (CHC_T00008858001_1) or (CHC_T00007222001_1) or (CHC_T00005163001_1) or (CHC_T00006166001_1) or (CHC_T00008858001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__194_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__NITROPHENOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2006" name="RXN-2006" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6458 , PWY-481 , P281-PWY , PWY-6443

GENE_ASSOCIATION: (CHC_T00009349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__514_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BENZOYLCOA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5469" name="RXN-5469" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00009519001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__5167_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__171_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5168_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8619" name="RXN-8619" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5434

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8843_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8847_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8844_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12171" name="Starch phosphorylase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6731 , PWY-6737

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Maltodextrins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Maltodextrins_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__11" name="TRANS-RXN1HP7-11" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007599001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18602_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18602_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__1__46__90__45__RXN" name="pyrophosphate-fructose-6-phosphate 1-phosphotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1042

GENE_ASSOCIATION: (CHC_T00007415001_1) or (CHC_T00009387001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FRUCTOSE__45__16__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15066" name="RXN-15066" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7416

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8343_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__2__45__DIPALMITOYLPHOSPHATIDYLCHOLINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14048" name="RXN-14048" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-801 , HOMOCYSDEGR-PWY

GENE_ASSOCIATION: (CHC_T00008547001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__CYSTATHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15056_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17782" name="RXN-17782" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19167_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15436_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10769" name="RXN-10769" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__11641_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__182_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_FE__43__2" name="TransportSeed_FE+2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FE__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FE__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15909" name="RXN-15909" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-842

GENE_ASSOCIATION: (CHC_T00008493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Linear__45__Malto__45__Oligosaccharides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15717_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__480" name="phytenoyl-CoA synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-389

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14927_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14928_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12414" name="RXN-12414" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12321_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acceptor_c" stoichiometry="4" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_CPD1F__45__114_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__13" name="TRANS-RXN1HP7-13" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001890001_1) or (CHC_T00006957001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NUCLEOTIDE__45__SUGARS_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NUCLEOTIDE__45__SUGARS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__5__46__1__46__20__45__RXN__45__5__45__METHYL__45__THF__47__NAD__47____47__METHYLENE__45__THF__47__NADH__47__PROTON__46__44__46__" name="1.5.1.20-RXN-5-METHYL-THF/NAD//METHYLENE-THF/NADH/PROTON.44." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_METHYLENE__45__THF_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__METHYL__45__THF_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSPHORIBULOKINASE__45__RXN" name="phosphoribulokinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5723 , CALVIN-PWY

GENE_ASSOCIATION: (CHC_T00008651001_1) or (CHC_T00008651001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RIBULOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__RIBULOSE__45__15__45__P2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5131" name="Transposase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001801001_1) or (CHC_T00008723001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_IS30__45__Insertion__45__Sequences_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_IS30__45__with__45__Integrated__45__Transposon_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FESO3OXI__45__RXN" name="FESO3OXI-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: FESULFOX-PWY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FE__43__3_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SULFATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FE__43__2_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__45__ACYLGLYCEROL__45__3__45__P__45__ACYLTRANSFER__45__RXN" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1319 , PWY-5981

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACYL__45__SN__45__GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__PHOSPHATIDATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17798" name="RXN-17798" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19151_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19153_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17730" name="RXN-17730" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7782

GENE_ASSOCIATION: (CHC_T00009530001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__Alkyl__45__2__45__acyl__45__glycerol__45__3__45__phosphate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__Alkyl__45__2__45__acyl__45__glycerol_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYCINE__45____45__TRNA__45__LIGASE__45__RXN" name="GLYCINE--TRNA-LIGASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00004794001_1) or (CHC_T00007645001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__GLY__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__19__46__12__45__RXN" name="3.4.19.12-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003069001_1) or (CHC_T00007357001_1) or (CHC_T00001665001_1) or (CHC_T00004996001_1) or (CHC_T00005836001_1) or (CHC_T00005132001_1) or (CHC_T00004011001_1) or (CHC_T00002764001_1) or (CHC_T00008803001_1) or (CHC_T00007146001_1) or (CHC_T00005609001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTEIN__45__N__45__UBIQUITYL__45__LYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ubiquitin__45__C__45__Terminal__45__Glycine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__5__46__1__46__27__45__RXN" name="3.5.1.27-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Charged__45__fMET__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__Methionylaminoacyl__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MRNA__45__GUANYLYLTRANSFERASE__45__RXN" name="MRNA-GUANYLYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7375

GENE_ASSOCIATION: (CHC_T00004765001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8630_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_G5__45__pppR__45__mRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12502" name="RXN-12502" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007905001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_p__45__his__45__tRNAS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_pppGp__45__his__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FUMHYDR__45__RXN" name="fumarate hydratase precursor" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P23-PWY , P42-PWY , P108-PWY , REDCITCYC , PWY-7384 , PWY-5913 , PWY-561 , PWY-5392 , PWY-5690 , P105-PWY , TCA , PWY-6969 , PWY66-398 , PWY-6728 , PWY-7254 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00008951001_1) or (CHC_T00008951001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MAL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__302" name="2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NONMEVIPP-PWY , PWY-7560

GENE_ASSOCIATION: (CHC_T00009483001) or (CHC_T00009483001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__26__46__12__45__RXN" name="ribonuclease E" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_120)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RNASE__45__E__45__DEGRADATION__45__SUBSTRATE__45__MRNA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_mRNA__45__Fragments_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PROTOHEMEFERROCHELAT__45__RXN" name="ferrochelatase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1415 , HEME-BIOSYNTHESIS-II , HEMESYN2-PWY

GENE_ASSOCIATION: (CHC_T00008918001_1) or (CHC_T00008918001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTOHEME_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTOPORPHYRIN_IX_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FE__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDROFOLATESYNTH__45__RXN" name="DIHYDROFOLATESYNTH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6614

GENE_ASSOCIATION: (CHC_T00000400001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_7__45__8__45__DIHYDROPTEROATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROFOLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__318" name="RXN66-318" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074 , PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00003646001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4702_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__4581_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7644" name="D-sorbitol 2-dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4101

GENE_ASSOCIATION: (CHC_T00007340001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SORBITOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15382_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2584" name="RXN0-2584" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004109001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DNA__45__with__45__Uracils_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DNA__45__containing__45__a__45__Apyrimidinic__45__Sites_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_URACIL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TOCOPHEROL__45__O__45__METHYLTRANSFERASE__45__RXN" name="TOCOPHEROL-O-METHYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1422

GENE_ASSOCIATION: (CHC_T00000837001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GAMA__45__TOCOPHEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALPHA__45__TOCOPHEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6601" name="RXN-6601" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4041

GENE_ASSOCIATION: (CHC_T00000071001_1) or (CHC_T00005245001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Amino__45__Acids__45__20_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS__45__GLY_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17808" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10793_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__P__45__HYDROXYPYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_SULFATE" name="ExchangeSeed_SULFATE" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SULFATE_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SULFATE_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETYLORNTRANSAM__45__RXN" name="ACETYLORNTRANSAM-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ARGSYNBSUB-PWY , GLUTORN-PWY , PWY-5154

GENE_ASSOCIATION: (CHC_T00008340001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__ALPHA__45__ACETYLORNITHINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__469_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14390" name="RXN-14390" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7250

GENE_ASSOCIATION: (CHC_T00008003001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Chap__45__ATP__45__Co__45__chaperone__45__SP__45__2Fe2S__45__Complex_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Apo__45__FeS__45__cluster__45__proteins_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Chap__45__ADP__45__apo__45__SP__45__Complex_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2Fe__45__2S__45__proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FeS__45__Cluster__45__Co__45__Chaperones_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DICHLOROMETHANE__45__DEHALOGENASE__45__RXN" name="DICHLOROMETHANE-DEHALOGENASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__681_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FORMALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CL__45___c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13740" name="D-galactose oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009130001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_D__45__galactopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14779_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UREA__45__CARBOXYLASE__45__RXN" name="Urea amidolyase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5703

GENE_ASSOCIATION: (CHC_T00009426001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UREA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__578_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12669" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6920

GENE_ASSOCIATION: (CHC_T00008400001_1) or (CHC_T00007910001_1) or (CHC_T00008478001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00009142001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__196_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2108_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17625" name="RXN-17625" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19065_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16995" name="RXN-16995" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009043001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Phosphorylated__45__beta__45__phosphoglucomutase_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__448_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUCOSE__45__16__45__DIPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Beta__45__phosphoglucomutase_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BETA__45__PHOSPHOGLUCOMUTASE__45__RXN" name="BETA-PHOSPHOGLUCOMUTASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2722 , MALTOSECAT-PWY , PWY-2721 , PWY-7459

GENE_ASSOCIATION: (CHC_T00009043001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__448_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__6__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__6485" name="ribonuclease E" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1479

GENE_ASSOCIATION: (CHC_120)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2350_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__2350_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2352_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10700" name="RXN-10700" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11524_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11525_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9510" name="NADH:flavin oxidoreductase/NADH oxidase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7723

GENE_ASSOCIATION: (CHC_T00010019001_1) or (CHC_T00000381001_1) or (CHC_T00005514001_1) or (CHC_T00005515001_1) or (CHC_T00009377001_1) or (CHC_T00009377001) or (CHC_T00010019001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FMNH2_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FMN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9536" name="3-oxo-meristoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994 , PWY-5971

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__oxo__45__myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_R__45__3__45__hydroxymyristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11842" name="RXN-11842" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006820001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Uridine32__45__in__45__tRNA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNA__45__pseudouridine32_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2562" name="RXN-2562" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1422

GENE_ASSOCIATION: (CHC_T00000837001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DELTA__45__TOCOPHEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BETA__45__TOCOPHEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__17" name="TRANS-RXN1HP7-17" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005193001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__1414_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__1414_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SUCCSEMIALDDEHYDROG__45__RXN" name="succinic semialdehyde dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6537 , P105-PWY , P181-PWY , 3-HYDROXYPHENYLACETATE-DEGRADATION-PWY , PWY-6993

GENE_ASSOCIATION: (CHC_T00008575001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUCC__45__S__45__ALD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12568__45__HEXANAL__47__CO__45__A__47__NADP__47____47__HEXANOYL__45__COA__47__NADPH__47__PROTON__46__45__46__" name="RXN-12568-HEXANAL/CO-A/NADP//HEXANOYL-COA/NADPH/PROTON.45." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HEXANAL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__25" name="TRANS-RXN1HP7-25" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000780001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TAURINE_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TAURINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_Transport_BIOMASS" name="Transport_BIOMASS" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BIOMASS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BIOMASS_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8759" name="RXN-8759" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007728001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__43__2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROSIROHYDROCHLORIN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__9039_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="4" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_R82__45__RXN" name="E1 enzyme family" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4361

GENE_ASSOCIATION: (CHC_T00010198001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8999_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__HYDROXY__45__3__45__KETO__45__5__45__METHYLTHIO__45__1__45__PHOSPHOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10949" name="RXN-10949" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002260001_1) or (CHC_T00001291001_1) or (CHC_T00007726001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Myo__45__inositol__45__monophosphates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FATTY__45__ACID__45__PEROXIDASE__45__RXN" name="FATTY-ACID-PEROXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PALMITATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__388_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6002" name="RXN-6002" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-3641

GENE_ASSOCIATION: (CHC_T00008341001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__16618_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5021" name="RXN0-5021" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000595001_1) or (CHC_T00003365001_1) or (CHC_T00000202001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Single__45__Stranded__45__DNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Short__45__RNA__45__Fragments_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5507" name="RXN0-5507" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6703

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDRONEOPTERIN__45__P3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_P3I_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__1699_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETALD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1F__45__66" name="RXN1F-66" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5068 , PWY-7764 , PWY-5086

GENE_ASSOCIATION: (CHC_T00008377001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHYTYL__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHLOROPHYLL__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHENYLALANINE__45____45__TRNA__45__LIGASE__45__RXN" name="phenylalanyl-tRNA synthetase alpha chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00002604001_1) or (CHC_T00003422001_1) or (CHC_T00009560001_1) or (CHC_T00001598001_1) or (CHC_270) or (CHC_T00009560001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHE__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Charged__45__PHE__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SHIKIMATE__45__KINASE__45__RXN" name="SHIKIMATE-KINASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6163

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SHIKIMATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SHIKIMATE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN3O__45__130" name="RXN3O-130" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_LANOSTEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16425" name="RXN-16425" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001867001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phosphoacetylglucosamine__45__Mutase__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Phosphoacetylglucosamine__45__Mutase_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__ACETYL__45__D__45__GLUCOSAMINE__45__16__45__BIS__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__1437" name="Trehalose 6-phosphate synthase, family GT20 / Trehalose 6-phosphate phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00002090001_1) or (CHC_T00009495001_1) or (CHC_T00010201001_1) or (CHC_T00008273001) or (CHC_T00010201001) or (CHC_T00009495001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1G__45__772_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1G__45__1346_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSPHATIDATE__45__PHOSPHATASE__45__RXN" name="PHOSPHATIDATE-PHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRIGLSYN-PWY

GENE_ASSOCIATION: (CHC_T00009530001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__PHOSPHATIDATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9626" name="RXN-9626" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TETRADECANOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7836_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7664" name="RXN-7664" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5064

GENE_ASSOCIATION: (CHC_T00009478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7005_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7004_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TIGLYLCOA__45__HYDROXY__45__RXN" name="Tiglyl-CoA hydratase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ILEUDEG-PWY , PWY-5109

GENE_ASSOCIATION: (CHC_T00009190001_1) or (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1) or (CHC_T00008882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__1083_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOMOGENTISATE__45__12__45__DIOXYGENASE__45__RXN" name="homogentisate 1,2-dioxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TYRFUMCAT-PWY

GENE_ASSOCIATION: (CHC_T00008952001_1) or (CHC_T00008952001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMOGENTISATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_4__45__MALEYL__45__ACETOACETATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__3__46__1__46__9__45__RXN" name="1.3.1.9-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRANS__45__D2__45__ENOYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17009" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10269_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18348_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18351_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PROLINE__45____45__TRNA__45__LIGASE__45__RXN" name="proline--tRNA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00009364001_1) or (CHC_T00008394001_1) or (CHC_T00009364001) or (CHC_T00008394001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PRO__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRO_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__PRO__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12504" name="RXN-12504" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007905001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_App__45__his__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_pppGp__45__his__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__6__46__3__46__8__45__RXN" name="3.6.3.8-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008559001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CA__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CA__43__2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__45__ISOPROPYLMALATESYN__45__RXN" name="2-isopropylmalate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6871 , LEUSYN-PWY

GENE_ASSOCIATION: (CHC_T00009551001_1) or (CHC_T00008989001_1) or (CHC_T00009551001) or (CHC_T00008989001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETO__45__ISOVALERATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12184" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6733

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17637_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17638_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16066" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACYL__45__SN__45__GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Long__45__Chain__45__Acyl__45__CoAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__PHOSPHATIDATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15378" name="succinate dehydrogenase (Complex II) flavoprotein subunit precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008943001_1) or (CHC_T00007584001_1) or (CHC_T00007286001_1) or (CHC_T00006990001_1) or (CHC_T00001817001_1) or (CHC_T00008943001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9612_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15301_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__4222" name="RXN0-4222" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1479

GENE_ASSOCIATION: (CHC_T00003097001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2351_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ribonucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2354_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16134" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7606

GENE_ASSOCIATION: (CHC_T00008400001_1) or (CHC_T00007910001_1) or (CHC_T00008478001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00009142001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17385_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17386_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14209" name="RXN-14209" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_4__45__AMINO__45__BUTYRALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__AMINO__45__BUTYRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12490" name="RXN-12490" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7094

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1) or (CHC_T00008882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2244_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2123_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYSTATHIONASE__45__RXN" name="CYSTATHIONASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__CYSTATHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HOMO__45__SER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SPERMIDINESYN__45__RXN" name="putrescine aminopropyltransferase (spermidine synthase)" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: BSUBPOLYAMSYN-PWY

GENE_ASSOCIATION: (CHC_T00009140001_1) or (CHC_T00002289001_1) or (CHC_T00009140001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PUTRESCINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__METHYLTHIOADENOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SPERMIDINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__142__45__RXN" name="2.4.1.142-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00008978001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NN__45__DIACETYLCHITOBIOSYLDIPHOSPHODOLICHO_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ALPHA__45__D__45__MANNOSYLCHITOBIO_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8988" name="RXN-8988" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5749

GENE_ASSOCIATION: (CHC_T00009212001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ITACONATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__1137_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SERINE__45__C__45__PALMITOYLTRANSFERASE__45__RXN" name="serine palmitoyltransferase, LCB1 subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SPHINGOLIPID-SYN-PWY , PWY3DJ-12 , PWY-5129

GENE_ASSOCIATION: (CHC_T00008697001_1) or (CHC_T00008326001_1) or (CHC_T00008326001) or (CHC_T00008697001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PALMITYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEHYDROSPHINGANINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16150" name="RXN-16150" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6433

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15365_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17397_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALDEHYDE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="ALDEHYDE-DEHYDROGENASE-NADP+-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7269

GENE_ASSOCIATION: (CHC_T00008341001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Aldehydes_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Carboxylates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17114" name="RXN-17114" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7726

GENE_ASSOCIATION: (CHC_T00009190001_1) or (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18492_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18493_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17155" name="Acyl carrier protein" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7735

GENE_ASSOCIATION: (CHC_T00009135001) or (CHC_655) or (CHC_T00009135001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18550_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_QXC__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__1__46__148__45__RXN" name="2.7.1.148-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NONMEVIPP-PWY , PWY-7560

GENE_ASSOCIATION: (CHC_T00003708001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10773" name="RXN-10773" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6788

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CELLOBIOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14788" name="RXN-14788" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7338

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15676_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15677_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_CA__43__2" name="ExchangeSeed_CA+2" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CA__43__2_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CA__43__2_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRROLINECARBREDUCT__45__RXN" name="PYRROLINECARBREDUCT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-3341 , PWY-6344 , PROSYN-PWY , PWY-4981 , ARG-PRO-PWY

GENE_ASSOCIATION: (CHC_T00001376001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRO_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14107" name="menaquinol-cytochrome c reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008759001_1) or (CHC_T00009218001_1) or (CHC_T00007973001_1) or (CHC_T00008759001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cytochromes__45__C__45__Oxidized_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Menaquinols_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Menaquinones_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Cytochromes__45__C__45__Reduced_e" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ARGSUCCINSYN__45__RXN" name="Argininosuccinate synthase (fragment)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5154 , ARGSYNBSUB-PWY , PWY-4983 , PWY-7400 , ARGSYN-PWY , PWY-4984

GENE_ASSOCIATION: (CHC_T00010073001) or (CHC_T00010073001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__CITRULLINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__ARGININO__45__SUCCINATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17010" name="Lysophosphatidic acid acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18346_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__PALMITOYLGLYCEROL__45__3__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18352_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_QOR__45__RXN" name="QOR-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003634001_1) or (CHC_T00002112001_1) or (CHC_T00002111001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Quinones_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Semiquinones_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7421" name="Cyclopropane-fatty-acyl-phospholipid synthase family" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4942

GENE_ASSOCIATION: (CHC_T00005488001_1) or (CHC_T00003092001_1) or (CHC_T00006042001_1) or (CHC_T00009019001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Oleoyl__45__lipid_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Lipid__45__dihydrosterculate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__5__46__5__46__1__45__RXN" name="electron transfer flavoprotein-ubiquinone oxidoreductase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008888001) or (CHC_T00008888001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Ubiquinones_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ubiquinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9532" name="3-oxo-dodecanoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994 , PWY-5971

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__oxo__45__dodecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_R__45__3__45__hydroxydodecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9235" name="RXN-9235" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5857 , PWY-5872

GENE_ASSOCIATION: (CHC_T00005416001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9869_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9871_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9540" name="3-oxo-palmitoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5994 , PWY-5971

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__oxo__45__palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_R__45__3__45__Hydroxypalmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THIOL__45__OXIDASE__45__RXN" name="THIOL-OXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004505001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Sulfhydryls_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8529_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DISULISOM__45__RXN" name="DISULISOM-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009389001_1) or (CHC_T00008626001_1) or (CHC_T00006120001_1) or (CHC_T00008968001_1) or (CHC_T00008734001_1) or (CHC_T00004331001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SELENOCYSTEINE__45__LYASE__45__RXN" name="SELENOCYSTEINE-LYASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008053001_1) or (CHC_T00000657001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__SELENOCYSTEINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SE__45__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10971" name="RXN-10971" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6369

GENE_ASSOCIATION: (CHC_T00003487001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MI__45__HEXAKISPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11937_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__384" name="RXN0-384" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DAMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__ISOPROPYLMALDEHYDROG__45__RXN" name="3-ISOPROPYLMALDEHYDROG-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6871 , LEUSYN-PWY

GENE_ASSOCIATION: (CHC_T00009293001_1) or (CHC_T00009162001_1) or (CHC_T00008852001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7100_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_ZN__43__2" name="TransportSeed_ZN+2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ZN__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ZN__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15131" name="RXN-15131" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-801 , HOMOSER-METSYN-PWY , PWY-702

GENE_ASSOCIATION: (CHC_T00008829001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__CYSTATHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__AMINOACRYLATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__4__46__1__46__101__45__RXN" name="2.4.1.101-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7426

GENE_ASSOCIATION: (CHC_T00004649001_1) or (CHC_T00009095001_1) or (CHC_T00008757001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Mannosyl5__45__N__45__Glycans_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Mannosyl5__45__N__45__acetyl__45__glucosamine2__45__R_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_RXN66__45__28_5A_CHOLESTA__45__7__45__24__45__DIENOL" name="extended_RXN66-28_5A_CHOLESTA-7-24-DIENOL" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: late_SSR

GENE_ASSOCIATION: (CHC_T00002789001_1)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5A_CHOLESTA__45__7__44__24__45__DIENOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LATHOSTEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6161" name="RXN-6161" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5486 , PWY3O-440 , PWY-6330 , PWY-6873 , PWY-5768 , PWY-7118

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETALD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__64__45__RXN" name="2.1.1.64-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5856 , PWY-5871

GENE_ASSOCIATION: (CHC_T00007491001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7158_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9957_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CODH-PWY , PWY-5497 , 1CMET2-PWY , PWY-3841 , PWY-2201 , PWY-1722

GENE_ASSOCIATION: (CHC_T00008670001_1) or (CHC_T00008680001_1) or (CHC_T00008680001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_METHYLENE__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__10__45__METHENYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12243" name="15-cis-phytoene desaturase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6475

GENE_ASSOCIATION: (CHC_T00009492001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PLASTOQUINONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12321_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13171_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Plastoquinols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7933" name="RXN-7933" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5154

GENE_ASSOCIATION: (CHC_T00003504001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7224_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__CITRULLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12201" name="Alpha-glucan water dikinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008789001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Maltodextrins_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_6__45__Phosphogluco__45__Maltodextrins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16133" name="RXN-16133" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__3__45__HYDROXYACYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__KETOACYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14189" name="RXN-14189" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007915001_1) or (CHC_T00005477001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_METOH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FORMALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10664" name="RXN-10664" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5987

GENE_ASSOCIATION: (CHC_T00009557001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PALMITYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__10269_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PEROXID__45__RXN" name="PEROXID-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002409001_1) or (CHC_T00009160001_1) or (CHC_T00008578001_1) or (CHC_T00000152001_1) or (CHC_T00010263001_1) or (CHC_T00002083001_1) or (CHC_T00010024001_1) or (CHC_T00008640001_1) or (CHC_T00010209001_1) or (CHC_T00010179001_1) or (CHC_T00009550001_1) or (CHC_T00008635001_1) or (CHC_T00009516001_1) or (CHC_T00010289001_1) or (CHC_T00010094001_1) or (CHC_T00010161001_1) or (CHC_T00009008001_1) or (CHC_T00007624001_1) or (CHC_T00008271001_1) or (CHC_T00008590001_1) or (CHC_T00009515001_1) or (CHC_T00009006001_1) or (CHC_T00009490001_1) or (CHC_T00010108001_1) or (CHC_T00004197001_1) or (CHC_T00010243001_1) or (CHC_T00010133001_1) or (CHC_T00008836001_1) or (CHC_T00009226001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Phenolic__45__Donors_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Phenoxyl__45__rad__45__of__45__phenolic__45__donors_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__3__46__46__45__RXN" name="3.1.3.46-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-423

GENE_ASSOCIATION: (CHC_T00009308001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__535_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12789" name="RXN-12789" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6948

GENE_ASSOCIATION: (CHC_T00003646001_1) or (CHC_T00007359001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4143_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13793_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RIB5PISOM__45__RXN" name="RIB5PISOM-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , NONOXIPENT-PWY , PWY-5723 , PWY-1861 , CALVIN-PWY , P185-PWY

GENE_ASSOCIATION: (CHC_T00009264001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RIBOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_RIBULOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__24" name="TRANS-RXN1HP7-24" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000551001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Guanine__45__Nucleotides_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Guanine__45__Nucleotides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9533" name="RXN-9533" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5994 , PWY-7664 , PWY-5971

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_R__45__3__45__hydroxydodecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Dodec__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16317" name="Mitogen-activated protein kinase kinase 6, MPKK6" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008752001) or (CHC_T00008994001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MAP__45__Kinase__45__L__45__Tyr_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MAP__45__Kinase__45__L__45__Phosphotyrosine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DTDPKIN__45__RXN" name="nucleoside-diphosphate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7210 , PWY-7184 , PWY0-166 , PWY-7187 , PWY-7197 , PWY-7198 , PWY-6545

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TTP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7673" name="RXN-7673" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008377001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7014_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GERANYLGERANYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7013_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14261" name="Disproportionating Enzyme type 2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009120001_1) or (CHC_T00009120001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOPENTAOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOHEXAOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__17__46__12__45__RXN" name="3.4.17.12-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006197001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alpha__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="BRANCHED-CHAINAMINOTRANSFERVAL-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: VALDEG-PWY , ALANINE-VALINESYN-PWY , VALSYN-PWY , PWY-5057

GENE_ASSOCIATION: (CHC_T00003864001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_VAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETO__45__ISOVALERATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7607" name="RXN-7607" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6596

GENE_ASSOCIATION: (CHC_T00000267001_1) or (CHC_T00008300001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_IMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_INOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__5__46__1__46__46__45__RXN" name="2.5.1.46-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005094001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_EIF5A__45__LYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SPERMIDINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9973_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__313_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12645" name="RXN-12645" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008374001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13613_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DEHYDROSPHINGANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_N__45__CARBAMOYLPUTRESCINE__45__AMIDASE__45__RXN" name="N-CARBAMOYLPUTRESCINE-AMIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ARGDEG-III-PWY , PWY-43

GENE_ASSOCIATION: (CHC_T00006316001_1) or (CHC_T00006315001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__597_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PUTRESCINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14136" name="Glycerophosphoryl diester phosphodiesterase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009254001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2030_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DUDPKIN__45__RXN" name="nucleoside-diphosphate kinase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7184 , PWY0-166 , PWY-6545

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DUDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DUTP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7931" name="RXN-7931" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7291

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7221_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7222_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5292" name="RXN0-5292" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000267001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DCMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEOXYCYTIDINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15829" name="Ubiquinol-cytochrome c reductase iron-sulfur subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6692

GENE_ASSOCIATION: (CHC_T00008759001_1) or (CHC_T00009218001_1) or (CHC_T00007973001_1) or (CHC_T00008759001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Ubiquinones_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_Reduced__45__CycA1__45__cytochromes_e" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__CycA1__45__cytochromes_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Ubiquinols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BIOTINLIG__45__RXN" name="BIOTINLIG-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1264

GENE_ASSOCIATION: (CHC_T00001081001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BCCP__45__monomers_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BCCP__45__biotin__45__monomers_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14273" name="trans-tetradec-2-enoyl-CoA hydratase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7654

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009110001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15568_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__2171_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9023" name="Disproportionating Enzyme type 2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5941

GENE_ASSOCIATION: (CHC_T00009120001_1) or (CHC_T00009120001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__971_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Truncated__45__Limit__45__Dextrins_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__DEHYDROQUINATE__45__SYNTHASE__45__RXN" name="3-dehydroquinate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6164

GENE_ASSOCIATION: (CHC_T00001993001_1) or (CHC_T00009338001_1) or (CHC_T00008976001_1) or (CHC_T00008976001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DEHYDROQUINATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_INORGPYROPHOSPHAT__45__RXN" name="INORGPYROPHOSPHAT-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7805 , PWY-7807

GENE_ASSOCIATION: (CHC_T00008316001_1) or (CHC_T00006490001_1) or (CHC_T00008749001_1) or (CHC_T00010119001_1) or (CHC_T00010343001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5424" name="indole-3-glycol dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-3162

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__INDOLYLGLYCOLALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_INDOLE__45__3__45__GLYCOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__45" name="TRANS-RXN1HP7-45" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004666001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GDP_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14380" name="RXN-14380" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-622

GENE_ASSOCIATION: (CHC_T00009540001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alpha__45__6__45__alpha__45__14__45__glucans_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Alpha__45__6__45__alpha__45__14__45__glucans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Malto__45__Oligosaccharides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2KETO__45__3METHYLVALERATE__45__RXN" name="(S)-3-methyl-2-oxopentanoate dehydrogenase (acylating)" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5108 , ILEUDEG-PWY

GENE_ASSOCIATION: (CHC_T00010287001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETO__45__3__45__METHYL__45__VALERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__METHYL__45__BUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5234" name="RXN0-5234" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009460001_1) or (CHC_T00008323001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ALLO__45__THR_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETALD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DXS__45__RXN" name="1-deoxyxylulose-5-phosphate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NONMEVIPP-PWY , PWY-7560 , PYRIDOXSYN-PWY , PWY-6892 , PWY-6891

GENE_ASSOCIATION: (CHC_T00008758001_1) or (CHC_T00003376001_1) or (CHC_T00001730001_1) or (CHC_T00001454001_1) or (CHC_T00000866001_1) or (CHC_T00000865001_1) or (CHC_T00003402001_1) or (CHC_T00009061001_1) or (CHC_T00008758001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEOXYXYLULOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17022" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18379_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD0__45__1425_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_N__45__ACETYLTRANSFER__45__RXN" name="glutamate N-acetyltransferase / amino-acid N-acetyltransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ARGSYNBSUB-PWY , PWY-5154 , GLUTORN-PWY

GENE_ASSOCIATION: (CHC_T00008260001_1) or (CHC_T00008357001_1) or (CHC_T00008260001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__GLU_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12588" name="RXN-12588" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009510001_1) or (CHC_T00008053001_1) or (CHC_T00000657001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYCEROL__45__KIN__45__RXN" name="glycerol kinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4261

GENE_ASSOCIATION: (CHC_T00008744001_1) or (CHC_T00008744001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11596" name="RXN-11596" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003709001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_23S__45__rRNA__45__adenine__45__1618_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_23S__45__rRNA__45__N6__45__m__45__adenine1618_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7790" name="RXN-7790" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5130 , PWY66-428

GENE_ASSOCIATION: (CHC_T00008584001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__OXOBUTANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROPIONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__747" name="ribonucleoside-diphosphate reductase alpha chain" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7220

GENE_ASSOCIATION: (CHC_T00008926001_1) or (CHC_T00008864001_1) or (CHC_T00008864001) or (CHC_T00008926001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__NrdH__45__Proteins_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__NrdH__45__Proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10727" name="myristoyl-ACP hydrolase activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7836_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__1__46__1__46__34__45__RXN" name="1.1.1.34-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6174 , PWY-922 , PWY-7524 , PWY-7391

GENE_ASSOCIATION: (CHC_T00006657001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_MEVALONATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8631" name="RXN-8631" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-373

GENE_ASSOCIATION: (CHC_T00008586001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FRU1P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIHYDROXY__45__ACETONE__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCERALD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7692" name="RXN-7692" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6871 , PWY-5076

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2K__45__4CH3__45__PENTANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7031_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LUMAZINESYN__45__RXN" name="LUMAZINESYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6168 , PWY-6167 , RIBOSYN2-PWY

GENE_ASSOCIATION: (CHC_T00007345001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIHYDROXY__45__BUTANONE__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN__45__141" name="TRANS-RXN-141" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004326001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MG__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MG__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17017" name="glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008773001) or (CHC_T00008773001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18379_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTAMINESYN__45__RXN" name="GLUTAMINESYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6549 , PWY490-3 , PWY-6964 , PWY-6963 , GLNSYN-PWY , PWY-381 , PWY-5675

GENE_ASSOCIATION: (CHC_T00005454001_1) or (CHC_T00005451001_1) or (CHC_T00010135001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17014" name="Lysophosphatidic acid acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__PALMITOYLGLYCEROL__45__3__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cis__45__vaccenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18352_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16761" name="RXN-16761" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001157001_1) or (CHC_T00009034001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OLIGOSACCHARIDE__45__DIPHOSPHODOLICHOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__Asparagine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__224_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycoprotein__45__Asn__45__oligosaccharides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__OXOACYL__45__ACP__45__SYNTH__45__BASE__45__RXN" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5966 , PWY-5965 , FASYN-INITIAL-PWY , PWY-7388

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acetoacetyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7737" name="RXN-7737" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5097

GENE_ASSOCIATION: (CHC_T00008432001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LL__45__DIAMINOPIMELATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15125" name="similar to serine dehydratase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5497 , PWY-3661 , SERDEG-PWY

GENE_ASSOCIATION: (CHC_T00009480001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__AMINOACRYLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CITSYN__45__RXN" name="CITSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6549 , REDCITCYC , PWY-5913 , PWY-5690 , PWY-5750 , PWY-7124 , TCA , PWY-6969 , P105-PWY , PWY66-398 , GLYOXYLATE-BYPASS , PWY-6728 , PWY-7254 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00007817001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXALACETIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CIT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CYTIDEAM2__45__RXN" name="CYTIDEAM2-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6556 , PWY0-1295 , PWY-7193

GENE_ASSOCIATION: (CHC_T00000921001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CYTIDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_URIDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17627" name="RXN-17627" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5451

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETOL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_METHYL__45__GLYOXAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__14__46__13__46__79__45__RXN" name="ent-kaurenoate monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5034 , PWY-5047

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__132_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1F__45__136_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALDOSE__45__1__45__EPIMERASE__45__RXN" name="ALDOSE-1-EPIMERASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1466

GENE_ASSOCIATION: (CHC_T00007315001_1) or (CHC_T00007314001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ALPHA__45__GLUCOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__8__46__11__45__RXN" name="CDP-diacylglycerol---inositol 3-phosphatidyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7625 , PWY-6351 , PHOSLIPSYN2-PWY , PWY-6352

GENE_ASSOCIATION: (CHC_T00008593001_1) or (CHC_T00008593001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MYO__45__INOSITOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CDPDIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__1__45__phosphatidyl__45__inositols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__526" name="trans-tetracos-2-enoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_trans__45__delta2__45__lignoceroyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Lignoceroyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16380" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5989

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_STEARIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_STEAROYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CREATINASE__45__RXN" name="CREATINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CRNFORCAT-PWY

GENE_ASSOCIATION: (CHC_T00005156001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CREATINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UREA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SARCOSINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14789" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7338

GENE_ASSOCIATION: (CHC_T00008400001_1) or (CHC_T00007910001_1) or (CHC_T00008478001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00009142001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15677_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15661_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11693" name="RXN-11693" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004631001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RAD21__45__Cohesin__45__Subunits_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10745" name="RXN-10745" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010210001_1) or (CHC_T00006445001_1) or (CHC_T00006174001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1884" name="RXN-1884" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-882

GENE_ASSOCIATION: (CHC_T00004134001_1) or (CHC_T00005083001_1) or (CHC_T00003588001_1) or (CHC_T00000573001_1) or (CHC_T00010069001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__Galactopyranose_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__330_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDLIPACETRANS__45__RXN" name="DIHYDLIPACETRANS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007380001_1) or (CHC_T00004322001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROLIPOAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ACETYLDIHYDROLIPOAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LYSINE__45____45__TRNA__45__LIGASE__45__RXN" name="Lysyl-tRNA synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00008735001_1) or (CHC_T00008917001_1) or (CHC_T00008917001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LYS__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__LYS__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1302" name="RXN-1302" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-481

GENE_ASSOCIATION: (CHC_T00009571001_1) or (CHC_T00008374001_1) or (CHC_T00008689001_1) or (CHC_T00004694001_1) or (CHC_T00000399001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__1__45__PHENYLETHANOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHENYL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14785" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7338

GENE_ASSOCIATION: (CHC_T00008478001_1) or (CHC_T00009142001_1) or (CHC_T00007910001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00008400001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15651_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15675_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SUCCCOASYN__45__RXN" name="SUCCCOASYN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P23-PWY , P42-PWY , PWY-7384 , PWY-5392 , PWY-5690 , PWY-5913 , PWY-6969 , TCA , PWY66-398 , PWY-5538 , PWY-6728 , PWY-5537

GENE_ASSOCIATION: (CHC_T00008602001_1) or (CHC_T00009212001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDROFOLATEREDUCT__45__RXN__45__THF__47__NADP__47____47__DIHYDROFOLATE__47__NADPH__47__PROTON__46__37__46__" name="DIHYDROFOLATEREDUCT-RXN-THF/NADP//DIHYDROFOLATE/NADPH/PROTON.37." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROFOLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETOLACTSYN__45__RXN" name="acetolactate synthase small subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7111 , PWY-6389 , PWY-5938 , VALSYN-PWY , PWY-5939

GENE_ASSOCIATION: (CHC_T00002409001_1) or (CHC_T00008160001_1) or (CHC_980)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__ACETO__45__LACTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MANNPISOM__45__RXN" name="MANNPISOM-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7456 , PWY-7586 , PWY-5659 , PWY-882 , PWY-3861 , PWY-6992 , MANNCAT-PWY , PWY-3881

GENE_ASSOCIATION: (CHC_T00005574001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__15979_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11476" name="3-oxo-glutaryl-[acp] methyl ester reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6519

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Ketoglutaryl__45__ACP__45__methyl__45__ester_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__Hydroxyglutaryl__45__ACP__45__methyl__45__ester_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NUCLEOSIDE__45__DIPHOSPHATASE__45__RXN" name="NUCLEOSIDE-DIPHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Nucleoside__45__Diphosphates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Nucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11757" name="RXN-11757" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007491001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_34__45__Dihydroxy__45__5__45__Polyprenylbenzoates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Methoxy__45__4__45__Hydroxy__45__5__45__Polyprenylbenzoate_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LONG__45__CHAIN__45__ALCOHOL__45__DEHYDROGENASE__45__RXN__45__CPD__45__7873__47__NAD__47__WATER__47____47__STEARIC_ACID__47__NADH__47__PROTON__46__45__46__" name="LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN-CPD-7873/NAD/WATER//STEARIC_ACID/NADH/PROTON.45." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7873_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_STEARIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14187" name="RXN-14187" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7210

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DCDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DCMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12642" name="RXN-12642" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008374001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13611_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13610_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_R344__45__RXN" name="R344-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5509 , PWY-5508

GENE_ASSOCIATION: (CHC_T00002690001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__694_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__690_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P3I_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__46__4__46__1__46__14__45__RXN" name="4.4.1.14-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ETHYL-PWY , PWY-7270

GENE_ASSOCIATION: (CHC_T00003413001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5__45__METHYLTHIOADENOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__68_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN3O__45__4113" name="RXN3O-4113" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY3O-4108 , PWY-6802

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDRPHENYLAC__45__CPD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD3O__45__4151_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_R223__45__RXN" name="octanoyl-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P221-PWY , PWY-6920

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__195_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__196_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9787" name="cysteine:[ThiI sulfur-carrier protein]-L-cysteine sulfurtransferase desulfurase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009510001_1) or (CHC_T00008053001_1) or (CHC_T00000657001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Sulfur__45__Carrier__45__Proteins__45__ThiI_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Sulfurylated__45__ThiI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_POLYNUCLEOTIDE__45__3__45__PHOSPHATASE__45__RXN" name="POLYNUCLEOTIDE-3-PHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002174001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__Phosphopolynucleotides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Polynucleotide__45__Holder_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17370" name="RXN-17370" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7751

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18776_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18779_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__475__45__CPD__45__14717__47____47__CPD__45__14719__47__FORMYL__45__COA__46__32__46__" name="RXN66-475-CPD-14717//CPD-14719/FORMYL-COA.32." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14717_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FORMYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14719_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__12__46__1__45__RXN" name="2.7.12.1-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008654001_1) or (CHC_T00008396001_1) or (CHC_T00009392001_1) or (CHC_T00009394001_1) or (CHC_T00008906001_1) or (CHC_T00008683001_1) or (CHC_T00006367001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__L__45__serines_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__Phosphoserines_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_KANAMYCIN__45__KINASE__45__RXN" name="aminoglycoside phosphotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009244001) or (CHC_T00008295001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Kanamycins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Kanamycin__45__3__45__phosphates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UNSPECIFIC__45__MONOOXYGENASE__45__RXN" name="UNSPECIFIC-MONOOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009303001_1) or (CHC_T00009187001_1) or (CHC_T00008616001_1) or (CHC_T00009131001_1) or (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1) or (CHC_T00009499001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008663001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RH__45__Group_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alcohols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__21" name="4&alpha;-hydroxymethyl-5&alpha;-cholesta-8-en-3&beta;-ol 4-dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8617_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8618_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14025" name="RXN-14025" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7821 , PWY-7185

GENE_ASSOCIATION: (CHC_T00000267001_1) or (CHC_T00008300001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_URIDINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__8__46__4__46__8__45__RXN" name="1.8.4.8-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SO4ASSIM-PWY

GENE_ASSOCIATION: (CHC_T00009224001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Ox__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__5__45__ADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Red__45__Thioredoxin_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PAPS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_OCTADECANAL__45__DECARBONYLASE__45__RXN" name="OCTADECANAL-DECARBONYLASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-6622

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__55_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HEPTADECANE__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENYLYLSULFKIN__45__RXN" name="ADENYLYLSULFKIN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5340

GENE_ASSOCIATION: (CHC_T00009458001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_APS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PAPS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12510" name="RXN-12510" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-3101

GENE_ASSOCIATION: (CHC_T00009499001_1) or (CHC_T00008616001_1) or (CHC_T00009131001_1) or (CHC_T00010004001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00008672001_1) or (CHC_T00009062001_1) or (CHC_T00008663001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__90_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__520_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12519" name="RXN-12519" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6837

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_trans__45__2__45__cis__45__5__45__dienoyl__45__CoA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_trans__45__3__45__cis__45__5__45__dienoyl__45__CoA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__5__46__1__46__26__45__RXN" name="3.5.1.26-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ASPARAGINE-DEG1-PWY-1

GENE_ASSOCIATION: (CHC_T00001474001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__ETCETERA__45__L__45__ASPARAGINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__ACETYL__45__BETA__45__GLUCOSAMINYLAMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GUANYL__45__KIN__45__RXN" name="guanylate kinase 1" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7221

GENE_ASSOCIATION: (CHC_T00009386001_1) or (CHC_T00007666001_1) or (CHC_T00009386001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GMP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1924" name="RXN0-1924" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004780001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CYS_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CYS_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUCOKIN__45__RXN" name="GLUCOKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P124-PWY , PWY-2723 , PWY-7385 , P122-PWY , ANAGLYCOLYSIS-PWY , PWY-621 , GLUCOSE1PMETAB-PWY , PWY-2722 , PWY-5514 , PWY-5661 , PWY0-1182 , GLYCOCAT-PWY , PWY-7238 , TREDEGLOW-PWY

GENE_ASSOCIATION: (CHC_T00001373001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__glucopyranose__45__6__45__phosphate_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLURS__45__RXN" name="GLURS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY , PWY-5188

GENE_ASSOCIATION: (CHC_T00008453001_1) or (CHC_T00002361001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__GLT__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16118" name="Lysophosphatidic acid acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6453

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17371_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17372_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__17373_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALANINE__45__DEHYDROGENASE__45__RXN" name="ALANINE-DEHYDROGENASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY1-2

GENE_ASSOCIATION: (CHC_T00008930001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__45__METHYLTHIOADENOSINE__45__PHOSPHORYLASE__45__RXN" name="5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6756

GENE_ASSOCIATION: (CHC_T00008714001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__METHYLTHIOADENOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__444_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__2962" name="RXN-2962" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1801

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__HYDROXYMETHYLGLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__548_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GCVP__45__RXN" name="glycine dehydrogenase (decarboxylating), mitochondrial precursor" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLYCINE-SYN2-PWY , GLYCLEAV-PWY

GENE_ASSOCIATION: (CHC_T00007880001_1) or (CHC_T00005686001_1) or (CHC_T00007347001_1) or (CHC_T00007428001_1) or (CHC_T00007762001_1) or (CHC_T00009122001_1) or (CHC_T00008727001_1) or (CHC_T00009122001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTEIN__45__LIPOYLLYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMINOMETHYLDIHYDROLIPOYL__45__GCVH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13414" name="RXN-13414" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5905

GENE_ASSOCIATION: (CHC_T00005094001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SPERMIDINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__14378_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_OHMETHYLBILANESYN__45__RXN" name="OHMETHYLBILANESYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5188 , PWY-5189

GENE_ASSOCIATION: (CHC_T00003649001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PORPHOBILINOGEN_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_HYDROXYMETHYLBILANE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__68__45__RXN" name="3.2.1.68-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009540001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_1__45__6__45__alpha__45__D__45__glucan_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__6__45__alpha__45__D__45__glucan_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17876" name="methionyl aminopeptidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7800

GENE_ASSOCIATION: (CHC_T00008747001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__methionyl__45__L__45__seryl__45__Protein_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__terminal__45__L__45__Serine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13724" name="RXN-13724" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6105

GENE_ASSOCIATION: (CHC_T00001581001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__465_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SQUALENE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_CU__43__" name="ExchangeSeed_CU+" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CU__43___C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CU__43___e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__20" name="TRANS-RXN1HP7-20" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009493001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NITRATE_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRITE_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NITRITE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10717" name="indole acetaldehyde reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6307

GENE_ASSOCIATION: (CHC_T00009372001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_INDOLE_ACETALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__341_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12518" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6837

GENE_ASSOCIATION: (CHC_T00008478001_1) or (CHC_T00009142001_1) or (CHC_T00007910001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00008400001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_cis__45__5__45__enoyl__45__CoA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_trans__45__2__45__cis__45__5__45__dienoyl__45__CoA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CHORISMATE__45__SYNTHASE__45__RXN" name="Chorismate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6163

GENE_ASSOCIATION: (CHC_T00008653001) or (CHC_T00008653001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHORISMATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOMOACONITATE__45__HYDRATASE__45__RXN" name="HOMOACONITATE-HYDRATASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P241-PWY , PWY-3081 , LYSINE-AMINOAD-PWY

GENE_ASSOCIATION: (CHC_T00009184001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMO__45__I__45__CIT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HOMO__45__CIS__45__ACONITATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_EDTA" name="TransportSeed_EDTA" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_EDTA_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_EDTA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14228" name="nucleoside-diphosphate kinase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009258001_1) or (CHC_T00009233001_1) or (CHC_T00009258001) or (CHC_T00009233001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2231_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DITP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__14" name="RXN66-14" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00003466001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8609_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8610_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10654" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6282

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Cis__45__Delta5__45__dodecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__cis__45__D7__45__tetradecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5216" name="alpha-mannosidase type II manG" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1300

GENE_ASSOCIATION: (CHC_T00008655001_1) or (CHC_T00008655001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__1063_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15979_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCERATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12302" name="Pullulanase, Pul1" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008915001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Pullulans_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOTRIOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CDPDIGLYSYN__45__RXN" name="Phosphatidate cytidylyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1319 , PWY-5667 , PWY-5981 , PWY-7817

GENE_ASSOCIATION: (CHC_T00010117001_1) or (CHC_T00009577001_1) or (CHC_T00001603001_1) or (CHC_T00010117001) or (CHC_T00009577001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__PHOSPHATIDATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CDPDIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN__45__139" name="TRANS-RXN-139" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005091001_1) or (CHC_T00007738001_1) or (CHC_T00001610001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CL__45___e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CL__45___c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRUVDEH__45__RXN" name="pyruvate dehydrogenase E1 alpha subunit, mitochondrial precursor" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLYCOLYSIS-TCA-GLYOX-BYPASS , PWY-5482 , PWY-7384 , PWY-6886 , PWY-7218 , PWY-5537

GENE_ASSOCIATION: (CHC_T00007380001_1) or (CHC_T00008732001_1) or (CHC_T00008442001_1) or (CHC_T00007488001_1) or (CHC_T00010287001_1) or (CHC_T00008441001_1) or (CHC_T00008732001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5063" name="RXN0-5063" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000153001_1) or (CHC_T00003933001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_6__45__Dimethylallyladenosine37__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11592_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_R621__45__RXN" name="R621-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006886001_1) or (CHC_T00008774001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRIC__45__OXIDE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NITRATE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BUTANAL__45__DEHYDROGENASE__45__RXN__45__BUTANAL__47__CO__45__A__47__NAD__47____47__BUTYRYL__45__COA__47__NADH__47__PROTON__46__42__46__" name="BUTANAL-DEHYDROGENASE-RXN-BUTANAL/CO-A/NAD//BUTYRYL-COA/NADH/PROTON.42." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BUTANAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MONOPHENOL__45__MONOOXYGENASE__45__RXN" name="MONOPHENOL-MONOOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6481

GENE_ASSOCIATION: (CHC_T00005217001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_TYR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DOPAQUINONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="FOLYLPOLYGLUTAMATESYNTH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2161

GENE_ASSOCIATION: (CHC_T00000400001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11347" name="RXN-11347" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6470

GENE_ASSOCIATION: (CHC_T00007237001_1) or (CHC_T00006227001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12258_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9646_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__12303_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15137" name="RXN-15137" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008829001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13717_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__AMINOACRYLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SELENOHOMOCYSTEINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17778" name="RXN-17778" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19169_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19144_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9728" name="RXN-9728" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5794

GENE_ASSOCIATION: (CHC_T00008765001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Holo__45__malonate__45__decarboxylases_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Malonate__45__Decarboxylases__45__Malonyl__45__Form_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ATPPHOSPHORIBOSYLTRANS__45__RXN" name="ATPPHOSPHORIBOSYLTRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HISTSYN-PWY

GENE_ASSOCIATION: (CHC_T00000167001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHORIBOSYL__45__ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PRPP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__28" name="TRANS-RXN1HP7-28" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007419001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Polysaccharides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Polysaccharides_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PSERTRANSAM__45__RXN" name="phosphoserine aminotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SERSYN-PWY

GENE_ASSOCIATION: (CHC_T00009221001_1) or (CHC_T00009221001) or (CHC_T00000094001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__P__45__SERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__P__45__HYDROXYPYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1TRANSKETO__45__RXN__45__CPD__45__19339__47__GAP__47____47__RIBOSE__45__5P__47__XYLULOSE__45__5__45__PHOSPHATE__46__46__46__" name="1TRANSKETO-RXN-CPD-19339/GAP//RIBOSE-5P/XYLULOSE-5-PHOSPHATE.46." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19339_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_XYLULOSE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_RIBOSE__45__5P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYCERATE__45__DEHYDROGENASE__45__RXN" name="glyoxylate reductase/hydroxypyruvate reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-181

GENE_ASSOCIATION: (CHC_T00009559001_1) or (CHC_T00009559001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OH__45__PYR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13684" name="RXN-13684" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000215001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Mercapturates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_S__45__Substituted__45__L__45__Cysteines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CARBOXYMETHYLENEBUTENOLIDASE__45__RXN" name="CARBOXYMETHYLENEBUTENOLIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6193 , PWY-6087

GENE_ASSOCIATION: (CHC_T00004692001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_4__45__CARBOXYMETHYLENEBUT__45__2__45__EN__45__4__45__OLIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__294_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7828" name="RXN-7828" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5139 , PWY-5268

GENE_ASSOCIATION: (CHC_T00001656001_1) or (CHC_T00000989001_1) or (CHC_T00003244001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PELARGONIDIN__45__3__45__GLUCOSIDE__45__CMPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7137_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GAPDHSYNEC__45__RXN" name="GAPDHSYNEC-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009438001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DPG_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16622" name="beta-ketoacyl reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7664

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_7Z__45__3__45__oxo__45__hexadec__45__7__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3R__45__7Z__45__3__45__hydroxy__45__hexadec__45__7__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17792" name="Putative Acyl-COA dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009166001) or (CHC_T00009166001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19147_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19161_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__478" name="phytol dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-389

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHYTOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14926_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9670" name="RXN-9670" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5368 , PWY-5995 , PWY-6433 , PWY-7618

GENE_ASSOCIATION: (CHC_T00007447001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glycerolipids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oleoyl__45__lipid_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__12" name="4,4-dimethyl-14&alpha;-hydroxymethyl-5&alpha;-cholesta-8-en-3&beta;-ol 14-dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__8607_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8608_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HYDROHEX__45__RXN" name="HYDROHEX-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5410

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_13__45__HYDROPEROXYOCTADECA__45__911__45__DIENOATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_12__45__OXO__45__CIS__45__9__45__DODECENOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HEXANAL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MALIC__45__NADP__45__RXN" name="MALIC-NADP-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-241 , GLUCONEO-PWY , PWY-7117

GENE_ASSOCIATION: (CHC_T00009563001_1) or (CHC_T00008878001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PREPHENATEDEHYDROG__45__RXN" name="PREPHENATEDEHYDROG-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: TYRSYN , PWY-7303

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PREPHENATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_P__45__HYDROXY__45__PHENYLPYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PABASYN__45__RXN" name="PABASYN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6543

GENE_ASSOCIATION: (CHC_T00006848001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHORISMATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_4__45__AMINO__45__4__45__DEOXYCHORISMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14214" name="RXN-14214" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14774" name="RXN-14774" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7337

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15667_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15668_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__6__46__3__46__4__45__RXN" name="3.6.3.4-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000800001_1) or (CHC_T00005829001_1) or (CHC_T00004889001_1) or (CHC_T00004800001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CU__43__2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CU__43__2_e" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RNA__45__3__45__PHOSPHATE__45__CYCLASE__45__RXN" name="RNA-3-PHOSPHATE-CYCLASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003937001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__Prime__45__Phosphate__45__Terminated__45__RNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cyclic__45__Phosphate__45__Terminated__45__RNAs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14161" name="RXN-14161" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000267001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DAMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEOXYADENOSINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14240" name="baicalein peroxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7214

GENE_ASSOCIATION: (CHC_T00002409001_1) or (CHC_T00009160001_1) or (CHC_T00008578001_1) or (CHC_T00000152001_1) or (CHC_T00010263001_1) or (CHC_T00002083001_1) or (CHC_T00010024001_1) or (CHC_T00008640001_1) or (CHC_T00010209001_1) or (CHC_T00010179001_1) or (CHC_T00009550001_1) or (CHC_T00008635001_1) or (CHC_T00009516001_1) or (CHC_T00010289001_1) or (CHC_T00010094001_1) or (CHC_T00010161001_1) or (CHC_T00009008001_1) or (CHC_T00007624001_1) or (CHC_T00008271001_1) or (CHC_T00008590001_1) or (CHC_T00009515001_1) or (CHC_T00009006001_1) or (CHC_T00009490001_1) or (CHC_T00010108001_1) or (CHC_T00004197001_1) or (CHC_T00010243001_1) or (CHC_T00010133001_1) or (CHC_T00008836001_1) or (CHC_T00009226001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12724_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__15172_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1102" name="RXN-1102" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-361

GENE_ASSOCIATION: (CHC_T00009372001_1) or (CHC_T00007340001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_COUMARALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_COUMARYL__45__ALCOHOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__4261" name="ATP-dependent DNA helicase RecQ putative" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009451001_1) or (CHC_T00007861001_1) or (CHC_T00004400001_1) or (CHC_T00010224001_1) or (CHC_T00004316001_1) or (CHC_T00010196001) or (CHC_345) or (CHC_T00009335001) or (CHC_T00006639001_1) or (CHC_T00009451001) or (CHC_T00010333001) or (CHC_T00010105001) or (CHC_T00008621001) or (CHC_T00008412001) or (CHC_T00010244001) or (CHC_T00010344001) or (CHC_T00010224001) or (CHC_T00008329001) or (CHC_T00010230001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Supercoiled__45__Duplex__45__DNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Single__45__Stranded__45__DNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1K__45__87" name="RXN1K-87" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010274001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__787_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__786_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ASPARTATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="aspartate-semialdehyde dehydrogenase (AsA dehydrogenase)" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2942 , PWY-7153 , P101-PWY , HOMOSERSYN-PWY , PWY-5097 , PWY-6559 , PWY-6562 , PWY-2941 , DAPLYSINESYN-PWY

GENE_ASSOCIATION: (CHC_T00009423001) or (CHC_T00009423001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE__45__SEMIALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__BETA__45__ASPARTYL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSNACMURPENTATRANS__45__RXN" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PEPTIDOGLYCANSYN-PWY

GENE_ASSOCIATION: (CHC_T00007237001_1) or (CHC_T00006227001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_C1_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9646_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_C5_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CHALCONE__45__ISOMERASE__45__RXN" name="CHALCONE-ISOMERASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008856001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Chalcones_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FLAVANONES_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__100__45__RXN" name="isoprenylcysteine carboxyl methyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009080001) or (CHC_T00007107001_1) or (CHC_T00007321001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTEIN__45__C__45__TERMINAL__45__S__45__FARNESYL__45__L__45__CYSTEINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__45__AMINOLEVULINIC__45__ACID__45__SYNTHASE__45__RXN" name="5-AMINOLEVULINIC-ACID-SYNTHASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7536 , PWY-5189

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__AMINO__45__LEVULINATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17777" name="RXN-17777" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19171_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19169_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__7__46__7__46__13__45__RXN" name="2.7.7.13-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-882 , PWY-5659

GENE_ASSOCIATION: (CHC_T00009182001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MANNOSE__45__1P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GDP__45__MANNOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9758" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6055 , PWY-6054

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10472_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_SS__45__DIMETHYL__45__BETA__45__PROPIOTHETIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_THREONINE__45__ALDOLASE__45__RXN" name="THREONINE-ALDOLASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5436 , GLYSYN-THR-PWY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_THR_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLY_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETALD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UDPNACETYLMURAMATEDEHYDROG__45__RXN" name="UDPNACETYLMURAMATEDEHYDROG-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6386 , PWY-6387

GENE_ASSOCIATION: (CHC_T00000692001_1) or (CHC_T00007033001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_UDP__45__N__45__ACETYLMURAMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_AMMONIA" name="TransportSeed_AMMONIA" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMMONIA_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17372" name="RXN-17372" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7751

GENE_ASSOCIATION: (CHC_T00001829001)

CATEGORIES: MANUAL and GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19339_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18773_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16625" name="Beta-ketoacyl synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7664

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_7Z__45__hexadec__45__7__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_9Z__45__3__45__oxo__45__octadec__45__9__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5462" name="RXN0-5462" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006198001_1) or (CHC_T00000060001_1) or (CHC_T00007176001_1) or (CHC_T00001236001_1) or (CHC_T00010157001_1) or (CHC_T00005746001_1) or (CHC_T00001332001_1) or (CHC_T00004941001_1) or (CHC_T00003677001_1) or (CHC_T00008909001_1) or (CHC_T00004301001_1) or (CHC_T00007503001_1) or (CHC_T00003610001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DLACTDEHYDROGNAD__45__RXN" name="DLACTDEHYDROGNAD-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6901 , P122-PWY , PWY-6454 , ALACAT2-PWY , PWY4LZ-257 , FERMENTATION-PWY

GENE_ASSOCIATION: (CHC_T00003974001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__LACTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__350" name="RXN66-350" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007359001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD66__45__23_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD66__45__27_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14271" name="(S)-3-hydroxypalmitoyl-CoA oxidoreductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7656 , PWY-7654

GENE_ASSOCIATION: (CHC_T00008882001_1) or (CHC_T00009349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD0__45__2232_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__OXOPALMITOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MANNITOL__45__1__45__PHOSPHATASE__45__RXN" name="MANNITOL-1-PHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

SUBSYSTEM: PWY-3881 , PWY-6531

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MANNITOL__45__1P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MANNITOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__18__46__1__46__2__45__RXN" name="Ferredoxin-NADP+ oxidoreductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-101 , PWY-7230

GENE_ASSOCIATION: (CHC_T00008519001) or (CHC_T00008519001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__ferredoxins_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__ferredoxins_e" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11911" name="RXN-11911" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5434

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12568_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8847_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__8844_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__3641" name="cis-&Delta;21-39-hydroxy-40-methyl-C59:1-[acp] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWYG-321

GENE_ASSOCIATION: (CHC_T00005488001_1) or (CHC_T00003092001_1) or (CHC_T00006042001_1) or (CHC_T00009019001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_cis__45__D21__45__39__45__oxo__45__40__45__Me__45__C59__45__1__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_cis__45__21__45__CP__45__39__45__keto__45__40__45__Me__45__C60__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14326" name="RXN-14326" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6482

GENE_ASSOCIATION: (CHC_T00008650001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_2__45__3__45__CARBOXY__45__3__45__AMINOPROPYL__45__L__45__HISTIDINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DIPHTINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12086" name="RXN-12086" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000853001_1) or (CHC_T00000197001_1) or (CHC_T00000198001_1) or (CHC_T00009491001_1) or (CHC_T00009452001_1) or (CHC_T00005737001_1) or (CHC_T00008615001_1) or (CHC_T00002434001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13014_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_BUTYRIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13040_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HYDROXYPYRUVATE__45__REDUCTASE__45__RXN" name="glyoxylate reductase/hydroxypyruvate reductase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1622

GENE_ASSOCIATION: (CHC_T00009559001_1) or (CHC_T00009559001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLYCERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OH__45__PYR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__882" name="RXN0-882" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7560

GENE_ASSOCIATION: (CHC_T00003814001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROXY__45__METHYL__45__BUTENYL__45__DIP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__2__46__1__46__13__45__RXN" name="1.2.1.13-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CALVIN-PWY

GENE_ASSOCIATION: (CHC_T00009438001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DPG_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17875" name="methionyl aminopeptidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7800

GENE_ASSOCIATION: (CHC_T00008747001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__methionyl__45__glycyl__45__Protein_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_N__45__terminal__45__glycine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16165" name="methionine--tRNA ligase, cytoplasmic" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00009091001_1) or (CHC_T00007020001_1) or (CHC_T00006241001_1) or (CHC_T00009091001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Initiation__45__tRNAmet_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__methionyl__45__tRNAfmet_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12280" name="RXN-12280" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6724

GENE_ASSOCIATION: (CHC_T00009540001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Branched__45__Unphos__45__Amylopectin__45__Tails_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Linear__45__Malto__45__Oligosaccharides_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7043_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_THIAMINE" name="ExchangeSeed_THIAMINE" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_THIAMINE_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_THIAMINE_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8991" name="3-isopropylmalate dehydratase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6871 , LEUSYN-PWY

GENE_ASSOCIATION: (CHC_T00009087001_1) or (CHC_T00009184001_1) or (CHC_T00009184001) or (CHC_T00009087001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9451_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ALCOHOL__45__DEHYDROG__45__GENERIC__45__RXN" name="ALCOHOL-DEHYDROG-GENERIC-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010066001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Primary__45__Alcohols_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Aldehydes_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9140" name="RXN-9140" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5818 , PWY-7752

GENE_ASSOCIATION: (CHC_T00009338001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__19339_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9663_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_ADENOSYLCOBALAMIN" name="TransportSeed_ADENOSYLCOBALAMIN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADENOSYLCOBALAMIN_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYLCOBALAMIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5514" name="1-acylglycerol-3-phosphate O-acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Saturated__45__2__45__Lysophosphatidates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Saturated__45__Fatty__45__Acyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__3__45__4__45__Saturated__45__L__45__Phosphatidates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__6__46__5__46__4__45__RXN" name="1.6.5.4-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6370

GENE_ASSOCIATION: (CHC_T00006866001_1) or (CHC_T00004739001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__318_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASCORBATE_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LYSDECARBOX__45__RXN" name="LYSDECARBOX-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6375 , PWY0-1303 , PWY-6376 , PWY0-461 , PWY-5468 , PWY-6381 , PWY-6328

GENE_ASSOCIATION: (CHC_T00000266001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CADAVERINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1141" name="lipoate--GcvH protein ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006203001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Gcv__45__H_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LIPOIC__45__ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTEIN__45__LIPOYLLYSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTAMATE__45__SYNTHASE__45__FERREDOXIN__45__RXN" name="ferredoxin-dependent glutamate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6549 , PWY-4341 , PWY-6964

GENE_ASSOCIATION: (CHC_1080)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ASNSYNB__45__RXN" name="ASNSYNB-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ASPARAGINE-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00000667001_1) or (CHC_T00004458001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PEPTIDE__45__ALPHA__45__N__45__ACETYLTRANSFERASE__45__RXN" name="PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007027001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__terminal__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__Alpha__45__Acetylated__45__N__45__terminal__45__Amino__45__Acid_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16653" name="aldehyde dehydrogenase, (NAD) activity" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8490_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__3617_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17473" name="biotin synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009361001) or (CHC_T00009361001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__5662_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MYRISTOYLACYLTRAN__45__RXN" name="MYRISTOYLACYLTRAN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: KDO-LIPASYN-PWY , KDO-NAGLIPASYN-PWY

GENE_ASSOCIATION: (CHC_T00003589001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_KDO2__45__LAUROYL__45__LIPID__45__IVA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_KDO2__45__LIPID__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1126" name="RXN-1126" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1121 , PWY-6673 , PWY-7398

GENE_ASSOCIATION: (CHC_T00008160001_1) or (CHC_T00008472001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__676_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CAFFEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_ADENOSYLCOBALAMIN" name="ExchangeSeed_ADENOSYLCOBALAMIN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADENOSYLCOBALAMIN_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYLCOBALAMIN_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DNA__45__DIRECTED__45__RNA__45__POLYMERASE__45__RXN" name="RNA polymerase beta'' subunit" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002934001_1) or (CHC_T00009400001_1) or (CHC_T00006864001_1) or (CHC_T00010106001_1) or (CHC_T00003816001_1) or (CHC_T00003644001_1) or (CHC_T00004176001_1) or (CHC_T00009547001_1) or (CHC_T00000161001_1) or (CHC_T00008183001_1) or (CHC_T00004684001_1) or (CHC_T00006285001_1) or (CHC_T00002624001_1) or (CHC_T00005995001_1) or (CHC_T00004174001_1) or (CHC_T00008967001_1) or (CHC_T00010010001_1) or (CHC_T00004238001_1) or (CHC_T00004711001_1) or (CHC_T00006604001_1) or (CHC_T00010010001) or (CHC_805) or (CHC_490) or (CHC_T00009400001) or (CHC_800) or (CHC_T00010106001) or (CHC_1085)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RNA__45__Holder_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Nucleoside__45__Triphosphates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_RNA__45__Holder_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DCTP__45__PYROPHOSPHATASE__45__RXN" name="DCTP-PYROPHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7206

GENE_ASSOCIATION: (CHC_T00009365001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DCTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DCMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16393" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DODECANOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_LAUROYLCOA__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9661" name="trans dodec-2-enoyl-[acp] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Dodec__45__2__45__enoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Dodecanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17779" name="Putative Acyl-COA dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009166001) or (CHC_T00009166001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Oxidized_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19144_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19170_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ETF__45__Reduced_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_FPPSYN__45__RXN" name="FPPSYN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7721 , PWY-6859 , PWY-7102 , PWY-5123 , PWY-7736

GENE_ASSOCIATION: (CHC_T00006851001_1) or (CHC_T00002324001_1) or (CHC_T00008265001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DELTA3__45__ISOPENTENYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GERANYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FARNESYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16135" name="RXN-16135" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7606

GENE_ASSOCIATION: (CHC_T00009190001_1) or (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17386_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17387_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOMOSERDEHYDROG__45__RXN" name="HOMOSERDEHYDROG-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: HOMOSERSYN-PWY

GENE_ASSOCIATION: (CHC_T00008550001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__ASPARTATE__45__SEMIALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HOMO__45__SER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__579" name="myo-inositol 1-phosphate synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008380001_1) or (CHC_T00009031001_1) or (CHC_T00008380001) or (CHC_T00009031001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLC__45__6__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_1__45__L__45__MYO__45__INOSITOL__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_UDP__45__GLUCURONATE__45__DECARBOXYLASE__45__RXN" name="UDP-GLUCURONATE-DECARBOXYLASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4821

GENE_ASSOCIATION: (CHC_T00008912001_1) or (CHC_T00008950001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_UDP__45__GLUCURONATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UDP__45__D__45__XYLOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__25__46__1__45__RXN" name="Proteasome subunit alpha type" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005699001_1) or (CHC_T00009185001_1) or (CHC_T00008987001_1) or (CHC_T00008941001_1) or (CHC_T00009373001_1) or (CHC_T00008406001_1) or (CHC_T00005235001_1) or (CHC_T00009346001_1) or (CHC_T00005811001_1) or (CHC_T00009004001_1) or (CHC_T00008367001_1) or (CHC_T00009544001_1) or (CHC_T00008527001_1) or (CHC_T00005533001_1) or (CHC_T00009464001_1) or (CHC_T00009012001_1) or (CHC_T00008356001_1) or (CHC_T00005557001_1) or (CHC_T00001498001_1) or (CHC_T00008987001) or (CHC_T00008406001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13064" name="RXN-13064" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6992

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9446_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__mannopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__1__46__1__46__135__45__RXN" name="2.1.1.135-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009055001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_METHIONINE__45__SYNTHASE__45__METHYLCOBALAMIN_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Methionine__45__synthase__45__cob__45__II__45__alamins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7784" name="RXN-7784" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5152

GENE_ASSOCIATION: (CHC_T00009538001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7087_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7088_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_URATE__45__OXIDASE__45__RXN" name="URATE-OXIDASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5691

GENE_ASSOCIATION: (CHC_T00000418001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_URATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__HYDROXYISOURATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__6269" name="methylsterol monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__5845_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__5846_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_KYNURENINASE__45__RXN" name="KYNURENINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6309 , TRPCAT-PWY

GENE_ASSOCIATION: (CHC_T00002784001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14736_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ALPHA__45__ALANINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ANTHRANILATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10696" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00008400001_1) or (CHC_T00007910001_1) or (CHC_T00008478001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00009142001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11517_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11518_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ANTHRANSYN__45__RXN" name="ANTHRANSYN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRPSYN-PWY , PWY-6660 , PWY-5958 , PWY-6661

GENE_ASSOCIATION: (CHC_T00004489001_1) or (CHC_T00008898001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CHORISMATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ANTHRANILATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14771" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7337

GENE_ASSOCIATION: (CHC_T00008478001_1) or (CHC_T00009142001_1) or (CHC_T00007910001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00008400001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15637_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15666_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14371" name="1,4-alpha-Glucan branching enzyme" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-622

GENE_ASSOCIATION: (CHC_T00008662001) or (CHC_T00008662001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_1__45__4__45__alpha__45__D__45__Glucan_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Alpha__45__6__45__alpha__45__14__45__glucans_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8340" name="RXN-8340" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6823

GENE_ASSOCIATION: (CHC_T00000814001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19179_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11698" name="RXN-11698" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003694001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Farnesylated__45__CAAX__45__proteins_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9516" name="3-oxo-hexanoyl-[acyl-carrier protein] synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971 , PWY-7388

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Butanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__hexanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__1__46__1__46__8__45__RXN" name="1.1.1.8-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7411 , PWY-7385 , PWY-6118

GENE_ASSOCIATION: (CHC_T00009494001_1) or (CHC_T00008461001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROXY__45__ACETONE__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PHOSPHATIDYLINOSITOL__45__BISPHOSPHATASE__45__RXN" name="PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6368

GENE_ASSOCIATION: (CHC_T00005773001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__1108_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETOACETATE__45__DECARBOXYLASE__45__RXN" name="ACETOACETATE-DECARBOXYLASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-5451 , PWY-6876 , PWY-7466 , PWY66-367 , PWY-6588

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__KETOBUTYRATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETONE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__5515" name="Phosphatidate cytidylyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010117001_1) or (CHC_T00009577001_1) or (CHC_T00001603001_1) or (CHC_T00009577001) or (CHC_T00010117001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__3__45__4__45__Saturated__45__L__45__Phosphatidates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CDP__45__2__45__3__45__4__45__Saturated__45__Diacylglycerols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9644" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5147 , PWY-6001

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008500001_1) or (CHC_T00008811001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OLEATE__45__CPD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OLEOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__11__46__14__45__RXN" name="3.4.11.14-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002758001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Amino__45__Acids__45__20_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17472" name="biotin synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009361001) or (CHC_T00009361001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DETHIOBIOTIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Sulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH33ADO_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Unsulfurated__45__Sulfur__45__Acceptors_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__2Fe__45__2S__45__Ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__5662_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9632" name="3-oxo-stearoyl-[acyl-carrier protein] synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5989

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Palmitoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__stearoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14249" name="RXN-14249" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007340001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_THR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMINO__45__ACETONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__3521" name="Ascorbate Peroxidase, APX2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2261

GENE_ASSOCIATION: (CHC_T00010024001_1) or (CHC_T00008640001_1) or (CHC_T00010024001) or (CHC_T00008640001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ASCORBATE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__318_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1321" name="Lipoxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5410 , PWY-735

GENE_ASSOCIATION: (CHC_T00008739001) or (CHC_T00008739001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_LINOLENIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__725_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10701" name="RXN-10701" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11528_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11529_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__11__46__2__45__RXN" name="3.4.11.2-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002549001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_POLYPEPTIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__Amino__45__Acids_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_POLYPEPTIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MALATE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="NADP-malic enzyme" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-241 , PWY-7117

GENE_ASSOCIATION: (CHC_T00009563001) or (CHC_T00008878001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXALACETIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__7023" name="RXN0-7023" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00002327001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_RNASE__45__R__45__DEGRADATION__45__SUBSTRATE__45__RNA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Diribonucleotide_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Nucleoside__45__Monophosphates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_OXYGEN__45__MOLECULE" name="TransportSeed_OXYGEN-MOLECULE" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_6__46__2__46__1__46__34__45__RXN" name="6.2.1.34-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1121 , PWY-6343

GENE_ASSOCIATION: (CHC_T00008160001_1) or (CHC_T00008472001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_FERULIC__45__ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERULOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12565" name="RXN-12565" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6863

GENE_ASSOCIATION: (CHC_T00008981001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BUTYRYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_K__45__HEXANOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8630" name="RXN-8630" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5451 , PWY-7466

GENE_ASSOCIATION: (CHC_T00009144001_1) or (CHC_T00008302001_1) or (CHC_T00008799001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Red__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETONE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ox__45__NADPH__45__Hemoprotein__45__Reductases_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_LINOLENOYL__45__RXN" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7049 , PWY-7724

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LINOLENIC_ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LINOLENOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13415" name="RXN-13415" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5905

GENE_ASSOCIATION: (CHC_T00005094001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Deoxyhypusine__45__Synthase__45__Lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14378_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__313_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__4__45__aminobutylidene__45__enzyme__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP-CYCLOHYDRO-I-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7442 , PWY-6703 , PWY-6983 , PWY0-1433 , PWY-5664 , PWY-6147 , PWY-5663

GENE_ASSOCIATION: (CHC_T00001932001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDRONEOPTERIN__45__P3_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GAMMA__45__GLUTAMYLTRANSFERASE__45__RXN" name="GAMMA-GLUTAMYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005245001_1) or (CHC_T00000071001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__L__45__GLUTAMYL__45__PEPTIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Amino__45__Acids_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__L__45__GLUTAMYL__45__AMINO__45__ACID_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7660" name="RXN-7660" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5063

GENE_ASSOCIATION: (CHC_T00009478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHYTYL__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7003_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14389" name="RXN-14389" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7250

GENE_ASSOCIATION: (CHC_T00008003001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Co__45__chaperone__45__SP__45__2Fe2S__45__Complex_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FeS__45__Cluster__45__Chaperones__45__ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Chap__45__ATP__45__Co__45__chaperone__45__SP__45__2Fe2S__45__Complex_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GUANOSINE__45__DIPHOSPHATASE__45__RXN" name="GUANOSINE-DIPHOSPHATASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ARGININE__45__DEIMINASE__45__RXN" name="ARGININE-DEIMINASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4981 , ARGDEGRAD-PWY

GENE_ASSOCIATION: (CHC_T00008387001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ARG_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__CITRULLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14727" name="RXN-14727" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009018001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROPIONAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROPIONATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__1623" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRIGLSYN-PWY , PWY-5667

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Long__45__Chain__45__Acyl__45__CoAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACYL__45__SN__45__GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__PHOSPHATIDATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTSEMIALDEHYDROG__45__RXN" name="glutamate-5-semialdehyde dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PROSYN-PWY , PWY-6922 , ARGININE-SYN4-PWY , CITRULBIO-PWY , PWY-3341

GENE_ASSOCIATION: (CHC_T00008349001) or (CHC_T00008349001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__GLUTAMATE__45__5__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13444" name="RXN-13444" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7606 , PWY-7727 , PWY-7053

GENE_ASSOCIATION: (CHC_T00008580001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14424_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14425_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__3661" name="RXN-3661" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5640

GENE_ASSOCIATION: (CHC_T00009131001_1) or (CHC_T00009303001_1) or (CHC_T00008663001_1) or (CHC_T00009499001_1) or (CHC_T00008672001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00010004001_1) or (CHC_T00009062001_1) or (CHC_T00008616001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BENZENE__45__NO2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CATECHOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NITRITE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ExchangeSeed_AMMONIA" name="ExchangeSeed_AMMONIA" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_AMMONIA_C__45__BOUNDARY" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIA_e" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11832" name="RXN-11832" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7205

GENE_ASSOCIATION: (CHC_T00004355001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_325__45__BISPHOSPHATE__45__NUCLEOTIDASE__45__RXN" name="3'(2'),5'-bisphosphate nucleotidase, SAL3" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008808001_1) or (CHC_T00008454001_1) or (CHC_T00008597001) or (CHC_T00008808001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__5__45__ADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_CA__43__2" name="TransportSeed_CA+2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CA__43__2_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CA__43__2_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_METHIONINE__45____45__TRNA__45__LIGASE__45__RXN" name="methionine--tRNA ligase, cytoplasmic" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: TRNA-CHARGING-PWY

GENE_ASSOCIATION: (CHC_T00009091001_1) or (CHC_T00007020001_1) or (CHC_T00006241001_1) or (CHC_T00009091001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Elongation__45__tRNAMet_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MET_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Charged__45__MET__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_PHOSPHASERDECARB__45__RXN_CPD__45__18778" name="extended_PHOSPHASERDECARB-RXN_CPD-18778" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008892001)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18778_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASTERINA__45__330_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__CH3__45__2__45__OXOBUTANOATE__45__OH__45__CH3__45__XFER__45__RXN" name="3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PANTO-PWY

GENE_ASSOCIATION: (CHC_T00001868001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_METHYLENE__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETO__45__ISOVALERATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__DEHYDROPANTOATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14382" name="RXN-14382" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6892

GENE_ASSOCIATION: (CHC_T00008053001_1) or (CHC_T00000657001_1) or (CHC_T00009510001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Sulfur__45__Carrier__45__Proteins__45__ThiI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__Cysteine__45__Desulfurase__45__persulfide_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Sulfurylated__45__ThiI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Cysteine__45__Desulfurase__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__45__HYDROXYISOBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: VALDEG-PWY

GENE_ASSOCIATION: (CHC_T00008882001_1) or (CHC_T00009349001_1) or (CHC_T00008689001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12175_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CH3__45__MALONATE__45__S__45__ALD_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12583" name="pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008732001_1) or (CHC_T00008442001_1) or (CHC_T00008732001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THIAMINE__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__ALPHA__45__HYDROXYETHYL__45__THPP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17113" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7726

GENE_ASSOCIATION: (CHC_T00008478001_1) or (CHC_T00009142001_1) or (CHC_T00007910001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00008400001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18491_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18492_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACYL__45__COA__45__OXIDASE__45__RXN" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7007

GENE_ASSOCIATION: (CHC_T00008478001_1) or (CHC_T00009142001_1) or (CHC_T00007910001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00008400001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRANS__45__D2__45__ENOYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="L-GLN-FRUCT-6-P-AMINOTRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: UDPNACETYLGALSYN-PWY , UDPNAGSYN-PWY , PWY-6749

GENE_ASSOCIATION: (CHC_T00000154001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__GLUCOSAMINE__45__6__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17830" name="alpha-galactosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008413001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__2500_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__galactopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_P__45__NITROPHENOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__21__46__12__45__RXN" name="3.4.21.12-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004250001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN3O__45__8214" name="RXN3O-8214" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Myristoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TETRADECANOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10699" name="RXN-10699" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-735

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11520_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__11521_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TCX8" name="PEROXISOMAL ABC TRANSPORTER 1" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009461001_1) or (CHC_T00002085001_1) or (CHC_T00001929001_1) or (CHC_T00000757001_1) or (CHC_T00006026001_1) or (CHC_T00003552001_1) or (CHC_T00006926001_1) or (CHC_T00004718001_1) or (CHC_T00005019001_1) or (CHC_T00001951001_1) or (CHC_T00000701001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ATP_x" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5841" name="RXN-5841" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NAD-BIOSYNTHESIS-II , PWY-5381

GENE_ASSOCIATION: (CHC_T00000267001_1) or (CHC_T00008300001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NICOTINAMIDE_NUCLEOTIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NICOTINAMIDE_RIBOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11758" name="RXN-11758" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Demethylated__45__Ubiquinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquinols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5466" name="RXN-5466" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS

GENE_ASSOCIATION: (CHC_T00009519001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__5164_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__171_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__5165_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DOLICHOLP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__1__46__4__46__11__45__RXN" name="3.1.4.11-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6351 , PWY-7039 , LIPASYN-PWY , PWY-6367

GENE_ASSOCIATION: (CHC_T00005154001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TransportSeed_THIAMINE" name="TransportSeed_THIAMINE" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_THIAMINE_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_THIAMINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11046" name="RXN-11046" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001339001_1) or (CHC_T00005416001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Demethylmenaquinols_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Menaquinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15512" name="RXN-15512" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001241001_1) or (CHC_T00007707001_1) or (CHC_T00000449001_1) or (CHC_T00001519001_1) or (CHC_T00004201001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__16758_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Protein__45__pi__45__phospho__45__L__45__histidines_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Protein__45__Histidines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_23__45__DIPHOSPHOGLYCERATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIMETHYLARGININASE__45__RXN" name="DIMETHYLARGININASE-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004102001_1) or (CHC_T00007155001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__596_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_L__45__CITRULLINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIMETHYLAMINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN1G__45__460" name="Beta-ketoacyl synthase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9965_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__oxo__45__behenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_MRNA__45__GUANINE__45__N7__45____45__METHYLTRANSFERASE__45__RXN" name="MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7375

GENE_ASSOCIATION: (CHC_T00002741001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_G5__45__pppR__45__mRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_m7G5__45__pppR__45__mRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__1281" name="dihydrouridine synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004349001_1) or (CHC_T00009368001_1) or (CHC_T00009368001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNA__45__uridines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_tRNA__45__Dihydrouridines_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AMYLOMALT__45__RXN" name="Disproportionating Enzyme type 2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLYCOCAT-PWY

GENE_ASSOCIATION: (CHC_T00009120001_1) or (CHC_T00009120001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALTOTRIOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOTETRAOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PEPTIDE__45__ASPARTATE__45__BETA__45__DIOXYGENASE__45__RXN" name="PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007294001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Protein__45__L__45__Aspartates_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SUC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Peptide__45__3__45__hydroxy__45__L__45__Aspartates_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__8__46__4__46__9__45__RXN" name="1.8.4.9-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: SULFMETII-PWY

GENE_ASSOCIATION: (CHC_T00009224001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_APS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXIDIZED__45__GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13711" name="4,4-dimethyl-5&alpha;-cholesta-8-en-3-&beta;-ol 4-monooxygenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_CPD__45__8610_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8613_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="4" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13602" name="linustatin &beta;-diglucosidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7091

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14594_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LINAMARIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10625" name="RXN-10625" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="3" constant="false"/>
         <speciesReference species="M_GERANYLGERANYL__45__PP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PHYTYL__45__PYROPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="3" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PROSTAGLANDIN__45__E__45__SYNTHASE__45__RXN" name="PROSTAGLANDIN-E-SYNTHASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-374

GENE_ASSOCIATION: (CHC_T00007112001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROSTAGLANDIN__45__H2_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_5Z13E__45__15S__45__1115__45__DIHYDROXY__45__9__45__OXOPROS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12729" name="RXN-12729" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6936

GENE_ASSOCIATION: (CHC_T00008829001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13717_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SELENOHOMOCYSTEINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__947" name="RXN0-947" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-501

GENE_ASSOCIATION: (CHC_T00001081001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Lipoyl__45__Protein__45__L__45__Lysine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Octanoylated__45__domains_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLU6PDEHYDROG__45__RXN" name="glucose 6 phosphate 1 dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7268 , RUMP-PWY , OXIDATIVEPENT-PWY , P122-PWY , GLYCOLYSIS-E-D

GENE_ASSOCIATION: (CHC_T00005901001_1) or (CHC_T00010152001_1) or (CHC_T00010152001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_D__45__glucopyranose__45__6__45__phosphate_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15089" name="RXN-15089" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7420

GENE_ASSOCIATION: (CHC_T00001533001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11690_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OLEATE__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16418" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-1121

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OCTADEC__45__9__45__ENE__45__118__45__DIOIC__45__ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17624_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__342" name="RXN66-342" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-378

GENE_ASSOCIATION: (CHC_T00007359001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__BETA__45__HYDROXYANDROST__45__5__45__EN__45__17__45__ONE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD66__45__29_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_4__46__1__46__1__46__68__45__RXN" name="4.1.1.68-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: 3-HYDROXYPHENYLACETATE-DEGRADATION-PWY

GENE_ASSOCIATION: (CHC_T00010274001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__785_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__786_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANS__45__RXN1HP7__45__27" name="TRANS-RXN1HP7-27" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000780001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SULFONATES_e" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SULFONATES_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANSENOYLCOARED__45__RXN" name="trans-2-enoyl-CoA reductase (NADPH)" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008438001) or (CHC_T00008594001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TRANS__45__D2__45__ENOYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Saturated__45__Fatty__45__Acyl__45__CoA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HOMSUCTRAN__45__RXN" name="HOMSUCTRAN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: HOMOSER-METSYN-PWY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_HOMO__45__SER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SUC__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_O__45__SUCCINYL__45__L__45__HOMOSERINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16117" name="glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6453

GENE_ASSOCIATION: (CHC_T00008773001) or (CHC_T00008773001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17370_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17372_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__106__45__RXN" name="3.2.1.106-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009379001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__13936_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__13937_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BIOTIN__45__CARBOXYL__45__RXN" name="BIOTIN-CARBOXYL-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-1264

GENE_ASSOCIATION: (CHC_T00009359001_1) or (CHC_T00007145001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BCCP__45__dimers_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HCO3_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Carboxybiotin__45__BCCP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRIDOXAL__45__4__45__DEHYDROGENASE__45__RXN" name="3-oxoacyl-(acyl-carrier-protein) reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5499

GENE_ASSOCIATION: (CHC_T00008477001) or (CHC_T00008496001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRIDOXAL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__375_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRUFLAVREDUCT__45__RXN" name="PYRUFLAVREDUCT-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P23-PWY , PWY-5497 , PWY-6876 , P42-PWY , PWY-6583 , PWY-5493 , PWY-5392 , PWY-6587 , GLUDEG-II-PWY , PWY-5483 , NPGLUCAT-PWY , P142-PWY , PWY-6588 , PWY-6142 , CENTFERM-PWY , PWY-6863 , PWY-5600 , PWY-5538

GENE_ASSOCIATION: (CHC_T00008442001_1) or (CHC_T00003376001_1) or (CHC_T00001730001_1) or (CHC_T00008758001_1) or (CHC_T00001454001_1) or (CHC_T00000866001_1) or (CHC_T00000865001_1) or (CHC_T00003402001_1) or (CHC_T00009061001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRUVATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9237" name="RXN-9237" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5857 , PWY-5872

GENE_ASSOCIATION: (CHC_T00007491001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__9873_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9958_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14142" name="RXN-14142" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000267001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DGMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEOXYGUANOSINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__17" name="4&alpha;-formyl-4&beta;-methyl-5&alpha;-cholesta-8-en-3&beta;-ol 4-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00010320001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8612_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8613_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11474" name="3-oxo-glutaryl-[acp] methyl ester synthase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6519

GENE_ASSOCIATION: (CHC_T00009465001_1) or (CHC_T00009465001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Malonyl__45__acp__45__methyl__45__ester_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALONYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__Ketoglutaryl__45__ACP__45__methyl__45__ester_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DEOXYRIBODIPYRIMIDINE__45__PHOTOLYASE__45__RXN" name="deoxyribodipyrimidine photolyase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00001477001_1) or (CHC_T00010314001_1) or (CHC_T00007328001_1) or (CHC_T00010174001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DNA__45__With__45__Pyrimidine__45__Dimers_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DNA__45__Adjacent__45__Pyrimidines_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__37" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-0

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008575001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__30_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__35_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5284" name="Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CHLOROPHYLL-SYN , PWY-7159

GENE_ASSOCIATION: (CHC_670)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__4__46__21__46__92__45__RXN" name="ATP-dependent Clp protease proteolytic subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008800001_1) or (CHC_T00008883001_1) or (CHC_T00002660001_1) or (CHC_T00008948001_1) or (CHC_T00008562001_1) or (CHC_T00008566001_1) or (CHC_T00008883001) or (CHC_T00008948001) or (CHC_T00008800001) or (CHC_T00008566001) or (CHC_T00008562001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_General__45__Protein__45__Substrates_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Peptides__45__holder_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PYRAZIN__45__RXN" name="PYRAZIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009018001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRAZINAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PYRAZINOIC__45__ACID_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7716" name="dihydrolipoamide dehydrogenase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5084

GENE_ASSOCIATION: (CHC_T00010287001_1) or (CHC_T00008441001_1) or (CHC_T00008312001_1) or (CHC_T00008441001) or (CHC_T00010287001) or (CHC_T00008312001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxo__45__glutarate__45__dehydrogenase__45__DH__45__lipoyl_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Oxo__45__glutarate__45__dehydrogenase__45__lipoyl_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14014" name="RXN-14014" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2941 , PWY-2942 , DAPLYSINESYN-PWY , PWY-5097

GENE_ASSOCIATION: (CHC_T00003353001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__14443_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14073" name="Glycerophosphoryl diester phosphodiesterase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009254001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROPHOSPHOGLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCEROL__45__3P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLYCEROL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14775" name="acyl-CoA oxidase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7337

GENE_ASSOCIATION: (CHC_T00008478001_1) or (CHC_T00009142001_1) or (CHC_T00007910001_1) or (CHC_T00009531001_1) or (CHC_T00008935001_1) or (CHC_T00008400001_1) or (CHC_T00008400001) or (CHC_T00009531001) or (CHC_T00008935001) or (CHC_T00009142001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15668_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_HYDROGEN__45__PEROXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15654_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_extended_RXN__45__17371" name="extended_RXN-17371" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (Scaffold115_53074_54093)

CATEGORIES: MANUAL

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__18777_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PORPHYRA__45__334_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9386" name="RXN-9386" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5921

GENE_ASSOCIATION: (CHC_T00008453001_1) or (CHC_T00002361001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GLN__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__glutamyl__45__tRNAGln_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14223" name="RXN-14223" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004774001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__DEOXYRIBOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DEOXY__45__RIBOSE__45__5P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_2__46__5__46__1__46__41__45__RXN" name="2.5.1.41-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6349

GENE_ASSOCIATION: (CHC_T00008265001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GERANYLGERANYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SN__45__GLYCEROL__45__1__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_SN__45__GERANYLGERANYLGLYCERYL__45__1__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__306" name="14-demethyllanosterol &Delta;14 reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074 , PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00003466001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__161" name="RXN-161" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

SUBSYSTEM: PWY-7396 , PWY-6883 , PWY-6583

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_BUTANOL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BUTANAL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16628" name="RXN-16628" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7664

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2E__45__9Z__45__octadeca__45__2__45__9__45__dienoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oleoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11737" name="aspartate aminotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6643 , PWY-6638 , PWY-6642

GENE_ASSOCIATION: (CHC_T00005085001_1) or (CHC_T00009477001_1) or (CHC_T00006498001_1) or (CHC_T00003344001_1) or (CHC_T00010197001) or (CHC_T00008432001) or (CHC_T00010017001) or (CHC_T00009477001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__CYSTEATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__380_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_3__46__2__46__1__46__21__45__RXN" name="3.2.1.21-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009266001_1) or (CHC_T00009011001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Beta__45__D__45__glucosides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Non__45__Glucosylated__45__Glucose__45__Acceptors_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN0__45__2023" name="RXN0-2023" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007882001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_tRNA__45__uridine34_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Donor__45__H2_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TusE__45__S__45__sulfanylcysteine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_TusE__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Acceptor_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_tRNA__45__2__45__thiouridine34_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17776" name="RXN-17776" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009110001_1) or (CHC_T00009349001_1) or (CHC_T00009422001_1) or (CHC_T00009190001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19172_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19171_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10659" name="beta-ketoacyl reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6282

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_3__45__oxo__45__cis__45__D9__45__hexadecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3__45__hydroxy__45__cis__45__D9__45__hexaecenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11838" name="RXN-11838" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006820001_1) or (CHC_T00003130001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_23S__45__rRNA__45__uridine955__45__2504__45__2580_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_23S__45__rRNA__45__pseudouridine955__45__2504__45__2580_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11835" name="RXN-11835" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00006820001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_23S__45__rRNA__45__uridine2604_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_23S__45__rRNA__45__pseudouridine2604_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_TRANSALDOL__45__RXN__45__CPD__45__19339__47__GAP__47____47__FRUCTOSE__45__6P__47__ERYTHROSE__45__4P__46__40__46__" name="TRANSALDOL-RXN-CPD-19339/GAP//FRUCTOSE-6P/ERYTHROSE-4P.40." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GAP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19339_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FRUCTOSE__45__6P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ERYTHROSE__45__4P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__10912" name="aldehyde dehydrogenase, (NAD) activity" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6342

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROXYPHENYLGLYCOLALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11879_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_SPERMINE__45__SYNTHASE__45__RXN" name="SPERMINE-SYNTHASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: POLYAMINSYN3-PWY , ARGSPECAT-PWY

GENE_ASSOCIATION: (CHC_T00009140001_1) or (CHC_T00002289001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_SPERMIDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINAMINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_SPERMINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__METHYLTHIOADENOSINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14177" name="RXN-14177" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008031001_1) or (CHC_T00008204001_1) or (CHC_T00000947001_1) or (CHC_T00006177001_1) or (CHC_T00008919001_1) or (CHC_T00005416001_1) or (CHC_T00001339001_1) or (CHC_T00000517001_1) or (CHC_T00000214001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15152_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__15153_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_PANTEPADENYLYLTRAN__45__RXN" name="PANTEPADENYLYLTRAN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: COA-PWY-1 , COA-PWY

GENE_ASSOCIATION: (CHC_T00003078001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PANTETHEINE__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_DEPHOSPHO__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__14__46__13__46__78__45__RXN" name="ent-kaurene 19-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5034 , PWY-5047

GENE_ASSOCIATION: (CHC_T00009499001_1) or (CHC_T00008616001_1) or (CHC_T00009131001_1) or (CHC_T00010004001_1) or (CHC_T00010245001_1) or (CHC_T00008813001_1) or (CHC_T00008672001_1) or (CHC_T00009062001_1) or (CHC_T00008663001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD1F__45__128_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ENT__45__KAUR__45__16__45__EN__45__19__45__OL_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14260" name="Disproportionating Enzyme type 2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009120001_1) or (CHC_T00009120001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_MALTOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_MALTOTETRAOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_MALTOPENTAOSE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Glucopyranose_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9556" name="3-oxo-cis-vaccenoyl-[acyl-carrier protein] reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5973

GENE_ASSOCIATION: (CHC_T00008557001) or (CHC_T00008477001) or (CHC_T00008496001) or (CHC_T00008517001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_3__45__oxo__45__cis__45__vaccenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_R__45__3__45__hydroxy__45__cis__45__vaccenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_1__46__3__46__7__46__4__45__RXN" name="1.3.7.4-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7170

GENE_ASSOCIATION: (CHC_T00003760001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Reduced__45__ferredoxins_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_BILIVERDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_3Z__45__PHYTOCHROMOBILIN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Oxidized__45__ferredoxins_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17781" name="RXN-17781" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009349001_1) or (CHC_T00008557001_1) or (CHC_T00009422001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__19168_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19167_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__7658" name="RXN-7658" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5063

GENE_ASSOCIATION: (CHC_T00009478001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7002_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GERANYLGERANYL__45__PP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16415__45__TETRACOSANOATE__47__ATP__47__CO__45__A__47____47__CPD__45__10280__47__AMP__47__PPI__46__43__46__" name="RXN-16415-TETRACOSANOATE/ATP/CO-A//CPD-10280/AMP/PPI.43." reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_TETRACOSANOATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__10280_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GART__45__RXN" name="GART-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6121 , PWY-6613

GENE_ASSOCIATION: (CHC_T00006609001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FORMYL__45__THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_THF__45__GLU__45__N_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_5__46__3__46__4__46__1__45__RXN" name="5.3.4.1-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009389001_1) or (CHC_T00008626001_1) or (CHC_T00006120001_1) or (CHC_T00008968001_1) or (CHC_T00008734001_1) or (CHC_T00004331001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Proteins__45__with__45__incorrect__45__disulfides_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Proteins__45__with__45__correct__45__disulfides_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9025" name="Starch phosphorylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5941 , GLYCOCAT-PWY

GENE_ASSOCIATION: (CHC_T00008988001_1) or (CHC_T00008988001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__1027_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__16401" name="long-chain-fatty-acid-CoA ligase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6733

GENE_ASSOCIATION: (CHC_T00009428001_1) or (CHC_T00008811001_1) or (CHC_T00008500001_1) or (CHC_T00008160001_1) or (CHC_T00009428001) or (CHC_T00008811001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__17640_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__17641_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15556" name="ubiquitin-conjugating enzyme E2" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7511

GENE_ASSOCIATION: (CHC_T00006794001_1) or (CHC_T00002999001_1) or (CHC_T00004619001_1) or (CHC_T00010007001_1) or (CHC_T00005531001_1) or (CHC_T00001326001_1) or (CHC_T00009159001_1) or (CHC_T00004299001_1) or (CHC_T00010346001_1) or (CHC_T00009526001_1) or (CHC_T00005234001_1) or (CHC_T00007701001_1) or (CHC_T00006980001_1) or (CHC_T00006427001_1) or (CHC_T00003966001_1) or (CHC_T00003230001_1) or (CHC_T00002417001_1) or (CHC_T00002791001_1) or (CHC_T00002169001_1) or (CHC_T00008828001_1) or (CHC_T00010352001_1) or (CHC_T00005498001_1) or (CHC_T00004379001_1) or (CHC_T00004399001_1) or (CHC_T00000123001_1) or (CHC_T00006277001_1) or (CHC_T00003204001_1) or (CHC_T00007651001_1) or (CHC_T00008502001_1) or (CHC_T00000387001_1) or (CHC_T00009466001_1) or (CHC_T00008443001_1) or (CHC_T00002451001_1) or (CHC_T00009358001_1) or (CHC_T00004841001_1) or (CHC_T00009526001) or (CHC_T00009358001) or (CHC_T00008443001) or (CHC_T00009466001) or (CHC_T00010346001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ubiquitinyl__45__UAP__45__E1__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquitin__45__carrier__45__protein__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Ubiquitin__45__activating__45__protein__45__E1__45__L__45__cys_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_S__45__ubiquitinyl__45__UCP__45__E2__45__L__45__cysteine_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GALACTURIDYLYLTRANS__45__RXN" name="GALACTURIDYLYLTRANS-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-422 , PWY-6527 , PWY-6317

GENE_ASSOCIATION: (CHC_T00010193001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_GALACTOSE__45__1P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__12575_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLC__45__1__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__14553_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__5822" name="RXN-5822" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: NADPHOS-DEPHOS-PWY , NAD-BIOSYNTHESIS-II , PWY-5083

GENE_ASSOCIATION: (CHC_T00002031001_1) or (CHC_T00000494001_1) or (CHC_T00001956001_1) or (CHC_T00005741001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACP__45__S__45__ACETYLTRANSFER__45__RXN" name="ACP-S-ACETYLTRANSFER-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5966 , FASYN-INITIAL-PWY

GENE_ASSOCIATION: (CHC_T00009465001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ACETYL__45__COA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACETYL__45__ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13334" name="RXN-13334" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00005154001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__1108_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_INOSITOL__45__1__45__4__45__BISPHOSPHATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIACYLGLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_OROTPDECARB__45__RXN" name="OROTPDECARB-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7791 , PWY-7790 , PWY-5686

GENE_ASSOCIATION: (CHC_T00002698001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OROTIDINE__45__5__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17607" name="nitrilase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00008379001_1) or (CHC_T00008379001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_2__45__HYDROXY__45__2__45__METHYLPROPANENITRILE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__19014_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_HISTONE__45__LYSINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00007737001_1) or (CHC_T00001983001_1) or (CHC_T00005569001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_S__45__ADENOSYLMETHIONINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Histone__45__L__45__lysine_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__8579_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADENOSYL__45__HOMO__45__CYS_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLYCERONE__45__KINASE__45__RXN" name="GLYCERONE-KINASE-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: P185-PWY , PWY-6131

GENE_ASSOCIATION: (CHC_T00009570001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DIHYDROXYACETONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDROXY__45__ACETONE__45__PHOSPHATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ISOCITRATE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Isocitrate dehydrogenase, NAD-dependent" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5690 , PWY66-398 , PWY-6549

GENE_ASSOCIATION: (CHC_T00009162001_1) or (CHC_T00008852001_1) or (CHC_T00009293001_1) or (CHC_T00009162001) or (CHC_T00009293001) or (CHC_T00008852001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_THREO__45__DS__45__ISO__45__CITRATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__13037" name="octanoyl:GcvH transferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7382 , PWY-6987

GENE_ASSOCIATION: (CHC_T00001081001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Gcv__45__H_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Octanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Octanoylated__45__Gcv__45__H_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9629" name="RXN-9629" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__9965_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ARACHIDIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_BADH__45__RXN" name="BADH-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY1F-353 , CHOLINE-BETAINE-ANA-PWY , PWY-3722 , PWY-7494 , BETSYN-PWY

GENE_ASSOCIATION: (CHC_T00008575001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_BETAINE_ALDEHYDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_BETAINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14046" name="Pyridoxal phosphatase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7204

GENE_ASSOCIATION: (CHC_T00008718001)

CATEGORIES: ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PYRIDOXAMINE__45__5P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PYRIDOXAMINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTKIN__45__RXN" name="GLUTKIN-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: CITRULBIO-PWY , PWY-3341 , ARGININE-SYN4-PWY , PROSYN-PWY , PWY-6922

GENE_ASSOCIATION: (CHC_T00008349001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__GLUTAMATE__45__5__45__P_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_NADH__45__DEHYDROG__45__A__45__RXN" name="NADH-DEHYDROG-A-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4302 , PWY0-1334 , PWY-3781 , PWY-6692 , PWY0-1335 , PWY-5083

GENE_ASSOCIATION: (CHC_T00008582001_1) or (CHC_T00003883001_1) or (CHC_T00007379001_1) or (CHC_T00010220001_1) or (CHC_T00009463001_1) or (CHC_T00000309001_1) or (CHC_T00009457001_1) or (CHC_T00004832001_1) or (CHC_T00006423001_1) or (CHC_T00008807001_1) or (CHC_T00010290001_1) or (CHC_T00009333001_1) or (CHC_T00010087001_1) or (CHC_T00008467001_1) or (CHC_T00007090001_1) or (CHC_T00001734001_1) or (CHC_T00010112001_1) or (CHC_T00004265001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="5" constant="false"/>
         <speciesReference species="M_Ubiquinones_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_e" stoichiometry="4" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Ubiquinols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN3O__45__218" name="RXN3O-218" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-2541 , PWY-6075

GENE_ASSOCIATION: (CHC_T00006481001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FERROCYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_EPISTEROL_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_FERRICYTOCHROME__45__B5_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_CPD__45__700_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DIHYDRONEOPTERIN__45__MONO__45__P__45__DEPHOS__45__RXN" name="DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7539 , PWY-6797 , PWY-6147

GENE_ASSOCIATION: (CHC_T00000109001_1) or (CHC_T00010215001_1) or (CHC_T00007861001_1) or (CHC_T00003907001_1) or (CHC_T00002083001_1) or (CHC_T00007752001_1) or (CHC_T00003258001_1) or (CHC_T00002743001_1) or (CHC_T00000137001_1) or (CHC_T00008309001_1) or (CHC_T00003277001_1) or (CHC_T00001386001_1) or (CHC_T00010142001_1) or (CHC_T00009449001_1) or (CHC_T00005127001_1) or (CHC_T00003332001_1) or (CHC_T00010119001_1) or (CHC_T00010343001_1) or (CHC_T00010240001_1) or (CHC_T00010340001_1) or (CHC_T00010060001_1) or (CHC_T00002646001_1) or (CHC_T00009294001_1) or (CHC_T00000427001_1) or (CHC_T00008748001_1) or (CHC_T00008721001_1) or (CHC_T00009222001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDRONEOPTERIN__45__P_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DIHYDRO__45__NEO__45__PTERIN_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11717" name="RXN-11717" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6627

GENE_ASSOCIATION: (CHC_T00009385001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__12673_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__11020_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14227" name="RXN-14227" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00000267001_1) or (CHC_T00008300001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NICOTINATE_NUCLEOTIDE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8259_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_URKI__45__RXN" name="GTP:uridine 5'-phosphotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00004071001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_URIDINE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_UMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9344__45__CPD__45__10279__47__NADPH__47__PROTON__47____47__CPD__45__7845__47__CO__45__A__47__NADP__46__43__46__" name="RXN-9344-CPD-10279/NADPH/PROTON//CPD-7845/CO-A/NADP.43." reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__10279_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7845_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ASPAMINOTRANS__45__RXN" name="aspartate aminotransferase" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLUTDEG-PWY , PWY-5913 , ASPARTATESYN-PWY , PWY-7115 , PWY-7117 , ASPARTATE-DEG1-PWY , MALATE-ASPARTATE-SHUTTLE-PWY , PWY-7383 , ASPARAGINE-DEG1-PWY-1

GENE_ASSOCIATION: (CHC_T00003344001_1) or (CHC_T00009477001_1) or (CHC_T00006498001_1) or (CHC_T00005085001_1) or (CHC_T00010197001) or (CHC_T00008432001) or (CHC_T00010017001) or (CHC_T00009477001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_2__45__KETOGLUTARATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXALACETIC_ACID_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__9660" name="trans-&Delta;2-decenoyl-[acp]-reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5971

GENE_ASSOCIATION: (CHC_T00009325001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Trans__45__D2__45__decenoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Decanoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__12244" name="15-cis-phytoene desaturase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6475

GENE_ASSOCIATION: (CHC_T00009492001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PLASTOQUINONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__13171_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__7535_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Plastoquinols_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTRNAREDUCT__45__RXN" name="glutamyl-tRNA reductase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5188

GENE_ASSOCIATION: (CHC_T00009215001) or (CHC_T00009215001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Charged__45__GLT__45__tRNAs_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLUTAMATE__45__1__45__SEMIALDEHYDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT__45__tRNAs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17013" name="1-acyl-sn-glycerol-3-phosphate acyltransferase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00009396001_1) or (CHC_T00008713001_1) or (CHC_T00009396001) or (CHC_T00009195001) or (CHC_T00008325001) or (CHC_T00008713001) or (CHC_T00008526001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Palmitoleoyl__45__ACPs_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__18348_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__18351_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ACP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__15088" name="RXN-15088" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7420

GENE_ASSOCIATION: (CHC_T00001533001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD0__45__1812_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLYCEROL_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OLEATE__45__CPD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-7219

GENE_ASSOCIATION: (CHC_T00009314001) or (CHC_T00009314001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_IMP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GTP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADENYLOSUCC_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GDP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="GLUTATHIONE-REDUCT-NADPH-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-4081 , GLUT-REDOX-PWY

GENE_ASSOCIATION: (CHC_T00004712001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXIDIZED__45__GLUTATHIONE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_GLUTATHIONE_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_CARBPSYN__45__RXN" name="carbamoyl phosphate synthase small subunit" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-5154 , PWY-5686 , ARGSYNBSUB-PWY , PWY-7400 , PWY-7791 , PWY-7790 , ARGSYN-PWY

GENE_ASSOCIATION: (CHC_T00008596001_1) or (CHC_T00010056001_1) or (CHC_70)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ATP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_GLN_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_HCO3_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ADP_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBAMOYL__45__P_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_GLT_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__17743" name="RXN-17743" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

CATEGORIES: GAP-FILLING

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_NADPH_c" stoichiometry="2" constant="false"/>
         <speciesReference species="M_PALMITYL__45__COA_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CO__45__A_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__348_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADP_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__11" name="24,25-dihydrolanosterol 14-hydroxylase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-3

GENE_ASSOCIATION: (CHC_T00009303001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_NADPH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8606_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_OXYGEN__45__MOLECULE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__8607_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ASPARAGHYD__45__RXN" name="ASPARAGHYD-RXN" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: ASPARAGINE-DEG1-PWY-1 , ASPARAGINE-DEG1-PWY , ASPASN-PWY

GENE_ASSOCIATION: (CHC_T00000306001_1) or (CHC_T00002545001_1) or (CHC_T00001474001_1) or (CHC_T00002449001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_ASN_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AMMONIUM_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ASPARTATE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__476" name="fatty aldehyde dehydrogenase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY66-388

GENE_ASSOCIATION: (CHC_T00008341001_1) or (CHC_T00008341001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_Odd__45__Straight__45__Chain__45__234__45__Sat__45__FALD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_NADH_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Odd__45__Straight__45__Chain__45__234__45__Sat__45__FA_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="2" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8042" name="Carotene isomerase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6475

GENE_ASSOCIATION: (CHC_T00008475001) or (CHC_T00008475001_1)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__7496_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD1F__45__114_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__11357" name="9,9&prime;-dicis-&zeta;-carotene desaturase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6475

GENE_ASSOCIATION: (CHC_T00008407001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ETR__45__Quinones_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7524_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ETR__45__Quinols_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CPD__45__7496_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN66__45__313" name="RXN66-313" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6074 , PWY66-4 , PWY66-341

GENE_ASSOCIATION: (CHC_T00003646001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_CPD__45__4577_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NAD__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_CPD__45__4578_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_CARBON__45__DIOXIDE_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_NADH__45__P__45__OR__45__NOP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_ACETYLORNDEACET__45__RXN" name="ACETYLORNDEACET-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: GLUTORN-PWY

GENE_ASSOCIATION: (CHC_T00003504001_1) or (CHC_T00000215001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_N__45__ALPHA__45__ACETYLORNITHINE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_ACET_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_L__45__ORNITHINE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__14218" name="RXN-14218" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

GENE_ASSOCIATION: (CHC_T00003677001_1) or (CHC_T00001236001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DGDP_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_Pi_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DGMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_AICARSYN__45__RXN" name="AICARSYN-RXN" reversible="true" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY-6124 , PWY-6123 , PWY-7234

GENE_ASSOCIATION: (CHC_T00008097001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_AICAR_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_FUM_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_RXN__45__8654" name="RXN-8654" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: PWY0-522 , PWY-6984

GENE_ASSOCIATION: (CHC_T00006203001_1)

CATEGORIES: ORTHOLOGY

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_ATP_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_PROTON_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LIPOIC__45__ACID_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_PPI_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_LIPOYL__45__AMP_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
     <reaction id="R_DTDPGLUCDEHYDRAT__45__RXN" name="dTDP-glucose 4,6-dehydratase" reversible="false" fast="false">
       <notes>
         <body xmlns="http://www.w3.org/1999/xhtml">

SUBSYSTEM: DTDPRHAMSYN-PWY , PWY-7318 , PWY-7301 , PWY-7413 , PWY-7315 , PWY-6808 , PWY-7104 , PWY-6974 , PWY-7414 , PWY-7688 , PWY-3221 , PWY-7440 , PWY-6973 , PWY-7316 , PWY-6942 , PWY-6953 , PWY-7657 , PWY-6976 , PWY-7312 , PWY-7814

GENE_ASSOCIATION: (CHC_T00008912001_1) or (CHC_T00008950001_1) or (CHC_T00009237001_1) or (CHC_T00009237001)

CATEGORIES: ORTHOLOGY and ANNOTATION

         </body>
       </notes>
       <listOfReactants>
         <speciesReference species="M_DTDP__45__D__45__GLUCOSE_c" stoichiometry="1" constant="false"/>
       </listOfReactants>
       <listOfProducts>
         <speciesReference species="M_WATER_c" stoichiometry="1" constant="false"/>
         <speciesReference species="M_DTDP__45__DEOH__45__DEOXY__45__GLUCOSE_c" stoichiometry="1" constant="false"/>
       </listOfProducts>
     </reaction>
   </listOfReactions>
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     <fbc:fluxBound fbc:reaction="R_RXN__45__6271" fbc:operation="greaterEqual" fbc:value="0"/>
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     <fbc:fluxBound fbc:reaction="R_2__46__4__46__1__46__119__45__RXN" fbc:operation="greaterEqual" fbc:value="0"/>
     <fbc:fluxBound fbc:reaction="R_PSERPHOSPHA__45__RXN" fbc:operation="lessEqual" fbc:value="1000"/>
     <fbc:fluxBound fbc:reaction="R_PSERPHOSPHA__45__RXN" fbc:operation="greaterEqual" fbc:value="0"/>
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     <fbc:fluxBound fbc:reaction="R_RXN__45__12193" fbc:operation="greaterEqual" fbc:value="0"/>
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     <fbc:fluxBound fbc:reaction="R_RXN__45__8665" fbc:operation="greaterEqual" fbc:value="0"/>
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     <fbc:fluxBound fbc:reaction="R_RXN__45__16137" fbc:operation="greaterEqual" fbc:value="0"/>
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     <fbc:fluxBound fbc:reaction="R_RXN0__45__6382" fbc:operation="greaterEqual" fbc:value="0"/>
     <fbc:fluxBound fbc:reaction="R_RXN__45__13892" fbc:operation="lessEqual" fbc:value="1000"/>
     <fbc:fluxBound fbc:reaction="R_RXN__45__13892" fbc:operation="greaterEqual" fbc:value="0"/>
     <fbc:fluxBound fbc:reaction="R_TYROSINE__45____45__TRNA__45__LIGASE__45__RXN" fbc:operation="lessEqual" fbc:value="1000"/>
     <fbc:fluxBound fbc:reaction="R_TYROSINE__45____45__TRNA__45__LIGASE__45__RXN" fbc:operation="greaterEqual" fbc:value="0"/>
     <fbc:fluxBound fbc:reaction="R_UBIQUITIN__45____45__PROTEIN__45__LIGASE__45__RXN" fbc:operation="lessEqual" fbc:value="1000"/>
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     <fbc:fluxBound fbc:reaction="R_RXN__45__14213" fbc:operation="greaterEqual" fbc:value="0"/>
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 </model>

</sbml>