Difference between revisions of "Main Page"

From metabolic_network
Jump to navigation Jump to search
(Created page with "Category:reaction == Reaction [http://metacyc.org/META/NEW-IMAGE?object=3.4.23.15-RXN 3.4.23.15-RXN] == * direction: ** left-to-right * common-name: ** renin-2 * ec-number...")
 
(Created page with "== SJAPGEM description == ''Saccharina japonica'' is the most cultivated alga worldwide, with nearly 8 millions tons of dry weight harvested in 2014, representing more than U...")
 
(9 intermediate revisions by 5 users not shown)
Line 1: Line 1:
[[Category:reaction]]
+
== SJAPGEM description ==
== Reaction [http://metacyc.org/META/NEW-IMAGE?object=3.4.23.15-RXN 3.4.23.15-RXN] ==
+
 
* direction:
+
''Saccharina japonica'' is the most cultivated alga worldwide, with nearly 8 millions tons of dry weight harvested in 2014, representing more than US $1.3 billion value ([http://www.fao.org/fishery/culturedspecies/Laminaria_japonica/en#tcNA008C Chen J., FAO website, accessed on january 10th, 2019]).
** left-to-right
+
Its draft genome sequence was published in 2015 ([http://doi.org/10.1038/ncomms7986 Ye et al., Nature Communications]). The genome version used here underwent an additional round of cleaning for bacterial contaminants using Taxoblast ([https://doi.org/10.7717/peerj.4073 Dittami and Corre, 2017]). The paper describing this GEM reconstruction in more detail was published in 2019 ([https://doi.org/10.3390/antiox8110564 Nègre et al., Antioxidants]). In this study, extensive manual curation was performed on the carotenoid biosynthesis pathway (CAROTENOID-PWY) and on the first cycle of xanthophylls (PWY-5945). In a follow-up study (Girard et al., in preparation) we are now curating the sterol biosynthesis pathways (PWY-8191, PWY-8238).  
* common-name:
+
 
** renin-2
+
== Automatic reconstruction with [https://aureme.genouest.org AuReMe] ==
* ec-number:
+
Model summary: [[MEDIA:summary.txt|summary]]
** [http://enzyme.expasy.org/EC/3.4.23.15 ec-3.4.23.15]
+
 
== Reaction formula ==
+
Download '''AuReMe''' Input/Output [LINK OR MEDIA data]
* 1 [[Angiotensinogens]][c] '''+''' 1 [[WATER]][c] '''=>''' 1 [[CPD-13004]][c] '''+''' 1 [[Cleaved-Angiotensinogen]][c]
+
 
== Gene(s) associated with this reaction  ==
+
The automatic reconstruction of ''Saccharina japonica'' results to a Genome scale [[MEDIA:S.japonica carotenoid curated.sbml|Model]] containing 3348 reactions, 3249 metabolites, 5018 genes and 1389 pathways. This GeM was obtained based on the following sources:
* Gene: [[SJ16973]]
+
* Based on annotation data:
** Category: [[annotation]]
+
** Tool: [http://bioinformatics.ai.sri.com/ptools/ Pathway tools]
*** Source: [[saccharina_japonica_genome]], Tool: [[pathwaytools]], Assignment: ec-number, Comment: n.a
+
*** Creation of a metabolic network containing 2551 reactions
== Pathway(s)  ==
+
* Based on orthology data:
== Reconstruction information  ==
+
** Tool: [http://pathtastic.gforge.inria.fr Pantograph]
* category: [[annotation]]; source: [[saccharina_japonica_genome]]; tool: [[pathwaytools]]; comment: n.a
+
*** From template ''NANNOCHLOROPSIS_SALINA'' ([https://doi.org/10.1186/s12918-017-0441-1 Loira et al., 2017]) creation of a metabolic network containing: 589 reactions
== External links  ==
+
*** From template ''ARABIDOPSIS_THALIANA'' ([https://doi.org/10.1104/pp.109.148817 De Oliveira dal'Molin et al., 2010]) creation of a metabolic network containing: 419 reactions
* UNIPROT:
+
*** From template ''[https://gem-aureme.genouest.org/esilgem/ ECTOCARPUS_SILICULOSUS]'' creation of a metabolic network containing: 1492 reactions
** [http://www.uniprot.org/uniprot/Q7M3D2 Q7M3D2]
+
* Based on expertise:
** [http://www.uniprot.org/uniprot/P52115 P52115]
+
** 99 reaction(s) added
** [http://www.uniprot.org/uniprot/P00797 P00797]
+
* Based on gap-filling:
** [http://www.uniprot.org/uniprot/P06281 P06281]
+
** Tool: [https://pypi.python.org/pypi/meneco meneco]
** [http://www.uniprot.org/uniprot/P00796 P00796]
+
*** 90 reaction(s) added
** [http://www.uniprot.org/uniprot/P08424 P08424]
+
 
{{#set: direction=left-to-right}}
+
[[FILE:venn.png|frameless|border]]
{{#set: common-name=renin-2}}
+
 
{{#set: ec-number=ec-3.4.23.15}}
+
 
{{#set: nb gene associated=1}}
+
== Collaborative curation ==  
{{#set: nb pathway associated=0}}
+
* Suggest reactions to add or remove:
{{#set: reconstruction category=annotation}}
+
** Download this [[MEDIA:Add_delete_reaction.csv|form]]
{{#set: reconstruction tool=pathwaytools}}
+
* Suggest new reactions to create and add:
{{#set: reconstruction comment=n.a}}
+
** Download this [[MEDIA:Reaction_creator.csv|form]]
{{#set: reconstruction source=saccharina_japonica_genome}}
+
* '''Follow the examples given in the form(s) to correctly share your suggestions'''
 +
* Send the filled form(s) to: gabriel.markov@sb-roscoff.fr

Latest revision as of 11:18, 18 March 2021

SJAPGEM description

Saccharina japonica is the most cultivated alga worldwide, with nearly 8 millions tons of dry weight harvested in 2014, representing more than US $1.3 billion value (Chen J., FAO website, accessed on january 10th, 2019). Its draft genome sequence was published in 2015 (Ye et al., Nature Communications). The genome version used here underwent an additional round of cleaning for bacterial contaminants using Taxoblast (Dittami and Corre, 2017). The paper describing this GEM reconstruction in more detail was published in 2019 (Nègre et al., Antioxidants). In this study, extensive manual curation was performed on the carotenoid biosynthesis pathway (CAROTENOID-PWY) and on the first cycle of xanthophylls (PWY-5945). In a follow-up study (Girard et al., in preparation) we are now curating the sterol biosynthesis pathways (PWY-8191, PWY-8238).

Automatic reconstruction with AuReMe

Model summary: summary

Download AuReMe Input/Output [LINK OR MEDIA data]

The automatic reconstruction of Saccharina japonica results to a Genome scale Model containing 3348 reactions, 3249 metabolites, 5018 genes and 1389 pathways. This GeM was obtained based on the following sources:

  • Based on annotation data:
    • Tool: Pathway tools
      • Creation of a metabolic network containing 2551 reactions
  • Based on orthology data:
  • Based on expertise:
    • 99 reaction(s) added
  • Based on gap-filling:
    • Tool: meneco
      • 90 reaction(s) added

Venn.png


Collaborative curation

  • Suggest reactions to add or remove:
  • Suggest new reactions to create and add:
  • Follow the examples given in the form(s) to correctly share your suggestions
  • Send the filled form(s) to: gabriel.markov@sb-roscoff.fr