HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN

Reaction HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN

• common-name:
  • hydroxymethyl glutaryl-coa synthase
• direction:
  • reversible
• ec-number:
  • ec-2.3.3.10

Reaction formula

• 1 ACETOACETYL-COA[c] + 1 ACETYL-COA[c] + 1 WATER[c] <=> 1 3-HYDROXY-3-METHYL-GLUTARYL-COA[c] + 1 CO-A[c] + 1 PROTON[c]

Gene(s) associated with this reaction

• Gene: g4023.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: g4145.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: output_pantograph_ectocarpus_siliculosus, Tool: pantograph, Assignment: n.a, Comment: n.a
    • Source: output_pantograph_arabidopsis_thaliana, Tool: pantograph, Assignment: n.a, Comment: n.a
    • Source: output_pantograph_saccharina_japonica, Tool: pantograph, Assignment: n.a, Comment: n.a

Pathway(s)

• PWY66-367, ketogenesis:
  • 4 reactions found over 5 reactions in the full pathway
• PWY-7524, mevalonate pathway III (Thermoplasma):
  • 5 reactions found over 8 reactions in the full pathway
• PWY-7391, isoprene biosynthesis II (engineered):
  • 7 reactions found over 8 reactions in the full pathway
• PWY-6174, mevalonate pathway II (haloarchaea):
  • 6 reactions found over 7 reactions in the full pathway
• PWY-922, mevalonate pathway I (eukaryotes and bacteria):
  • 7 reactions found over 7 reactions in the full pathway
• PWY-7571, ferrichrome A biosynthesis:
  • 1 reactions found over 5 reactions in the full pathway

Reconstruction information

• category: annotation; source: cladosiphon_okamuranus; tool: pathwaytools; comment: n.a
• category: orthology; source: output_pantograph_arabidopsis_thaliana; tool: pantograph; comment: n.a
• category: orthology; source: output_pantograph_ectocarpus_siliculosus; tool: pantograph; comment: n.a
• category: orthology; source: output_pantograph_saccharina_japonica; tool: pantograph; comment: n.a

External links

• METANETX-RXN : MNXR107257
• RHEA:
  • 10191
• LIGAND-RXN:
  • R01978
• UNIPROT:
  • P13704
  • P22791
  • P54870
  • P54869
  • O51626
  • Q9CFA9
  • P17425
  • Q7LZE7
  • Q01581
  • P54961
  • P54839
  • P54874
  • P54868
  • P54873
  • P93773