2.4.1.224-RXN

Reaction 2.4.1.224-RXN

• common-name:
  • n-acetylglucosaminyl-proteoglycan 4-β-glucuronosyltransferase
  • glucuronosyl-n-acetylglucosaminyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase
• direction:
  • left-to-right
• ec-number:
  • ec-2.4.1.224

Reaction formula

• 1 GlcA-GlcNAc-GlcA-Gal-Gal-Xyl-Protein[c] + 1 UDP-N-ACETYL-D-GLUCOSAMINE[c] => 1 GlcNAc-GlcA-GlcNAc-GlcA-Gal-Gal-Xyl-Core[c] + 1 PROTON[c] + 1 UDP[c]

Gene(s) associated with this reaction

• Gene: g5428.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: output_pantograph_saccharina_japonica, Tool: pantograph, Assignment: n.a, Comment: n.a
• Gene: g14997.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: g13333.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: output_pantograph_saccharina_japonica, Tool: pantograph, Assignment: n.a, Comment: n.a
• Gene: g18599.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: g13335.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: output_pantograph_saccharina_japonica, Tool: pantograph, Assignment: n.a, Comment: n.a
• Gene: g10340.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: g18599.t2
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: g13334.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: output_pantograph_saccharina_japonica, Tool: pantograph, Assignment: n.a, Comment: n.a
• Gene: g4449.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: g13335.t2
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: go-term, Comment: n.a
  • Category: orthology
    • Source: output_pantograph_saccharina_japonica, Tool: pantograph, Assignment: n.a, Comment: n.a
• Gene: g10341.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: go-term, Comment: n.a
• Gene: g16308.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: g7975.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
• Gene: g10339.t1
  • Category: annotation
    • Source: cladosiphon_okamuranus, Tool: pathwaytools, Assignment: ec-number, Comment: n.a

Pathway(s)

• PWY-6558, heparan sulfate biosynthesis (late stages):
  • 7 reactions found over 13 reactions in the full pathway

Reconstruction information

• category: orthology; source: output_pantograph_saccharina_japonica; tool: pantograph; comment: n.a
• category: annotation; source: cladosiphon_okamuranus; tool: pathwaytools; comment: n.a

External links

• METANETX-RXN : MNXR115129
• RHEA:
  • 16214
• LIGAND-RXN:
  • R07334