############# Model summary Number of compounds: 1586 Number of reactions: 1565 Number of genes: 1317 Ratio rxn with genes/rxns: 77.38019169329074% ############# Analyzing targets #Topological analysis Number of targets: 85 #Flux Balance Analysis ACET_c // ACET_c 1000.0 positive ACETYL__45__COA_c // ACETYL-COA_c 1000.0 positive L__45__ALPHA__45__ALANINE_c // L-ALPHA-ALANINE_c 1000.0 positive ARG_c // ARG_c 375.00000000000057 positive ASN_c // ASN_c 750.0000000000009 positive L__45__ASPARTATE_c // L-ASPARTATE_c 1000.0 positive BIOTIN_c // BIOTIN_c 1000.0 positive CIT_c // CIT_c 1000.0 positive CYS_c // CYS_c 1000.0 positive CPD__45__12826_c // CPD-12826_c 639.5631067961119 positive FORMATE_c // FORMATE_c 1000.0 positive FRUCTOSE__45__6P_c // FRUCTOSE-6P_c 1000.0 positive FRUCTOSE__45__16__45__DIPHOSPHATE_c // FRUCTOSE-16-DIPHOSPHATE_c 1000.0 positive GAP_c // GAP_c 1000.0 positive DPG_c // DPG_c 1000.0 positive G3P_c // G3P_c 1000.0 positive 2__45__PG_c // 2-PG_c 1000.0 positive GLY_c // GLY_c 1000.0 positive Glycogens_c // Glycogens_c 1000.0 positive GLT_c // GLT_c 1000.0 positive GLN_c // GLN_c 750.0000000000005 positive HIS_c // HIS_c 444.7513812154699 positive THREO__45__DS__45__ISO__45__CITRATE_c // THREO-DS-ISO-CITRATE_c 1000.0 positive ILE_c // ILE_c 849.9999999999998 positive LEU_c // LEU_c 850.0 positive LYS_c // LYS_c 653.8461538461542 positive MAL_c // MAL_c 1000.0 positive MESO__45__DIAMINOPIMELATE_c // MESO-DIAMINOPIMELATE_c 687.5000000000005 positive MET_c // MET_c 1000.0000000000014 positive OXALACETIC_ACID_c // OXALACETIC_ACID_c 1000.0 positive 2__45__KETOGLUTARATE_c // 2-KETOGLUTARATE_c 1000.0 positive PANTOTHENATE_c // PANTOTHENATE_c 800.0000000000036 positive PHE_c // PHE_c 642.857142857143 positive PHOSPHO__45__ENOL__45__PYRUVATE_c // PHOSPHO-ENOL-PYRUVATE_c 1000.0 positive PRO_c // PRO_c 1000.0 positive PYRUVATE_c // PYRUVATE_c 1000.0 positive RIBOSE__45__5P_c // RIBOSE-5P_c 1000.0 positive RIBULOSE__45__5P_c // RIBULOSE-5P_c 1000.0 positive SER_c // SER_c 1000.0 positive SUC__45__COA_c // SUC-COA_c 1000.0 positive SUC_c // SUC_c 1000.0 positive THR_c // THR_c 1000.0000000000005 positive TRP_c // TRP_c 470.58823529411796 positive TYR_c // TYR_c 727.2727272727276 positive VAL_c // VAL_c 999.9999999999998 positive XYLULOSE__45__5__45__PHOSPHATE_c // XYLULOSE-5-PHOSPHATE_c 1000.0 positive C3_c // C3_c 139.81762917933128 positive C1_c // C1_c 139.81762917933136 positive CPD0__45__1456_c // CPD0-1456_c 291.1392405063291 positive CPD__45__7695_c // CPD-7695_c 56.149732620320854 positive UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE_c // UDP-AAGM-DIAMINOHEPTANEDIOATE_c 174.90494296577944 positive ADENINE_c // ADENINE_c 1000.0 positive GUANINE_c // GUANINE_c 1000.0000000000048 positive CYTOSINE_c // CYTOSINE_c 0.0 NULL THYMINE_c // THYMINE_c 6.3779128863135 positive DCTP_c // DCTP_c 424.24242424242425 positive TTP_c // TTP_c 538.4615384615386 positive GTP_c // GTP_c 1000.0 positive NADP_c // NADP_c 1000.0 positive 5__45__METHYL__45__THF_c // 5-METHYL-THF_c 825.5813953488378 positive PYRIDOXAL_PHOSPHATE_c // PYRIDOXAL_PHOSPHATE_c 727.2727272727271 positive CO__45__A_c // CO-A_c 1000.0 positive SPERMIDINE_c // SPERMIDINE_c 404.7619047619045 positive THF_c // THF_c 737.5000000000001 positive CTP_c // CTP_c 437.5 positive CPD__45__9649_c // CPD-9649_c 69.00328587075575 positive FAD_c // FAD_c 1000.0 positive PROTOHEME_c // PROTOHEME_c 149.99999999999991 positive ATP_c // ATP_c 1000.0 positive S__45__ADENOSYLMETHIONINE_c // S-ADENOSYLMETHIONINE_c 1000.0000000000001 positive DGTP_c // DGTP_c 1000.0000000000001 positive ADENOSYLCOBALAMIN_c // ADENOSYLCOBALAMIN_c 999.9999999999999 positive 10__45__FORMYL__45__THF_c // 10-FORMYL-THF_c 719.5121951219512 positive CPD__45__12125_c // CPD-12125_c 91.8367346938775 positive UTP_c // UTP_c 583.3333333333337 positive Glutamates_c // Glutamates_c 0.0 NULL ACP_c // ACP_c 0.0 NULL NAD_c // NAD_c 1000.0 positive RIBOFLAVIN_c // RIBOFLAVIN_c 500.00000000000006 positive REDUCED__45__MENAQUINONE_c // REDUCED-MENAQUINONE_c 81.924577373212 positive DATP_c // DATP_c 1000.0 positive PPI_c // PPI_c 1000.0 positive Pi_c // Pi_c 1000.0 positive PROTON_c // PROTON_c 1000.0 positive ADP_c // ADP_c 1000.0 positive ############# Computing optimization Testing reaction biomass Growth rate: 136.93483723478303 Status: optimal IN FLUXES OUT FLUXES OBJECTIVES ------------------------ --------------- ------------ AMMONIUM_e 1e+03 PROTON_e 1e+03 biomass 137 ATP_e 1e+03 CL__45___e 1e+03 FE__43__2_e 1e+03 K__43___e 1e+03 ZN__43__2_e 1e+03 CELLULOSE_e 500 NAD_e 221 NADP_e 165 Pi_e 119 CYS_e 33.3 P__45__AMINO... 1.92 BIOTIN_e 0.639 CA__43__2_e 0.639 COB__45__I__... 0.639 CO__43__2_e 0.639 FAD_e 0.639 FE__43__3_e 0.639 KCL_e 0.639 MG__43__2_e 0.639 MN__43__2_e 0.639 Na__43___e 0.639 CO__45__A_e 0.639 FVA analysis: Blocked reactions: 902 Essential reactions: 137 RXN__45__15130 3__45__DEHYDROQUINATE__45__DEHYDRATASE__45__RXN CHORISMATEMUT__45__RXN ACETOLACTSYN__45__RXN R00946 THRESYN__45__RXN PREPHENATEDEHYDRAT__45__RXN ATPPHOSPHORIBOSYLTRANS__45__RXN RXN__45__12002 HISTAMINOTRANS__45__RXN OROTPDECARB__45__RXN RXN__45__19366 R04560 3__45__DEHYDROQUINATE__45__SYNTHASE__45__RXN GPPSYN__45__RXN COBALADENOSYLTRANS__45__RXN O__45__SUCCINYLBENZOATE__45__COA__45__SYN__45__RXN ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN PRTRANS__45__RXN ACETOOHBUTREDUCTOISOM__45__RXN HOMOSERKIN__45__RXN RXN__45__8992 RXN__45__19775 NAPHTHOATE__45__SYN__45__RXN PRIBFAICARPISOM__45__RXN ASPARTATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN ASPARTATEKIN__45__RXN DMK__45__RXN GTP__45__CYCLOHYDRO__45__I__45__RXN DTDPKIN__45__RXN THYMIDYLATESYN__45__RXN GTP__45__CYCLOHYDRO__45__II__45__RXN ISOCHORSYN__45__RXN ACETOOHBUTSYN__45__RXN RIBOFLAVIN__45__SYN__45__RXN OHMETHYLBILANESYN__45__RXN 2__46__5__46__1__46__19__45__RXN 2__45__ISOPROPYLMALATESYN__45__RXN IGPSYN__45__RXN RXN__45__12590 DTMPKI__45__RXN DAHPSYN__45__RXN CDPKIN__45__RXN RIBOFLAVINSYNDEAM__45__RXN GLYCOLALD__45__DEHYDROG__45__RXN RXN__45__17518 ASPCARBTRANS__45__RXN RXN__45__9138 OROPRIBTRANS__45__RXN RXN__45__9190 GLYCOLATE__45__REDUCTASE__45__RXN RXN0__45__723 BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN IMIDPHOSDEHYD__45__RXN DXPREDISOM__45__RXN BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN RIBOFLAVINSYNREDUC__45__RXN CHORISMATE__45__SYNTHASE__45__RXN RXN__45__9191 RXN0__45__302 RIBOPHOSPHAT__45__RXN IMP__45__DEHYDROG__45__RXN RXN__45__17519 RXN__45__9310 ACETOLACTREDUCTOISOM__45__RXN GUANYL__45__KIN__45__RXN IMPCYCLOHYDROLASE__45__RXN ADENOSYLHOMOCYSTEINASE__45__RXN O__45__SUCCHOMOSERLYASE__45__RXN 1__46__5__46__1__46__20__45__RXN PRAISOM__45__RXN ExchangeSeed__45__BIOTIN FPPSYN__45__RXN ExchangeSeed__45__CA__43__2 2__46__5__46__1__46__64__45__RXN ExchangeSeed__45__KCL ExchangeSeed__45__MG__43__2 DIHYDRODIPICSYN__45__RXN ExchangeSeed__45__MN__43__2 DIHYDROFOLATEREDUCT__45__RXN DIOHBUTANONEPSYN__45__RXN TransportSeed__45__KCL RXN__45__9311 UDPKIN__45__RXN ExchangeSeed__45__CO__43__2 LCYSDESULF__45__RXN RXN__45__19329 DXS__45__RXN ExchangeSeed__45__COB__45__I__45__ALAMIN DIHYDROFOLATESYNTH__45__RXN RXN__45__19334 RXN__45__11832 UROGENDECARBOX__45__RXN HISTIDPHOS__45__RXN SHIKIMATE__45__5__45__DEHYDROGENASE__45__RXN UROGENIIISYN__45__RXN ExchangeSeed__45__Na__43__ GLCS1 AICARTRANSFORM__45__RXN biomass LUMAZINESYN__45__RXN ExchangeSeed__45__P__45__AMINO__45__BENZOATE H2PTERIDINEPYROPHOSPHOKIN__45__RXN H2PTEROATESYNTH__45__RXN 1__46__6__46__5__46__6__45__RXN SHIKIMATE__45__KINASE__45__RXN ADOMET__45__DMK__45__METHYLTRANSFER__45__RXN DIHYDROOROT__45__RXN 2__46__7__46__1__46__148__45__RXN HISTPRATPHYD__45__RXN RXN0__45__7325 TransportSeed__45__BIOTIN PORPHOBILSYNTH__45__RXN RXN__45__11564 RXN__45__19340 ANTHRANSYN__45__RXN TransportSeed__45__Na__43__ TransportSeed__45__CYS ExchangeSeed__45__CYS RXN__45__11566 S__45__ADENMETSYN__45__RXN TransportSeed__45__P__45__AMINO__45__BENZOATE RXN__45__19341 DIAMINOPIMDECARB__45__RXN Export_Bio TransportSeed__45__CA__43__2 DIHYDROXYISOVALDEHYDRAT__45__RXN ExchangeSeed__45__FE__43__2 ExchangeSeed__45__ZN__43__2 DIHYDROXYMETVALDEHYDRAT__45__RXN ExchangeSeed__45__FE__43__3 HOMOSERDEHYDROG__45__RXN TRIPHOSPHATASE__45__RXN 2__46__7__46__7__46__60__45__RXN HOMOCYSMETB12__45__RXN HISTCYCLOHYD__45__RXN RXN__45__14014 Essential genes: 16 56/56 compounds with positive flux 0/56 compounds without flux WATER_c // WATER_c 42.65833242858074 positive 5__45__METHYL__45__THF_c // 5-METHYL-THF_c 37.949013043020486 positive L__45__ALPHA__45__ALANINE_c // L-ALPHA-ALANINE_c 37.93985463600021 positive PRO_c // PRO_c 37.885545320146036 positive CO__43__2_c // CO+2_c 37.9466145505608 positive ARG_c // ARG_c 37.9232426162849 positive PYRIDOXAL_PHOSPHATE_c // PYRIDOXAL_PHOSPHATE_c 37.94377462261496 positive CA__43__2_c // CA+2_c 37.94661455056057 positive L__45__ASPARTATE_c // L-ASPARTATE_c 37.96566221526099 positive FE__43__2_c // FE+2_c 37.946614550560064 positive SPERMIDINE_c // SPERMIDINE_c 37.94427946762613 positive THF_c // THF_c 37.94958115143495 positive PHE_c // PHE_c 37.79343461396555 positive CTP_c // CTP_c 37.911525875624385 positive CPD__45__9649_c // CPD-9649_c 37.32432156782815 positive LEU_c // LEU_c 37.781271455501184 positive FAD_c // FAD_c 37.94964427564196 positive ATP_c // ATP_c 85.23777807336002 positive PROTOHEME_c // PROTOHEME_c 37.92920301497574 positive BIOTIN_c // BIOTIN_c 37.946614550560575 positive FE__43__3_c // FE+3_c 37.94661455056057 positive SER_c // SER_c 37.969310301347015 positive S__45__ADENOSYLMETHIONINE_c // S-ADENOSYLMETHIONINE_c 37.9485080720432 positive DGTP_c // DGTP_c 37.96537254514791 positive Na__43___c // Na+_c 37.946614550560525 positive THR_c // THR_c 37.943279983787214 positive ADENOSYLCOBALAMIN_c // ADENOSYLCOBALAMIN_c 37.94964427564198 positive 10__45__FORMYL__45__THF_c // 10-FORMYL-THF_c 37.94945490365077 positive GLN_c // GLN_c 37.932773949460596 positive CPD__45__12125_c // CPD-12125_c 37.919999025146254 positive DCTP_c // DCTP_c 37.937401312240176 positive MET_c // MET_c 37.91030429123989 positive HIS_c // HIS_c 37.924086173759335 positive TYR_c // TYR_c 37.84884937969715 positive TTP_c // TTP_c 37.93486051651529 positive LYS_c // LYS_c 37.856632404506705 positive GTP_c // GTP_c 38.139840408869304 positive ASN_c // ASN_c 37.96248627665029 positive ILE_c // ILE_c 37.839948232392615 positive UTP_c // UTP_c 37.910614538145424 positive NADP_c // NADP_c 37.94661455056046 positive TRP_c // TRP_c 37.88927805826159 positive KCL_c // KCL_c 37.94661455056052 positive GLT_c // GLT_c 37.93623315310855 positive VAL_c // VAL_c 37.84117174061785 positive GLY_c // GLY_c 38.01116884494104 positive CYS_c // CYS_c 37.94661455056057 positive NAD_c // NAD_c 37.946614550560454 positive Glycogens_c // Glycogens_c 37.94661455056039 positive RIBOFLAVIN_c // RIBOFLAVIN_c 37.94661455056059 positive MN__43__2_c // MN+2_c 37.94661455056063 positive ZN__43__2_c // ZN+2_c 37.9466145505609 positive MG__43__2_c // MG+2_c 37.94661455056063 positive REDUCED__45__MENAQUINONE_c // REDUCED-MENAQUINONE_c 37.91703704728645 positive DATP_c // DATP_c 37.96250995753962 positive CO__45__A_c // CO-A_c 37.94661455056059 positive