3-ISOPROPYLMALISOM-RXN

Reaction 3-ISOPROPYLMALISOM-RXN

• direction:
  • reversible
• common-name:
  • 3-isopropylmalate dehydratase
  • (2s)-2-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
• synonymous:
  • α-isopropylmalate isomerase
  • 3-isopropylmalate hydro-lyase
  • (2r,3s)-3-isopropylmalate hydro-lyase
  • β-isopropylmalate dehydratase

Reaction formula

• 1 CPD-9451[c] + 1 WATER[c] <=> 1 3-CARBOXY-3-HYDROXY-ISOCAPROATE[c]

Gene(s) associated with this reaction

• Gene: SJ22396
  • Category: annotation
    • Source: saccharina_japonica_genome, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: output_pantograph_nannochloropsis_salina, Tool: pantograph, Assignment: n.a, Comment: n.a
    • Source: output_pantograph_arabidopsis_thaliana, Tool: pantograph, Assignment: n.a, Comment: n.a
    • Source: output_pantograph_ectocarpus_siliculosus, Tool: pantograph, Assignment: n.a, Comment: n.a
• Gene: SJ09771
  • Category: annotation
    • Source: saccharina_japonica_genome, Tool: pathwaytools, Assignment: ec-number, Comment: n.a
  • Category: orthology
    • Source: output_pantograph_nannochloropsis_salina, Tool: pantograph, Assignment: n.a, Comment: n.a
    • Source: output_pantograph_arabidopsis_thaliana, Tool: pantograph, Assignment: n.a, Comment: n.a
    • Source: output_pantograph_ectocarpus_siliculosus, Tool: pantograph, Assignment: n.a, Comment: n.a

Pathway(s)

• LEUSYN-PWY, L-leucine biosynthesis:
  • 5 reactions found over 6 reactions in the full pathway
• PWY-6871, 3-methylbutanol biosynthesis (engineered):
  • 5 reactions found over 7 reactions in the full pathway

Reconstruction information

• category: annotation; source: saccharina_japonica_genome; tool: pathwaytools; comment: n.a
• category: orthology; source: output_pantograph_nannochloropsis_salina; tool: pantograph; comment: n.a
• category: orthology; source: output_pantograph_ectocarpus_siliculosus; tool: pantograph; comment: n.a
• category: orthology; source: output_pantograph_arabidopsis_thaliana; tool: pantograph; comment: n.a

External links

• METANETX-RXN : MNXR100826
• RHEA:
  • 16296
• LIGAND-RXN:
  • R03968
• UNIPROT:
  • Q9PLW1
  • Q9JU82
  • P80858
  • Q9UZ07
  • Q9JU81
  • Q58673
  • Q02144
  • P44968
  • Q58667
  • P44438
  • P0A6A6
  • Q9PLW2
  • Q44022
  • Q44023
  • Q44427
  • P17279
  • P04787
  • P15717
  • P18250
  • Q02142
  • P30126
  • P50181
  • P07264
  • P74207
  • O86534
  • O86535